{"id":"https://openalex.org/W2913809202","doi":"https://doi.org/10.1093/cid/ciz038","title":"Glycocalyx Breakdown Is Associated With Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria","display_name":"Glycocalyx Breakdown Is Associated With Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria","publication_year":2019,"publication_date":"2019-01-15","ids":{"openalex":"https://openalex.org/W2913809202","doi":"https://doi.org/10.1093/cid/ciz038","mag":"2913809202","pmid":"https://pubmed.ncbi.nlm.nih.gov/30753363","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6821254"},"language":"en","primary_location":{"id":"doi:10.1093/cid/ciz038","doi":"https://doi.org/10.1093/cid/ciz038","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cid/ciz038","pdf_url":"https://academic.oup.com/cid/article-pdf/69/10/1712/30327398/ciz038.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/cid/article-pdf/69/10/1712/30327398/ciz038.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089350667","display_name":"Tsin Wen Yeo","orcid":"https://orcid.org/0000-0002-4060-7902","observed_orcids":["https://orcid.org/0000-0002-4060-7902"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I2802408685","display_name":"Tan Tock Seng Hospital","ror":"https://ror.org/032d59j24","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2802408685"]},{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}],"countries":["AU","SG"],"is_corresponding":true,"raw_author_name":"Tsin W Yeo","raw_affiliation_strings":["Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia","Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore","Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia","institution_ids":["https://openalex.org/I4210085939"]},{"raw_affiliation_string":"Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore","institution_ids":["https://openalex.org/I2802408685"]},{"raw_affiliation_string":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102751703","display_name":"Joe Brice Weinberg","orcid":"https://orcid.org/0000-0003-4052-5576","observed_orcids":["https://orcid.org/0000-0003-4052-5576"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Brice Weinberg","raw_affiliation_strings":["Duke University School of Medicine and VA Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of Medicine and VA Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107890897","display_name":"Daniel A. Lampah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel A Lampah","raw_affiliation_strings":["Papuan Health and Community Development Foundation, Timika, Papua, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Papuan Health and Community Development Foundation, Timika, Papua, Indonesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069443424","display_name":"Enny Kenangalem","orcid":"https://orcid.org/0000-0002-0481-7435","observed_orcids":["https://orcid.org/0000-0002-0481-7435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enny Kenangalem","raw_affiliation_strings":["Mimika District Health Authority, Timika, Papua, Indonesia","Papuan Health and Community Development Foundation, Timika, Papua, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mimika District Health Authority, Timika, Papua, Indonesia","institution_ids":[]},{"raw_affiliation_string":"Papuan Health and Community Development Foundation, Timika, Papua, Indonesia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027936406","display_name":"Margaret A. Bush","orcid":"https://orcid.org/0000-0003-1937-2640","observed_orcids":["https://orcid.org/0000-0003-1937-2640"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peggy Bush","raw_affiliation_strings":["Duke University School of Medicine and VA Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of Medicine and VA Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101644544","display_name":"Youwei Chen","orcid":"https://orcid.org/0000-0002-5663-6118","observed_orcids":["https://orcid.org/0000-0002-5663-6118"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youwei Chen","raw_affiliation_strings":["Duke University School of Medicine and VA Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of Medicine and VA Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019034894","display_name":"Ric N. Price","orcid":"https://orcid.org/0000-0003-2000-2874","observed_orcids":["https://orcid.org/0000-0003-2000-2874"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Richard N Price","raw_affiliation_strings":["Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom","Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia","institution_ids":["https://openalex.org/I4210085939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090945180","display_name":"Sarah P. Young","orcid":"https://orcid.org/0000-0002-7671-016X","observed_orcids":["https://orcid.org/0000-0002-7671-016X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Young","raw_affiliation_strings":["Duke University School of Medicine and VA Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of Medicine and VA Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hao Y Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Y Zhang","raw_affiliation_strings":["Duke University School of Medicine and VA Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of Medicine and VA Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013074721","display_name":"David S. Millington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Millington","raw_affiliation_strings":["Duke University School of Medicine and VA Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of Medicine and VA Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004060010","display_name":"Donald L. Granger","orcid":"https://orcid.org/0000-0002-0617-3231","observed_orcids":["https://orcid.org/0000-0002-0617-3231"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald L Granger","raw_affiliation_strings":["University of Utah and VA Medical Centers, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah and VA Medical