{"id":"https://openalex.org/W2913991553","doi":"https://doi.org/10.1016/j.bpj.2018.11.580","title":"A Computational Approach to Predict Mechanisms of Phenotypic Variability in Induced Pluripotent Stem Cell-Derived Cardiomyocytes","display_name":"A Computational Approach to Predict Mechanisms of Phenotypic Variability in Induced Pluripotent Stem Cell-Derived Cardiomyocytes","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2913991553","doi":"https://doi.org/10.1016/j.bpj.2018.11.580","mag":"2913991553"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2018.11.580","doi":"https://doi.org/10.1016/j.bpj.2018.11.580","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.580","pdf_url":"http://www.cell.com/article/S0006349518318459/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349518318459/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034241351","display_name":"Divya C. Kernik","orcid":"https://orcid.org/0000-0002-8216-9744","observed_orcids":["https://orcid.org/0000-0002-8216-9744"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divya C. Kernik","raw_affiliation_strings":["Dept Physiology and Membrane Biology, Univ Calif Davis, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Physiology and Membrane Biology, Univ Calif Davis, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077580168","display_name":"Stefano Morotti","orcid":"https://orcid.org/0000-0001-8679-665X","observed_orcids":["https://orcid.org/0000-0001-8679-665X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefano Morotti","raw_affiliation_strings":["Dept Pharmacology, Univ Calif Davis, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Pharmacology, Univ Calif Davis, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101463738","display_name":"Priyanka Garg","orcid":"https://orcid.org/0000-0003-2875-5256","observed_orcids":["https://orcid.org/0000-0003-2875-5256"]},"institutions":[{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garg Priyanka","raw_affiliation_strings":["Stanford Cardiovascular Institute and Department of Medicine, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Cardiovascular Institute and Department of Medicine, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047561254","display_name":"Joseph C. Wu","orcid":"https://orcid.org/0000-0002-6068-8041","observed_orcids":["https://orcid.org/0000-0002-6068-8041","https://orcid.org/0000-0003-4274-0413"]},"institutions":[{"id":"https://openalex.org/I4405269264","display_name":"Stanford Cardiovascular Institute","ror":"https://ror.org/03kk52s14","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4405269264","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C. Wu","raw_affiliation_strings":["Stanford Cardiovascular Institute and Department of Medicine, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Cardiovascular Institute and Department of Medicine, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I4405269264","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055910478","display_name":"Jos\u00e9 Jalife","orcid":"https://orcid.org/0000-0003-0080-3500","observed_orcids":["https://orcid.org/0000-0003-0080-3500"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Jalife","raw_affiliation_strings":["Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001770484","display_name":"Eleonora Grandi","orcid":"https://orcid.org/0000-0002-4401-8857","observed_orcids":["https://orcid.org/0000-0002-4401-8857"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleonora Grandi","raw_affiliation_strings":["Dept Pharmacology, Univ Calif Davis, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Pharmacology, Univ Calif Davis, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031553126","display_name":"Colleen E. Clancy","orcid":"https://orcid.org/0000-0001-6849-4885","observed_orcids":["https://orcid.org/0000-0001-6849-4885"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen E. Clancy","raw_affiliation_strings":["Dept Physiology and Membrane Biology, Univ Calif Davis, Davis, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept Physiology and Membrane Biology, Univ Calif Davis, Davis, CA, USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01345602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"3","first_page":"101a","last_page":"101a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-cardiomyocytes","display_name":"iPSC-derived cardiomyocytes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/phenotypic-variation","display_name":"phenotypic variability","score":0.859000027179718},{"id":"https://openalex.org/keywords/ionic-currents","display_name":"ionic currents","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.5619999766349792},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"long QT syndrome","score":0.7490000128746033},{"id":"https://openalex.org/keywords/long-qt-syndrome-type-2","display_name":"long QT syndrome type 2","score":0.8809999823570251},{"id":"https://openalex.org/keywords/kcnh2-mutation","display_name":"KCNH2 mutation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/patient-specific-modeling","display_name":"patient-specific modeling","score":0.5910000205039978},{"id":"https://openalex.org/keywords/cell-to-cell-variability","display_name":"cell-to-cell variability","score":0.6859999895095825},{"id":"https://openalex.org/keywords/inward-rectifier-potassium-current","display_name":"inward rectifier potassium current","score":0.6579999923706055},{"id":"https://openalex.org/keywords/inas","display_name":"InAs","score":0.9169999957084656},{"id":"https://openalex.org/keywords/if","display_name":"If","score":0.7910000085830688},{"id":"https://openalex.org/keywords/rare-events","display_name":"rare events","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8854933977127075},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7606251239776611},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6479896903038025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6095491051673889},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4990272521972656},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.49418333172798157},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.4721650779247284},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4274009168148041},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.4193497896194458},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36448195576667786},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32381388545036316},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20232263207435608},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.15704354643821716},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14985427260398865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14916256070137024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14289450645446777},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1262434422969818},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.06907889246940613},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2018.11.580","doi":"https://doi.org/10.1016/j.bpj.2018.11.580","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.580","pdf_url":"http://www.cell.com/article/S0006349518318459/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2018.11.580","doi":"https://doi.org/10.1016/j.bpj.2018.11.580","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.580","pdf_url":"http://www.cell.com/article/S0006349518318459/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913991553.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2956154393","https://openalex.org/W2793796894","https://openalex.org/W3011585939","https://openalex.org/W2969624235","https://openalex.org/W3049589497","https://openalex.org/W4402437249","https://openalex.org/W2901002535","https://openalex.org/W4412781812","https://openalex.org/W4403246981","https://openalex.org/W2107789728"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2019-02-21T00:00:00"}
