{"id":"https://openalex.org/W2914685299","doi":"https://doi.org/10.1158/0008-5472.can-18-3837","title":"Transcriptomics Associates Molecular Features with 18F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma","display_name":"Transcriptomics Associates Molecular Features with 18F-Fluorocholine PET/CT Imaging Phenotype and Its Potential Relationship to Survival in Hepatocellular Carcinoma","publication_year":2019,"publication_date":"2019-02-13","ids":{"openalex":"https://openalex.org/W2914685299","doi":"https://doi.org/10.1158/0008-5472.can-18-3837","mag":"2914685299","pmid":"https://pubmed.ncbi.nlm.nih.gov/30760520","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6494445"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-18-3837","doi":"https://doi.org/10.1158/0008-5472.can-18-3837","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-18-3837","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6494445","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028096127","display_name":"Sandi Alexander Kwee","orcid":"https://orcid.org/0000-0002-4624-8787","observed_orcids":["https://orcid.org/0000-0002-4624-8787"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandi A. Kwee","raw_affiliation_strings":["1Hamamatsu/Queen's PET Imaging Center, The Queen's Medical Center, Honolulu, Hawaii","2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii"],"raw_orcid":"https://orcid.org/0000-0002-4624-8787","affiliations":[{"raw_affiliation_string":"1Hamamatsu/Queen's PET Imaging Center, The Queen's Medical Center, Honolulu, Hawaii","institution_ids":["https://openalex.org/I4210104115"]},{"raw_affiliation_string":"2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014295522","display_name":"Maarit Tiirikainen","orcid":"https://orcid.org/0000-0002-8124-3818","observed_orcids":["https://orcid.org/0000-0002-8124-3818"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maarit Tiirikainen","raw_affiliation_strings":["2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii"],"raw_orcid":"https://orcid.org/0000-0002-8124-3818","affiliations":[{"raw_affiliation_string":"2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068946104","display_name":"Miles M. Sato","orcid":"https://orcid.org/0000-0002-1691-5198","observed_orcids":["https://orcid.org/0000-0002-1691-5198"]},"institutions":[{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miles M. Sato","raw_affiliation_strings":["3The Queen's Medical Center, Queen's Cancer Center, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Queen's Medical Center, Queen's Cancer Center, Honolulu, Hawaii","institution_ids":["https://openalex.org/I4210104115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009845696","display_name":"Jared David Acoba","orcid":"https://orcid.org/0000-0003-4145-8010","observed_orcids":["https://orcid.org/0000-0003-4145-8010"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I4210104115","display_name":"Queen's Medical Center","ror":"https://ror.org/016gbn942","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104115"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared D. Acoba","raw_affiliation_strings":["2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii","3The Queen's Medical Center, Queen's Cancer Center, Honolulu, Hawaii"],"raw_orcid":"https://orcid.org/0000-0003-4145-8010","affiliations":[{"raw_affiliation_string":"2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"3The Queen's Medical Center, Queen's Cancer Center, Honolulu, Hawaii","institution_ids":["https://openalex.org/I4210104115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018164370","display_name":"Runmin Wei","orcid":"https://orcid.org/0000-0001-7707-0160","observed_orcids":["https://orcid.org/0000-0001-7707-0160"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Runmin Wei","raw_affiliation_strings":["2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii"],"raw_orcid":"https://orcid.org/0000-0001-7707-0160","affiliations":[{"raw_affiliation_string":"2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404644","display_name":"Wei Ping Jia","orcid":"https://orcid.org/0000-0002-3739-8994","observed_orcids":["https://orcid.org/0000-0002-3739-8994"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Jia","raw_affiliation_strings":["2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053074659","display_name":"Lo\u0131\u0308c Le Marchand","orcid":"https://orcid.org/0000-0001-5013-980X","observed_orcids":["https://orcid.org/0000-0001-5013-980X"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loic Le Marchand","raw_affiliation_strings":["2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069748932","display_name":"Linda