{"id":"https://openalex.org/W2914188196","doi":"https://doi.org/10.1158/1538-7445.prca2017-b014","title":"Abstract B014: Simulating prostate cancer stem cell dynamics to predict patient-specific sensitivity or resistance to intermittent androgen-deprivation therapy","display_name":"Abstract B014: Simulating prostate cancer stem cell dynamics to predict patient-specific sensitivity or resistance to intermittent androgen-deprivation therapy","publication_year":2018,"publication_date":"2018-08-14","ids":{"openalex":"https://openalex.org/W2914188196","doi":"https://doi.org/10.1158/1538-7445.prca2017-b014","mag":"2914188196"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.prca2017-b014","doi":"https://doi.org/10.1158/1538-7445.prca2017-b014","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.prca2017-b014","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011596516","display_name":"Renee Brady\u2010Nicholls","orcid":"https://orcid.org/0000-0003-1759-8283","observed_orcids":["https://orcid.org/0000-0003-1759-8283"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee Brady","raw_affiliation_strings":["1H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL,","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071572024","display_name":"John D. Nagy","orcid":"https://orcid.org/0000-0003-3870-0494","observed_orcids":["https://orcid.org/0000-0003-3870-0494"]},"institutions":[{"id":"https://openalex.org/I124718575","display_name":"Scottsdale Community College","ror":"https://ror.org/02rgx8605","country_code":"US","type":"education","lineage":["https://openalex.org/I124718575"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Nagy","raw_affiliation_strings":["2School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ,","3Scottsdale Community College, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ,","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"3Scottsdale Community College, Scottsdale, AZ","institution_ids":["https://openalex.org/I124718575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071572024","display_name":"John D. Nagy","orcid":"https://orcid.org/0000-0003-3870-0494","observed_orcids":["https://orcid.org/0000-0003-3870-0494"]},"institutions":[{"id":"https://openalex.org/I124718575","display_name":"Scottsdale Community College","ror":"https://ror.org/02rgx8605","country_code":"US","type":"education","lineage":["https://openalex.org/I124718575"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Nagy","raw_affiliation_strings":["2School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ,","3Scottsdale Community College, Scottsdale, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ,","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"3Scottsdale Community College, Scottsdale, AZ","institution_ids":["https://openalex.org/I124718575"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014796235","display_name":"Heiko Enderling","orcid":"https://orcid.org/0000-0002-9696-6410","observed_orcids":["https://orcid.org/0000-0002-9696-6410"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heiko Enderling","raw_affiliation_strings":["1H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL,","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"16_Supplement","first_page":"B014","last_page":"B014"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/intermittent-androgen-suppression","display_name":"intermittent androgen suppression","score":0.7879999876022339},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mathematical-modeling","display_name":"mathematical modeling","score":0.75},{"id":"https://openalex.org/keywords/stem-cell-dynamics","display_name":"stem cell dynamics","score":0.6060000061988831},{"id":"https://openalex.org/keywords/biochemically-recurrent-prostate-cancer","display_name":"biochemically recurrent prostate cancer","score":0.8500000238418579},{"id":"https://openalex.org/keywords/patient-specific-prediction","display_name":"patient-specific prediction","score":0.7720000147819519},{"id":"https://openalex.org/keywords/stem-cell-proliferation","display_name":"stem cell proliferation","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8313195109367371},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6849960088729858},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.6209110021591187},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6056994795799255},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5367492437362671},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5104088187217712},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5049992203712463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45923078060150146},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4500860273838043},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.44238054752349854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35468560457229614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13905510306358337},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.09979361295700073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.prca2017-b014","doi":"https://doi.org/10.1158/1538-7445.prca2017-b014","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.prca2017-b014","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2953875106","https://openalex.org/W3036851122","https://openalex.org/W2943345232","https://openalex.org/W2903953968","https://openalex.org/W1975742490","https://openalex.org/W2158564451","https://openalex.org/W6987902349","https://openalex.org/W2327525276","https://openalex.org/W3185809037","https://openalex.org/W7117567973"],"abstract_inverted_index":{"Abstract":[0],"Intermittent":[1],"androgen":[2,76,125],"suppression":[3],"is":[4],"an":[5],"attractive":[6],"treatment":[7,20],"approach":[8],"for":[9],"biochemically":[10],"recurrent":[11],"locally":[12],"advanced":[13],"prostate":[14,30,154],"cancer":[15,31,49,53,84,155],"to":[16,64,82,99,113,123,159,165],"delay":[17],"evolution":[18,102],"of":[19,29,41,48,68,74,103,172],"resistance":[21,42,104,122,164],"(PMID:":[22],"16783817).":[23],"We":[24,44,78],"developed":[25],"a":[26,38,132,140],"mathematical":[27],"model":[28,62,80,96],"stem":[32,50,85,156],"cell":[33,86,157],"dynamics":[34,47,81,158],"during":[35],"therapy":[36,168],"as":[37],"plausible":[39],"mechanism":[40],"evolution.":[43],"simulate":[45],"division":[46],"cells,":[51,54],"non-stem":[52],"and":[55,58,94,118,183],"PSA":[56],"concentration":[57],"generate":[59],"highly":[60],"accurate":[61],"fits":[63],"the":[65,173],"longitudinal":[66],"data":[67,134],"55":[69],"patients":[70,115],"undergoing":[71],"2-4":[72],"cycles":[73],"intermittent":[75,124,166],"suppression.":[77,126],"analyze":[79],"identify":[83],"proliferation":[87],"patterns":[88],"that":[89],"correlate":[90],"with":[91],"patient":[92],"outcomes,":[93],"score":[95],"predictive":[97,129],"power":[98,130],"accurately":[100],"forecast":[101],"in":[105,139,180],"individual":[106],"patients.":[107],"The":[108,127],"presented":[109],"framework":[110],"may":[111],"contribute":[112],"identifying":[114],"who":[116],"do":[117,119],"not":[120],"develop":[121],"obtained":[128],"on":[131],"retrospective":[133],"set":[135],"warrants":[136],"prospective":[137],"evaluation":[138],"clinical":[141],"setting.":[142],"Citation":[143],"Format:":[144],"Renee":[145],"Brady,":[146],"John":[147,149],"Nagy,":[148,150],"Heiko":[151],"Enderling.":[152],"Simulating":[153],"predict":[160],"patient-specific":[161],"sensitivity":[162],"or":[163],"androgen-deprivation":[167],"[abstract].":[169],"In:":[170],"Proceedings":[171],"AACR":[174],"Special":[175],"Conference:":[176],"Prostate":[177],"Cancer:":[178],"Advances":[179],"Basic,":[181],"Translational,":[182],"Clinical":[184],"Research;":[185],"2017":[186],"Dec":[187],"2-5;":[188],"Orlando,":[189],"Florida.":[190],"Philadelphia":[191],"(PA):":[192],"AACR;":[193],"Cancer":[194],"Res":[195],"2018;78(16":[196],"Suppl):Abstract":[197],"nr":[198],"B014.":[199]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2019-02-21T00:00:00"}
