{"id":"https://openalex.org/W2914495457","doi":"https://doi.org/10.32598/bcn.9.10.352","title":"Characterization of Functional Effects of Two New Active Fractions Isolated From Scorpion Venom on Neuronal Ca2+ Spikes: A Possible Action on Ca2+-Dependent Dependent K+ Channels","display_name":"Characterization of Functional Effects of Two New Active Fractions Isolated From Scorpion Venom on Neuronal Ca2+ Spikes: A Possible Action on Ca2+-Dependent Dependent K+ Channels","publication_year":2019,"publication_date":"2019-01-30","ids":{"openalex":"https://openalex.org/W2914495457","doi":"https://doi.org/10.32598/bcn.9.10.352","mag":"2914495457"},"language":"en","primary_location":{"id":"doi:10.32598/bcn.9.10.352","doi":"https://doi.org/10.32598/bcn.9.10.352","is_oa":true,"landing_page_url":"https://doi.org/10.32598/bcn.9.10.352","pdf_url":"http://bcn.iums.ac.ir/files/site1/user_files_c424bc/mahyarjanahamdi-A-10-1247-1-d8490a7.pdf","source":{"id":"https://openalex.org/S2764856787","display_name":"Basic and Clinical Neuroscience Journal","issn_l":"2008-126X","issn":["2008-126X","2228-7442"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319130","host_organization_name":"Iran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319130"],"host_organization_lineage_names":["Iran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic and Clinical Neuroscience Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://bcn.iums.ac.ir/files/site1/user_files_c424bc/mahyarjanahamdi-A-10-1247-1-d8490a7.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052404161","display_name":"Hanieh Tamadon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hanieh Tamadon","raw_affiliation_strings":["Department of Physiology, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101680129","display_name":"Zahra Ghasemi","orcid":"https://orcid.org/0000-0002-2136-0553","observed_orcids":["https://orcid.org/0000-0002-2136-0553"]},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zahra Ghasemi","raw_affiliation_strings":["Department of Physiology, School of Medicine, Tarbiat Modares University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Tarbiat Modares University, Tehran, Iran","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fatemeh Ghasemi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Ghasemi","raw_affiliation_strings":["Department of Physiology, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063739505","display_name":"Narges Hosseinmardi","orcid":"https://orcid.org/0000-0003-1349-3900","observed_orcids":["https://orcid.org/0000-0003-1349-3900","https://orcid.org/0000-0003-4661-1248"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Narges Hosseinmardi","raw_affiliation_strings":["Department of Physiology, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019880073","display_name":"Hossein Vatanpour","orcid":"https://orcid.org/0000-0002-1940-3024","observed_orcids":["https://orcid.org/0000-0002-1940-3024"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Vatanpour","raw_affiliation_strings":["Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007815716","display_name":"Mahyar Janahmadi","orcid":"https://orcid.org/0000-0002-7242-3964","observed_orcids":["https://orcid.org/0000-0002-7242-3964"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mahyar Janahmadi","raw_affiliation_strings":["Department of Physiology, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007815716"],"corresponding_institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"],"apc_list":null,"apc_paid":null,"fwci":0.2197,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.43120886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"49","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.18230000138282776,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scorpion-venom","display_name":"scorpion venom","score":0.8610000014305115},{"id":"https://openalex.org/keywords/kaliotoxin","display_name":"kaliotoxin","score":0.996999979019165},{"id":"https://openalex.org/keywords/calcium-activated-potassium-channels","display_name":"calcium-activated potassium channels","score":0.9620000123977661},{"id":"https://openalex.org/keywords/afterhyperpolarization","display_name":"afterhyperpolarization","score":0.7749999761581421},{"id":"https://openalex.org/keywords/neuronal-hyperexcitability","display_name":"neuronal