{"id":"https://openalex.org/W2914645682","doi":"https://doi.org/10.3389/fimmu.2019.00069","title":"Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis","display_name":"Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis","publication_year":2019,"publication_date":"2019-02-08","ids":{"openalex":"https://openalex.org/W2914645682","doi":"https://doi.org/10.3389/fimmu.2019.00069","mag":"2914645682","pmid":"https://pubmed.ncbi.nlm.nih.gov/30800122","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6376951"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2019.00069","doi":"https://doi.org/10.3389/fimmu.2019.00069","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00069","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00069/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00069/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076056175","display_name":"Maria Camila Alvarez Silva","orcid":"https://orcid.org/0000-0002-7905-2967","observed_orcids":["https://orcid.org/0000-0002-7905-2967"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I4391767703","display_name":"Novo Nordisk Foundation Center for Basic Metabolic Research","ror":"https://ror.org/02s32fb62","country_code":"DK","type":"other","lineage":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Camila Alvarez-Silva","raw_affiliation_strings":["Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030752242","display_name":"Robert Schierwagen","orcid":"https://orcid.org/0000-0002-2195-3666","observed_orcids":["https://orcid.org/0000-0002-2195-3666"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Schierwagen","raw_affiliation_strings":["Department of Internal Medicine I, Goethe University Clinic Frankfurt, Frankfurt, Germany","Department of Internal Medicine I, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Goethe University Clinic Frankfurt, Frankfurt, Germany","institution_ids":["https://openalex.org/I4210132578"]},{"raw_affiliation_string":"Department of Internal Medicine I, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008293338","display_name":"Alessandra Pohlmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alessandra Pohlmann","raw_affiliation_strings":["Department of Internal Medicine I, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089549128","display_name":"Fernando Magdaleno","orcid":"https://orcid.org/0000-0002-4121-6743","observed_orcids":["https://orcid.org/0000-0002-4121-6743"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fernando Magdaleno","raw_affiliation_strings":["Department of Internal Medicine I, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058024088","display_name":"Frank Erhard Uschner","orcid":"https://orcid.org/0000-0002-3760-2887","observed_orcids":["https://orcid.org/0000-0002-3760-2887"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank E. Uschner","raw_affiliation_strings":["Department of Internal Medicine I, Goethe University Clinic Frankfurt, Frankfurt, Germany","Department of Internal Medicine I, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Goethe University Clinic Frankfurt, Frankfurt, Germany","institution_ids":["https://openalex.org/I4210132578"]},{"raw_affiliation_string":"Department of Internal Medicine I, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065153070","display_name":"Patrick B. Ryan","orcid":"https://orcid.org/0000-0002-9727-2138","observed_orcids":["https://orcid.org/0000-0002-9727-2138"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Ryan","raw_affiliation_strings":["Department of Internal Medicine I, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067383538","display_name":"Maria J. G. T. Vehreschild","orcid":"https://orcid.org/0000-0003-0446-3224","observed_orcids":["https://orcid.org/0000-0003-0446-3224"]},"institutions":[{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maria J. G. T. Vehreschild","raw_affiliation_strings":["Medical Clinic II, University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Clinic II, University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt, Germany","institution_ids":["https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004460072","display_name":"Joan Cl\u00e0ria","orcid":"https://orcid.org/0000-0003-4333-7749","observed_orcids":["https://orcid.org/0000-0003-4333-7749"]},"institutions":[{"id":"https://openalex.org/I4210098051","display_name":"European Foundation for the Study of Chronic Liver Failure","ror":"https://ror.org/00xvxvn83","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210098051"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joan Claria","raw_affiliation_strings":["European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain","institution_ids":["https://openalex.org/I4210098051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009349672","display_name":"Eicke Latz","orcid":"https://orcid.org/0000-0003-1488-5666","observed_orcids":["https://orcid.org/0000-0003-1488-5666"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE","NO","US"],"is_corresponding":false,"raw_author_name":"Eicke Latz","raw_affiliation_strings":["Centre for Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway","Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, United States","German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany","Institute of Innate Immunity, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway","institution_ids":["https://openalex.org/I204778367"]},{"raw_affiliation_string":"Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, United States","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062840410","display_name":"Benjamin Lelouvier","orcid":"https://orcid.org/0000-0002-8710-6777","observed_orcids":["https://orcid.org/0000-0002-8710-6777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Lelouvier","raw_affiliation_strings":["Vaiomer, Lab\u00e8ge, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaiomer, Lab\u00e8ge, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058914957","display_name":"Manimozhiyan Arumugam","orcid":"https://orcid.org/0000-0002-0886-9101","observed_orcids":["https://orcid.org/0000-0002-0886-9101","https://orcid.org/0000-0002-3065-3745"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]},{"id":"https://openalex.org/I4391767703","display_name":"Novo Nordisk Foundation Center for Basic Metabolic Research","ror":"https://ror.org/02s32fb62","country_code":"DK","type":"other","lineage":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Manimozhiyan Arumugam","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark","Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]},{"raw_affiliation_string":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I4391767703"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029282864","display_name":"Jonel Trebicka","orcid":"https://orcid.org/0000-0002-7028-3881","observed_orcids":["https://orcid.org/0000-0002-7028-3881"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]},{"id":"https://openalex.org/I4210098051","display_name":"European Foundation for the Study of Chronic Liver Failure","ror":"https://ror.org/00xvxvn83","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210098051"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]},{"id":"https://openalex.org/I4210147769","display_name":"Institute for Bioengineering of Catalonia","ror":"https://ror.org/056h71x09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210147769","https://openalex.org/I4387153040"]}],"countries":["DE","DK","ES"],"is_corresponding":true,"raw_author_name":"Jonel Trebicka","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark","Department of Internal Medicine I, Goethe University Clinic Frankfurt, Frankfurt, Germany","Department of Internal Medicine I, University of Bonn, Bonn, Germany","European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain","Institute for Bioengineering of Catalonia, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]},{"raw_affiliation_string":"Department of Internal Medicine I, Goethe University Clinic Frankfurt, Frankfurt, Germany","institution_ids":["https://openalex.org/I4210132578"]},{"raw_affiliation_string":"Department of Internal Medicine I, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain","institution_ids":["https://openalex.org/I4210098051"]},{"raw_affiliation_string":"Institute for Bioengineering of Catalonia, Barcelona, Spain","institution_ids":["https://openalex.org/I4210147769"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5029282864","https://openalex.org/A5058914957"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I135140700","https://openalex.org/I2801498763","https://openalex.org/I4210098051","https://openalex.org/I4210132578","https://openalex.org/I4210147769","https://openalex.org/I4391767703"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2014,"currency":"EUR","value_usd":2172},"fwci":4.4045,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.95133739,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"69","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decompensated-cirrhosis","display_name":"decompensated cirrhosis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/microbial-translocation","display_name":"microbial translocation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/spontaneous-bacterial-peritonitis","display_name":"spontaneous bacterial peritonitis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.7570000290870667},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8970000147819519},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8799999952316284},{"id":"https://openalex.org/keywords/bacterial-dna","display_name":"bacterial DNA","score":0.8669999837875366},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.906000018119812},{"id":"https://openalex.org/keywords/myeloid-cells","display_name":"myeloid