{"id":"https://openalex.org/W2913976500","doi":"https://doi.org/10.3390/nano9020139","title":"Differential Cytotoxicity of Different Sizes of Graphene Oxide Nanoparticles in Leydig (TM3) and Sertoli (TM4) Cells","display_name":"Differential Cytotoxicity of Different Sizes of Graphene Oxide Nanoparticles in Leydig (TM3) and Sertoli (TM4) Cells","publication_year":2019,"publication_date":"2019-01-22","ids":{"openalex":"https://openalex.org/W2913976500","doi":"https://doi.org/10.3390/nano9020139","mag":"2913976500","pmid":"https://pubmed.ncbi.nlm.nih.gov/30678270","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6410280"},"language":"en","primary_location":{"id":"doi:10.3390/nano9020139","doi":"https://doi.org/10.3390/nano9020139","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nano9020139","pdf_url":"https://www.mdpi.com/2079-4991/9/2/139/pdf?version=1548674564","source":{"id":"https://openalex.org/S2764646681","display_name":"Nanomaterials","issn_l":"2079-4991","issn":["2079-4991"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomaterials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2079-4991/9/2/139/pdf?version=1548674564","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051210077","display_name":"Sangiliyandi Gurunathan","orcid":"https://orcid.org/0000-0001-9924-8433","observed_orcids":["https://orcid.org/0000-0001-9924-8433"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sangiliyandi Gurunathan","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"],"raw_orcid":"https://orcid.org/0000-0001-9924-8433","affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025835928","display_name":"Min-Hee Kang","orcid":"https://orcid.org/0000-0003-4402-7064","observed_orcids":["https://orcid.org/0000-0003-4402-7064"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Hee Kang","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"],"raw_orcid":"https://orcid.org/0000-0003-4402-7064","affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110161616","display_name":"Muniyandi Jeyaraj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Muniyandi Jeyaraj","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001188270","display_name":"Jin\u2010Hoi Kim","orcid":"https://orcid.org/0000-0003-1232-5307","observed_orcids":["https://orcid.org/0000-0003-1232-5307"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jin-Hoi Kim","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1232-5307","affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea","institution_ids":["https://openalex.org/I24062138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001188270"],"corresponding_institution_ids":["https://openalex.org/I24062138"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1621},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1621},"fwci":3.5974,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.9396745,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"9","issue":"2","first_page":"139","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12627","display_name":"Graphene and Nanomaterials Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12627","display_name":"Graphene and Nanomaterials Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graphene-oxide","display_name":"graphene oxide","score":0.8980000019073486},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/sertoli-cells","display_name":"Sertoli cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/germ-cell-toxicity","display_name":"germ cell toxicity","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.7699999809265137},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.8100000023841858},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.8640000224113464},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/egfr-akt-signaling","display_name":"EGFR/AKT signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.574999988079071},{"id":"https://openalex.org/keywords/male-reproductive-toxicity","display_name":"male reproductive