hyperexcitability","score":0.9860000014305115},{"id":"https://openalex.org/keywords/voltage-gated-ion-channels","display_name":"voltage-gated ion channels","score":0.8629999756813049},{"id":"https://openalex.org/keywords/helix-aspersa","display_name":"Helix aspersa","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2777884321","wikidata":"https://www.wikidata.org/wiki/Q19125","display_name":"Scorpion","level":3,"score":0.8502240777015686},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.810420036315918},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5251510143280029},{"id":"https://openalex.org/C2910159647","wikidata":"https://www.wikidata.org/wiki/Q19125","display_name":"Scorpion Venoms","level":4,"score":0.49823999404907227},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4623952805995941},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.4370206594467163},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4021882712841034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3499537408351898},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2455541491508484},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17697155475616455},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.32598/bcn.9.10.352","doi":"https://doi.org/10.32598/bcn.9.10.352","is_oa":true,"landing_page_url":"https://doi.org/10.32598/bcn.9.10.352","pdf_url":"http://bcn.iums.ac.ir/files/site1/user_files_c424bc/mahyarjanahamdi-A-10-1247-1-d8490a7.pdf","source":{"id":"https://openalex.org/S2764856787","display_name":"Basic and Clinical Neuroscience Journal","issn_l":"2008-126X","issn":["2008-126X","2228-7442"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319130","host_organization_name":"Iran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319130"],"host_organization_lineage_names":["Iran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic and Clinical Neuroscience Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e30f2a1dde794cdf98e8b94fdd935bdb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e30f2a1dde794cdf98e8b94fdd935bdb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Basic and Clinical Neuroscience, Vol 10, Iss 1, Pp 49-58 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.32598/bcn.9.10.352","doi":"https://doi.org/10.32598/bcn.9.10.352","is_oa":true,"landing_page_url":"https://doi.org/10.32598/bcn.9.10.352","pdf_url":"http://bcn.iums.ac.ir/files/site1/user_files_c424bc/mahyarjanahamdi-A-10-1247-1-d8490a7.pdf","source":{"id":"https://openalex.org/S2764856787","display_name":"Basic and Clinical Neuroscience Journal","issn_l":"2008-126X","issn":["2008-126X","2228-7442"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319130","host_organization_name":"Iran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319130"],"host_organization_lineage_names":["Iran University of Medical Sciences"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic and Clinical Neuroscience Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323457","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326"},{"id":"https://openalex.org/F4320327863","display_name":"Razi Vaccine and Serum Research Institute","ror":"https://ror.org/011xesh37"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2914495457.pdf","grobid_xml":"https://content.openalex.org/works/W2914495457.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1504378765","https://openalex.org/W1531932938","https://openalex.org/W1534574452","https://openalex.org/W1545263835","https://openalex.org/W1749433136","https://openalex.org/W1845358967","https://openalex.org/W1876408798","https://openalex.org/W1963544717","https://openalex.org/W1963821603","https://openalex.org/W1966308003","https://openalex.org/W1969348498","https://openalex.org/W1975367098","https://openalex.org/W1978128123","https://openalex.org/W1990141054","https://openalex.org/W1992209399","https://openalex.org/W1992670328","https://openalex.org/W1996051526","https://openalex.org/W1996101944","https://openalex.org/W2002328780","https://openalex.org/W2002522097","https://openalex.org/W2015768084","https://openalex.org/W2018333855","https://openalex.org/W2018835472","https://openalex.org/W2020477012","https://openalex.org/W2022117071","https://openalex.org/W2028077169","https://openalex.org/W2028614141","https://openalex.org/W2035845442","https://openalex.org/W2037366275","https://openalex.org/W2047985837","https://openalex.org/W2051873231","https://openalex.org/W2054879572","https://openalex.org/W2061695857","https://openalex.org/W2078894239","https://openalex.org/W2082054238","https://openalex.org/W2085957678","https://openalex.org/W2087432925","https://openalex.org/W2096051735","https://openalex.org/W2096457479","https://openalex.org/W2111653544","https://openalex.org/W2115540466","https://openalex.org/W2116144264","https://openalex.org/W2119397841","https://openalex.org/W2119866964","https://openalex.org/W2130930961","https://openalex.org/W2134301794","https://openalex.org/W2141056714","https://openalex.org/W2143214435","https://openalex.org/W2144432708","https://openalex.org/W2145100019","https://openalex.org/W2160627028","https://openalex.org/W2166732719","https://openalex.org/W2275079805","https://openalex.org/W2335862980","https://openalex.org/W2412803181","https://openalex.org/W2429108044","https://openalex.org/W2581312177","https://openalex.org/W2746387233","https://openalex.org/W2945792041","https://openalex.org/W4288076435"],"related_works":["https://openalex.org/W2903160281","https://openalex.org/W1993802295","https://openalex.org/W1545263835","https://openalex.org/W2088306747","https://openalex.org/W1971903448","https://openalex.org/W1982032992","https://openalex.org/W2621386780","https://openalex.org/W2024905449","https://openalex.org/W1893392654","https://openalex.org/W4233900723"],"abstract_inverted_index":{"Introduction:":[0],"It":[1],"is":[2,10],"a":[3,135],"long":[4],"time":[5],"that":[6,168],"natural":[7],"toxin":[8,130,195],"research":[9],"conducted":[11],"to":[12,27,133],"unlock":[13],"the":[14,48,77,93,99,121,145,150,158],"medical":[15],"potential":[16],"of":[17,53,73,79,95,101,104,124,147,153,160,201],"toxins.Although":[18],"venoms-toxins":[19],"cause":[20],"pathophysiological":[21],"conditions,":[22],"they":[23,39],"may":[24,40,197],"be":[25,59,166],"effective":[26],"treat":[28],"several":[29],"diseases.Since":[30],"toxins":[31,34,57,108],"including":[32],"scorpion":[33,56],"target":[35],"voltagegated":[36],"ion":[37],"channels,":[38],"have":[41],"profound":[42],"effects":[43],"on":[44],"excitable":[45],"cells.Therefore,":[46],"elucidating":[47],"cellular":[49],"and":[50,87,106,109,114,156],"electrophysiological":[51,122],"impacts":[52],"toxins,":[54],"particularly":[55],"would":[58],"helpful":[60],"in":[61,76,83,98,177],"future":[62],"drug":[63],"development":[64],"opportunities.Methods:":[65],"Intracellular":[66],"recording":[67],"was":[68,117],"made":[69],"from":[70],"F1":[71],"cells":[72],"Helix":[74],"aspersa":[75],"presence":[78,100],"calcium":[80,125,154],"Ringer":[81],"solution":[82],"which":[84],"Na":[85],"+":[86,89,141],"K":[88,140],"channels":[90],"were":[91],"blocked.Then,":[92],"modulation":[94],"channel":[96,142,183],"function":[97],"extracellular":[102],"application":[103],"F4":[105],"F6":[107],"kaliotoxin":[110],"(KTX;":[111],"50":[112],"nM":[113],"1":[115],"\u03bcM)":[116],"examined":[118],"by":[119,179],"assessing":[120],"characteristics":[123],"spikes.Results:":[126],"The":[127],"two":[128,170],"active":[129],"fractions,":[131],"similar":[132],"KTX,":[134],"known":[136],"Ca":[137,161],"2+":[138,162],"-activated":[139],"blocker,":[143],"reduced":[144],"amplitude":[146],"AHP,":[148],"enhanced":[149],"firing":[151],"frequency":[152],"spikes":[155],"broadened":[157],"duration":[159],"spikes.Therefore,":[163],"it":[164],"might":[165],"inferred":[167],"these":[169],"new":[171],"fractions":[172,196],"induce":[173],"neuronal":[174],"hyperexcitability":[175],"possibly,":[176],"part,":[178],"blocking":[180],"calcium-activated":[181,202],"potassium":[182,203],"current.However,":[184],"this":[185],"supposition":[186],"requires":[187],"further":[188],"investigation":[189],"using":[190],"voltage":[191],"clamping":[192],"technique.Conclusion:":[193],"These":[194],"act":[198],"as":[199],"blocker":[200],"channels.":[204]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-02-21T00:00:00"}