cells","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.8734790086746216},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6818742752075195},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.565379798412323},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.39668333530426025},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3685477375984192},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36149924993515015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34963011741638184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11695024371147156},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010538","descriptor_name":"Peritonitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":11,"locations":[{"id":"doi:10.3389/fimmu.2019.00069","doi":"https://doi.org/10.3389/fimmu.2019.00069","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00069","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00069/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5380320","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6376951","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6376951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6376951","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:30800122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30800122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/5da1ba63-9ad2-4b5d-83fa-46f1598400d1","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/5da1ba63-9ad2-4b5d-83fa-46f1598400d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alvarez-Silva, C, Schierwagen, R, Pohlmann, A, Magdaleno, F, Uschner, F E, Ryan, P, Vehreschild, M J G T, Claria, J, Latz, E, Lelouvier, B, Arumugam, M & Trebicka, J 2019, 'Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis', Frontiers in Immunology, vol. 10, 69. https://doi.org/10.3389/fimmu.2019.00069","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:sdu.dk:openaire/3ef84c80-130b-4dce-8ab3-d11e08a52768","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/files/146729060/Compartmentalization_of_Immune_Response_and_Microbial_Translocation_in_Decompensated_Cirrhosis.pdf","pdf_url":"https://findresearcher.sdu.dk/ws/files/146729060/Compartmentalization_of_Immune_Response_and_Microbial_Translocation_in_Decompensated_Cirrhosis.pdf","source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alvarez-Silva, C, Schierwagen, R, Pohlmann, A, Magdaleno, F, Uschner, F E, Ryan, P, Vehreschild, M J G T, Claria, J, Latz, E, Lelouvier, B, Arumugam, M & Trebicka, J 2019, 'Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis', Frontiers in Immunology, vol. 10, no. FEB, 69. https://doi.org/10.3389/fimmu.2019.00069","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-4788","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/3774","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Articles","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9eabf3045a3540a286b8da84a69a182a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9eabf3045a3540a286b8da84a69a182a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 10 (2019)","raw_type":"article"},{"id":"pmh:oai:ntnuopen.ntnu.no:11250/2993618","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11250/2993618","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"10","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pub.dzne.de:140478","doi":null,"is_oa":true,"landing_page_url":"https://pub.dzne.de/record/140478","pdf_url":null,"source":{"id":"https://openalex.org/S7407051172","display_name":"DZNE Pub","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801533059","host_organization_name":"German Center for Neurodegenerative Diseases","host_organization_lineage":["https://openalex.org/I2801533059"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in immunology 10, 69 (2019). doi:10.3389/fimmu.2019.00069","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publikationen.ub.uni-frankfurt.de:49941","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:hebis:30:3-499416","pdf_url":null,"source":{"id":"https://openalex.org/S4306400432","display_name":"Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114090438","host_organization_name":"Goethe University Frankfurt","host_organization_lineage":["https://openalex.org/I114090438"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2019.00069","doi":"https://doi.org/10.3389/fimmu.2019.00069","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.00069","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.00069/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1392329581","display_name":null,"funder_award_id":"TRR57","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2086451654","display_name":"GALAXY: Gut-and-liver axis in alcoholic liver fibrosis","funder_award_id":"668031","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2325551686","display_name":null,"funder_award_id":"NNF10CC1016515","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G4208438675","display_name":null,"funder_award_id":"SFB\u2010TRR57","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G451163213","display_name":null,"funder_award_id":"NNF10CC1016515","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G6047679155","display_name":null,"funder_award_id":"NNF16CC0020896","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G6167129240","display_name":null,"funder_award_id":"NNF15OC0016692","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G6438180334","display_name":null,"funder_award_id":"NNF15OC0016692","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320310210","display_name":"Fundaci\u00f3n Cellex","ror":"https://ror.org/019dmpq73"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2914645682.pdf","grobid_xml":"https://content.openalex.org/works/W2914645682.