L. Wong","orcid":"https://orcid.org/0000-0003-3143-5384","observed_orcids":["https://orcid.org/0000-0003-3143-5384"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]},{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda L. Wong","raw_affiliation_strings":["2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii","4Department of Surgery, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii"],"raw_orcid":"https://orcid.org/0000-0003-3143-5384","affiliations":[{"raw_affiliation_string":"2Cancer Biology Program, Clinical Sciences Program, and Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I4390039246"]},{"raw_affiliation_string":"4Department of Surgery, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5629,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.81479967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"79","issue":"7","first_page":"1696","last_page":"1704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.10989999771118164,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.09669999778270721,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/18f-choline-pet-ct","display_name":"18F-choline PET/CT","score":0.9700000286102295},{"id":"https://openalex.org/keywords/choline-metabolism","display_name":"choline metabolism","score":0.9100000262260437},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.7170000076293945},{"id":"https://openalex.org/keywords/prognostic-signature","display_name":"prognostic signature","score":0.8209999799728394},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7900000214576721},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.8550000190734863},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.9279999732971191},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/molecular-classification","display_name":"molecular classification","score":0.37299999594688416}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8410725593566895},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6994366645812988},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.47745588421821594},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4437204897403717},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4353838264942169},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.405042827129364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38579806685447693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3727722764015198},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32475948333740234},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18343114852905273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14372298121452332},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12864717841148376}],"mesh":[{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-18-3837","doi":"https://doi.org/10.1158/0008-5472.can-18-3837","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-18-3837","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:30760520","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30760520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5718824","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6494445","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6494445","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6494445","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5718824","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6494445","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1035472155","display_name":"RCMI Multidisciplinary And Translational Research Infrastructure EXpansion (RAMAT","funder_award_id":"U54MD007584","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"},{"id":"https://openalex.org/G8846445174","display_name":"Functional Genomics and Molecular Imaging of Liver Disease and Cancer","funder_award_id":"R01CA161209","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000870016","display_name":"University of Hawaii Cancer Center