{"id":"https://openalex.org/W2914112166","doi":"https://doi.org/10.1534/genetics.118.301062","title":"Purine Homeostasis Is Necessary for Developmental Timing, Germline Maintenance and Muscle Integrity in Caenorhabditis elegans","display_name":"Purine Homeostasis Is Necessary for Developmental Timing, Germline Maintenance and Muscle Integrity in Caenorhabditis elegans","publication_year":2019,"publication_date":"2019-01-30","ids":{"openalex":"https://openalex.org/W2914112166","doi":"https://doi.org/10.1534/genetics.118.301062","mag":"2914112166","pmid":"https://pubmed.ncbi.nlm.nih.gov/30700528","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6456310"},"language":"en","primary_location":{"id":"doi:10.1534/genetics.118.301062","doi":"https://doi.org/10.1534/genetics.118.301062","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.118.301062","pdf_url":"https://www.genetics.org/content/genetics/211/4/1297.full.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.genetics.org/content/genetics/211/4/1297.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036674809","display_name":"Roxane Marsac","orcid":"https://orcid.org/0000-0003-2800-9288","observed_orcids":["https://orcid.org/0000-0003-2800-9288"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roxane Marsac","raw_affiliation_strings":["Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083989677","display_name":"Beno\u0131\u0302t Pinson","orcid":"https://orcid.org/0000-0003-2936-9058","observed_orcids":["https://orcid.org/0000-0003-2936-9058"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Beno\u00eet Pinson","raw_affiliation_strings":["Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France"],"raw_orcid":"https://orcid.org/0000-0003-2936-9058","affiliations":[{"raw_affiliation_string":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008557150","display_name":"Christelle Saint\u2010Marc","orcid":"https://orcid.org/0000-0001-9537-1848","observed_orcids":["https://orcid.org/0000-0001-9537-1848"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christelle Saint-Marc","raw_affiliation_strings":["Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063367485","display_name":"Mar\u00eda Olmedo","orcid":"https://orcid.org/0000-0002-5701-2665","observed_orcids":["https://orcid.org/0000-0002-5701-2665"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210111405","display_name":"Centro Andaluz de Biolog\u00eda del Desarrollo","ror":"https://ror.org/01v5e3436","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210111405","https://openalex.org/I918821925","https://openalex.org/I95013407"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]},{"id":"https://openalex.org/I918821925","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82","country_code":"ES","type":"government","lineage":["https://openalex.org/I918821925"]},{"id":"https://openalex.org/I95013407","display_name":"Universidad Pablo de Olavide","ror":"https://ror.org/02z749649","country_code":"ES","type":"education","lineage":["https://openalex.org/I95013407"]}],"countries":["ES","FR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Olmedo","raw_affiliation_strings":["Andalusian Center for Developmental Biology, Consejo Superior de Investigaciones Cient\u00edficas/Junta de Andaluc\u00eda/Universidad Pablo de Olavide, Department of Molecular Biology and Biochemical Engineering. 41013, Seville, Spain","Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France"],"raw_orcid":"https://orcid.org/0000-0002-5701-2665","affiliations":[{"raw_affiliation_string":"Andalusian Center for Developmental Biology, Consejo Superior de Investigaciones Cient\u00edficas/Junta de Andaluc\u00eda/Universidad Pablo de Olavide, Department of Molecular Biology and Biochemical Engineering. 41013, Seville, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210111405","https://openalex.org/I918821925","https://openalex.org/I95013407"]},{"raw_affiliation_string":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016951873","display_name":"Marta Artal\u2010Sanz","orcid":"https://orcid.org/0000-0003-1126-0492","observed_orcids":["https://orcid.org/0000-0003-1126-0492"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210111405","display_name":"Centro Andaluz de Biolog\u00eda del Desarrollo","ror":"https://ror.org/01v5e3436","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210111405","https://openalex.org/I918821925","https://openalex.org/I95013407"]},{"id":"https://openalex.org/I918821925","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82","country_code":"ES","type":"government","lineage":["https://openalex.org/I918821925"]},{"id":"https://openalex.org/I95013407","display_name":"Universidad Pablo de Olavide","ror":"https://ror.org/02z749649","country_code":"ES","type":"education","lineage":["https://openalex.org/I95013407"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta ArtalSanz","raw_affiliation_strings":["Andalusian Center for Developmental Biology, Consejo Superior de Investigaciones Cient\u00edficas/Junta de Andaluc\u00eda/Universidad Pablo de Olavide, Department of Molecular Biology and Biochemical Engineering. 41013, Seville, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1126-0492","affiliations":[{"raw_affiliation_string":"Andalusian Center for Developmental Biology, Consejo Superior de Investigaciones Cient\u00edficas/Junta de Andaluc\u00eda/Universidad Pablo de Olavide, Department of Molecular Biology and Biochemical Engineering. 