{"id":"https://openalex.org/W2913745575","doi":"https://doi.org/10.1182/blood-2018-99-118453","title":"Comprehensive Genomic Analysis of Flow-Sorted Hodgkin Reed Sternberg Cells Reveals Additional Genetic Bases of Immune Evasion","display_name":"Comprehensive Genomic Analysis of Flow-Sorted Hodgkin Reed Sternberg Cells Reveals Additional Genetic Bases of Immune Evasion","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2913745575","doi":"https://doi.org/10.1182/blood-2018-99-118453","mag":"2913745575"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-118453","doi":"https://doi.org/10.1182/blood-2018-99-118453","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-118453","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087362622","display_name":"Kirsty Wienand","orcid":"https://orcid.org/0000-0001-9548-4420","observed_orcids":["https://orcid.org/0000-0001-9548-4420"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kirsty Wienand","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074215180","display_name":"Bjoern Chapuy","orcid":"https://orcid.org/0000-0002-6485-8773","observed_orcids":["https://orcid.org/0000-0002-6485-8773"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Bjoern Chapuy","raw_affiliation_strings":["Department of Hematology and Oncology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003120045","display_name":"Chip Stewart","orcid":"https://orcid.org/0000-0003-2245-9552","observed_orcids":["https://orcid.org/0000-0003-2245-9552"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chip Stewart","raw_affiliation_strings":["Broad Institute, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000496024","display_name":"Andrew J Dunford","orcid":"https://orcid.org/0000-0002-6152-3169","observed_orcids":["https://orcid.org/0000-0002-6152-3169"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew Dunford","raw_affiliation_strings":["Broad Institute, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103186489","display_name":"David Wu","orcid":"https://orcid.org/0000-0001-7729-5730","observed_orcids":["https://orcid.org/0000-0001-7729-5730"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Wu","raw_affiliation_strings":["University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103208897","display_name":"Jaegil Kim","orcid":"https://orcid.org/0000-0003-4588-5618","observed_orcids":["https://orcid.org/0000-0003-4588-5618","https://orcid.org/0000-0001-8091-095X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jaegil Kim","raw_affiliation_strings":["Broad Institute, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016610225","display_name":"Atanas Kamburov","orcid":"https://orcid.org/0000-0002-0580-0619","observed_orcids":["https://orcid.org/0000-0002-0580-0619"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Atanas Kamburov","raw_affiliation_strings":["Broad Institute, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055960268","display_name":"Fathima Zumla Cader","orcid":"https://orcid.org/0000-0001-5107-0146","observed_orcids":["https://orcid.org/0000-0001-5107-0146"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fathima Zumla Cader","raw_affiliation_strings":["Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022657765","display_name":"Matthew D. Ducar","orcid":"https://orcid.org/0000-0003-4635-1300","observed_orcids":["https://orcid.org/0000-0003-4635-1300"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew D. Ducar","raw_affiliation_strings":["Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050754309","display_name":"Aaron R. Thorner","orcid":"https://orcid.org/0000-0002-9160-7881","observed_orcids":["https://orcid.org/0000-0002-9160-7881"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aaron R. Thorner","raw_affiliation_strings":["Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055857253","display_name":"Alexander T. Heubeck","orcid":"https://orcid.org/0000-0002-9312-4090","observed_orcids":["https://orcid.org/0000-0002-9312-4090"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander T Heubeck","raw_affiliation_strings":["Hematologic Neoplasia Flow Cytometry Core, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematologic Neoplasia Flow Cytometry Core, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017668890","display_name":"Michael J. Buonopane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J Buonopane","raw_affiliation_strings":["Hematologic