{"id":"https://openalex.org/W2914466645","doi":null,"title":"Monocyte Anti-Inflammatory Activity Is Dictated by Metabolic Status during Staphylococcus Aureus Biofilm Infection","display_name":"Monocyte Anti-Inflammatory Activity Is Dictated by Metabolic Status during Staphylococcus Aureus Biofilm Infection","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2914466645","mag":"2914466645"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.unmc.edu:etd-1342","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/etd/339","pdf_url":"https://digitalcommons.unmc.edu/etd/339","source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses & Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.unmc.edu/etd/339","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002520520","display_name":"Kelsey J. Yamada","orcid":"https://orcid.org/0000-0003-1071-8836","observed_orcids":["https://orcid.org/0000-0003-1071-8836"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kelsey J. Yamada","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1071-8836","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002520520"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.5189999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.35740000009536743,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus-biofilm","display_name":"Staphylococcus aureus biofilm","score":0.8759999871253967},{"id":"https://openalex.org/keywords/periprosthetic-joint-infection","display_name":"periprosthetic joint infection","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.972000002861023},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/arginase-1","display_name":"arginase-1","score":0.8640000224113464},{"id":"https://openalex.org/keywords/atp-synthase-inhibition","display_name":"ATP synthase inhibition","score":0.8050000071525574},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.7300000190734863},{"id":"https://openalex.org/keywords/biofilm-clearance","display_name":"biofilm clearance","score":0.6359999775886536},{"id":"https://openalex.org/keywords/antibiotic-synergy","display_name":"antibiotic synergy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.8544155359268188},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.7887051105499268},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6701326370239258},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6631689071655273},{"id":"https://openalex.org/C2777334864","wikidata":"https://www.wikidata.org/wiki/Q34879","display_name":"Staphylococcal infections","level":4,"score":0.5071978569030762},{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.47750014066696167},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45207077264785767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4042164385318756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35353171825408936},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.265657901763916},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.unmc.edu:etd-1342","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/etd/339","pdf_url":"https://digitalcommons.unmc.edu/etd/339","source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses & Dissertations","raw_type":"text"},{"id":"mag:2914466645","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.unmc.edu/cgi/viewcontent.cgi?article=1342&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.unmc.edu:etd-1342","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unmc.edu/etd/339","pdf_url":"https://digitalcommons.unmc.edu/etd/339","source":{"id":"https://openalex.org/S7407097584","display_name":"DigitalCommons@UNMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I59130452","host_organization_name":"University of Nebraska Medical Center","host_organization_lineage":["https://openalex.org/I59130452"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses & Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2914466645.pdf","grobid_xml":"https://content.openalex.org/works/W2914466645.grobid-xml"},"referenced_works_count":140,"referenced_works":["https://openalex.org/W253874724","https://openalex.org/W633326766","https://openalex.org/W1200633968","https://openalex.org/W1486200716","https://openalex.org/W1491567812","https://openalex.org/W1518907982","https://openalex.org/W1531268983","https://openalex.org/W1543202257","https://openalex.org/W1580678794","https://openalex.org/W1595293335","https://openalex.org/W1628984902","https://openalex.org/W1636698109","https://openalex.org/W1659719165","https://openalex.org/W1848320945","https://openalex.org/W1877245175","https://openalex.org/W1878342528","https://openalex.org/W1886201331","https://openalex.org/W1907075739","https://openalex.org/W1915363187","https://openalex.org/W1933913391","https://openalex.org/W1958301401","https://openalex.org/W1963878748","https://openalex.org/W1964539025","https://openalex.org/W1967377218","https://openalex.org/W1976771829","https://openalex.org/W1977978795","https://openalex.org/W1982601297","https://openalex.org/W1983784984","https://openalex.org/W1985129442","https://openalex.org/W1986523962","https://openalex.org/W1988663075","https://openalex.org/W1990621187","https://openalex.org/W1994942139","https://openalex.org/W1999308297","https://openalex.org/W2000725338","https://openalex.org/W2002863473","https://openalex.org/W2003208348","https://openalex.org/W2008543742","https://openalex.org/W2009029230","https://openalex.org/W2012077190","https://openalex.org/W2017105892","https://openalex.org/W2018422556","https://openalex.org/W2018576241","https://openalex.org/W2019347117","https://openalex.org/W2022101765","https://openalex.org/W2024275882","https://openalex.org/W2025520038","https://openalex.org/W2028596323","https://openalex.org/W2032234779","https://openalex.org/W2032710678","https://openalex.org/W2034401000","https://openalex.org/W2036177806","https://openalex.org/W2036736570","https://openalex.org/W2038329167","https://openalex.org/W2038461328","https://openalex.org/W2040159335","https://openalex.org/W2040986265","https://openalex.org/W2044206705","https://openalex.org/W2051674499","https://openalex.org/W2054792605","https://openalex.org/W2058148650","https://openalex.org/W2061123122","https://openalex.org/W2061878956","https://openalex.org/W2062015512","https://openalex.org/W2062501841","https://openalex.org/W2064463571","https://openalex.org/W2066573870","https://openalex.org/W2069197358","https://openalex.org/W2070855360","https://openalex.org/W2072451938","https://openalex.org/W2073351779","https://openalex.org/W2076272449","https://openalex.org/W2076374435","https://openalex.org/W2079793296","https://openalex.org/W2081756284","https://openalex.org/W2090401570","https://openalex.org/W2092157690","https://openalex.org/W2093892740","https://openalex.org/W2096873727","https://openalex.org/W2096978856","https://openalex.org/W2098014021","https://openalex.org/W2105453815","https://openalex.org/W2113638991","https://openalex.org/W2115127793","https://openalex.org/W2115848484","https://openalex.org/W2117576368","https://openalex.org/W2118021257","https://openalex.org/W2119142140","https://openalex.org/W2122571791","https://openalex.org/W2122806101","https://openalex.org/W2124334590","https://openalex.org/W2125066910","https://openalex.org/W2126467473","https://openalex.org/W2127113854","https://openalex.org/W2127433511","https://openalex.org/W2127819002","https://openalex.org/W2127911225","https://openalex.org/W2130121916","https://openalex.org/W2132114933","https://openalex.org/W2135161828","https://openalex.org/W2138281334","https://openalex.org/W2140039415","https://openalex.org/W2140380746","https://openalex.org/W2144440398","https://openalex.org/W2150491739","https://openalex.org/W2153136603","https://openalex.org/W2154136299","https://openalex.org/W2157339124","https://openalex.org/W2158685996","https://openalex.org/W2160780417","https://openalex.org/W2161021025","https://openalex.org/W2162472433","https://openalex.org/W2163803918","https://openalex.org/W2167059596","https://openalex.org/W2168595347","https://openalex.org/W2171567992","https://openalex.org/W2172089049","https://openalex.org/W2206617731","https://openalex.org/W2255234694","https://openalex.org/W2280143307","https://openalex.org/W2280715617","https://openalex.org/W2313564746","https://openalex.org/W2342789743","https://openalex.org/W2396457064","https://openalex.org/W2414802097","https://openalex.org/W2469909519","https://openalex.org/W2507250701","https://openalex.org/W2518557131","https://openalex.org/W2540530180","https://openalex.org/W2560204698","https://openalex.org/W2594886173","https://openalex.org/W2596650357","https://openalex.org/W2611360243","https://openalex.org/W2753106278","https://openalex.org/W2763098842","https://openalex.org/W2769063900","https://openalex.org/W2790327646","https://openalex.org/W2793511401","https://openalex.org/W2888582455","https://openalex.org/W2894198721"],"related_works":["https://openalex.org/W3010465594","https://openalex.org/W6991840991","https://openalex.org/W7220375031","https://openalex.org/W2749600102","https://openalex.org/W4400017141","https://openalex.org/W4307336513","https://openalex.org/W4387461144","https://openalex.org/W4392297924","https