41013, Seville, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210111405","https://openalex.org/I918821925","https://openalex.org/I95013407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088388229","display_name":"Bertrand Daignan\u2010Fornier","orcid":"https://orcid.org/0000-0003-2352-9700","observed_orcids":["https://orcid.org/0000-0003-2352-9700"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bertrand Daignan-Fornier","raw_affiliation_strings":["Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France"],"raw_orcid":"https://orcid.org/0000-0003-2352-9700","affiliations":[{"raw_affiliation_string":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069117296","display_name":"Jos\u00e9\u2010Eduardo Gomes","orcid":"https://orcid.org/0000-0001-7264-9448","observed_orcids":["https://orcid.org/0000-0001-7264-9448"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210140961","display_name":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires","ror":"https://ror.org/048xwe611","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210096427","https://openalex.org/I4210140961"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jos\u00e9-Eduardo Gomes","raw_affiliation_strings":["Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France"],"raw_orcid":"https://orcid.org/0000-0001-7264-9448","affiliations":[{"raw_affiliation_string":"Institut de Biochimie et G\u00e9n\u00e9tique Cellulaires, Universit\u00e9 de Bordeaux and CNRS UMR5095, 33077 Bordeaux cedex, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210140961"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5069117296"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210140961"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":0.9522,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.71033642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"211","issue":"4","first_page":"1297","last_page":"1313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/purine-biosynthesis","display_name":"purine biosynthesis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/adenylosuccinate-lyase","display_name":"adenylosuccinate lyase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/de-novo-purine-synthesis","display_name":"de novo purine synthesis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/developmental-timing","display_name":"developmental timing","score":0.8109999895095825},{"id":"https://openalex.org/keywords/muscle-integrity","display_name":"muscle integrity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9035279154777527},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.7861744165420532},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.6042931079864502},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.5943852663040161},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.5927987098693848},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48091623187065125},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.41325584053993225},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32515549659729004},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28574979305267334},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24087974429130554},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0951080322265625}],"mesh":[{"descriptor_ui":"D000264","descriptor_name":"Adenylosuccinate Lyase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000264","descriptor_name":"Adenylosuccinate Lyase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1534/genetics.118.301062","doi":"https://doi.org/10.1534/genetics.118.301062","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.118.301062","pdf_url":"https://www.genetics.org/content/genetics/211/4/1297.full.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"doi:10.1101/277640","doi":"https://doi.org/10.1101/277640","is_oa":true,"landing_page_url":"https://doi.org/10.1101/277640","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/04/06/277640.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:6058724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6456310","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6456310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6456310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},{"id":"pmid:30700528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30700528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-02346559v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-02346559","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genetics, 2019, 211 (4), pp.1297-1313. ⟨10.1534/genetics.118.301062⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.csic.es:10261/202325","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/202325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:idus.us.es:11441/133349","doi":null,"is_oa":true,"landing_page_url":"https://idus.us.es/handle//11441/133349","pdf_url":null,"source":{"id":"https://openalex.org/S4306400333","display_name":"idUS (Universidad de Sevilla)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79238269","host_organization_name":"Universidad de Sevilla","host_organization_lineage":["https://openalex.org/I79238269"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1534/genetics.118.301062","doi":"https://doi.org/10.1534/genetics.118.301062","is_oa":true,"landing_page_url":"https://doi.org/10.1534/genetics.118.301062","pdf_url":"https://www.genetics.org/content/genetics/211/4/1297.full.pdf","source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3047890022","display_name":"WormBase:  a core data resource for C. elegans and other nematodes","funder_award_id":"U41HG002223","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6812869445","display_name":null,"funder_award_id":"RYC-2010","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G7494650190","display_name":null,"funder_award_id":"RYC-2014-15551","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G9000865705","display_name":"Caenorhabditis Genetics Center","funder_award_id":"P40OD010440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337901","display_name":"Office of Research Infrastructure Programs, National Institutes of Health","ror":"https://ror.org/01jdyfj45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2914112166.pdf","grobid_xml":"https://content.openalex.org/works/W2914112166.