{"id":"https://openalex.org/W29142234","doi":null,"title":"VARIABILITE INTERINDIVIDUELLE PHARMACOCINETIQUE ET PHARMACODYNAMIQUE EN ONCOLOGIE : APPLICATION AU DOCETAXEL ET A LA VINORELBINE","display_name":"VARIABILITE INTERINDIVIDUELLE PHARMACOCINETIQUE ET PHARMACODYNAMIQUE EN ONCOLOGIE : APPLICATION AU DOCETAXEL ET A LA VINORELBINE","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W29142234","mag":"29142234"},"language":"fr","primary_location":{"id":"mag:29142234","doi":null,"is_oa":false,"landing_page_url":"http://thesesups.ups-tlse.fr/79/1/Puisset_Florent.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017026685","display_name":"Florent Puisset","orcid":"https://orcid.org/0000-0002-3083-5784","observed_orcids":["https://orcid.org/0000-0002-3083-5784"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Florent Puisset","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3083-5784","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017026685"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.8119999766349792},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8119999766349792},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.996999979019165},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9810000061988831},{"id":"https://openalex.org/keywords/vinorelbine","display_name":"vinorelbine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cyp3a-substrates","display_name":"CYP3A substrates","score":0.8479999899864197},{"id":"https://openalex.org/keywords/drug-elimination","display_name":"drug elimination","score":0.39100000262260437},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.48500001430511475},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.878000020980835},{"id":"https://openalex.org/keywords/chemotherapy-dosing","display_name":"chemotherapy dosing","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.6547701358795166},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5747868418693542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4930543601512909},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10792064666748047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10272592306137085}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:29142234","doi":null,"is_oa":false,"landing_page_url":"http://thesesups.ups-tlse.fr/79/1/Puisset_Florent.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":157,"referenced_works":["https://openalex.org/W94870893","https://openalex.org/W109255500","https://openalex.org/W123359632","https://openalex.org/W144668201","https://openalex.org/W1505376713","https://openalex.org/W1518575821","https://openalex.org/W1542404140","https://openalex.org/W1550111394","https://openalex.org/W1550666015","https://openalex.org/W1609440971","https://openalex.org/W1623357808","https://openalex.org/W1734451748","https://openalex.org/W1748454469","https://openalex.org/W1764040454","https://openalex.org/W1811085086","https://openalex.org/W1811706705","https://openalex.org/W1837121308","https://openalex.org/W1875053328","https://openalex.org/W1877687332","https://openalex.org/W1892571469","https://openalex.org/W1902765013","https://openalex.org/W1909700020","https://openalex.org/W1912531397","https://openalex.org/W1946638503","https://openalex.org/W1963733180","https://openalex.org/W1963984456","https://openalex.org/W1969085061","https://openalex.org/W1970568381","https://openalex.org/W1971559706","https://openalex.org/W1973369172","https://openalex.org/W1975048166","https://openalex.org/W1978228326","https://openalex.org/W1984073388","https://openalex.org/W1986538569","https://openalex.org/W1988722349","https://openalex.org/W1988858173","https://openalex.org/W1989045169","https://openalex.org/W1989644741","https://openalex.org/W1992052906","https://openalex.org/W1994301580","https://openalex.org/W1999468683","https://openalex.org/W2003494055","https://openalex.org/W2005769414","https://openalex.org/W2009605072","https://openalex.org/W2012436282","https://openalex.org/W2013181468","https://openalex.org/W2013301732","https://openalex.org/W2015399502","https://openalex.org/W2016353182","https://openalex.org/W2016359652","https://openalex.org/W2016380061","https://openalex.org/W2016827828","https://openalex.org/W2017022511","https://openalex.org/W2017109601","https://openalex.org/W2018111497","https://openalex.org/W2018198278","https://openalex.org/W2020303409","https://openalex.org/W2021847316","https://openalex.org/W2023162917","https://openalex.org/W2026103827","https://openalex.org/W2027765878","https://openalex.org/W2028691616","https://openalex.org/W2030488800","https://openalex.org/W2032967171","https://openalex.org/W2035090151","https://openalex.org/W2035484878","https://openalex.org/W2037605675","https://openalex.org/W2039796430","https://openalex.org/W2042528426","https://openalex.org/W2048302836","https://openalex.org/W2049135459","https://openalex.org/W2050088