{"id":"https://openalex.org/W2914101161","doi":"https://doi.org/10.1093/nop/npz004","title":"Immunotherapy is associated with improved survival and decreased neurologic death after SRS for brain metastases from lung and melanoma primaries","display_name":"Immunotherapy is associated with improved survival and decreased neurologic death after SRS for brain metastases from lung and melanoma primaries","publication_year":2019,"publication_date":"2019-02-05","ids":{"openalex":"https://openalex.org/W2914101161","doi":"https://doi.org/10.1093/nop/npz004","mag":"2914101161","pmid":"https://pubmed.ncbi.nlm.nih.gov/31555455"},"language":"en","primary_location":{"id":"doi:10.1093/nop/npz004","doi":"https://doi.org/10.1093/nop/npz004","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nop/npz004","pdf_url":null,"source":{"id":"https://openalex.org/S2735333031","display_name":"Neuro-Oncology Practice","issn_l":"2054-2577","issn":["2054-2577","2054-2585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6753360","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002293223","display_name":"C.M. Lanier","orcid":"https://orcid.org/0000-0003-0127-9253","observed_orcids":["https://orcid.org/0000-0003-0127-9253"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Claire M Lanier","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057426956","display_name":"Ryan T. Hughes","orcid":"https://orcid.org/0000-0003-1548-9753","observed_orcids":["https://orcid.org/0000-0003-1548-9753"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Hughes","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057545412","display_name":"Tamjeed Ahmed","orcid":"https://orcid.org/0000-0002-3606-9048","observed_orcids":["https://orcid.org/0000-0002-3606-9048"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamjeed Ahmed","raw_affiliation_strings":["Department of Medicine (Hematology & Oncology), Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Hematology & Oncology), Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062186012","display_name":"Michael C. LeCompte","orcid":"https://orcid.org/0000-0002-3116-007X","observed_orcids":["https://orcid.org/0000-0002-3116-007X"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael LeCompte","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014450416","display_name":"Adrianna Henson Masters","orcid":"https://orcid.org/0000-0001-7261-2477","observed_orcids":["https://orcid.org/0000-0001-7261-2477"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrianna H Masters","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051036544","display_name":"William Jeffrey Petty","orcid":"https://orcid.org/0000-0002-1553-1838","observed_orcids":["https://orcid.org/0000-0002-1553-1838"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J Petty","raw_affiliation_strings":["Department of Medicine (Hematology & Oncology), Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Hematology & Oncology), Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050923145","display_name":"Jimmy Ruiz","orcid":"https://orcid.org/0000-0002-7242-3315","observed_orcids":["https://orcid.org/0000-0002-7242-3315"]},"institutions":[{"id":"https://openalex.org/I4210111379","display_name":"W. G. (Bill) Hefner VA Medical Center","ror":"https://ror.org/01bqvph43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210111379","https://openalex.org/I4210159720"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimmy Ruiz","raw_affiliation_strings":["Department of Medicine (Hematology & Oncology), Wake Forest School of Medicine, Winston-Salem, NC","W.G. (Bill) Hefner Veteran Administration Medical Center, Cancer Center, Salisbury, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Hematology & Oncology), Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"W.G. (Bill) Hefner Veteran Administration Medical Center, Cancer Center, Salisbury, NC","institution_ids":["https://openalex.org/I4210111379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087285442","display_name":"Pierre L. Triozzi","orcid":"https://orcid.org/0000-0003-2488-6136","observed_orcids":["https://orcid.org/0000-0003-2488-6136"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre Triozzi","raw_affiliation_strings":["Department of Medicine (Hematology & Oncology), Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Hematology & Oncology), Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034140883","display_name":"Jing Su","orcid":"https://orcid.org/0000-0003-4917-6173","observed_orcids":["https://orcid.org/0000-0003-4917-6173"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Su","raw_affiliation_strings":["Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017123910","display_name":"Stacy O\u2019Neill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacy O\u2019Neill","raw_affiliation_strings":["Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023534649","display_name":"Kuonosuke Watabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuonosuke Watabe","raw_affiliation_strings":["Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056464333","display_name":"Christina Kehl Cramer","orcid":"https://orcid.org/0000-0001-7618-3921","observed_orcids":["https://orcid.org/0000-0001-7618-3921"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina K Cramer","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053135133","display_name":"Adrian W. Laxton","orcid":"https://orcid.org/0000-0002-4631-5476","observed_orcids":["https://orcid.org/0000-0002-4631-5476"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian W Laxton","raw_affiliation_strings":["Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059467122","display_name":"Stephen B. Tatter","orcid":"https://orcid.org/0000-0002-1063-0431","observed_orcids":["https://orcid.org/0000-0002-1063-0431"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B Tatter","raw_affiliation_strings":["Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400458","display_name":"Ge Wang","orcid":"https://orcid.org/0000-0002-2656-7705","observed_orcids":["https://orcid.org/0000-0002-2656-7705"]},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ge Wang","raw_affiliation_strings":["Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000092822","display_name":"Christopher T. Whitlow","orcid":"https://orcid.org/0000-0003-2392-8293","observed_orcids":["https://orcid.org/0000-0003-2392-8293"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Whitlow","raw_affiliation_strings":["Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053414244","display_name":"Michael David Chan","orcid":"https://orcid.org/0000-0002-5278-6709","observed_orcids":["https://orcid.org/0000-0002-5278-6709"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D Chan","raw_affiliation_strings":["Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002293223"],"corresponding_institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":{"value":5036,"currency":"USD","value_usd":5036},"apc_paid":null,"fwci":7.7667,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.98169585,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"6","issue":"5","first_page":"402","last_page":"409"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9359999895095825},{"id":"https://openalex.org/keywords/stereotactic-radiosurgery","display_name":"stereotactic radiosurgery","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9559999704360962},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":1.0},{"id":"https://openalex.org/keywords/neurologic-death","display_name":"neurologic death","score":0.8999999761581421},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.984000027179718},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9290000200271606},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":1.0},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/salvage-stereotactic-radiosurgery","display_name":"salvage stereotactic radiosurgery","score":0.828000009059906},{"id":"https://openalex.org/keywords/whole-brain-radiotherapy","display_name":"whole brain radiotherapy","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.92088383436203},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.8892403841018677},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.7902223467826843},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.7356542348861694},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6340878009796143},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.6125819683074951},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.5509232878684998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5370990037918091},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5235832929611206},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5160946249961853},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4364899694919586},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3958660960197449},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3780248761177063},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2991933822631836},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25065889954566956},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/nop/npz004","doi":"https://doi.org/10.1093/nop/npz004","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nop/npz004","pdf_url":null,"source":{"id":"https://openalex.org/S2735333031","display_name":"Neuro-Oncology Practice","issn_l":"2054-2577","issn":["2054-2577","2054-2585"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Practice","raw_type":"journal-article"},{"id":"pmid:31555455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31555455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-oncology