{"id":"https://openalex.org/W2913906524","doi":null,"title":"Influence of a dietary-induced hypercholesterolemia on the pathogenesis of Theiler\u00b4s murine encephalomyelitis with special emphasis on transcriptional changes","display_name":"Influence of a dietary-induced hypercholesterolemia on the pathogenesis of Theiler\u00b4s murine encephalomyelitis with special emphasis on transcriptional changes","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2913906524","mag":"2913906524"},"language":"en","primary_location":{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-029597467","doi":null,"is_oa":false,"landing_page_url":"http://d-nb.info/1122117973/04","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Hochschulschrift"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041378711","display_name":"Barbara B. Raddatz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Barbara B. Raddatz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041378711"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/theiler-s-murine-encephalomyelitis-virus","display_name":"Theiler's murine encephalomyelitis virus","score":0.6290000081062317},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.6850000023841858},{"id":"https://openalex.org/keywords/remyelination","display_name":"remyelination","score":0.8059999942779541},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/galactocerebroside","display_name":"galactocerebroside","score":0.8870000243186951},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":1.0},{"id":"https://openalex.org/keywords/myelin-lipids","display_name":"myelin lipids","score":0.800000011920929},{"id":"https://openalex.org/keywords/hepatic-lipidosis","display_name":"hepatic lipidosis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.6269999742507935},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2777619251","wikidata":"https://www.wikidata.org/wiki/Q7312279","display_name":"Remyelination","level":4,"score":0.9198383092880249},{"id":"https://openalex.org/C2778531937","wikidata":"https://www.wikidata.org/wiki/Q1186703","display_name":"Demyelinating disease","level":3,"score":0.7357638478279114},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7348703145980835},{"id":"https://openalex.org/C2781017270","wikidata":"https://www.wikidata.org/wiki/Q2756638","display_name":"Galactocerebroside","level":5,"score":0.5263308882713318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46400490403175354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4601690173149109},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.44053179025650024},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.43457871675491333},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4101482033729553},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.33111196756362915},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.21729826927185059},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19836318492889404}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-029597467","doi":null,"is_oa":false,"landing_page_url":"http://d-nb.info/1122117973/04","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Hochschulschrift"},{"id":"mag:2913906524","doi":null,"is_oa":false,"landing_page_url":"https://elib.tiho-hannover.de/dissertations/raddatzb_ss16","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1849188524","https://openalex.org/W2896991939","https://openalex.org/W2037897155","https://openalex.org/W2943340056","https://openalex.org/W2581477543","https://openalex.org/W4211135425","https://openalex.org/W2280782552","https://openalex.org/W4320913605","https://openalex.org/W4394717220","https://openalex.org/W2014625189"],"abstract_inverted_index":{"In\n":[0],"multiples":[2,64],"sclerosis":[3],"(MS),":[4],"an":[5,123,506],"immune-mediated":[6],"disease":[7,34,173],"of":[8,26,59,113,126,145,153,157,174,185,195,233,254,261,306,315,336,365,369,447,471,483,489,501,524,526,562,567,578,583,619,626,638,656,664],"the":[9,24,60,71,110,142,150,251,304,311,363,366,439,472,481,498,502,522,533,549,568,573,576,623,636],"central":[10],"nervous\n":[11],"system":[13],"(CNS),":[14],"inflammation,":[15],"demyelination":[16,307,668],"and":[17,40,81,103,192,202,236,263,279,287,303,308,348,390,410,418,424,435,455,474,493,546,594,600,642,651,667],"axonal":[18,49],"degeneration":[19],"are\n":[20,456],"responsible":[22],"for":[23,31,86,133,331,515,554,635],"variety":[25],"neurological":[27],"disabilities.":[28],"The":[29,318,395],"basis":[30],"the\n":[32,158,175,196,466,563,579],"progression":[35],"is":[36,68,327,495,570],"ongoing":[37],"myelin":[38],"destruction":[39],"a":[41,76,97,130,328,382,432,486,555,587],"failure":[42,77],"of\n":[43,78,323],"remyelination":[45,80,135,309],"resulting":[46],"in":[47,63,100,109,119,162,179,209,250,296,310,345,392,413,465,575,612,631],"progressive":[48,138,231],"damage":[50],"with":[51,243],"limited":[52],"capacity":[53],"to\n":[54,105],"regenerate.":[56],"Therefore,":[57,141,497],"one":[58],"main":[61,560],"objectives":[62],"sclerosis\n":[65],"research":[67,102,557],"to":[69,75,82,189,291,385,404,509,537,571,595,645],"identify":[70,83],"molecular":[72],"mechanisms":[73],"leading":[74],"potential":[84,482,625],"targets":[85],"future":[87],"therapeutic\n":[88],"approaches.