{"id":"https://openalex.org/W2914089740","doi":"https://doi.org/10.1016/j.bpj.2018.11.2349","title":"Explorations of Drug Transport by P-Glycoprotein using Molecular Dynamics Enabled by High Resolution Crystal Structures","display_name":"Explorations of Drug Transport by P-Glycoprotein using Molecular Dynamics Enabled by High Resolution Crystal Structures","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2914089740","doi":"https://doi.org/10.1016/j.bpj.2018.11.2349","mag":"2914089740"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2018.11.2349","doi":"https://doi.org/10.1016/j.bpj.2018.11.2349","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.2349","pdf_url":"http://www.cell.com/article/S0006349518336142/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349518336142/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102399164","display_name":"Lauren E. Ammerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178169726","display_name":"Southern Methodist University","ror":"https://ror.org/042tdr378","country_code":"US","type":"education","lineage":["https://openalex.org/I178169726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren E. Ammerman","raw_affiliation_strings":["Department of Biological Sciences, Southern Methodist University, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Southern Methodist University, Dallas, TX, USA","institution_ids":["https://openalex.org/I178169726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025846620","display_name":"Pia D. Vogel","orcid":"https://orcid.org/0000-0002-8135-4649","observed_orcids":["https://orcid.org/0000-0002-8135-4649"]},"institutions":[{"id":"https://openalex.org/I178169726","display_name":"Southern Methodist University","ror":"https://ror.org/042tdr378","country_code":"US","type":"education","lineage":["https://openalex.org/I178169726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pia D. Vogel","raw_affiliation_strings":["Department of Biological Sciences, Southern Methodist University, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Southern Methodist University, Dallas, TX, USA","institution_ids":["https://openalex.org/I178169726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084263586","display_name":"John G. Wise","orcid":"https://orcid.org/0000-0001-5398-8794","observed_orcids":["https://orcid.org/0000-0001-5398-8794"]},"institutions":[{"id":"https://openalex.org/I178169726","display_name":"Southern Methodist University","ror":"https://ror.org/042tdr378","country_code":"US","type":"education","lineage":["https://openalex.org/I178169726"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John G. Wise","raw_affiliation_strings":["Department of Biological Sciences, Southern Methodist University, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Southern Methodist University, Dallas, TX, USA","institution_ids":["https://openalex.org/I178169726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I178169726"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01350552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"3","first_page":"436a","last_page":"436a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.996999979019165},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9879999756813049},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.828000009059906},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.8100000023841858},{"id":"https://openalex.org/keywords/substrate-binding-site","display_name":"substrate binding site","score":0.7680000066757202},{"id":"https://openalex.org/keywords/transport-inhibitors","display_name":"transport inhibitors","score":0.6729999780654907},{"id":"https://openalex.org/keywords/membrane-transport-mechanisms","display_name":"membrane transport mechanisms","score":0.4020000100135803},{"id":"https://openalex.org/keywords/homology-model","display_name":"homology model","score":0.5920000076293945},{"id":"https://openalex.org/keywords/gpu-accelerated-molecular-dynamics","display_name":"GPU-accelerated molecular dynamics","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.740705132484436},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.7064958810806274},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.7047998309135437},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6577054858207703},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6070336103439331},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5136772990226746},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48851287364959717},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.48144739866256714},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4539877474308014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4476100206375122},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4436700940132141},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.42480528354644775},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.4230010509490967},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34534671902656555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3442126512527466},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34318971633911133},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3428493142127991},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30435940623283386},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21470874547958374},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10819381475448608},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2018.11.2349","doi":"https://doi.org/10.1016/j.bpj.2018.11.2349","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.2349","pdf_url":"http://www.cell.com/article/S0006349518336142/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2018.11.2349","doi":"https://doi.org/10.1016/j.bpj.2018.11.2349","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.2349","pdf_url":"http://www.cell.com/article/S0006349518336142/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2914089740.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1575277100","https://openalex.org/W4200169367","https://openalex.org/W4391658591","https://openalex.org/W6911813648","https://openalex.org/W2315961269","https://openalex.org/W2315418438","https://openalex.org/W1968931590","https://openalex.org/W1996969897","https://openalex.org/W4416738513","https://openalex.org/W2327968288"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2019-02-21T00:00:00"}