practice","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6753360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6753360","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurooncol Pract","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6753360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6753360","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurooncol Pract","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1809627231","https://openalex.org/W2003917401","https://openalex.org/W2015998836","https://openalex.org/W2060654645","https://openalex.org/W2083128109","https://openalex.org/W2103363373","https://openalex.org/W2112121482","https://openalex.org/W2136568031","https://openalex.org/W2158777895","https://openalex.org/W2166662937","https://openalex.org/W2169923878","https://openalex.org/W2172075995","https://openalex.org/W2177244913","https://openalex.org/W2416791964","https://openalex.org/W2511092051","https://openalex.org/W2527905628","https://openalex.org/W2529484692","https://openalex.org/W2572174216","https://openalex.org/W2582449552","https://openalex.org/W2588916311","https://openalex.org/W2752227448","https://openalex.org/W2753065806","https://openalex.org/W2753432434","https://openalex.org/W2758205050","https://openalex.org/W2769596292","https://openalex.org/W2772183668","https://openalex.org/W2782652081","https://openalex.org/W2791043965","https://openalex.org/W2794627893","https://openalex.org/W2796582438","https://openalex.org/W2806614796","https://openalex.org/W2888298425","https://openalex.org/W6744680727"],"related_works":["https://openalex.org/W4313890856","https://openalex.org/W2766929851","https://openalex.org/W4236421112","https://openalex.org/W2973740076","https://openalex.org/W3043703771","https://openalex.org/W4241093956","https://openalex.org/W2899127460","https://openalex.org/W3108601240","https://openalex.org/W2800160190","https://openalex.org/W4362545845"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,156,186,242],"effect":[3,19],"of":[4,26,55,110,138,161,190,234,244,268],"immunotherapy":[5,79,126,165,199,245],"on":[6,20],"brain":[7,67,145,223,256],"metastasis":[8,224],"patients":[9,39,61,162,196,247],"remains":[10],"incompletely":[11],"understood.":[12],"Our":[13],"goal":[14],"was":[15,129,168,193,212],"to":[16,46,173,180,254],"evaluate":[17],"its":[18],"survival,":[21],"neurologic":[22,139,191,269],"death,":[23,140],"and":[24,42,71,80,112,135,141,143,232,237,265],"patterns":[25],"failure":[27,146],"after":[28],"stereotactic":[29],"radiosurgery":[30],"(SRS)":[31],"without":[32,167,205],"prior":[33],"whole-brain":[34],"radiation":[35],"therapy":[36],"(WBRT)":[37],"in":[38,195,202,246],"with":[40,63,89,95,101,107,118,124,164,198,248,258,262],"lung":[41,58,249],"melanoma":[43,60,252],"primaries":[44],"metastatic":[45,253],"the":[47,132,255],"brain.":[48],"Methods":[49],"We":[50],"performed":[51],"a":[52,108,152],"retrospective":[53],"analysis":[54],"271":[56],"consecutive":[57],"or":[59,251],"treated":[62,88,94,100,106,117,123,163,197,204,257],"upfront":[64],"SRS":[65,236,259],"for":[66],"metastases":[68],"between":[69,230],"2013":[70],"2018.":[72],"Of":[73],"these":[74],"patients,":[75],"101":[76],"(37%)":[77],"received":[78],"170":[81],"(63%)":[82],"did":[83,227],"not.":[84],"Forty-three":[85],"percent":[86,92,98,104,115,121],"were":[87,93,99,105,116,122,147,239],"nivolumab.":[90],"Thirty-seven":[91],"pembrolizumab.":[96],"Fifteen":[97],"ipilimumab.":[102,113],"One":[103,114],"combination":[109],"nivolumab":[111],"atezolizumab.":[119],"Three":[120],"another":[125],"regimen.":[127],"Survival":[128],"estimated":[130,148],"by":[131],"Kaplan\u2013Meier":[133],"method":[134],"cumulative":[136,188],"incidences":[137],"local":[142],"distant":[144],"using":[149],"death":[150,192,211],"as":[151],"competing":[153],"risk.":[154],"Results":[155],"median":[157],"overall":[158],"survival":[159],"(OS)":[160],"vs":[166,175,200,217],"15.9":[169],"(95%":[170,177],"CI:":[171,178],"13.3":[172],"24.8)":[174],"6.1":[176],"5.1":[179],"8.8)":[181],"months":[182],"(P":[183,206],"<":[184],".01).":[185],"1-year":[187],"incidence":[189,267],"9%":[194],"23%":[201],"those":[203],"=":[207,220],".01),":[208],"while":[209],"nonneurologic":[210],"not":[213,228],"significantly":[214],"different":[215],"(29%":[216],"41%,":[218],"P":[219],".51).":[221],"Median":[222],"velocity":[225],"(BMV)":[226],"differ":[229],"groups,":[231],"rates":[233],"salvage":[235],"WBRT":[238],"similar.":[240],"Conclusions":[241],"use":[243],"cancer":[250],"is":[260],"associated":[261],"improved":[263],"OS":[264],"decreased":[266],"death.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":14},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
