{"id":"https://openalex.org/W2913794840","doi":"https://doi.org/10.1155/2019/5763595","title":"Evaluation of a Rapid Kit for Detection of IgM against Leptospira in Human","display_name":"Evaluation of a Rapid Kit for Detection of IgM against Leptospira in Human","publication_year":2019,"publication_date":"2019-02-07","ids":{"openalex":"https://openalex.org/W2913794840","doi":"https://doi.org/10.1155/2019/5763595","mag":"2913794840","pmid":"https://pubmed.ncbi.nlm.nih.gov/30881530","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6383415"},"language":"en","primary_location":{"id":"doi:10.1155/2019/5763595","doi":"https://doi.org/10.1155/2019/5763595","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/5763595","pdf_url":"https://downloads.hindawi.com/journals/cjidmm/2019/5763595.pdf","source":{"id":"https://openalex.org/S165423614","display_name":"Canadian Journal of Infectious Diseases and Medical Microbiology","issn_l":"1180-2332","issn":["1180-2332","1712-9532","1918-1493"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313016","host_organization_name":"Pulsus Group","host_organization_lineage":["https://openalex.org/P4310313016","https://openalex.org/P4310320466"],"host_organization_lineage_names":["Pulsus Group","OMICS Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Infectious Diseases and Medical Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/cjidmm/2019/5763595.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101435361","display_name":"Mohan Rao","orcid":"https://orcid.org/0000-0001-9331-0486","observed_orcids":["https://orcid.org/0000-0001-9331-0486"]},"institutions":[{"id":"https://openalex.org/I105292261","display_name":"Ministry of Health","ror":"https://ror.org/05ddxe180","country_code":"MY","type":"government","lineage":["https://openalex.org/I105292261"]},{"id":"https://openalex.org/I4210130795","display_name":"Institute for Medical Research","ror":"https://ror.org/03bpc5f92","country_code":"MY","type":"facility","lineage":["https://openalex.org/I4210130795"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Mohan Rao","raw_affiliation_strings":["Bacteriology Unit, Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, 50588 Kuala Lumpur, Malaysia"],"raw_orcid":"https://orcid.org/0000-0001-9331-0486","affiliations":[{"raw_affiliation_string":"Bacteriology Unit, Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, 50588 Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I105292261","https://openalex.org/I4210130795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007556467","display_name":"Fairuz binti Amran","orcid":"https://orcid.org/0000-0001-8903-487X","observed_orcids":["https://orcid.org/0000-0001-8903-487X"]},"institutions":[{"id":"https://openalex.org/I105292261","display_name":"Ministry of Health","ror":"https://ror.org/05ddxe180","country_code":"MY","type":"government","lineage":["https://openalex.org/I105292261"]},{"id":"https://openalex.org/I4210130795","display_name":"Institute for Medical Research","ror":"https://ror.org/03bpc5f92","country_code":"MY","type":"facility","lineage":["https://openalex.org/I4210130795"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Fairuz Amran","raw_affiliation_strings":["Bacteriology Unit, Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, 50588 Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Unit, Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, 50588 Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I105292261","https://openalex.org/I4210130795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066074196","display_name":"Nadia Aqilla Shamsusah","orcid":"https://orcid.org/0000-0003-4278-5785","observed_orcids":["https://orcid.org/0000-0003-4278-5785"]},"institutions":[{"id":"https://openalex.org/I105292261","display_name":"Ministry of Health","ror":"https://ror.org/05ddxe180","country_code":"MY","type":"government","lineage":["https://openalex.org/I105292261"]},{"id":"https://openalex.org/I4210130795","display_name":"Institute for Medical Research","ror":"https://ror.org/03bpc5f92","country_code":"MY","type":"facility","lineage":["https://openalex.org/I4210130795"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Nadia Aqilla","raw_affiliation_strings":["Bacteriology Unit, Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, 50588 Kuala Lumpur, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacteriology Unit, Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, 50588 Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I105292261","https://openalex.org/I4210130795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101435361"],"corresponding_institution_ids":["https://openalex.org/I105292261","https://openalex.org/I4210130795"],"apc_list":{"value":2160,"currency":"USD","value_usd":2160},"apc_paid":{"value":2160,"currency":"USD","value_usd":2160},"fwci":2.1369,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.85816791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"2019","issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12223","display_name":"Leptospirosis research and findings","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptospirosis","display_name":"leptospirosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/igm-antibody-detection","display_name":"IgM antibody detection","score":0.8090000152587891},{"id":"https://openalex.org/keywords/rapid-diagnostic-tests","display_name":"rapid diagnostic tests","score":0.8330000042915344},{"id":"https://openalex.org/keywords/microscopic-agglutination-test","display_name":"microscopic agglutination test","score":0.859000027179718},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.8579999804496765},{"id":"https://openalex.org/keywords/acute-febrile-illness","display_name":"acute febrile illness","score":0.7300000190734863},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.6579999923706055},{"id":"https://openalex.org/keywords/leptospira","display_name":"Leptospira","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C2778033228","wikidata":"https://www.wikidata.org/wiki/Q155098","display_name":"Leptospirosis","level":2,"score":0.9096104502677917},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.7797778844833374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7428802847862244},{"id":"https://openalex.org/C2780542935","wikidata":"https://www.wikidata.org/wiki/Q133841","display_name":"Leptospira","level":3,"score":0.7368903160095215},{"id":"https://openalex.org/C73878171","wikidata":"https://www.wikidata.org/wiki/Q5280305","display_name":"Direct agglutination