{"id":"https://openalex.org/W2914538391","doi":"https://doi.org/10.1111/php.13091","title":"Ferrochelatase Deficiency Abrogated the Enhancement of Aminolevulinic Acid\u2010mediated Protoporphyrin IX by Iron Chelator Deferoxamine","display_name":"Ferrochelatase Deficiency Abrogated the Enhancement of Aminolevulinic Acid\u2010mediated Protoporphyrin IX by Iron Chelator Deferoxamine","publication_year":2019,"publication_date":"2019-02-15","ids":{"openalex":"https://openalex.org/W2914538391","doi":"https://doi.org/10.1111/php.13091","mag":"2914538391","pmid":"https://pubmed.ncbi.nlm.nih.gov/30767226","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6642023"},"language":"en","primary_location":{"id":"doi:10.1111/php.13091","doi":"https://doi.org/10.1111/php.13091","is_oa":true,"landing_page_url":"https://doi.org/10.1111/php.13091","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/php.13091","source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/php.13091","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064069998","display_name":"Pratheeba Palasuberniam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratheeba Palasuberniam","raw_affiliation_strings":["Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences Philadelphia PA","institution_ids":["https://openalex.org/I110357561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077558284","display_name":"Daniel Kraus","orcid":"https://orcid.org/0000-0001-5328-7111","observed_orcids":["https://orcid.org/0000-0001-5328-7111"]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Kraus","raw_affiliation_strings":["Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences Philadelphia PA","institution_ids":["https://openalex.org/I110357561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031121788","display_name":"Matthew Mansi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Mansi","raw_affiliation_strings":["Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences Philadelphia PA","institution_ids":["https://openalex.org/I110357561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103087961","display_name":"Alexander Braun","orcid":"https://orcid.org/0000-0003-2994-4032","observed_orcids":["https://orcid.org/0000-0003-2994-4032"]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Braun","raw_affiliation_strings":["Department of Biological Sciences Misher College of Arts & Sciences University of the Sciences Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Misher College of Arts & Sciences University of the Sciences Philadelphia PA","institution_ids":["https://openalex.org/I110357561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090770946","display_name":"Richard Howley","orcid":"https://orcid.org/0009-0002-2335-770X","observed_orcids":["https://orcid.org/0009-0002-2335-770X"]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Howley","raw_affiliation_strings":["Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences Philadelphia PA","institution_ids":["https://openalex.org/I110357561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102961094","display_name":"Kenneth A. Myers","orcid":"https://orcid.org/0000-0003-4677-5146","observed_orcids":["https://orcid.org/0000-0003-4677-5146"]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth A. Myers","raw_affiliation_strings":["Department of Biological Sciences Misher College of Arts & Sciences University of the Sciences Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences Misher College of Arts & Sciences University of the Sciences Philadelphia PA","institution_ids":["https://openalex.org/I110357561"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100427364","display_name":"Bin Chen","orcid":"https://orcid.org/0000-0002-6708-4101","observed_orcids":["https://orcid.org/0000-0002-6708-4101","https://orcid.org/0000-0002-7736-4158"]},"institutions":[{"id":"https://openalex.org/I110357561","display_name":"University of the Sciences","ror":"https://ror.org/048gmay44","country_code":"US","type":"education","lineage":["https://openalex.org/I110357561"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bin Chen","raw_affiliation_strings":["Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences Philadelphia PA","Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences Philadelphia College of Pharmacy University of the Sciences Philadelphia PA","institution_ids":["https://openalex.org/I110357561"]},{"raw_affiliation_string":"Department of Radiation Oncology Perelman School of Medicine University of Pennsylvania Philadelphia PA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100427364"],"corresponding_institution_ids":["https://openalex.org/I110357561","https://openalex.org/I79576946"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":1.1378,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.71763827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"95","issue":"4","first_page":"1052","last_page":"1059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferrochelatase","display_name":"ferrochelatase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/protoporphyrin-ix","display_name":"protoporphyrin IX","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.8930000066757202},{"id":"https://openalex.org/keywords/iron-chelation","display_name":"iron chelation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6579999923706055},{"id":"https://openalex.org/keywords/skbr-3-cells","display_name":"SK-BR-3 cells","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tumor-selectivity","display_name":"tumor selectivity","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2779671804","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin IX","level":3,"score":0.9343270659446716},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.7962533235549927},{"id":"https://openalex.org/C2781149050","wikidata":"https://www.wikidata.org/wiki/Q408712","display_name":"Ferrochelatase","level":4,"score":0.7744879722595215},{"id":"https://openalex.org/C191560914","wikidata":"https://www.wikidata.org/wiki/Q7390592","display_name":"SKBR3","level":5,"score":0.6350303888320923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6258841753005981},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.571450412273407},{"id":"https://openalex.org/C2781447869","wikidata":"https://www.wikidata.org/wiki/Q204594","display_name":"Zinc