{"id":"https://openalex.org/W2913969995","doi":null,"title":"Dual targeting of histone methyltransferase G9a and DNMT1 for the treatment of experimental hepatocellular carcinoma","display_name":"Dual targeting of histone methyltransferase G9a and DNMT1 for the treatment of experimental hepatocellular carcinoma","publication_year":2019,"publication_date":"2019-02-04","ids":{"openalex":"https://openalex.org/W2913969995","mag":"2913969995"},"language":"en","primary_location":{"id":"pmh:oai:dadun.unav.edu:10171/56392","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10171/56392","pdf_url":null,"source":{"id":"https://openalex.org/S4306401514","display_name":"Deposito Adademico Digital Universidad De Navarra (University of Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88155538","host_organization_name":"Universidad de Navarra","host_organization_lineage":["https://openalex.org/I88155538"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10171/56392","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077198687","display_name":"Marina B\u00e1rcena\u2010Varela","orcid":"https://orcid.org/0000-0001-7868-7939","observed_orcids":["https://orcid.org/0000-0001-7868-7939"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marina B\u00e1rcena\u2010Varela","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7868-7939","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5077198687"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ehmt2","display_name":"G9a","score":0.8830000162124634},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.902999997138977},{"id":"https://openalex.org/keywords/dual-enzyme-inhibitors","display_name":"dual enzyme inhibitors","score":0.6299999952316284},{"id":"https://openalex.org/keywords/uhrf1","display_name":"UHRF1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.40799999237060547},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.8949999809265137},{"id":"https://openalex.org/keywords/lx-2-cells","display_name":"LX-2 cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8080000281333923},{"id":"https://openalex.org/keywords/metabolic-adaptation","display_name":"metabolic adaptation","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5410000085830688},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6850000023841858},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.786946177482605},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5267341136932373},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.39823001623153687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3869294822216034},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2775578796863556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2568957209587097},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.1137336790561676}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dadun.unav.edu:10171/56392","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10171/56392","pdf_url":null,"source":{"id":"https://openalex.org/S4306401514","display_name":"Deposito Adademico Digital Universidad De Navarra (University of Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88155538","host_organization_name":"Universidad de Navarra","host_organization_lineage":["https://openalex.org/I88155538"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2913969995","doi":null,"is_oa":false,"landing_page_url":"https://dadun.unav.edu/bitstream/10171/56392/1/Tesis_BarcenaVarela18.