test","level":4,"score":0.7090080976486206},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.606399655342102},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.549742579460144},{"id":"https://openalex.org/C2780261877","wikidata":"https://www.wikidata.org/wiki/Q3519062","display_name":"Rapid diagnostic test","level":3,"score":0.45814651250839233},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.45223280787467957},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42807790637016296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4221368134021759},{"id":"https://openalex.org/C37977956","wikidata":"https://www.wikidata.org/wiki/Q1806946","display_name":"Latex fixation test","level":3,"score":0.4109118580818176},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.4084295332431793},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.23844072222709656},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2166043221950531},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.21007341146469116},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.1818242073059082}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1155/2019/5763595","doi":"https://doi.org/10.1155/2019/5763595","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/5763595","pdf_url":"https://downloads.hindawi.com/journals/cjidmm/2019/5763595.pdf","source":{"id":"https://openalex.org/S165423614","display_name":"Canadian Journal of Infectious Diseases and Medical Microbiology","issn_l":"1180-2332","issn":["1180-2332","1712-9532","1918-1493"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313016","host_organization_name":"Pulsus Group","host_organization_lineage":["https://openalex.org/P4310313016","https://openalex.org/P4310320466"],"host_organization_lineage_names":["Pulsus Group","OMICS Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Infectious Diseases and Medical Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5404388","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6383415","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30881530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30881530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6383415","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6383415/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Can J Infect Dis Med Microbiol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5293a13681c14d329a72b19b2c7732a1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5293a13681c14d329a72b19b2c7732a1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 2019 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2019/5763595","doi":"https://doi.org/10.1155/2019/5763595","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/5763595","pdf_url":"https://downloads.hindawi.com/journals/cjidmm/2019/5763595.pdf","source":{"id":"https://openalex.org/S165423614","display_name":"Canadian Journal of Infectious Diseases and Medical Microbiology","issn_l":"1180-2332","issn":["1180-2332","1712-9532","1918-1493"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313016","host_organization_name":"Pulsus Group","host_organization_lineage":["https://openalex.org/P4310313016","https://openalex.org/P4310320466"],"host_organization_lineage_names":["Pulsus Group","OMICS Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Infectious Diseases and Medical Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328177","display_name":"Kementerian Kesihatan Malaysia","ror":"https://ror.org/05ddxe180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913794840.pdf","grobid_xml":"https://content.openalex.org/works/W2913794840.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W75505851","https://openalex.org/W2015028608","https://openalex.org/W2034435065","https://openalex.org/W2035602960","https://openalex.org/W2119259412","https://openalex.org/W2122999487","https://openalex.org/W2152164461","https://openalex.org/W2170160075","https://openalex.org/W2290423355","https://openalex.org/W2299051528","https://openalex.org/W2614853943","https://openalex.org/W4211105424"],"related_works":["https://openalex.org/W2573424042","https://openalex.org/W2614853943","https://openalex.org/W2802877165","https://openalex.org/W2902335568","https://openalex.org/W1851501616","https://openalex.org/W2174404470","https://openalex.org/W7062017092","https://openalex.org/W4310249281","https://openalex.org/W2096765283","https://openalex.org/W2312797458"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Leptospirosis":[1],"is":[2,25,125,128,147,167],"an":[3,40],"acute":[4,47,177],"febrile":[5,179],"illness,":[6],"known":[7],"for":[8,57],"its":[9],"protean":[10],"clinical":[11],"manifestations":[12],"and":[13,28,66,96,100,106,115,134,144,149,162],"the":[14,32,104,109,174],"challenge":[15],"in":[16,45,130,151,156],"differentiating":[17],"from":[18],"other":[19],"infectious":[20],"diseases.":[21],"Standardized":[22],"confirmatory":[23],"test":[24,84,166],"antibody":[26,133],"dependent":[27],"not":[29],"accessible":[30],"by":[31,73,140],"suburban":[33],"community.":[34],"This":[35],"study":[36],"measures":[37],"efficiency":[38,120],"of":[39,52,98,108,121,137,176],"immune-chromatographic":[41],"assay,":[42],"Leptocheck":[43],"WB,":[44],"detecting":[46,131],"leptospirosis.":[48],"METHODS:":[49],"A":[50],"total":[51],"142":[53],"sera":[54],"were":[55,71],"used":[56],"kit":[58,76,91,110,124],"evaluation.":[59],"Sensitivity,":[60],"specificity,":[61],"positive":[62],"predictive":[63,68],"value":[64,69],"(PPV),":[65],"negative":[67],"(NPV)":[70],"calculated":[72],"comparing":[74],"rapid":[75,90,123,165],"results":[77],"with":[78,153],"gold":[79],"standard":[80],"laboratory,":[81],"microscopic":[82],"agglutination":[83],"(MAT).":[85],"RESULTS:":[86],"We":[87],"found":[88],"this":[89,122],"to":[92,112,172],"have":[93],"a":[94,169],"sensitivity":[95,161],"specificity":[97,163],"66.6%":[99],"78.9%,":[101],"respectively,":[102],"whereas":[103],"PPV":[105,143],"NPV":[107],"appeared":[111],"be":[113],"73.3%":[114],"73.2%,":[116],"respectively.":[117],"DISCUSSION:":[118],"Test":[119],"reasonable.":[126],"It":[127,146],"specific":[129],"leptospiral":[132],"assures":[135],"clinician":[136],"accurate":[138],"diagnosis":[139,175],"having":[141],"higher":[142],"NPV.":[145],"prompt":[148],"efficient":[150],"comparison":[152],"conventional":[154],"methods":[155],"assisting":[157],"differential":[158],"diagnosis.":[159],"High":[160],"leptospirosis":[164],"indeed":[168],"crucial":[170],"measure":[171],"assist":[173],"undifferentiated":[178],"illnesses.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-02-21T00:00:00"}