{"id":"https://openalex.org/W2914799396","doi":"https://doi.org/10.1016/j.ajo.2019.02.001","title":"The Genetic Influence on Corticosteroid-Induced Ocular Hypertension: A Field Positioned for Discovery","display_name":"The Genetic Influence on Corticosteroid-Induced Ocular Hypertension: A Field Positioned for Discovery","publication_year":2019,"publication_date":"2019-02-11","ids":{"openalex":"https://openalex.org/W2914799396","doi":"https://doi.org/10.1016/j.ajo.2019.02.001","mag":"2914799396","pmid":"https://pubmed.ncbi.nlm.nih.gov/30763540"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajo.2019.02.001","doi":"https://doi.org/10.1016/j.ajo.2019.02.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ajo.2019.02.001","pdf_url":null,"source":{"id":"https://openalex.org/S50016660","display_name":"American Journal of Ophthalmology","issn_l":"0002-9394","issn":["0002-9394","1879-1891"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091067995","display_name":"Weilin Chan","orcid":"https://orcid.org/0000-0003-1417-9606","observed_orcids":["https://orcid.org/0000-0003-1417-9606"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weilin Chan","raw_affiliation_strings":["Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086641481","display_name":"Janey L. Wiggs","orcid":"https://orcid.org/0000-0003-1890-3278","observed_orcids":["https://orcid.org/0000-0003-1890-3278"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janey L. Wiggs","raw_affiliation_strings":["Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076751606","display_name":"Lucia Sobrin","orcid":"https://orcid.org/0000-0003-1575-0819","observed_orcids":["https://orcid.org/0000-0003-1575-0819"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lucia Sobrin","raw_affiliation_strings":["Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: lucia_sobrin@meei.harvard.edu","Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: lucia_sobrin@meei.harvard.edu","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076751606"],"corresponding_institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.4622,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.34451613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"202","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticosteroid-induced-ocular-hypertension","display_name":"corticosteroid-induced ocular hypertension","score":0.996999979019165},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.75},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.8659999966621399},{"id":"https://openalex.org/keywords/primary-open-angle-glaucoma","display_name":"primary open-angle glaucoma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/family-history-medicine","display_name":"family history (medicine)","score":0.7860000133514404},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gene-sequencing","display_name":"gene sequencing","score":0.4429999887943268},{"id":"https://openalex.org/keywords/corticosteroid-side-effects","display_name":"corticosteroid adverse effects","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5096747875213623},{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.4695703983306885},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.32194843888282776},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.1594938337802887}],"mesh":[{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009798","descriptor_name":"Ocular Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009798","descriptor_name":"Ocular Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009798","descriptor_name":"Ocular Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ajo.2019.02.001","doi":"https://doi.org/10.1016/j.ajo.2019.02.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ajo.2019.02.001","pdf_url":null,"source":{"id":"https://openalex.org/S50016660","display_name":"American Journal of Ophthalmology","issn_l":"0002-9394","issn":["0002-9394","1879-1891"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmid:30763540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30763540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of ophthalmology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5299999713897705}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W205401210","https://openalex.org/W1528523709","https://openalex.org/W1597473244","https://openalex.org/W1965205901","https://openalex.org/W1972726442","https://openalex.org/W1976850484","https://openalex.org/W1979552814","https://openalex.org/W1994624502","https://openalex.org/W2000248319","https://openalex.org/W2020862949","https://openalex.org/W2023036475","https://openalex.org/W2023513569","https://openalex.org/W2052351336","https://openalex.org/W2053290948","https://openalex.org/W2074278622","https://openalex.org/W2085532914","https://openalex.org/W2086857319","https://openalex.org/W2096747572","https://openalex.org/W2106529000","https://openalex.org/W2108437390","https://openalex.org/W2127642207","https://openalex.org/W2136188592","https://openalex.org/W2141969663","https://openalex.org/W2145192598","https://openalex.org/W2165714304","https://openalex.org/W2397854391","https://openalex.org/W2413901835","https://openalex.org/W2499240546","https://openalex.org/W2521871063","https://openalex.org/W2585778931","https://openalex.org/W2762058314","https://openalex.org/W2771217310","https://openalex.org/W2803323905","https://openalex.org/W2807017062","https://openalex.org/W2897631476","https://openalex.org/W3023308821","https://openalex.org/W4245578354"],"related_works":["https://openalex.org/W2944875294","https://openalex.org/W2369428464","https://openalex.org/W1997697441","https://openalex.org/W2521871063","https://openalex.org/W2129985473","https://openalex.org/W1965753563","https://openalex.org/W4413158931","https://openalex.org/W7222397951","https://openalex.org/W7161958723","https://openalex.org/W4293094314"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-02-21T00:00:00"}