\n":[90],"Transcriptional\n":[92],"profiling":[94,377],"has":[95],"become":[96],"powerful":[98],"tool":[99],"exploratory":[101],"led":[104,290],"essential":[107],"insights":[108],"complex":[111,393,406],"pathomechanisms":[112],"demyelinating":[114,120,139,172,237],"diseases.\n":[115],"Transcriptional":[117],"analysis":[118,219,512,542,634],"diseases":[121],"suggested":[122],"involvement\n":[124],"cholesterol":[127,160,190,244,288,325,341,665],"metabolism":[128,161,666],"as":[129],"possible":[131,151,490],"cause":[132],"inadequate":[134],"in\n":[136],"diseases.":[140,394],"first":[143,367],"part":[144,368,500,566],"this":[146,370,484,620],"study\n":[147],"addresses":[149],"interaction":[152],"dyslipidemia":[154],"or":[155,469],"disturbances":[156],"Theiler's":[163],"murine":[164],"encephalomyelitis":[165],"(TME),":[166],"an\n":[167,659],"experimentally,":[169],"virus-induced,":[170],"inflammatory,":[171],"spinal":[177,252],"cord":[178,253,314],"susceptible":[180],"mouse":[181],"strains.":[182],"Consequently,":[183],"expression":[184,241,450],"genes\n":[186],"associated":[188,242],"biosynthesis":[191,245,326],"metabolism,":[193],"composition":[194],"body's":[198],"major":[199],"lipid":[200],"repositories":[201],"diet-induced,":[203],"systemic\n":[204],"hypercholesterolemia":[206,278,350],"were":[207,265,453],"examined":[208],"TME":[210],"using":[211,378],"histology,\n":[212],"immunohistochemistry,":[214],"serum":[215,277,349],"clinical":[216,297],"chemistry,":[217],"microarray":[218,379,428,448,510],"and\n":[220],"high-performance":[222],"thin":[223],"layer":[224],"chromatography.":[225],"TME-virus":[226],"(TMEV)-infected":[227],"mice\n":[228],"showed":[230],"loss":[232,335],"motor":[234],"performance":[235],"leukomyelitis.\n":[238],"Gene":[240],"was":[246],"overall\n":[247],"down-regulated":[249],"TMEV-infected":[255,316],"animals.":[256,317],"Spinal":[257],"cord\n":[258],"levels":[260],"galactocerebroside":[262],"sphingomyelin":[264],"reduced":[266],"on":[267,356],"day":[268],"196":[269],"post\n":[270],"TMEV":[272,357],"infection.":[273,358],"Paigen":[274],"diet":[275],"induced":[276],"hepatic\n":[280],"lipidosis.":[282],"However,":[283],"high":[284],"dietary":[285],"fat":[286],"intake":[289],"no\n":[292,352],"significant":[294,354],"differences":[295],"course,":[298],"inflammatory":[299],"response,\n":[300],"astrocytosis,":[302],"amount":[305,446,582],"spinal\n":[312],"results":[319,364],"suggest":[320],"that":[321,608],"down-regulation":[322],"transcriptional":[329],"marker":[330],"demyelination,\n":[332],"quantitative":[334],"myelin-specific":[337],"lipids,":[338],"but":[339],"not":[340],"occurs":[342],"late\n":[343],"chronic":[346],"demyelination,":[347],"exhibited":[351],"effect":[355],"As\n":[361],"thesis":[371,621],"have":[372],"shown,":[373],"gene":[374,449],"expression\n":[375],"technology":[380],"represents":[381],"potent":[383],"method":[384,437],"discover\n":[386],"novel":[388,627,662],"relationships":[389],"interactions":[391],"large-scale\n":[396],"data":[398,451,511,541,607,613],"sets":[399,452],"generated":[400],"by":[401,586,602],"microarrays":[402],"help":[403],"understand":[405],"signaling":[407],"pathways\n":[408],"pathomechanistic":[411],"processes":[412],"different":[414],"somatic":[415],"cell":[416],"types":[417],"tissues,\n":[419],"under":[421],"various":[422],"extrinsic":[423],"intrinsic":[425],"conditions.":[426],"Because":[427],"analysis\n":[429],"became":[431],"sensitive,":[433],"reliable":[434],"robust":[436],"during":[438],"last":[440],"few":[441,525],"years":[442],"a\n":[443,527],"vast":[445],"produced":[454],"available":[458,545],"through":[459],"public":[460],"repositories.":[461],"New":[462],"possibilities":[463],"lay":[464],"re-analysis":[468],"combination":[470],"freely":[473],"easily":[475],"accessible":[476],"information.\n":[477],"To":[479],"explore":[480],"data,":[485],"basic":[487],"knowledge":[488,520,593],"methods\n":[491],"applications":[494],"crucial.":[496],"second":[499,565],"study":[503,569,646],"presents\n":[504],"application-oriented":[507],"introduction":[508],"techniques\n":[513],"users":[516],"without":[517],"detailed":[518],"bioinformatic":[519],"from":[521],"point":[523,596],"veterinary":[529],"pathologist.":[530],"In":[531],"particular,":[532],"present":[534],"report":[535],"aims":[536],"clarify,\n":[538],"which":[540],"techniques":[543],"are":[544,548],"what":[547],"most\n":[550],"appropriate":[552],"methods":[553],"specific":[556],"purpose.":[558],"A":[559],"goal":[561],"assist":[572],"reader":[574],"transformation":[577],"huge":[581],"information":[584],"obtained":[585],"single":[588],"experiment":[589],"into":[590],"biological\n":[591],"out":[597],"important":[598],"challenges":[599],"pitfalls":[601],"presenting\n":[603],"real":[605],"representative":[606],"illustrate":[609],"common":[610],"problems":[611],"analysis.\n":[614],"Both\n":[616],"parts":[618],"highlight":[622],"great":[624],"high-throughput\n":[628],"technologies":[630],"both,":[632],"data-driven":[633],"generation":[637],"new\n":[639],"hypothesis,":[641],"hypothesis-driven":[643],"approaches":[644],"particular":[647],"signaling\n":[648],"pathways":[650],"regulatory":[652],"interactions.":[653],"By":[654],"means":[655],"these":[657],"methodologies":[658],"interesting":[661],"association":[663],"was\n":[669],"found.":[671]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2019-02-21T00:00:00"}