toxicity","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C30080830","wikidata":"https://www.wikidata.org/wiki/Q169917","display_name":"Graphene","level":2,"score":0.8265669345855713},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8003426790237427},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.779233455657959},{"id":"https://openalex.org/C2779851234","wikidata":"https://www.wikidata.org/wiki/Q50690","display_name":"Oxide","level":2,"score":0.623689591884613},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5567474365234375},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5533556342124939},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.37643754482269287},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2952055335044861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14070123434066772},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11049202084541321},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09561273455619812},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07827907800674438},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.057399213314056396},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/nano9020139","doi":"https://doi.org/10.3390/nano9020139","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nano9020139","pdf_url":"https://www.mdpi.com/2079-4991/9/2/139/pdf?version=1548674564","source":{"id":"https://openalex.org/S2764646681","display_name":"Nanomaterials","issn_l":"2079-4991","issn":["2079-4991"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomaterials","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5418240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6410280","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:30678270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30678270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomaterials (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6410280","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6410280/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomaterials (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8978369a62b24b119fd0fae4f6b4eb7f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8978369a62b24b119fd0fae4f6b4eb7f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nanomaterials, Vol 9, Iss 2, p 139 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/nano9020139","doi":"https://doi.org/10.3390/nano9020139","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/nano9020139","pdf_url":"https://www.mdpi.com/2079-4991/9/2/139/pdf?version=1548674564","source":{"id":"https://openalex.org/S2764646681","display_name":"Nanomaterials","issn_l":"2079-4991","issn":["2079-4991"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nanomaterials","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321372","display_name":"Konkuk University","ror":"https://ror.org/025h1m602"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913976500.pdf","grobid_xml":"https://content.openalex.org/works/W2913976500.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1546117988","https://openalex.org/W1836250711","https://openalex.org/W1861213326","https://openalex.org/W1879097209","https://openalex.org/W1976073956","https://openalex.org/W1988310931","https://openalex.org/W1997390869","https://openalex.org/W2003210979","https://openalex.org/W2009953362","https://openalex.org/W2012296461","https://openalex.org/W2012588499","https://openalex.org/W2013328140","https://openalex.org/W2017181626","https://openalex.org/W2017581710","https://openalex.org/W2020383780","https://openalex.org/W2023590633","https://openalex.org/W2030730002","https://openalex.org/W2032126593","https://openalex.org/W2047305537","https://openalex.org/W2051024318","https://openalex.org/W2054576677","https://openalex.org/W2058122340","https://openalex.org/W2058645214","https://openalex.org/W2058909257","https://openalex.org/W2060009331","https://openalex.org/W2065062234","https://openalex.org/W2078532788","https://openalex.org/W2078792724","https://openalex.org/W2087985414","https://openalex.org/W2089642489","https://openalex.org/W2091756261","https://openalex.org/W2093844373","https://openalex.org/W2095111998","https://openalex.org/W2099039595","https://openalex.org/W2099779584","https://openalex.org/W2125203621","https://openalex.org/W2126941192","https://openalex.org/W2127407145","https://openalex.org/W2128654538","https://openalex.org/W2143161893","https://openalex.org/W2164393253","https://openalex.org/W2168460979","https://openalex.org/W2169466952","https://openalex.org/W2278924796","https://openalex.org/W2294571275","https://openalex.org/W2299861964","https://openalex.org/W2301602703","https://openalex.org/W2345784910","https://openalex.org/W2409248716","https://openalex.org/W2519678626","https://openalex.org/W2519786994","https://openalex.org/W2562566161","https://openalex.org/W2575006808","https://openalex.org/W2752862273","https://openalex.org/W2753932015","https://openalex.org/W2768818187","https://openalex.org/W2792774489","https://openalex.org/W2805957615","https://openalex.org/W2884447006","https://openalex.org/W2886080030","https://openalex.org/W2888340962","https://openalex.org/W4233194460","https://openalex.org/W4235535170","https://openalex.org/W4237139417","https://openalex.org/W4294214970"],"related_works":["https://openalex.org/W3187441745","https://openalex.org/W7028850330","https://openalex.org/W3115905980","https://openalex.org/W4245765212","https://openalex.org/W2027616800","https://openalex.org/W2912352630","https://openalex.org/W2418770803","https://openalex.org/W2012588499","https://openalex.org/W2801985436","https://openalex.org/W3044867260"],"abstract_inverted_index":{"Graphene":[0],"oxide":[1],"(GO)":[2],"is":[3,183,206],"an":[4,101],"common":[5],"nanomaterial":[6],"and":[7,14,21,74,90,106,115,124,130,135,145,156,167,179,192,216,225,242,249,264,270,279,297],"has":[8,257],"attracted":[9],"unlimited":[10],"interest":[11],"in":[12,31,33,47,63,83,177,304,327],"academia":[13],"industry":[15],"due":[16,285],"to":[17,163,197,239,277,286,313,318],"its":[18,28],"physical,":[19],"chemical,":[20],"biological":[22,57],"properties,":[23],"as":[24,26],"well":[25],"for":[27,68,187,222],"tremendous":[29],"potential":[30,175],"applications":[32,324],"various":[34,119,219],"fields,":[35],"including":[36],"nanomedicine.":[37],"Whereas":[38],"studies":[39,54],"have":[40,51],"evaluated":[41],"the":[42,56,69,72,201,266,273],"size-dependent":[43,300],"cytotoxicity":[44],"of":[45,59,78,81,104,112,142,150,152,172,203,211,232,268,325],"GO":[46,82,98,326],"cancer":[48],"cells,":[49,93,181,307,310],"there":[50],"been":[52],"no":[53],"on":[55,213],"behavior":[58],"ultra-small":[60],"graphene":[61],"nanosheets":[62,99],"germ":[64,301],"cells.":[65],"To":[66],"investigate,":[67],"first":[70],"time,":[71],"cyto-":[73],"geno-":[75],"toxic":[76,260],"effects":[77,261],"different":[79,85,96],"sizes":[80],"two":[84],"cell":[86,143,146,240,302],"types,":[87],"Leydig":[88],"(TM3)":[89],"Sertoli":[91],"(TM4)":[92],"we":[94],"synthesized":[95],"sized":[97],"with":[100,133],"average":[102],"size":[103],"100":[105],"20":[107],"nm":[108],"by":[109,118,199,208],"a":[110,184],"modification":[111],"Hummers'":[113],"method,":[114],"characterized":[116],"them":[117],"analytical":[120],"techniques.":[121],"Cell":[122],"viability":[123,144],"proliferation":[125],"assays":[126],"showed":[127,254],"significant":[128,140,170],"size-":[129],"dose-dependent":[131],"toxicity":[132,275,303],"GO-20":[134,138,168,193,217,250,256,280,298],"GO-100.":[136,164],"Interestingly,":[137],"induced":[139,169],"loss":[141,171,267],"proliferation,":[147],"higher":[148],"levels":[149,202,231],"leakage":[151],"lactate":[153],"dehydrogenase":[154],"(LDH)":[155],"reactive":[157],"oxygen":[158],"species":[159],"(ROS)":[160],"generation":[161],"compared":[162,317],"Both":[165],"GO-100":[166,191,215,248,278,296],"mitochondrial":[173],"membrane":[174],"(MMP)":[176],"TM3":[178,309],"TM4":[180],"which":[182,205,236,282,311,320],"critical":[185],"factor":[186],"ROS":[188,212],"generation.":[189],"Furthermore,":[190],"caused":[194],"oxidative":[195],"damage":[196,224],"DNA":[198,223],"increasing":[200],"8-oxo-dG,":[204],"formed":[207],"direct":[209],"attack":[210],"DNA;":[214],"upregulate":[218],"genes":[220],"responsible":[221],"apoptosis.":[226],"We":[227],"found":[228],"that":[229,255,265,294,323],"phosphorylation":[230],"EGFR/AKT":[233,287],"signaling":[234],"molecules,":[235],"are":[237,272],"related":[238],"survival":[241],"apoptosis,":[243],"were":[244],"significantly":[245],"altered":[246],"after":[247],"exposure.":[251],"Our":[252],"results":[253,292],"more":[258,315],"potent":[259],"than":[262],"GO-100,":[263],"MMP":[269],"apoptosis":[271],"main":[274],"responses":[276],"treatments,":[281],"likely":[283],"occur":[284],"pathway":[288],"regulation.":[289],"Collectively,":[290],"our":[291],"suggest":[293],"both":[295],"exhibit":[299],"male":[305],"somatic":[306],"particularly":[308],"seem":[312],"be":[314,331],"sensitive":[316],"TM4,":[319],"strongly":[321],"suggests":[322],"commercial":[328],"products":[329],"must":[330],"carefully":[332],"evaluated.":[333]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-02-21T00:00:00"}