Centers, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032095213","display_name":"Nicholas M. Anstey","orcid":"https://orcid.org/0000-0002-2192-0506","observed_orcids":["https://orcid.org/0000-0002-2192-0506"]},"institutions":[{"id":"https://openalex.org/I4210085939","display_name":"Menzies School of Health Research","ror":"https://ror.org/006mbby82","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I29894533","https://openalex.org/I4210085939"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicholas M Anstey","raw_affiliation_strings":["Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global and Tropical Health Division, Menzies School of Health Research, Darwin, Northern Territory, Australia","institution_ids":["https://openalex.org/I4210085939"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5089350667"],"corresponding_institution_ids":["https://openalex.org/I172675005","https://openalex.org/I2802408685","https://openalex.org/I4210085939"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":{"value":4763,"currency":"USD","value_usd":4763},"fwci":6.2135,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.96821615,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"69","issue":"10","first_page":"1712","last_page":"1720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/falciparum-malaria","display_name":"falciparum malaria","score":0.949999988079071},{"id":"https://openalex.org/keywords/severe-malaria","display_name":"severe malaria","score":0.9629999995231628},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.8309999704360962},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.6899999976158142},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9129999876022339},{"id":"https://openalex.org/keywords/parasite-sequestration","display_name":"parasite sequestration","score":0.7350000143051147},{"id":"https://openalex.org/keywords/microvascular-dysfunction","display_name":"microvascular dysfunction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.414000004529953},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.5009999871253967},{"id":"https://openalex.org/keywords/malaria-pathogenesis","display_name":"malaria pathogenesis","score":0.49799999594688416},{"id":"https://openalex.org/keywords/endothelial-glycocalyx","display_name":"endothelial glycocalyx","score":0.43700000643730164},{"id":"https://openalex.org/keywords/infected-red-blood-cells","display_name":"infected erythrocytes","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2780098789","wikidata":"https://www.wikidata.org/wiki/Q898356","display_name":"Glycocalyx","level":2,"score":0.7617855072021484},{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.6683629751205444},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6182811260223389},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6135669350624084},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.577323853969574},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.527668297290802},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46892932057380676},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43047863245010376},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3737115263938904}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007214","descriptor_name":"Indonesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019276","descriptor_name":"Glycocalyx","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/cid/ciz038","doi":"https://doi.org/10.1093/cid/ciz038","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cid/ciz038","pdf_url":"https://academic.oup.com/cid/article-pdf/69/10/1712/30327398/ciz038.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6821254","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6821254","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Infect Dis","raw_type":"Text"},{"id":"pmid:30753363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30753363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","raw_type":"Journal Article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/149019","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/149019","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/cid/ciz038","doi":"https://doi.org/10.1093/cid/ciz038","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cid/ciz038","pdf_url":"https://academic.oup.com/cid/article-pdf/69/10/1712/30327398/ciz038.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1438335371","display_name":"Nitric Oxide and Microvascular Dysfunction in Severe Malaria","funder_award_id":"R01HL130763","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1617459808","display_name":null,"funder_award_id":"1135820","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2056219030","display_name":"Research & Training to reduce morbidity & mortality from malaria in Papua ( Indonesia)& Papua New Guinea","funder_award_id":"283321","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G3134990145","display_name":"Pathophysiology and treatment of malaria in our region","funder_award_id":"1135820","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G3164689820","display_name":null,"funder_award_id":"CSA INV 15nov007","funder_id":"https://openalex.org/F4320334737","funder_display_name":"National Medical Research Council"},{"id":"https://openalex.org/G3544314491","display_name":null,"funder_award_id":"ME928457MES","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G469980627","display_name":"Improving Health Outcomes in the Tropical North: A Multidisciplinary Collaboration","funder_award_id":"1131932","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G4727761779","display_name":null,"funder_award_id":"92845","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4951795592","display_name":null,"funder_award_id":"1132975","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5291964276","display_name":"Improving the treatment of Plasmodium