{"id":"https://openalex.org/W2913951562","doi":"https://doi.org/10.1101/540005","title":"MS.liverK: an R package for transcriptome-based computation of molecular subtypes and functional signatures in liver cancer","display_name":"MS.liverK: an R package for transcriptome-based computation of molecular subtypes and functional signatures in liver cancer","publication_year":2019,"publication_date":"2019-02-07","ids":{"openalex":"https://openalex.org/W2913951562","doi":"https://doi.org/10.1101/540005","mag":"2913951562"},"language":"en","primary_location":{"id":"doi:10.1101/540005","doi":"https://doi.org/10.1101/540005","is_oa":true,"landing_page_url":"https://doi.org/10.1101/540005","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/02/07/540005.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2019/02/07/540005.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010029786","display_name":"Florent Petitprez","orcid":"https://orcid.org/0000-0002-5117-6466","observed_orcids":["https://orcid.org/0000-0002-5117-6466"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florent Petitprez","raw_affiliation_strings":["INSERM UMR_S 1138, Cordeliers Research Centre, Paris, France","Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France","Pierre and Marie Curie University, Paris, France","Programme Cartes d\u2019Identit\u00e9 des Tumeurs (CIT), Ligue Nationale Contre le Cancer, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-5117-6466","affiliations":[{"raw_affiliation_string":"INSERM UMR_S 1138, Cordeliers Research Centre, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Pierre and Marie Curie University, Paris, France","institution_ids":["https://openalex.org/I4405264447"]},{"raw_affiliation_string":"Programme Cartes d\u2019Identit\u00e9 des Tumeurs (CIT), Ligue Nationale Contre le Cancer, Paris, France","institution_ids":["https://openalex.org/I4210095243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081173912","display_name":"L\u00e9a Meunier","orcid":"https://orcid.org/0000-0003-1855-7467","observed_orcids":["https://orcid.org/0000-0003-1855-7467"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L\u00e9a Meunier","raw_affiliation_strings":["INSERM UMR-1162, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-1855-7467","affiliations":[{"raw_affiliation_string":"INSERM UMR-1162, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079404707","display_name":"\u00c9ric Letouz\u00e9","orcid":"https://orcid.org/0000-0002-6369-2839","observed_orcids":["https://orcid.org/0000-0002-6369-2839"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Letouz\u00e9","raw_affiliation_strings":["INSERM UMR-1162, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-6369-2839","affiliations":[{"raw_affiliation_string":"INSERM UMR-1162, Paris, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007607351","display_name":"Yujin Hoshida","orcid":"https://orcid.org/0000-0001-9430-1426","observed_orcids":["https://orcid.org/0000-0001-9430-1426"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yujin Hoshida","raw_affiliation_strings":["Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059651582","display_name":"Augusto Villanueva","orcid":"https://orcid.org/0000-0003-3585-3727","observed_orcids":["https://orcid.org/0000-0003-3585-3727"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Augusto Villanueva","raw_affiliation_strings":["Division of Haematology and Medical Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Haematology and Medical Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"raw_affiliation_string":"Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052975894","display_name":"Josep Maria Llovet","orcid":"https://orcid.org/0000-0003-0547-2667","observed_orcids":["https://orcid.org/0000-0003-0547-2667"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4210160192","display_name":"Consorci Institut D'Investigacions Biomediques August Pi I Sunyer","ror":"https://ror.org/054vayn55","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210115097","https://openalex.org/I4210160192","https://openalex.org/I4387153040","https://openalex.org/I4403928279"]},{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Josep Llovet","raw_affiliation_strings":["BCLC, Liver Unit, IDIBAPS, CIBERehd, Hospital Cl\u00ednic, Universitat de Barcelona, ICREA, Barcelona, Catalonia, Spain","Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BCLC, Liver Unit, IDIBAPS, CIBERehd, Hospital Cl\u00ednic, Universitat de Barcelona, ICREA, Barcelona, Catalonia, Spain","institution_ids":["https://openalex.org/I4210115097","https://openalex.org/I4210132431","https://openalex.org/I4210160192","https://openalex.org/I71999127"]},{"raw_affiliation_string":"Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087862269","display_name":"Snorri S. Thorgeirsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Snorri Thorgeirsson","raw_affiliation_strings":["Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100765872","display_name":"Xin Wei Wang","orcid":"https://orcid.org/0000-0001-9735-606X","observed_orcids":["https://orcid.org/0000-0001-9735-606X","https://orcid.org/0000-0002-3346-8537"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Wei Wang","raw_affiliation_strings":["Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD, USA"],"raw_orcid":"https://orcid.org/0000-0001-9735-606X","affiliations":[{"raw_affiliation_string":"Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075098122","display_name":"Wolf H. Fridman","orcid":"https://orcid.org/0000-0002-1332-0973","observed_orcids":["https://orcid.org/0000-0002-1332-0973"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Wolf H Fridman","raw_affiliation_strings":["INSERM UMR_S 1138, Cordeliers Research Centre, Paris, France","Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France","Pierre and Marie Curie University, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR_S 1138, Cordeliers Research Centre, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I4387156284"]},{"raw_affiliation_string":"Pierre and Marie Curie University, Paris, France","institution_ids":["https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055995633","display_name":"Jessica Zucman\u2010Rossi","orcid":"https://orcid.org/0000-0002-5687-0334","observed_orcids":["https://orcid.org/0000-0002-5687-0334"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102325","display_name":"H\u00f4pital Europ\u00e9en Georges-Pompidou","ror":"https://ror.org/016vx5156","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jessica Zucman-Rossi","raw_affiliation_strings":["AP-HP; HEGP, Department of Oncology, Paris, France","INSERM UMR-1162, Paris, France","AP-HP","HEGP, Department of Oncology, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-5687-0334","affiliations":[{"raw_affiliation_string":"AP-HP; HEGP, Department of Oncology, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102325"]},{"raw_affiliation_string":"INSERM UMR-1162, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"AP-HP","institution_ids":["https://openalex.org/I4210097159"]},{"raw_affiliation_string":"HEGP, Department of Oncology, Paris, France","institution_ids":["https://openalex.org/I4210102325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042627121","display_name":"Aur\u00e9lien de Reyni\u00e8s","orcid":"https://orcid.org/0000-0002-1328-5290","observed_orcids":["https://orcid.org/0000-0002-1328-5290"]},"institutions":[{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Aur\u00e9lien de Reyni\u00e8s","raw_affiliation_strings":["Programme Cartes d\u2019Identit\u00e9 des Tumeurs (CIT), Ligue Nationale Contre le Cancer, Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-1328-5290","affiliations":[{"raw_affiliation_string":"Programme Cartes d\u2019Identit\u00e9 des Tumeurs (CIT), Ligue Nationale Contre le Cancer, Paris, France","institution_ids":["https://openalex.org/I4210095243"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5042627121"],"corresponding_institution_ids":["https://openalex.org/I4210095243"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.24609999358654022,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/functional-signatures","display_name":"functional signatures","score":0.8410000205039978},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.7509999871253967},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7929999828338623},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7889999747276306},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.8100000023841858},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.707082211971283},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.690828800201416},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.5719678401947021},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.553657054901123},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.5013091564178467},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48293086886405945},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.47500598430633545},{"id":"https://openalex.org/C2992176824","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver tissue","level":2,"score":0.42679983377456665},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.39384302496910095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39289242029190063},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36599600315093994},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3377910256385803},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3291480541229248},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2885892987251282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23440593481063843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2252063751220703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12614300847053528},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.08679789304733276},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/540005","doi":"https://doi.org/10.1101/540005","is_oa":true,"landing_page_url":"https://doi.org/10.1101/540005","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/02/07/540005.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/540005","doi":"https://doi.org/10.1101/540005","is_oa":true,"landing_page_url":"https://doi.org/10.1101/540005","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/02/07/540005.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913951562.pdf","grobid_xml":"https://content.openalex.org/works/W2913951562.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1979728979","https://openalex.org/W2023815439","https://openalex.org/W2036922484","https://openalex.org/W2042571415","https://openalex.org/W2059234749","https://openalex.org/W2085114559","https://openalex.org/W2093035112","https://openalex.org/W2099789788","https://openalex.org/W2136415416","https://openalex.org/W2137211337","https://openalex.org/W2170845559"],"related_works":["https://openalex.org/W2613330960","https://openalex.org/W4391942020","https://openalex.org/W3163951630","https://openalex.org/W4285272066","https://openalex.org/W6902167127","https://openalex.org/W3097017969","https://openalex.org/W6958435062","https://openalex.org/W4309690053","https://openalex.org/W4409448605","https://openalex.org/W6920987331"],"abstract_inverted_index":{"Abstract":[0],"Summary":[1],"Liver":[2],"cancer":[3],"is":[4,85],"a":[5,69],"highly":[6],"heterogeneous":[7],"disease":[8],"in":[9,43],"terms":[10],"of":[11,38,55,72],"etiology,":[12],"tissue":[13],"and":[14,22,79],"cellular":[15],"morphology,":[16],"tumor":[17,28,49],"molecular":[18,36,53],"characteristics,":[19],"microenvironment":[20],"composition":[21],"prognosis.":[23],"Several":[24],"studies,":[25],"based":[26],"on":[27],"gene-expression":[29],"profiling":[30],"(GEP)":[31],"data,":[32],"have":[33],"dissected":[34],"the":[35],"heterogeneity":[37],"liver":[39],"cancer.":[40],"They":[41],"resulted":[42],"various":[44],"tools,":[45,74],"either":[46],"delineating":[47],"homogeneous":[48],"subtypes":[50],"or":[51,57],"calculating":[52],"scores":[54],"prognostic":[56],"biological":[58],"functions.":[59],"Here,":[60],"we":[61],"present":[62],"MS.liverK,":[63],"an":[64],"easy-to-use":[65],"R":[66,83],"package":[67,84],"providing":[68],"comprehensive":[70],"implementation":[71,80],"these":[73],"for":[75],"research":[76],"use.":[77],"Availability":[78],"The":[81],"MS.liverK":[82],"available":[86],"from":[87],"GitHub":[88],"(":[89],"https://github.com/cit-bioinfo/MS.liverK":[90],").":[91]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-02-21T00:00:00"}