{"id":"https://openalex.org/W2913807307","doi":"https://doi.org/10.1002/jcb.28384","title":"Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker\u2010256 tumor\u2010bearing rats","display_name":"Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker\u2010256 tumor\u2010bearing rats","publication_year":2019,"publication_date":"2019-02-05","ids":{"openalex":"https://openalex.org/W2913807307","doi":"https://doi.org/10.1002/jcb.28384","mag":"2913807307","pmid":"https://pubmed.ncbi.nlm.nih.gov/30719751"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.28384","doi":"https://doi.org/10.1002/jcb.28384","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.28384","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083641302","display_name":"Isabele Gon\u00e7alves Frasson\u2010Uemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isabele Gon\u00e7alves Frasson\u2010Uemura","raw_affiliation_strings":["Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055282423","display_name":"Giuliana Regina Biazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giuliana Regina Biazi","raw_affiliation_strings":["Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088649222","display_name":"Daniele Romani Miksza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniele Romani Miksza","raw_affiliation_strings":["Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103524650","display_name":"Carolina Campos Lima Moreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carolina Campos Lima Moreira","raw_affiliation_strings":["Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012692881","display_name":"Priscila Cassolla","orcid":"https://orcid.org/0000-0001-6713-4079","observed_orcids":["https://orcid.org/0000-0001-6713-4079"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Priscila Cassolla","raw_affiliation_strings":["Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018514871","display_name":"Gisele Lopes Bertolini","orcid":"https://orcid.org/0000-0002-0161-937X","observed_orcids":["https://orcid.org/0000-0002-0161-937X"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gisele Lopes Bertolini","raw_affiliation_strings":["Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I127110123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045674056","display_name":"Roberto Barbosa Bazotte","orcid":"https://orcid.org/0000-0001-8563-7913","observed_orcids":["https://orcid.org/0000-0001-8563-7913","https://orcid.org/0000-0002-9018-4944"]},"institutions":[{"id":"https://openalex.org/I123443094","display_name":"Universidade Estadual de Maring\u00e1","ror":"https://ror.org/04bqqa360","country_code":"BR","type":"education","lineage":["https://openalex.org/I123443094"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Roberto Barbosa Bazotte","raw_affiliation_strings":["Department of Pharmacology and Therapeutics State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I123443094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068890397","display_name":"Helenir Medri de Souza","orcid":"https://orcid.org/0000-0003-1426-4069","observed_orcids":["https://orcid.org/0000-0003-1426-4069"]},"institutions":[{"id":"https://openalex.org/I127110123","display_name":"Universidade Estadual de Londrina","ror":"https://ror.org/01585b035","country_code":"BR","type":"education","lineage":["https://openalex.org/I127110123"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Helenir Medri de Souza","raw_affiliation_strings":["Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1426-4069","affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences State University of Londrina Londrina Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I127110123"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068890397"],"corresponding_institution_ids":["https://openalex.org/I127110123"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.1465,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.39181876,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"120","issue":"7","first_page":"11068","last_page":"11080"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4392000138759613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4392000138759613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.2865999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hyperlactatemia","display_name":"hyperlactatemia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nadh","display_name":"NADH","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.7889999747276306},{"id":"https://openalex.org/keywords/walker-256-carcinosarcoma","display_name":"Walker 256 carcinosarcoma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/perfused-liver","display_name":"perfused liver","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.9110000133514404},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/glycemia","display_name":"glycemia","score":0.6840000152587891},{"id":"https://openalex.org/keywords/tumor-bearing-rats","display_name":"tumor-bearing