CCSG","funder_award_id":"P30CA071789","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1506842637","https://openalex.org/W1813458856","https://openalex.org/W1932207593","https://openalex.org/W1968812902","https://openalex.org/W1976280151","https://openalex.org/W1997712087","https://openalex.org/W2023815439","https://openalex.org/W2036922484","https://openalex.org/W2041250508","https://openalex.org/W2046257690","https://openalex.org/W2051621411","https://openalex.org/W2083166156","https://openalex.org/W2088955697","https://openalex.org/W2093035112","https://openalex.org/W2093312253","https://openalex.org/W2097795961","https://openalex.org/W2099789788","https://openalex.org/W2103198304","https://openalex.org/W2118220366","https://openalex.org/W2121833624","https://openalex.org/W2123339548","https://openalex.org/W2123673510","https://openalex.org/W2130410032","https://openalex.org/W2136415416","https://openalex.org/W2158217645","https://openalex.org/W2170845559","https://openalex.org/W2203982515","https://openalex.org/W2292250576","https://openalex.org/W2406021653","https://openalex.org/W2413324865","https://openalex.org/W2543902130","https://openalex.org/W2546772022","https://openalex.org/W2560179362","https://openalex.org/W2560575016","https://openalex.org/W2582878252","https://openalex.org/W2592635067","https://openalex.org/W2612400171","https://openalex.org/W2769505173","https://openalex.org/W2782108316","https://openalex.org/W2789641075","https://openalex.org/W2789953627","https://openalex.org/W2796067155","https://openalex.org/W2808233088","https://openalex.org/W2915809836","https://openalex.org/W6630208819","https://openalex.org/W6640445628","https://openalex.org/W6715721929"],"related_works":["https://openalex.org/W2345269653","https://openalex.org/W2543902130","https://openalex.org/W4210645568","https://openalex.org/W2085330774","https://openalex.org/W2073835458","https://openalex.org/W2969974018","https://openalex.org/W2108266128","https://openalex.org/W2608785020","https://openalex.org/W1645436188","https://openalex.org/W2605165366"],"abstract_inverted_index":{"Abstract":[0],"Studies":[1],"involving":[2],"transcriptomics":[3],"have":[4],"revealed":[5],"multiple":[6,247],"molecular":[7,22,47,152,233],"subtypes":[8],"of":[9,39,49,58,82],"hepatocellular":[10],"carcinoma":[11],"(HCC).":[12],"Positron":[13],"emission":[14],"tomography/computed":[15],"tomography":[16],"(PET/CT)":[17],"has":[18],"also":[19,201],"identified":[20],"distinct":[21],"imaging":[23,60,257],"subtypes,":[24],"including":[25,146],"those":[26,147],"with":[27,93,115,136,175,182,254],"increased":[28],"and":[29,55,74,79,95,122,155,218,234],"decreased":[30],"choline":[31],"metabolism":[32],"as":[33,231],"measured":[34],"by":[35,71,108,120],"the":[36,40,46,53,166],"tissue":[37],"uptake":[38,98,140,199],"radiopharmaceutical":[41],"18F-fluorocholine.":[42],"Gene":[43],"signatures":[44,86,158,181,251],"reflecting":[45],"heterogeneity":[48],"HCC":[50,132,160,244],"may":[51],"identify":[52],"biological":[54],"clinical":[56,151],"significance":[57],"these":[59,180],"subtypes.":[61],"In":[62],"this":[63],"study,":[64],"41":[65],"patients":[66],"underwent":[67],"18F-fluorocholine":[68,97,139,172,198,229,255],"PET/CT,":[69],"followed":[70],"tumor":[72,138],"resection":[73],"gene":[75,85,100,104,128,250],"expression":[76],"profiling.":[77],"Over-":[78],"underexpressed":[80],"components":[81],"previously":[83],"published":[84],"were":[87,106,118,133,200],"evaluated":[88],"for":[89,159,171,203,243],"enrichment":[90],"between":[91],"tumors":[92],"high":[94,137,197],"low":[96],"using":[99],"set":[101],"analysis.":[102],"Significant":[103],"sets":[105,129],"enumerated":[107],"FDR":[109,142],"based":[110,178,185],"on":[111,179,186],"phenotype":[112],"permutation.":[113],"Associations":[114],"overall":[116],"survival":[117,187],"analyzed":[119],"univariate":[121],"multivariate":[123],"proportional":[124],"hazards":[125],"regression.":[126],"Ten":[127],"related":[130],"to":[131,226],"significantly":[134],"associated":[135,174],"at":[141],"q":[143],"<":[144],"0.05,":[145],"from":[148],"three":[149],"different":[150],"classification":[153],"systems":[154],"two":[156],"prognostic":[157,235],"that":[161],"showed":[162],"predictive":[163],"value":[164],"in":[165,206,237],"study":[167],"cohort.":[168],"Tumor":[169],"avidity":[170],"was":[173],"favorable":[176],"characteristics":[177],"lower":[183],"mortality":[184],"analysis":[188],"(HR":[189],"0.36;":[190],"95%":[191],"confidence":[192],"interval,":[193],"0.14\u20130.95).":[194],"Tumors":[195],"demonstrating":[196],"enriched":[202],"genes":[204],"involved":[205],"oxidative":[207],"phosphorylation,":[208],"fatty":[209],"acid":[210,214],"metabolism,":[211,215,217],"peroxisome,":[212],"bile":[213],"xenobiotic":[216],"adipogenesis.":[219],"These":[220],"results":[221],"provide":[222],"a":[223,232],"pathobiological":[224,241],"framework":[225,242],"further":[227],"evaluate":[228],"PET/CT":[230,256],"classifier":[236],"HCC.":[238],"Significance:":[239],"A":[240],"brings":[245],"together":[246],"prognostically":[248],"relevant":[249],"via":[252],"convergence":[253],"phenotype.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-02-21T00:00:00"}
