{"id":"https://openalex.org/W2913892298","doi":"https://doi.org/10.14309/00000434-201802001-00093","title":"Improvement of Disability in Ulcerative Colitis Patients After One Year With Anti-TNF Agents","display_name":"Improvement of Disability in Ulcerative Colitis Patients After One Year With Anti-TNF Agents","publication_year":2018,"publication_date":"2018-02-01","ids":{"openalex":"https://openalex.org/W2913892298","doi":"https://doi.org/10.14309/00000434-201802001-00093","mag":"2913892298"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-201802001-00093","doi":"https://doi.org/10.14309/00000434-201802001-00093","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201802001-00093","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037229905","display_name":"Bissoli Gabriela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bissoli Gabriela","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054898820","display_name":"Rosemary da Silva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosemary da Silva","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047632152","display_name":"Baima Julio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baima Julio","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041181847","display_name":"Elen Farinelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farinelli Elen","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030005645","display_name":"Carina F\u00e1tima S\u00edbia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S\u00edbia Carina","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110348453","display_name":"Jaqueline de Barros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaqueline de Barros","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032256842","display_name":"Robertha Biondi","orcid":"https://orcid.org/0000-0002-8258-4382","observed_orcids":["https://orcid.org/0000-0002-8258-4382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Biondi Robertha","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008955702","display_name":"Fernanda Lofiego Renosto","orcid":"https://orcid.org/0000-0002-2540-4920","observed_orcids":["https://orcid.org/0000-0002-2540-4920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renosto Fernanda","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103832822","display_name":"Saad-Hossne Rogerio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saad-Hossne Rogerio","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013244630","display_name":"L\u00edgia Yukie Sassaki","orcid":"https://orcid.org/0000-0002-7319-8906","observed_orcids":["https://orcid.org/0000-0002-7319-8906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sassaki Ligia","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17311173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"113","issue":null,"first_page":"S22","last_page":"S22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.8899999856948853},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.8299999833106995},{"id":"https://openalex.org/keywords/disability","display_name":"disability","score":0.9269999861717224},{"id":"https://openalex.org/keywords/karnofsky-performance-status","display_name":"Karnofsky performance status","score":0.796999990940094},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease-questionnaire","display_name":"IBDQ","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mayo-score","display_name":"Mayo score","score":0.7760000228881836},{"id":"https://openalex.org/keywords/clinical-remission","display_name":"clinical remission","score":0.8119999766349792},{"id":"https://openalex.org/keywords/endoscopic-response","display_name":"endoscopic response","score":0.8930000066757202},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7260000109672546},{"id":"https://openalex.org/keywords/psychosocial-impact-of-chronic-disease","display_name":"psychosocial impact of chronic disease","score":0.6169999837875366},{"id":"https://openalex.org/keywords/steroid-refractory-colitis","display_name":"steroid-refractory colitis","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9647117853164673},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.8258618116378784},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7311519384384155},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6795268654823303},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.6429654955863953},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5783184170722961},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.4880937337875366},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4742523729801178},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4707164168357849},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4410543441772461},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43457353115081787},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.4268796145915985},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3663169741630554},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.14309/00000434-201802001-00093","doi":"https://doi.org/10.14309/00000434-201802001-00093","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201802001-00093","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:repositorio.unesp.br:11449/160116","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11449/160116","pdf_url":null,"source":{"id":"https://openalex.org/S4377196277","display_name":"UNESP Institutional Repository (S\u00e3o Paulo