rats","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C2909186138","wikidata":"https://www.wikidata.org/wiki/Q1500373","display_name":"Hyperlactatemia","level":2,"score":0.9161051511764526},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.7127252817153931},{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.707794189453125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7042437791824341},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7020882368087769},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.5605787634849548},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5322670340538025},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5291236639022827},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.48800936341285706},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4620717167854309},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30554959177970886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27939704060554504},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2673090100288391},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10632577538490295},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.08372560143470764},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.28384","doi":"https://doi.org/10.1002/jcb.28384","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.28384","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:30719751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30719751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W73977321","https://openalex.org/W1504140615","https://openalex.org/W1559276839","https://openalex.org/W1566830427","https://openalex.org/W1674054972","https://openalex.org/W1893681319","https://openalex.org/W1901274456","https://openalex.org/W1951412576","https://openalex.org/W1965041525","https://openalex.org/W1968390752","https://openalex.org/W1971581781","https://openalex.org/W1979024939","https://openalex.org/W1990251709","https://openalex.org/W1996110540","https://openalex.org/W1999704557","https://openalex.org/W2003721498","https://openalex.org/W2007662343","https://openalex.org/W2012608509","https://openalex.org/W2020950228","https://openalex.org/W2027430515","https://openalex.org/W2027502805","https://openalex.org/W2034127653","https://openalex.org/W2049203431","https://openalex.org/W2071078997","https://openalex.org/W2071209569","https://openalex.org/W2085252139","https://openalex.org/W2089486926","https://openalex.org/W2094846592","https://openalex.org/W2095295489","https://openalex.org/W2096471914","https://openalex.org/W2107251975","https://openalex.org/W2166428553","https://openalex.org/W2170873736","https://openalex.org/W2245763891","https://openalex.org/W2259134248","https://openalex.org/W2279428213","https://openalex.org/W2464168710","https://openalex.org/W2566101653","https://openalex.org/W3190277186","https://openalex.org/W6637117565"],"related_works":["https://openalex.org/W2027430515","https://openalex.org/W6982461237","https://openalex.org/W147006074","https://openalex.org/W2071078997","https://openalex.org/W2089579967","https://openalex.org/W2572506060","https://openalex.org/W2137375183","https://openalex.org/W2051661378","https://openalex.org/W2012608509","https://openalex.org/W2053487144"],"abstract_inverted_index":{"Abstract":[0],"Gluconeogenesis":[1],"(GN)":[2],"is":[3,11,246],"increased":[4,98,148,200,233],"in":[5,13,45,86,104,135,154,186,221,241,250,258,261],"patients":[6],"with":[7],"cancer":[8],"cachexia,":[9],"but":[10,94,144],"reduced":[12],"liver":[14,262],"perfusion":[15,263],"of":[16,25,34,37,48,70,76,83,115,129,167,180,191,203,219,224,255,257],"Walker\u2010256":[17],"tumor\u2010bearing":[18],"cachectic":[19],"rats":[20,106,156,245],"(TB":[21],"rats).":[22],"The":[23],"causes":[24],"these":[26],"differences":[27],"are":[28],"unknown.":[29],"We":[30],"investigated":[31],"the":[32,71,74,127,178,201,217,232,238,253],"influence":[33],"circulating":[35],"concentrations":[36,53,114],"lactate":[38,81,103,211],"(NADH":[39,169],"generator)":[40],"and":[41,66,121,205],"NADH":[42,118,176],"on":[43,58],"GN":[44,77,99,130,149,181,220,240],"perfused":[46,222],"livers":[47,223,242],"TB":[49,87,105,136,155,187,206,225,244],"rats.":[50,88,112,137,164,188,207],"Lactate,":[51],"at":[52,248],"similar":[54,158,213],"to":[55,107,157,214,252],"those":[56],"found":[57],"days":[59],"5":[60],"(3.0":[61],"mM),":[62,65],"8":[63],"(5.5":[64],"12":[67],"(8.0":[68],"mM)":[69,123,172],"tumor,":[72],"prevented":[73,177,216],"reduction":[75,128,179,218],"from":[78,100,131,150,182,243],"2.0":[79,101,132,151],"mM":[80,102,133,152,184],"(lactatemia":[82],"healthy":[84,111,163,204],"rat)":[85],"NADH,":[89,143],"50":[90,139,174],"or":[91,140,159,173,195],"75":[92,141],"\u03bcM,":[93,97,147],"not":[95,125,145],"25":[96,146],"higher":[108,160],"values":[109,161],"than":[110,162],"High":[113,165],"pyruvate":[116,134,153,192],"(no":[117],"generator,":[119,170],"5.0":[120],"8.0":[122],"did":[124],"prevent":[126],"However,":[138],"\u03bcM":[142,175],"concentration":[166],"glutamine":[168,185,196],"2.5":[171],"1":[183],"Intraperitoneal":[189],"administration":[190],"(1.0":[193],"mg/kg)":[194,198],"(0.5":[197],"similarly":[199],"glycemia":[202],"In":[208],"conclusion,":[209],"high":[210],"concentration,":[212],"hyperlactatemia,":[215],"rats,":[226],"an":[227],"effect":[228],"probably":[229],"caused":[230],"by":[231],"redox":[234],"potential":[235],"(NADH/NAD+).":[236],"Thus,":[237],"decreased":[239],"due,":[247],"least":[249],"part,":[251],"absence":[254],"simulation":[256],"vivo":[259],"hyperlactatemia":[260],"studies.":[264]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-02-21T00:00:00"}