{"id":"https://openalex.org/W2914680535","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b067","title":"Abstract B067: Distinct necessity of mitochondrial complex I and III for regulatory T-cell function","display_name":"Abstract B067: Distinct necessity of mitochondrial complex I and III for regulatory T-cell function","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2914680535","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b067","mag":"2914680535"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6074.cricimteatiaacr18-b067","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b067","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b067","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026368461","display_name":"Elizabeth M. Steinert","orcid":"https://orcid.org/0000-0002-6947-2271","observed_orcids":["https://orcid.org/0000-0002-6947-2271","https://orcid.org/0000-0002-9939-7401"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth M. Steinert","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089713817","display_name":"Samuel Edward Weinberg","orcid":"https://orcid.org/0000-0002-9532-7051","observed_orcids":["https://orcid.org/0000-0002-9532-7051"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel E. Weinberg","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046518034","display_name":"Navdeep S. Chandel","orcid":"https://orcid.org/0000-0001-7208-3886","observed_orcids":["https://orcid.org/0000-0001-7208-3886"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navdeep S. Chandel","raw_affiliation_strings":["Northwestern University, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"2_Supplement","first_page":"B067","last_page":"B067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitochondrial-complex-i","display_name":"mitochondrial complex I","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mitochondrial-complex-iii","display_name":"mitochondrial complex III","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitochondrial-respiratory-chain","display_name":"mitochondrial respiratory chain","score":0.8709999918937683},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9020000100135803},{"id":"https://openalex.org/keywords/treg-suppressive-function","display_name":"Treg suppressive function","score":0.8610000014305115},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.5699999928474426},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.7680000066757202},{"id":"https://openalex.org/keywords/complex-i-inhibitors","display_name":"complex I inhibitors","score":0.5630000233650208},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7256060838699341},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5419067740440369},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.512794554233551},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5108594298362732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5016012191772461},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49517956376075745},{"id":"https://openalex.org/C3020761558","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Mitochondrial respiratory chain","level":3,"score":0.4866081476211548},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4555682837963104},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4438285231590271},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44210273027420044},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.4324907660484314},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37982285022735596},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36654457449913025},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17060178518295288}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6074.cricimteatiaacr18-b067","doi":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b067","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b067","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2909014200","https://openalex.org/W2913705963","https://openalex.org/W2912409784","https://openalex.org/W2954903029","https://openalex.org/W4235402474","https://openalex.org/W4412509019","https://openalex.org/W2913720497","https://openalex.org/W2745181231","https://openalex.org/W2124411878","https://openalex.org/W4403997913"],"abstract_inverted_index":{"Abstract":[0],"Regulatory":[1],"T-cells":[2],"(Treg":[3],"cells)":[4],"are":[5,21,161,168],"major":[6],"mediators":[7],"of":[8,83,97,119,130,145,152,175,196,209],"immunological":[9],"homeostasis":[10],"and":[11,13,44,111,200],"tolerance,":[12],"their":[14,67],"actions":[15],"suppress":[16],"responses":[17],"to":[18,33],"self-antigens":[19],"that":[20,78,124],"aberrant":[22],"as":[23,25],"well":[24],"anti-tumor.":[26],"Recent":[27],"studies":[28],"have":[29],"demonstrated":[30],"that,":[31],"relative":[32],"other":[34],"CD4+":[35],"T-cell":[36,204],"subsets,":[37],"Treg":[38,46,59,80,105,138],"cells":[39,60,106,139],"display":[40],"increased":[41],"mitochondrial":[42,63,84,131,157,197],"metabolism":[43],"the":[45,62,95,150,170,210],"cell":[47],"lineage-defining":[48],"transcription":[49],"factor,":[50],"FOXP3,":[51],"promotes":[52],"respiration.":[53],"However,":[54],"it":[55],"remains":[56],"unknown":[57],"whether":[58],"require":[61],"respiratory":[64,85],"chain":[65,86],"for":[66,164,202],"suppressive":[68,120],"capacity,":[69,114],"lineage":[70],"stability,":[71],"or":[72,134],"survival.":[73],"Our":[74],"lab":[75],"recently":[76],"found":[77,123],"constitutive":[79],"cell-specific":[81],"ablation":[82],"complex":[87,91,108,132,135,146,158,176,198],"III":[88,109,133,147,201],"but":[89,115],"not":[90],"I":[92,136,159,177,199],"resulted":[93,148],"in":[94,103,125,149,179],"development":[96,151],"a":[98,117],"fatal":[99,153],"inflammatory":[100,154],"disease":[101],"early":[102],"life.":[104],"lacking":[107],"survived":[110],"maintained":[112],"proliferative":[113],"displayed":[116],"loss":[118,144,174],"function.":[121],"We":[122],"adults,":[126],"tamoxifen":[127],"induced":[128],"deletion":[129],"from":[137],"impaired":[140],"tumorigenesis.":[141,182],"Surprisingly,":[142],"only":[143],"disease.":[155],"Because":[156],"inhibitors":[160],"being":[162],"explored":[163],"cancer":[165],"treatments,":[166],"we":[167],"investigating":[169],"mechanism":[171],"by":[172],"which":[173],"activity":[178],"Tregs":[180],"prevents":[181],"Citation":[183],"Format:":[184],"Elizabeth":[185],"M.":[186],"Steinert,":[187],"Samuel":[188],"E.":[189],"Weinberg,":[190],"Navdeep":[191],"S.":[192],"Chandel.":[193],"Distinct":[194],"necessity":[195],"regulatory":[203],"function":[205],"[abstract].":[206],"In:":[207],"Proceedings":[208],"Fourth":[211],"CRI-CIMT-EATI-AACR":[212],"International":[213],"Cancer":[214,231],"Immunotherapy":[215],"Conference:":[216],"Translating":[217],"Science":[218],"into":[219],"Survival;":[220],"Sept":[221],"30-Oct":[222],"3,":[223],"2018;":[224],"New":[225],"York,":[226],"NY.":[227],"Philadelphia":[228],"(PA):":[229],"AACR;":[230],"Immunol":[232],"Res":[233],"2019;7(2":[234],"Suppl):Abstract":[235],"nr":[236],"B067.":[237]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-02-21T00:00:00"}