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dadun.unav.edu:10171/56392","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10171/56392","pdf_url":null,"source":{"id":"https://openalex.org/S4306401514","display_name":"Deposito Adademico Digital Universidad De Navarra (University of Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I88155538","host_organization_name":"Universidad de Navarra","host_organization_lineage":["https://openalex.org/I88155538"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2883824376","https://openalex.org/W7055821124","https://openalex.org/W2612034430","https://openalex.org/W7144313712","https://openalex.org/W4250952796","https://openalex.org/W4323808570","https://openalex.org/W2313165034","https://openalex.org/W2486768307","https://openalex.org/W3160966907","https://openalex.org/W3124873137"],"abstract_inverted_index":{"Las":[0],"modificaciones":[1],"epigen\u00e9ticas,":[2],"como":[3,307],"la":[4,39,45,59,63,83,101,135,230,254,262,298,325],"metilaci\u00f3n":[5],"del":[6,35,241,277,296,316],"ADN":[7],"e":[8,169,264],"histonas,":[9],"cooperan":[10],"funcionalmente":[11],"para":[12,313],"fomentar":[13],"el":[14,18,49,132,145,221,239,288,314,322,330],"crecimiento":[15,146,222,240],"tumoral,":[16],"incluido":[17],"carcinoma":[19],"hepatocelular":[20],"(HCC).":[21],"La":[22,93,155,211,275],"inhibici\u00f3n":[23,136,212,299],"farmacol\u00f3gica":[24,213],"de":[25,52,54,58,95,102,111,125,134,140,147,157,180,198,215,223,232,245,257,280,301,324,327],"estos":[26],"mecanismos":[27],"puede":[28],"abrir":[29],"nuevas":[30],"v\u00edas":[31],"terap\u00e9uticas.":[32],"El":[33],"objetivo":[34],"trabajo":[36],"desarrollado":[37],"en":[38,67,82,109,144,164,203,205,243,269,287,329],"presente":[40],"tesis":[41],"doctoral":[42],"fue":[43,290],"determinar":[44],"eficacia":[46],"terap\u00e9utica":[47],"y":[48,62,71,86,97,122,138,142,153,175,178,196,201,217,235,237,247,273],"potencial":[50,323],"mecanismo":[51],"acci\u00f3n":[53],"nuevos":[55],"inhibidores":[56,78],"duales":[57],"histona-metiltransferasa":[60],"G9a":[61,96,141,216,302],"ADN-metiltransferasa":[64],"1":[65],"(DNMT1)":[66],"c\u00e9lulas":[68,75,124,148,165,171,176,184,187,225,233,259,271],"HCC":[69,112,126,149,166,185,188,204,234,246,248,260,272],"humanas":[70,113,174],"su":[72,103],"interferencia":[73],"con":[74,100,207,250,305],"fibrog\u00e9nicas.":[76,274],"Estos":[77],"han":[79],"sido":[80],"desarrollados":[81],"propia":[84],"Instituci\u00f3n":[85],"sujetos":[87],"a":[88,261],"patente":[89],"(EPOPatent":[90],"application":[91],"#14-382230.2-1462).":[92],"expresi\u00f3n":[94,276],"DNMT1,":[98],"junto":[99],"adaptador":[104],"molecular":[105],"UHRF1,":[106],"se":[107,162],"midi\u00f3":[108],"muestras":[110],"(n":[114,119,127],"=":[115,120,128],"268),":[116],"tejidos":[117],"peritumorales":[118],"154)":[121],"l\u00edneas":[123],"32).":[129],"Se":[130],"evalu\u00f3":[131],"efecto":[133],"individual":[137],"combinada":[139,300],"DNMT1":[143,200,218,304],"mediante":[150],"enfoques":[151],"farmacol\u00f3gicos":[152],"gen\u00e9ticos.":[154],"actividad":[156],"nuestro":[158],"compuesto":[159],"principal,":[160],"CM-272,":[161],"examin\u00f3":[163],"bajo":[167],"normoxia":[168],"hipoxia,":[170,263],"estelares":[172],"hep\u00e1ticas":[173],"LX2,":[177,236],"tumores":[179,281],"xenoinjerto":[181],"formados":[182],"por":[183,292],"o":[186],"+":[189],"LX2":[190],"combinadas.":[191],"Encontramos":[192],"una":[193,310],"sobreexpresi\u00f3n":[194],"significativa":[195],"correlativa":[197],"G9a,":[199],"UHRF1":[202],"asociaci\u00f3n":[206],"un":[208,266],"mal":[209],"pron\u00f3stico.":[210],"independiente":[214],"redujo":[219],"sin\u00e9rgicamente":[220],"las":[224,258,270],"HCC.":[226,317,331],"CM-272":[227,252,308],"inhibi\u00f3":[228],"potentemente":[229],"proliferaci\u00f3n":[231],"detuvo":[238],"tumor":[242],"xenoinjertos":[244],"combinadas":[249],"LX2.":[251],"impidi\u00f3":[253],"adaptaci\u00f3n":[255],"metab\u00f3lica":[256],"indujo":[265],"fenotipo":[267],"diferenciado":[268],"gen":[278],"supresor":[279],"metab\u00f3licos":[282],"fructosa-1,6-bifosfatasa":[283],"(FBP1),":[284],"reprimido":[285],"epigen\u00e9ticamente":[286],"HCC,":[289],"restaurada":[291],"CM-272.":[293],"Como":[294],"conclusi\u00f3n":[295],"trabajo,":[297],"/":[303],"compuestos":[306],"es":[309],"estrategia":[311],"prometedora":[312],"tratamiento":[315],"Nuestros":[318],"hallazgos":[319],"tambi\u00e9n":[320],"subrayan":[321],"terapia":[326],"diferenciaci\u00f3n":[328]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2019-02-21T00:00:00"}