Neoplasia Flow Cytometry Core, Dana-Farber Cancer Institute, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematologic Neoplasia Flow Cytometry Core, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053410437","display_name":"Philippe A. Armand","orcid":"https://orcid.org/0000-0001-6098-1603","observed_orcids":["https://orcid.org/0000-0001-6098-1603"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philippe Armand","raw_affiliation_strings":["Dana Farber Cancer Institute, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058975989","display_name":"Scott J. Rodig","orcid":"https://orcid.org/0000-0003-1761-9769","observed_orcids":["https://orcid.org/0000-0003-1761-9769"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott J Rodig","raw_affiliation_strings":["Department of Pathology, Brigham & Women's Hospital, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham & Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020858509","display_name":"Jonathan R. Fromm","orcid":"https://orcid.org/0000-0002-2287-5284","observed_orcids":["https://orcid.org/0000-0002-2287-5284"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan R. Fromm","raw_affiliation_strings":["Laboratory Medicine/Hematopathology, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Medicine/Hematopathology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001392592","display_name":"Gad A. Getz","orcid":"https://orcid.org/0000-0002-0936-0753","observed_orcids":["https://orcid.org/0000-0002-0936-0753"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gad Getz","raw_affiliation_strings":["Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA","Department of Pathology, Harvard Medical School, Boston, MA","Department of Pathology, Massachusetts General Hospital, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Pathology, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pathology, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021363179","display_name":"Margaret Ann Shipp","orcid":"https://orcid.org/0000-0002-3949-6897","observed_orcids":["https://orcid.org/0000-0002-3949-6897"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Shipp","raw_affiliation_strings":["Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA","Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5000496024","https://openalex.org/A5001392592","https://openalex.org/A5003120045","https://openalex.org/A5016610225","https://openalex.org/A5022657765","https://openalex.org/A5050754309","https://openalex.org/A5087362622","https://openalex.org/A5103186489","https://openalex.org/A5103208897"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I201448701","https://openalex.org/I4210087915","https://openalex.org/I4210117453"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"1559","last_page":"1559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/classical-hodgkin-lymphoma","display_name":"classical Hodgkin lymphoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/reed-sternberg-cells","display_name":"Reed-Sternberg cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.9639999866485596},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.7229999899864197},{"id":"https://openalex.org/keywords/somatic-copy-number-alterations","display_name":"somatic copy number alterations","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pd-l2","display_name":"PD-L2","score":0.972000002861023},{"id":"https://openalex.org/keywords/jak2","display_name":"JAK2","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.9819999933242798},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.5920000076293945},{"id":"https://openalex.org/keywords/hypermutator-phenotype","display_name":"hypermutator phenotype","score":0.4480000138282776},{"id":"https://openalex.org/keywords/msh2","display_name":"MSH2","score":0.6370000243186951},{"id":"https://openalex.org/keywords/poles","display_name":"poles","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cd4-t-cell-responses","display_name":"CD4+ T cell responses","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C2779390272","wikidata":"https://www.wikidata.org/wiki/Q2167074","display_name":"Reed\u2013Sternberg