vivax","funder_award_id":"200909/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5403359577","display_name":null,"funder_award_id":"1132975","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5650507700","display_name":null,"funder_award_id":"283321","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6033910826","display_name":"Tropical diseases: Translating discoveries into better health","funder_award_id":"1132975","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G6203466744","display_name":"Arginine, Nitric Oxide, and Severe Malaria","funder_award_id":"R01AI041764","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8199452781","display_name":"Improving the treatment of Plasmodium vivax","funder_award_id":"200909","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320316255","display_name":"International Center for Responsible Gaming","ror":"https://ror.org/03xeqqt61"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913809202.pdf","grobid_xml":"https://content.openalex.org/works/W2913809202.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W428785717","https://openalex.org/W1578062386","https://openalex.org/W1767153609","https://openalex.org/W1966641545","https://openalex.org/W1971770267","https://openalex.org/W2007745105","https://openalex.org/W2020755315","https://openalex.org/W2029510081","https://openalex.org/W2030965342","https://openalex.org/W2051664736","https://openalex.org/W2058093556","https://openalex.org/W2076139670","https://openalex.org/W2077134099","https://openalex.org/W2097483988","https://openalex.org/W2108555819","https://openalex.org/W2118621907","https://openalex.org/W2120370984","https://openalex.org/W2132575805","https://openalex.org/W2140081746","https://openalex.org/W2143090715","https://openalex.org/W2148087131","https://openalex.org/W2148910661","https://openalex.org/W2152252241","https://openalex.org/W2153986831","https://openalex.org/W2158325787","https://openalex.org/W2230203535","https://openalex.org/W2246898682","https://openalex.org/W2289693608","https://openalex.org/W2291444995","https://openalex.org/W2472611930","https://openalex.org/W2587131188","https://openalex.org/W2605979119","https://openalex.org/W2608789756","https://openalex.org/W2612077120","https://openalex.org/W2613341725","https://openalex.org/W2728222150","https://openalex.org/W2788073857","https://openalex.org/W2890618162","https://openalex.org/W4211136995","https://openalex.org/W4292329967"],"related_works":["https://openalex.org/W2982486958","https://openalex.org/W3016282069","https://openalex.org/W3194033852","https://openalex.org/W3159124266","https://openalex.org/W3213850586","https://openalex.org/W2143090715","https://openalex.org/W2904104264","https://openalex.org/W2997279595","https://openalex.org/W2890618162","https://openalex.org/W2347129285"],"abstract_inverted_index":{"BACKGROUND:":[0],"Interactions":[1],"between":[2],"the":[3,13,36,47,53],"endothelium":[4],"and":[5,21,52,87,94,121,144,158,167,170,174,184,202,213,234,242,251,258,275],"infected":[6],"erythrocytes":[7],"play":[8],"a":[9,31,117,191,276],"major":[10],"role":[11,45],"in":[12,41,49,150,188,227,279],"pathogenesis":[14],"of":[15,46,102,131],"falciparum":[16,50,78,282],"malaria,":[17,79],"with":[18,25,38,55,71,100,190,224,261,272,281],"microvascular":[19],"dysfunction":[20],"parasite":[22,225],"sequestration":[23],"associated":[24,223,260,271],"worsening":[26],"outcomes.":[27],"The":[28,44],"glycocalyx":[29,48,112,268],"is":[30,270],"carbohydrate-rich":[32],"layer":[33],"that":[34],"lines":[35],"endothelium,":[37],"multiple":[39],"roles":[40],"vascular":[42,103],"homeostasis.":[43],"malaria":[51],"association":[54],"disease":[56,274],"severity":[57],"has":[58],"not":[59],"been":[60],"investigated.":[61],"METHODS:":[62],"We":[63],"prospectively":[64],"enrolled":[65],"Indonesian":[66],"inpatients":[67],"(aged":[68],"\u226518":[69],"years)":[70],"severe":[72,76,273],"(SM)":[73],"or":[74],"moderately":[75],"(MSM)":[77],"as":[80],"defined":[81],"by":[82],"World":[83],"Health":[84],"Organization":[85],"criteria,":[86],"healthy":[88],"controls":[89],"(HCs).":[90],"On":[91],"enrollment,":[92],"blood":[93],"urine":[95],"samples":[96],"were":[97,141,148,186],"collected":[98],"concurrently":[99],"measurements":[101],"nitric":[104],"oxide":[105],"(NO)":[106],"bioavailability.":[107,264],"Urine":[108],"was":[109,221],"assayed":[110],"for":[111],"breakdown":[113,269],"products":[114],"(glycosaminoglycans)":[115],"using":[116],"dimethylmethylene":[118],"blue":[119],"(GAG-DMMB)":[120],"liquid":[122],"chromatography-tandem":[123],"mass":[124],"spectrometry":[125],"(GAG-MS)":[126],"assay.":[127],"RESULTS:":[128],"A":[129],"total":[130],"129":[132],"patients":[133,164,244],"(SM":[134],"=":[135,138,195,209,217,231,236,246,249,253,256],"43,":[136],"MSM":[137,163,229],"57,":[139],"HC=29)":[140],"recruited.":[142],"GAG-DMMB":[143,183,233],"GAG-MS":[145,185],"(g/mol":[146],"creatinine)":[147],"increased":[149,187],"SM":[151,181,243],"(mean,":[152],"95%":[153],"confidence":[154],"interval:":[155],"3.98,":[156],"2.44-5.53":[157],"6.82,":[159],"5.19-8.44)":[160],"compared":[161,205],"to":[162,206],"(1.78,":[165],"1.27-2.29":[166],"4.87,":[168],"4.27-5.46)":[169],"HCs":[171],"(0.22,":[172],"0.06-0.37":[173],"1.24,":[175],"0.89-1.59;":[176],"P":[177,216,239,248,255],"<":[178,240],"0.001).":[179],"In":[180],"patients,":[182],"those":[189],"fatal":[192,277],"outcome":[193,278],"(n":[194,208],"3;":[196],"median,":[197],"interquartile":[198],"range:":[199],"6.72,":[200],"3.80-27.87":[201],"12.15,":[203],"7.88-17.20)":[204],"survivors":[207],"39;":[210],"3.10,":[211],"0.46-4.5":[212],"4.64,":[214],"2.02-15.20;":[215],"0.03).":[218],"Glycocalyx":[219],"degradation":[220],"significantly":[222],"biomass":[226],"both":[228],"(r":[230,245],"0.48,":[232],"r":[235,252],"0.43,":[237],"GAG-MS;":[238],"0.001)":[241],"0.47,":[247],"0.002":[250],"0.33,":[254],"0.04)":[257],"inversely":[259],"endothelial":[262,267],"NO":[263],"CONCLUSIONS:":[265],"Increased":[266],"adults":[280],"malaria.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-02-21T00:00:00"}