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W27486670","https://openalex.org/W182543335","https://openalex.org/W1486450190","https://openalex.org/W1571414277","https://openalex.org/W1857695392","https://openalex.org/W1889401850","https://openalex.org/W1911220294","https://openalex.org/W1944127002","https://openalex.org/W1954391111","https://openalex.org/W1966145280","https://openalex.org/W1968315432","https://openalex.org/W1980515463","https://openalex.org/W1983377872","https://openalex.org/W1993519767","https://openalex.org/W1995679486","https://openalex.org/W1996646041","https://openalex.org/W1996783999","https://openalex.org/W1997197922","https://openalex.org/W1997338257","https://openalex.org/W1997873485","https://openalex.org/W1999955453","https://openalex.org/W2006938530","https://openalex.org/W2009906860","https://openalex.org/W2011490248","https://openalex.org/W2021469756","https://openalex.org/W2024798023","https://openalex.org/W2027271710","https://openalex.org/W2055377404","https://openalex.org/W2058615553","https://openalex.org/W2061075485","https://openalex.org/W2062955020","https://openalex.org/W2078388909","https://openalex.org/W2079783863","https://openalex.org/W2079911379","https://openalex.org/W2087576311","https://openalex.org/W2089974780","https://openalex.org/W2097572585","https://openalex.org/W2100365580","https://openalex.org/W2101221992","https://openalex.org/W2102335229","https://openalex.org/W2114329214","https://openalex.org/W2119920331","https://openalex.org/W2122163057","https://openalex.org/W2128570365","https://openalex.org/W2129900247","https://openalex.org/W2130233455","https://openalex.org/W2134556357","https://openalex.org/W2140315679","https://openalex.org/W2140380026","https://openalex.org/W2143015660","https://openalex.org/W2145332211","https://openalex.org/W2157028755","https://openalex.org/W2159565935","https://openalex.org/W2162448144","https://openalex.org/W2164230996","https://openalex.org/W2168397517","https://openalex.org/W2168974900","https://openalex.org/W2172087298","https://openalex.org/W2174361280","https://openalex.org/W2271734275","https://openalex.org/W2408378333","https://openalex.org/W2409549369","https://openalex.org/W2433871124","https://openalex.org/W2512645704","https://openalex.org/W2537388355","https://openalex.org/W2771787069","https://openalex.org/W2793496983","https://openalex.org/W4252308397"],"related_works":["https://openalex.org/W2796020741","https://openalex.org/W4392486239","https://openalex.org/W7148648334","https://openalex.org/W4415053619","https://openalex.org/W4387177482","https://openalex.org/W7135869217","https://openalex.org/W2187187847","https://openalex.org/W1969977824","https://openalex.org/W2069305247","https://openalex.org/W4407095555"],"abstract_inverted_index":{"Abstract":[0],"Purine":[1],"homeostasis":[2],"is":[3,46,128,143,167,176],"ensured":[4],"through":[5,66],"a":[6,109],"metabolic":[7,204],"network":[8,54,127,205],"widely":[9],"conserved":[10,130],"from":[11],"prokaryotes":[12],"to":[13,63,97,113,179,195,198],"humans.":[14],"Purines":[15],"can":[16],"either":[17],"be":[18,196],"synthesized":[19],"de":[20,85,164],"novo,":[21],"reused,":[22],"or":[23,43],"produced":[24],"by":[25],"interconversion":[26],"of":[27,50,201],"extant":[28],"metabolites":[29],"using":[30],"the":[31,51,73,83,99,124,163,183,202],"so-called":[32],"recycling":[33,88,184],"pathway.":[34,185],"Although":[35],"thoroughly":[36],"characterized":[37],"in":[38,55,75,82,131,140,182,206],"microorganisms,":[39],"such":[40],"as":[41,67,108],"yeast":[42],"bacteria,":[44],"little":[45],"known":[47],"about":[48],"regulation":[49],"purine":[52,64,84,115,125,203],"biosynthesis":[53,126],"metazoans.":[56],"In":[57,95],"humans,":[58],"several":[59],"diseases":[60],"are":[61,158],"linked":[62,177],"metabolism":[65],"yet":[68],"poorly":[69],"understood":[70],"etiologies.":[71],"Particularly,":[72],"deficiency":[74],"adenylosuccinate":[76],"lyase":[77],"(ADSL)\u2014an":[78],"enzyme":[79],"involved":[80],"both":[81],"novo":[86,165],"and":[87,92,152,169,191],"pathways\u2014causes":[89],"severe":[90],"muscular":[91],"neuronal":[93],"symptoms.":[94],"order":[96],"address":[98],"mechanisms":[100],"underlying":[101],"this":[102],"deficiency,":[103],"we":[104,170],"established":[105],"Caenorhabditis":[106],"elegans":[107],"metazoan":[110],"model":[111],"organism":[112],"study":[114],"metabolism,":[116],"while":[117],"focusing":[118],"on":[119],"ADSL.":[120],"We":[121],"show":[122],"that":[123,173],"functionally":[129],"C.":[132,141],"elegans.":[133],"Moreover,":[134],"adsl-1":[135],"(the":[136],"gene":[137],"encoding":[138],"ADSL":[139,180],"elegans)":[142],"required":[144],"for":[145],"developmental":[146,190],"timing,":[147],"germline":[148,174],"stem":[149],"cell":[150],"maintenance":[151,175],"muscle":[153],"integrity.":[154],"Importantly,":[155],"these":[156],"traits":[157],"not":[159],"affected":[160],"when":[161],"solely":[162],"pathway":[166],"abolished,":[168],"present":[171],"evidence":[172],"specifically":[178],"activity":[181],"Hence,":[186],"our":[187],"results":[188],"allow":[189],"tissue":[192],"specific":[193],"phenotypes":[194],"ascribed":[197],"separable":[199],"steps":[200],"an":[207],"animal":[208],"model.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-02-21T00:00:00"}