084","https://openalex.org/W2051227554","https://openalex.org/W2054458932","https://openalex.org/W2057808899","https://openalex.org/W2060350273","https://openalex.org/W2061539226","https://openalex.org/W2062664484","https://openalex.org/W2063268943","https://openalex.org/W2064458956","https://openalex.org/W2065519386","https://openalex.org/W2066178728","https://openalex.org/W2066919313","https://openalex.org/W2067145171","https://openalex.org/W2068082885","https://openalex.org/W2069520922","https://openalex.org/W2071025146","https://openalex.org/W2071742513","https://openalex.org/W2072714833","https://openalex.org/W2073213000","https://openalex.org/W2079694825","https://openalex.org/W2080471848","https://openalex.org/W2082535104","https://openalex.org/W2082953355","https://openalex.org/W2083356003","https://openalex.org/W2085271326","https://openalex.org/W2085566855","https://openalex.org/W2089618673","https://openalex.org/W2096104385","https://openalex.org/W2097877048","https://openalex.org/W2098876188","https://openalex.org/W2100590742","https://openalex.org/W2104093795","https://openalex.org/W2104508749","https://openalex.org/W2106804959","https://openalex.org/W2108208897","https://openalex.org/W2110886272","https://openalex.org/W2112443004","https://openalex.org/W2116996913","https://openalex.org/W2118353624","https://openalex.org/W2122866527","https://openalex.org/W2123002505","https://openalex.org/W2123768561","https://openalex.org/W2124516480","https://openalex.org/W2125573444","https://openalex.org/W2126310184","https://openalex.org/W2126871433","https://openalex.org/W2127232551","https://openalex.org/W2131770017","https://openalex.org/W2136428431","https://openalex.org/W2139483516","https://openalex.org/W2141447350","https://openalex.org/W2141664618","https://openalex.org/W2142405102","https://openalex.org/W2143432220","https://openalex.org/W2144766106","https://openalex.org/W2147839112","https://openalex.org/W2151774137","https://openalex.org/W2152780528","https://openalex.org/W2152988472","https://openalex.org/W2153921870","https://openalex.org/W2154730142","https://openalex.org/W2156127723","https://openalex.org/W2157298598","https://openalex.org/W2157759791","https://openalex.org/W2158234609","https://openalex.org/W2159305151","https://openalex.org/W2161797915","https://openalex.org/W2162924104","https://openalex.org/W2163636362","https://openalex.org/W2168399625","https://openalex.org/W2169984670","https://openalex.org/W2171372527","https://openalex.org/W2240258872","https://openalex.org/W2243153136","https://openalex.org/W2256453366","https://openalex.org/W2268171795","https://openalex.org/W2288991238","https://openalex.org/W2346794707","https://openalex.org/W2400384365","https://openalex.org/W2403154765","https://openalex.org/W2404959529","https://openalex.org/W2409155054","https://openalex.org/W2414548406","https://openalex.org/W2425282278","https://openalex.org/W2993920066","https://openalex.org/W4229510792"],"related_works":["https://openalex.org/W2240160932","https://openalex.org/W7061129070","https://openalex.org/W1991970935","https://openalex.org/W6964068818","https://openalex.org/W2142405102","https://openalex.org/W4392397742","https://openalex.org/W2161797915","https://openalex.org/W2026738950","https://openalex.org/W2566306586","https://openalex.org/W2169984670"],"abstract_inverted_index":{"Pour":[0],"optimiser":[1],"l'utilisation":[2],"des":[3,12,27],"cytotoxiques,":[4],"leurs":[5],"doses":[6],"doivent":[7],"etre":[8],"adaptees":[9],"en":[10,69],"fonction":[11],"capacites":[13],"individuelle":[14],"d'elimination,":[15],"et":[16,43,49,80,114],"de":[17,21,33,36,50,54,60,62,77,90,108],"la":[18,47,74,78,81,88,91,101,110],"sensibilite":[19,55],"propre":[20],"chaque":[22],"patient":[23],"vis":[24,26],"a":[25,46,96],"cytotoxiques.\r\nNos":[28],"travaux":[29],"avaient":[30],"pour":[31,99],"objectif":[32],"predire":[34],"l'elimination":[35],"deux":[37],"substrats":[38],"du":[39,83],"cytochrome":[40],"P4503A":[41],"(docetaxel":[42],"vinorelbine)":[44],"gr\u00e2ce":[45],"dexamethasone,":[48],"rechercher":[51],"les":[52,116],"facteurs":[53,117],"au":[56],"docetaxel.\r\nPar":[57],"une":[58,71],"approche":[59],"pharmacocinetique":[61],"population":[63],"(NONMEM)":[64],"nous":[65],"avons":[66],"pu":[67],"mettre":[68],"evidence":[70],"relation":[72],"entre":[73],"clairance":[75],"(CL)":[76],"dexamethasone":[79],"CL":[82,89],"docetaxel":[84],"comme":[85],"avec":[87],"vinorelbine.\r\nUn":[92],"modele":[93],"pharmacocinetique-pharmacodynamique":[94],"semi-physiologiue":[95],"ete":[97],"utilise":[98],"decrire":[100],"neutropenie":[102],"induite":[103],"par":[104],"le":[105],"docetaxel,":[106],"permettant":[107],"quantifier":[109],"variabilite":[111],"inter-individuelle":[112],"pharmacodynamique":[113],"d'etudier":[115],"influents":[118],"cette":[119],"variabilite.":[120]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}