protoporphyrin","level":4,"score":0.44759565591812134},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.4461546540260315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4176659882068634},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4168045222759247},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3949657678604126},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3332476317882538},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31195229291915894},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3112303912639618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2671709656715393},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.193389892578125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10450884699821472},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000622","descriptor_name":"Aminolevulinic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003676","descriptor_name":"Deferoxamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005294","descriptor_name":"Ferrochelatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005294","descriptor_name":"Ferrochelatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011524","descriptor_name":"Protoporphyrins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011524","descriptor_name":"Protoporphyrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017262","descriptor_name":"Siderophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/php.13091","doi":"https://doi.org/10.1111/php.13091","is_oa":true,"landing_page_url":"https://doi.org/10.1111/php.13091","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/php.13091","source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},{"id":"pmid:30767226","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30767226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and photobiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6642023","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6642023","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Photochem Photobiol","raw_type":"Text"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/285583","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11343/285583","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/php.13091","doi":"https://doi.org/10.1111/php.13091","is_oa":true,"landing_page_url":"https://doi.org/10.1111/php.13091","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/php.13091","source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5231888146","display_name":"Optimization of aminolevulinic acid-protoporphyrin IX for fluorescence-guided tumor resection and treatment","funder_award_id":"R15EB026208","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2914538391.pdf","grobid_xml":"https://content.openalex.org/works/W2914538391.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1487956274","https://openalex.org/W1574573897","https://openalex.org/W1610046461","https://openalex.org/W1891095862","https://openalex.org/W1932705370","https://openalex.org/W1983747031","https://openalex.org/W1986914063","https://openalex.org/W1997189138","https://openalex.org/W2000454510","https://openalex.org/W2018664136","https://openalex.org/W2019094347","https://openalex.org/W2028733665","https://openalex.org/W2034013141","https://openalex.org/W2035997627","https://openalex.org/W2040858046","https://openalex.org/W2050753593","https://openalex.org/W2055534257","https://openalex.org/W2071219983","https://openalex.org/W2071417746","https://openalex.org/W2076565678","https://openalex.org/W2077884169","https://openalex.org/W2093448085","https://openalex.org/W2095912523","https://openalex.org/W2100592740","https://openalex.org/W2104184378","https://openalex.org/W2107437510","https://openalex.org/W2134286645","https://openalex.org/W2146833848","https://openalex.org/W2151734986","https://openalex.org/W2154130903","https://openalex.org/W2168974794","https://openalex.org/W2170447022","https://openalex.org/W2419531088","https://openalex.org/W2497407287","https://openalex.org/W2514227379","https://openalex.org/W2517988891","https://openalex.org/W2739185028","https://openalex.org/W2806489088"],"related_works":["https://openalex.org/W4286007745","https://openalex.org/W2168974794","https://openalex.org/W2018664136","https://openalex.org/W2034013141","https://openalex.org/W1487956274","https://openalex.org/W4416305175","https://openalex.org/W2060661255","https://openalex.org/W2119745503","https://openalex.org/W106950212","https://openalex.org/W4413113168"],"abstract_inverted_index":{"Aminolevulinic":[0],"acid":[1],"(ALA)":[2],"is":[3,7,60,188],"a":[4,49,132],"prodrug":[5],"that":[6,76,98,154,185],"metabolized":[8],"in":[9,105,125,135,141,145,160,163,174],"the":[10,42,74,91,112,146],"heme":[11],"biosynthesis":[12],"pathway":[13],"to":[14,36,47,57,62,195],"produce":[15],"protoporphyrin":[16],"IX":[17],"(PpIX)":[18],"for":[19],"tumor":[20,149,164,175,193],"fluorescence":[21,121,162],"detection":[22],"and":[23,66,122],"photodynamic":[24],"therapy":[25],"(PDT).":[26],"The":[27],"iron":[28],"chelator":[29],"deferoxamine":[30],"(DFO)":[31],"has":[32],"been":[33],"widely":[34],"used":[35],"enhance":[37],"PpIX":[38,46],"accumulation":[39],"by":[40,52,102],"inhibiting":[41],"iron-dependent":[43],"bioconversion":[44],"of":[45,115,192],"heme,":[48],"reaction":[50],"catalyzed":[51],"ferrochelatase":[53],"(FECH).":[54],"Tumor":[55],"response":[56,124,194],"DFO":[58,92,118,155,196],"treatment":[59,156],"known":[61],"be":[63],"highly":[64],"variable,":[65],"some":[67],"tumors":[68,77],"even":[69],"show":[70],"no":[71,142],"response.":[72],"Given":[73],"fact":[75],"often":[78],"exhibit":[79],"reduced":[80],"FECH":[81,88,100,104,168,179,186],"expression/enzymatic":[82],"activity,":[83],"we":[84],"examined":[85],"how":[86],"reducing":[87,99],"level":[89,101],"affected":[90],"enhancement":[93,113],"effect.":[94],"Our":[95,182],"results":[96],"showed":[97],"silencing":[103],"SkBr3":[106,126],"breast":[107,137],"cancer":[108],"cells":[109,165,176],"completely":[110],"abrogated":[111],"effect":[114],"DFO.":[116],"Although":[117],"enhanced":[119],"ALA-PpIX":[120,161],"PDT":[123],"vector":[127],"control":[128],"cells,":[129,139],"it":[130],"caused":[131],"similar":[133],"increase":[134,159],"MCF10A":[136],"epithelial":[138],"resulting":[140],"net":[143],"gain":[144],"selectivity":[147],"toward":[148],"cells.":[150],"We":[151],"also":[152],"found":[153],"induced":[157],"less":[158],"with":[166,177],"lower":[167],"activity":[169,180,187],"(MDA-MB-231,":[170],"Hs":[171],"578T)":[172],"than":[173],"higher":[178],"(MDA-MB-453).":[181],"study":[183],"demonstrates":[184],"an":[189],"important":[190],"determinant":[191],"treatment.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-02-21T00:00:00"}