://openalex.org/W4390617273","https://openalex.org/W1831386441"],"abstract_inverted_index":{"Staphylococcus":[0],"aureus":[1,50,83,106,225,275,333,354,369],"biofilms":[2,107],"represent":[3,298],"a":[4,30,164,270,299,315,336,362],"significant":[5,271,363],"cause":[6,43],"of":[7,45,75,129,136,144,148,178,221,234,247,253,317,327,341,386],"morbidity":[8],"and":[9,12,55,78,139,141,229,240,262,357],"economic":[10],"burden":[11],"are":[13,29,65,124,180],"often":[14],"associated":[15,56,113],"with":[16,57,114,284],"nosocomial":[17],"infections,":[18],"including":[19],"medically":[20],"implanted":[21],"devices.":[22],"In":[23,278],"particular,":[24],"prosthetic":[25],"joint":[26],"infections":[27,64,85,116,123],"(PJIs)":[28],"growing":[31],"concern":[32],"due":[33,70],"to":[34,67,71,117,182,210,249,286,324,330],"the":[35,52,58,73,94,110,142,218,231,254,288,325,383],"continued":[36],"increase":[37],"in":[38,171,269,273,365],"orthopedic":[39,226],"procedures.":[40],"Staphylococcal":[41],"species":[42],">50%":[44],"all":[46],"PJIs,":[47],"while":[48,347],"S.":[49,61,82,105,224,274,332,353,368],"represents":[51],"most":[53,59],"invasive":[54],"morbidity.":[60],"aureus-associated":[62],"biofilm":[63,84,119,122,173,241,276,289,355,387,395],"recalcitrant":[66],"antibiotic":[68],"therapy,":[69],"both":[72],"acquisition":[74],"genetic":[76],"elements":[77],"metabolic":[79,184,219,232,295],"dormancy.":[80],"Furthermore,":[81],"remain":[86],"chronic":[87],"because":[88],"they":[89],"cannot":[90],"be":[91],"cleared":[92],"by":[93,126,153],"immune":[95,111],"system.":[96],"Recent":[97],"studies":[98,373],"from":[99,307],"our":[100,308],"laboratory":[101,309],"have":[102],"demonstrated":[103],"that":[104,203,292,311,346,375,389],"actively":[108],"polarize":[109],"response":[112],"these":[115,372],"promote":[118,237],"persistence.":[120,174],"Specifically,":[121,243],"characterized":[125,217],"an":[127],"influx":[128],"myeloid":[130,328,342],"derived":[131],"suppressor":[132],"cells":[133,138,329],"(MDSCs),":[134],"paucity":[135],"T":[137],"neutrophils,":[140],"polarization":[143,170],"anti-inflammatory":[145,187,318],"monocytes.":[146],"Augmentation":[147],"monocyte":[149,251,260,294,376],"pro-inflammatory":[150,196,238,264,391],"activity,":[151,185,392],"either":[152],"adoptive":[154],"transfer":[155],"or":[156],"MDSC":[157],"depletion":[158],"studies,":[159],"promotes":[160],"bacterial":[161],"clearance,":[162],"highlighting":[163],"critical":[165],"role":[166,364],"for":[167],"monocyte/macrophage":[168],"inflammatory":[169,176],"dictating":[172],"The":[175],"properties":[177],"leukocytes":[179],"linked":[181],"their":[183,208],"where":[186],"macrophages":[188,197],"primarily":[189],"rely":[190],"on":[191],"oxidative":[192],"phosphorylation":[193],"(OxPhos),":[194],"whereas":[195],"utilize":[198],"aerobic":[199],"glycolysis.":[200,214],"This":[201],"suggests":[202],"biofilm-associated":[204],"monocytes":[205,222,235],"likely":[206],"shift":[207],"metabolism":[209,261,377],"favor":[211],"OxPhos":[212,381],"over":[213],"Therefore,":[215],"we":[216,344],"state":[220],"during":[223,303,382],"implant":[227],"infection":[228],"whether":[230],"reprogramming":[233],"would":[236],"activity":[239,296],"clearance.":[242],"nanoparticle":[244,280],"targeted":[245],"delivery":[246],"oligomycin":[248],"inhibit":[250],"ATP-synthase":[252],"electron":[255],"transport":[256],"chain":[257],"significantly":[258],"altered":[259],"increased":[263],"gene":[265],"expression,":[266,314],"which":[267],"resulted":[268],"reduction":[272],"burdens.":[277],"addition,":[279],"treatment":[281],"acted":[282],"synergistically":[283],"antibiotics":[285],"clear":[287,331],"infection,":[290],"suggesting":[291],"targeting":[293],"may":[297,321],"novel":[300],"therapeutic":[301],"target":[302],"PJIs.":[304],"Prior":[305],"work":[306],"suggested":[310],"arginase-1":[312],"(Arg-1)":[313],"marker":[316],"polarized":[319],"monocytes/macrophages,":[320],"also":[322],"contribute":[323],"inability":[326],"biofilms.":[334],"Using":[335],"conditional":[337],"knockout":[338],"mouse":[339],"model":[340],"Arg-1,":[343],"show":[345],"myeloid-derived":[348],"Arginase-1":[349],"does":[350,360],"not":[351],"influence":[352],"establishment":[356],"persistence,":[358],"it":[359],"play":[361],"controlling":[366],"planktonic":[367],"infection.":[370],"Collectively,":[371],"reveal":[374],"is":[378],"skewed":[379],"towards":[380],"early":[384],"stages":[385],"formation":[388],"limits":[390],"effectively":[393],"facilitating":[394],"establishment.":[396]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2019-02-21T00:00:00"}