cell","level":4,"score":0.6856504082679749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5339862704277039},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49441003799438477},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4564951956272125},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4515940845012665},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4509713649749756},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.4329453706741333},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.42759230732917786},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4244644045829773},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3969899117946625},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3776785135269165},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37006843090057373},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3448188900947571},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21846824884414673},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.13778790831565857},{"id":"https://openalex.org/C2992779791","wikidata":"https://www.wikidata.org/wiki/Q209369","display_name":"Hodgkin lymphoma","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-118453","doi":"https://doi.org/10.1182/blood-2018-99-118453","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-118453","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2994220347","https://openalex.org/W2902172441","https://openalex.org/W2769754957","https://openalex.org/W2988647003","https://openalex.org/W2979607501","https://openalex.org/W3096669114","https://openalex.org/W2736482103","https://openalex.org/W2053146807","https://openalex.org/W2786224778","https://openalex.org/W4411333232"],"abstract_inverted_index":{"Abstract":[0],"Classical":[1],"Hodgkin":[2,10],"lymphoma":[3],"(cHL)":[4],"is":[5,360],"composed":[6],"of":[7,56,87,110,121,129,141,159,191,255,257,328,337,353,372,405,422,474,548,552,559,584,602,610,615,670],"rare":[8,53],"malignant":[9],"Reed":[11],"Sternberg":[12],"(HRS)":[13],"cells":[14,41,82,182,186,199,204,605],"within":[15,333],"an":[16,211,219,546,667],"extensive,":[17],"but":[18,114],"ineffective,":[19],"inflammatory/immune":[20],"cell":[21,108,119],"infiltrate.":[22],"Emerging":[23],"data":[24],"suggests":[25],"that":[26,39,331],"cHLs":[27,298,322,410],"use":[28],"multiple":[29,419,453,490],"genetic":[30,139,400,420,454,491,608],"mechanisms":[31,492,593,614],"to":[32,101,106,145,176,208,223,233,305,619],"evade":[33],"immune":[34,457,611],"recognition.":[35],"We":[36,162,228,295,345,450],"previously":[37,166,349],"found":[38],"HRS":[40,81,107,118,160,181,198,260,604],"exhibit":[42],"near-universal":[43],"somatic":[44],"copy":[45,69,415,428,469,472,507,517,541],"number":[46],"alterations":[47,500,565],"(SCNAs)":[48],"involving":[49,434],"chromosome":[50],"9p24.1/PD-1-L1/PD-L2":[51],"and":[52,74,89,143,148,183,200,218,245,252,277,281,287,291,368,390,418,438,444,467,479,505,515,520,538,550,570,573,575,617,622,630,636],"chromosomal":[54],"rearrangements":[55],"PD-L1":[57],"or":[58,91,311,672],"PD-L2.":[59],"The":[60,196,524],"9p24.1":[61,414,576],"amplicon":[62],"also":[63,83,346,411,451,579],"includes":[64],"JAK2,":[65],"which":[66],"increases":[67,365],"JAK2":[68,427],"numbers,":[70],"augments":[71,369],"JAK2/STAT":[72],"signaling":[73,425,485],"further":[75],"induces":[76],"PD-1":[77,102,146,373,406,620],"ligand":[78],"expression.":[79,96],"However,":[80],"have":[84],"inactivating":[85,446,461,480],"mutations":[86,308,313,355,394,432,448,462,465,503,513,522,536,572],"B2M":[88,460],"decreased":[90],"absent":[92],"MHC":[93,111,122],"class":[94,112,123],"I":[95,113],"In":[97,597],"cHL,":[98],"clinical":[99],"responses":[100],"blockade":[103,147,374,621],"are":[104],"unrelated":[105],"expression":[109,120],"closely":[115],"associated":[116],"with":[117,301],"II,":[124],"highlighting":[125,590],"the":[126,188,258,317,320,334,370,382,403,441,475,527],"potential":[127,399,613],"role":[128],"CD4+":[130],"T-cell":[131],"effectors":[132],"(J":[133],"Clin":[134],"Oncol":[135],"2018;36:942-50).":[136],"To":[137],"define":[138],"bases":[140,401,421,455,609],"response":[142,616],"resistance":[144,618],"identify":[149,234],"complementary":[150],"treatment":[151],"targets,":[152],"we":[153,262],"performed":[154],"whole":[155],"exome":[156],"sequencing":[157],"(WES)":[158],"cells.":[161],"first":[163],"used":[164,229],"a":[165,324,348],"described":[167],"multi-color":[168],"flow":[169],"cytometric":[170],"sorting":[171],"protocol":[172],"(Methods":[173],"2012;":[174],"57:368-75)":[175],"obtain":[177],"highly":[178],"purified":[179