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1228830179","https://openalex.org/W1981270981","https://openalex.org/W2017620207","https://openalex.org/W2034285706","https://openalex.org/W2035378093","https://openalex.org/W2044280032","https://openalex.org/W2044348724","https://openalex.org/W2056279562","https://openalex.org/W2067504868","https://openalex.org/W2070260704","https://openalex.org/W2095292434","https://openalex.org/W2112006696","https://openalex.org/W2132551814","https://openalex.org/W2133017002","https://openalex.org/W2137532917","https://openalex.org/W2145386339","https://openalex.org/W2170024099","https://openalex.org/W2272721999","https://openalex.org/W2328023807","https://openalex.org/W2401404581","https://openalex.org/W2418438757","https://openalex.org/W2462303459","https://openalex.org/W2467200611","https://openalex.org/W2489468486","https://openalex.org/W2507864999","https://openalex.org/W2514899465","https://openalex.org/W2523689809","https://openalex.org/W2624410121","https://openalex.org/W2753521833","https://openalex.org/W2766277817","https://openalex.org/W2787340881","https://openalex.org/W2791786910","https://openalex.org/W2802906787","https://openalex.org/W2887025881","https://openalex.org/W2951421422","https://openalex.org/W2982084702"],"related_works":["https://openalex.org/W2095292434","https://openalex.org/W2044348724","https://openalex.org/W4396545433","https://openalex.org/W2298129330","https://openalex.org/W2084830964","https://openalex.org/W2108457513","https://openalex.org/W4403154199","https://openalex.org/W2053810350","https://openalex.org/W2018513334","https://openalex.org/W307485254"],"abstract_inverted_index":{"Background":[0],"Acquired":[1],"dysfunctional":[2],"immunity":[3],"in":[4,34,77,121,160,167,173,188,220,231,267,283,292,313],"cirrhosis":[5,105],"predisposes":[6],"patients":[7,101,126,193,205],"to":[8,18,164,204,223,264,281],"frequent":[9],"bacterial":[10,14,43,93,136],"infections,":[11],"especially":[12,312],"spontaneous":[13],"peritonitis":[15],"(SBP),":[16],"leading":[17],"systemic":[19,28,82,183,247,258,275],"inflammation":[20,29,83,86,248,259,276],"that":[21],"is":[22,286],"associated":[23,80],"with":[24,81,102,177,194,206,244,309],"poor":[25],"outcome.":[26],"But":[27],"can":[30],"also":[31,217],"be":[32,250,265],"found":[33],"the":[35,89,224,288,301,307,310,314],"absence":[36],"of":[37,42,51,57,68,91,112,124,132,158,182,246,257,300,306],"a":[38,49,55,130,272],"confirmed":[39],"infection.":[40],"Detection":[41],"DNA":[44,137],"has":[45],"been":[46],"investigated":[47,65],"as":[48,54],"marker":[50],"SBP":[52,201],"and":[53,70,84,96,114,117,142,180,234,238,260,269,277,304],"predictor":[56],"prognosis.":[58],"Data":[59],"is,":[60],"however,":[61],"contradictory.":[62],"Here":[63],"we":[64,108],"whether":[66,85],"levels":[67,157,172,187,198],"IL-6":[69,116,159,171,186],"IL-8":[71,118],"putatively":[72],"produced":[73],"by":[74,146],"myeloid":[75],"cells":[76],"ascites":[78,141,161,189,221,237,268,291],"are":[79],"depends":[87],"on":[88],"presence":[90],"specific":[92],"DNA.":[94],"Methods":[95],"material":[97],"We":[98,228],"enrolled":[99],"33":[100],"decompensated":[103,254],"liver":[104],"from":[106,140],"whom":[107],"collected":[109],"paired":[110],"samples":[111,123,166],"blood":[113,165,174,196,315],"ascites.":[115],"were":[119,154],"measured":[120],"serum":[122],"all":[125,168],"using":[127],"ELISA.":[128],"In":[129,253],"subset":[131],"10":[133],"representative":[134],"patients,":[135],"was":[138,216],"extracted":[139],"whole":[143],"blood,":[144,239,284],"followed":[145],"16S":[147],"rRNA":[148],"gene":[149],"amplicon":[150],"sequencing.":[151],"Results":[152],"There":[153],"significantly":[155,218],"higher":[156,195,219],"fluid":[162],"compared":[163,203,222],"patients.":[169],"Interestingly,":[170],"correlated":[175],"tightly":[176],"disease":[178],"severity":[179],"surrogates":[181,245],"inflammation,":[184],"while":[185],"did":[190],"not.":[191],"Moreover,":[192],"CRP":[197],"showed":[199],"greater":[200],"prevalence":[202],"lower":[207],"levels,":[208],"despite":[209],"similar":[210],"positive":[211],"culture":[212],"results.":[213],"Bacterial":[214],"richness":[215],"corresponding":[225],"patient":[226],"blood.":[227,270],"identified":[229],"differences":[230],"microbial":[232],"composition":[233,262,279],"diversity":[235],"between":[236,274],"but":[240],"no":[241],"tight":[242],"relationship":[243,273],"could":[249],"observed.":[251],"Discussion":[252],"cirrhosis,":[255],"markers":[256],"microbiota":[261,278,311],"seem":[263],"dysregulated":[266],"While":[271],"seems":[280],"exist":[282],"this":[285],"not":[287],"case":[289],"for":[290],"our":[293],"hands.":[294],"These":[295],"data":[296],"may":[297],"suggest":[298],"compartmentalization":[299],"immune":[302],"response":[303],"interaction":[305],"latter":[308],"compartment.":[316]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-02-21T00:00:00"}
