{"id":"https://openalex.org/W2914698403","doi":"https://doi.org/10.1016/j.jaci.2018.12.710","title":"Stimulating Oxidative DNA-Base Excision Repair in Mice Subjected to Klebsiella pneumoniae\u2013induced Acute Respiratory Distress Syndrome (ARDS) Improves Genomic Integrity of Topoisomerase and Facilitates Innate Lung Inflammation","display_name":"Stimulating Oxidative DNA-Base Excision Repair in Mice Subjected to Klebsiella pneumoniae\u2013induced Acute Respiratory Distress Syndrome (ARDS) Improves Genomic Integrity of Topoisomerase and Facilitates Innate Lung Inflammation","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2914698403","doi":"https://doi.org/10.1016/j.jaci.2018.12.710","mag":"2914698403"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2018.12.710","doi":"https://doi.org/10.1016/j.jaci.2018.12.710","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.12.710","pdf_url":"http://www.jacionline.org/article/S0091674918324527/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jacionline.org/article/S0091674918324527/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104937550","display_name":"Cleavon Covington","orcid":"https://orcid.org/0000-0003-1983-8893","observed_orcids":["https://orcid.org/0000-0003-1983-8893"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cleavon J. Covington","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020297413","display_name":"Koa Hosoki","orcid":"https://orcid.org/0000-0003-4228-2176","observed_orcids":["https://orcid.org/0000-0003-4228-2176"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koa Hosoki","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jian Sha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian Sha","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103223399","display_name":"Anirban Chakraborty","orcid":"https://orcid.org/0000-0002-6558-0179","observed_orcids":["https://orcid.org/0000-0002-6558-0179","https://orcid.org/0009-0003-9492-8335"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anirban Chakraborty","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066447821","display_name":"Nisha Tapryal","orcid":"https://orcid.org/0000-0002-7598-4273","observed_orcids":["https://orcid.org/0000-0002-7598-4273"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nisha Tapryal","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027227041","display_name":"Julia W. Tripple","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Tripple","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102804483","display_name":"Victor J. Cardenas","orcid":"https://orcid.org/0000-0003-2077-9915","observed_orcids":["https://orcid.org/0000-0003-2077-9915"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Cardenas","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050993676","display_name":"Sarah Ainsworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Ainsworth","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061702912","display_name":"Tapas K. Hazra","orcid":"https://orcid.org/0000-0002-4587-687X","observed_orcids":["https://orcid.org/0000-0002-4587-687X"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tapas Hazra","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102821029","display_name":"Ashok K. Chopra","orcid":"https://orcid.org/0000-0002-5223-3012","observed_orcids":["https://orcid.org/0000-0002-5223-3012"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashok Chopra","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076015973","display_name":"Sanjiv A. Sur","orcid":"https://orcid.org/0000-0002-7267-0025","observed_orcids":["https://orcid.org/0000-0002-7267-0025"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjiv Sur","raw_affiliation_strings":["University of Texas Medical Branch, Galveston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston, TX","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01725845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"143","issue":"2","first_page":"AB233","last_page":"AB233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6904000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.6904000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.7879999876022339},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dna-base-excision-repair","display_name":"DNA base excision repair","score":0.8429999947547913},{"id":"https://openalex.org/keywords/neil2","display_name":"NEIL2","score":0.972000002861023},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.8880000114440918},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.8149999976158142},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.9490000009536743},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.6930000185966492},{"id":"https://openalex.org/keywords/early-response-genes","display_name":"early response genes","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5847538113594055},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.5615367293357849},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5426225662231445},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5313084125518799},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5287071466445923},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5023825168609619},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.43667834997177124},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41695427894592285},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41189679503440857},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35179173946380615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2879308760166168},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07042267918586731}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jaci.2018.12.710","doi":"https://doi.org/10.1016/j.jaci.2018.12.710","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.12.710","pdf_url":"http://www.jacionline.org/article/S0091674918324527/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jaci.2018.12.710","doi":"https://doi.org/10.1016/j.jaci.2018.12.710","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.12.710","pdf_url":"http://www.jacionline.org/article/S0091674918324527/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2914698403.pdf","grobid_xml":"https://content.openalex.org/works/W2914698403.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4319333703","https://openalex.org/W113959871","https://openalex.org/W2324684210","https://openalex.org/W2203735107","https://openalex.org/W2512901888","https://openalex.org/W7099049614","https://openalex.org/W4404285060","https://openalex.org/W1976831386","https://openalex.org/W2116829887","https://openalex.org/W2580942140"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2019-02-21T00:00:00"}