,603],"CD30+":[180],"normal":[184,202],"B":[185,203],"from":[187],"excisional":[189],"biopsies":[190],"25":[192],"newly":[193,391],"diagnosed":[194],"cHLs.":[195,495],"isolated":[197,259],"paired":[201],"were":[205,487,578],"then":[206],"subjected":[207],"WES":[209],"using":[210],"optimized":[212],"workflow":[213],"for":[214,402,456],"low":[215,292],"input":[216],"samples":[217],"expanded":[220],"bait":[221],"set":[222],"capture":[224],"structural":[225],"variants":[226],"(SVs).":[227],"established":[230],"analytical":[231],"pipelines":[232],"significantly":[235,265],"mutated":[236,266,556],"genes":[237,240],"(candidate":[238],"cancer":[239,339],"[CCGs],":[241],"MutSig2CV),":[242],"SCNAs":[243,577],"(GISTIC2.0)":[244],"SVs":[246,482],"(4":[247,275],"algorithms).":[248],"With":[249],"improved":[250],"methodology":[251],"purity":[253],"(median":[254],"80%)":[256],"cells,":[261],"defined":[263],"15":[264,282],"CCGs,":[267],"21":[268],"recurrent":[269,413,564],"SCNAs,":[270],"including":[271,426,459,566],"6":[272],"CN":[273,283],"gains":[274],"focal":[276,286],"2":[278,297,318],"arm":[279,289],"level)":[280],"losses":[284],"(14":[285],"1":[288],"level),":[290],"frequency":[293],"SVs.":[294],"identified":[296,347,392,452,580],"as":[299],"hypermutators":[300],"MSI":[302,384],"signatures":[303],"due":[304],"splice":[306],"site":[307],"in":[309,314,357,375,395,440,493,557,581,594],"MSH2":[310],"missense":[312],"POLE.":[315],"Excluding":[316],"hypermutators,":[319],"analyzed":[321],"had":[323],"median":[325],"mutational":[326,340,366,388],"density":[327],"6.4":[329],"mutations/Mb,":[330],"falls":[332],"top":[335],"quartile":[336],"reported":[338],"frequencies":[341],"(Nature":[342,378],"2013":[343],"499:214).":[344],"unappreciated":[350],"high":[351,387],"incidence":[352],"ARID1A":[354,363,393],"(24%)":[356,504,514,537],"cHL.":[358],"This":[359],"noteworthy":[361],"because":[362],"deficiency":[364],"load":[367],"efficacy":[371,404],"murine":[376],"models":[377],"Med":[379],"2018;24:556).":[380],"Together,":[381],"observed":[383],"signatures,":[385],"relatively":[386],"burden":[389],"cHL":[396,563],"represent":[397],"additional":[398,623],"blockade.":[407],"Notably,":[408],"these":[409,494,595],"exhibited":[412],"gain":[416,429,542],"(80%)":[417],"enhanced":[423],"JAK/STAT":[424],"(80%),":[430],"STAT6":[431],"(32%)":[433],"known":[435],"hotspots":[436],"(D419":[437],"N421)":[439],"DNA-binding":[442],"domain":[443],"frequent":[445,539],"SOCS1":[447],"(68%).":[449],"evasion,":[458,612],"(36%),":[463],"HLA-B":[464],"(16%)":[466],"6p21.32/HLA-B":[468],"loss":[470,473,508,518],"(28%),":[471],"larger":[476],"6p21.32":[477],"region":[478],"CIITA":[481],"(8%).":[483],"Additional":[484],"pathways":[486],"perturbed":[488,533],"by":[489,534],"For":[496],"example,":[497],"NF-\u03baB":[498],"pathway":[499],"included:":[501],"TNFAIP3":[502],"6q23.2/TNFAIP3":[506],"(56%),":[509],"12%":[510],"biallelic;":[511],"NFKBIE":[512],"6q21.32/NFKBIE":[516],"(12%);":[519],"NFKBIA":[521],"(16%).":[523],"gene":[525],"encoding":[526],"nuclear":[528],"export":[529],"protein,":[530],"XPO1,":[531],"was":[532,555],"E571K":[535],"2p15/XPO1":[540],"(72%).":[543],"Additionally,":[544],"GNA13,":[545],"activator":[547],"RHOA":[549],"modifier":[551],"PI3K":[553],"signaling,":[554],"24%":[558],"cases.":[560],"Of":[561],"interest,":[562],"B2M,":[567],"TNFAIP3,":[568],"STAT6,":[569],"GNA13":[571],"6q23.2":[574],">":[582],"20%":[583],"examined":[585],"primary":[586],"mediastinal":[587],"B-cell":[588],"lymphomas,":[589],"shared":[591],"pathogenetic":[592],"diseases.":[596],"summary,":[598],"comprehensive":[599],"genomic":[600],"analyses":[601],"reveal":[606],"new":[607],"targetable":[624],"alterations.":[625],"KW,":[626],"BC,":[627],"CS,":[628],"AD":[629],"DW":[631],"contributed":[632,638],"equally.":[633,639],"JF,":[634],"GG":[635],"MS":[637],"Disclosures":[640],"Rodig:":[641],"Affimed:":[642],"Research":[643,646,649,654,657,660,675],"Funding;":[644,647,650,658,661,676],"KITE:":[645],"Merck:":[648],"Bristol":[651],"Myers":[652],"Squibb:":[653,663],"Funding.":[655],"Shipp:Merck:":[656],"Bayer:":[659],"Bristol-Myers":[662],"Honoraria,":[664],"Membership":[665],"on":[666],"entity's":[668],"Board":[669],"Directors":[671],"advisory":[673],"committees,":[674],"AstraZeneca:":[677],"Honoraria.":[678]},"counts_by_year":[{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-02-21T00:00:00"}