State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I879563668","host_organization_name":"Universidade Estadual Paulista (Unesp)","host_organization_lineage":["https://openalex.org/I879563668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2586333596","https://openalex.org/W2321822787","https://openalex.org/W2329110227","https://openalex.org/W2026550604","https://openalex.org/W2222256843","https://openalex.org/W2332801911","https://openalex.org/W2112108870","https://openalex.org/W3188680290","https://openalex.org/W2123089570","https://openalex.org/W2790434004"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ulcerative":[1],"Colitis":[2],"(UC)":[3],"is":[4,259,264],"an":[5,482],"inflammatory":[6,219],"bowel":[7,220],"disease":[8,221,320],"characterized":[9],"by":[10,290],"a":[11,172,190],"chronic":[12],"relapsing":[13],"colon":[14],"inflammation.":[15],"The":[16,52,218,239,249,342,414,444],"symptoms":[17],"can":[18,24],"have":[19,45],"significant":[20],"psychosocial":[21],"implications":[22],"that":[23],"affect":[25],"the":[26,55,61,64,70,143,161,228,283,291,312,319,354,395,403],"health-related":[27],"quality":[28,73],"of":[29,54,63,72,74,107,164,174,194,278,344,402],"life":[30,75],"(HRQoL)":[31],"and":[32,76,109,114,128,139,232,237,262,318,336,353,369,394,436,466,486],"cause":[33],"disability.":[34,248,488],"Anti-TNF":[35,362],"agents":[36,68,95,480],"are":[37],"not":[38],"only":[39],"effective":[40],"in":[41,78,302,366,371,378,382,388,392,400,484,487],"inducing":[42],"remission":[43,186,385],"but":[44],"also":[46],"been":[47],"shown":[48],"to":[49,59,105,132,142,159,226,246,255,423,437,453,467],"improve":[50],"HRQoL.":[51],"purpose":[53],"present":[56],"study":[57,85,287],"was":[58,86,122,157,169,187,208,224,244,288,315,322,349,358,376,386,398],"determine":[60],"impact":[62],"treatment":[65,108,121],"with":[66,90,93,126,145,199,282,330,333,339,478],"anti-TNF":[67,94,118,479],"on":[69,88,179],"improvement":[71,483],"disability":[77],"UC":[79,91,165,475],"patients.":[80,166,373,404],"METHODS:":[81],"A":[82],"prospective,":[83],"longitudinal":[84],"performed":[87],"patients":[89,125,299,338,368,380,390,476],"treated":[92,477],"for":[96,124],"one":[97],"year.":[98],"Data":[99],"were":[100,150,269,300,307],"collected":[101],"at":[102,110,230,233,271,347,421,426,432,440,451,456,462,470],"baseline":[103,231,348,422,452],"prior":[104],"initiation":[106],"weeks":[111,234],"14,":[112,235],"30":[113,236,434,464],"54":[115,442,472],"after":[116],"starting":[117],"treatment.":[119],"Biological":[120],"indicated":[123],"moderate":[127],"severe":[129,146],"colitis":[130],"refractory":[131,135,152],"immunosuppressants,":[133],"steroids":[134,137],"or":[136,153,177,197,216],"dependent,":[138],"those":[140],"admitted":[141],"hospital":[144],"colitis,":[147,335],"when":[148],"they":[149],"steroid":[151],"dependent.":[154],"Mayo":[155,181,192,211,345],"Score":[156],"used":[158,225,245],"assess":[160],"clinical":[162,384],"response":[163,168,207,375,397],"Clinical":[167,185,374],"defined":[170,188,209],"as":[171,189,210],"reduction":[173],"3":[175],"points":[176,196,274,352],"more":[178],"total":[180,191],"score":[182,193,202,214,251,346,357,416,446],"from":[183,253,418,448],"baseline.":[184],"2":[195],"lower,":[198],"no":[200,337],"sub":[201,213,356],"exceeding":[203],"1":[204],"point.":[205],"Endoscopic":[206],"endoscopic":[212],"0":[215,263],"1.":[217],"questionnaire":[222],"(IBDQ)":[223],"measure":[227,247],"HRQoL":[229,485],"54.":[238],"Karnofsky":[240,250,445],"Performance":[241],"Scale":[242],"Index":[243],"runs":[252],"100":[254,258],"0,":[256],"where":[257],"\"perfect\"":[260],"health":[261],"death.":[265],"Statistical":[266],"Analysis:":[267],"variables":[268],"analyzed":[270],"four":[272],"time":[273],"using":[275],"variance":[276],"analysis":[277],"repeated":[279],"measurements":[280],"(ANOVA)":[281],"Tukey":[284],"post-test.":[285],"This":[286],"approved":[289],"Research":[292],"Ethics":[293],"Committee":[294],"(CAAE:":[295],"48594815.8.0000.5411).":[296],"RESULTS:":[297],"Thirty":[298],"included":[301,328,364],"this":[303],"study.":[304],"Sixteen":[305],"(53.33%)":[306],"male,":[308],"96.67%":[309],"Caucasian":[310],"race,":[311],"mean":[313,343],"age":[314],"40.47y":[316],"(\u00b115.87)":[317],"duration":[321],"4.80y":[323],"(\u00b1":[324],"4.13).":[325],"Location":[326],"data":[327],"80%":[329],"pancolitis,":[331],"20%":[332],"left":[334],"distal":[340],"colitis.":[341],"7.63":[350],"(\u00b13.12)":[351],"endoscopy":[355,396],"2.83":[359],"(\u00b10.38)":[360],"points.":[361],"therapy":[363],"adalimumab":[365],"8":[367],"infliximab":[370],"22":[372,379],"achieved":[377,387,399],"(73.33%)":[381],"total;":[383],"15":[389],"(50%)":[391],"total,":[393],"50%":[401],"Patients":[405],"improved":[406],"their":[407],"HRQoL,":[408],"without":[409],"differences":[410],"between":[411],"groups":[412],"(P=0.99).":[413],"IBDQ":[415],"ranges":[417,447],"118.93":[419],"(\u00b146.02)":[420],"147.52":[424],"(\u00b147.21)":[425],"week":[427,433,441,457,463,471],"14":[428,458],"(P=0.11),":[429],"164.88":[430],"(\u00b148.14)":[431],"(P=0.003)":[435],"165.13":[438],"(\u00b149.24)":[439],"(P=0.004).":[443],"68.00":[449],"(\u00b117.10)":[450],"80.00":[454],"(\u00b111.74)":[455],"(P=0.003),":[459],"84.62":[460],"(\u00b110.67)":[461],"(P<0.0001)":[465],"88.75":[468],"(\u00b110.76)":[469],"(P<0.0001).":[473],"CONCLUSION(S):":[474],"presented":[481]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2019-02-21T00:00:00"}
