{"id":"https://openalex.org/W2913726331","doi":"https://doi.org/10.1182/blood-2018-99-119199","title":"CPSF1-Mediated Acute Myeloid Leukemia Fusion 3'UTR Alternation Is a Potential Therapeutic Target","display_name":"CPSF1-Mediated Acute Myeloid Leukemia Fusion 3'UTR Alternation Is a Potential Therapeutic Target","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2913726331","doi":"https://doi.org/10.1182/blood-2018-99-119199","mag":"2913726331"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-119199","doi":"https://doi.org/10.1182/blood-2018-99-119199","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-119199","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017089248","display_name":"Takahiro Shima","orcid":"https://orcid.org/0000-0003-0062-6161","observed_orcids":["https://orcid.org/0000-0003-0062-6161"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Takahiro Shima","raw_affiliation_strings":["Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004918190","display_name":"Amanda G Davis","orcid":"https://orcid.org/0000-0003-4356-7480","observed_orcids":["https://orcid.org/0000-0003-4356-7480"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amanda G Davis","raw_affiliation_strings":["Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014787512","display_name":"D. T. Johnson","orcid":"https://orcid.org/0000-0003-4669-037X","observed_orcids":["https://orcid.org/0000-0003-4669-037X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel T Johnson","raw_affiliation_strings":["Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035260690","display_name":"Yu Kochi","orcid":"https://orcid.org/0000-0002-9411-7239","observed_orcids":["https://orcid.org/0000-0002-9411-7239"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yu Kochi","raw_affiliation_strings":["Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039398008","display_name":"Sayuri Miyauchi","orcid":"https://orcid.org/0009-0000-8439-7751","observed_orcids":["https://orcid.org/0009-0000-8439-7751"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sayuri Miyauchi","raw_affiliation_strings":["Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081240237","display_name":"Samuel A. Stoner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel A Stoner","raw_affiliation_strings":["Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089109876","display_name":"Junichiro Yuda","orcid":"https://orcid.org/0000-0002-4908-1636","observed_orcids":["https://orcid.org/0000-0002-4908-1636"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Junichiro Yuda","raw_affiliation_strings":["Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066039877","display_name":"Toshihiro Miyamoto","orcid":"https://orcid.org/0000-0002-6533-1594","observed_orcids":["https://orcid.org/0000-0002-6533-1594","https://orcid.org/0000-0001-5941-4679"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Miyamoto","raw_affiliation_strings":["Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102843809","display_name":"Jiehua Zhou","orcid":"https://orcid.org/0000-0002-2088-1218","observed_orcids":["https://orcid.org/0000-0002-2088-1218"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie-Hua Zhou","raw_affiliation_strings":["BMT Division, Department of Medicine, University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BMT Division, Department of Medicine, University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112134025","display_name":"Edward David Ball","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward D. Ball","raw_affiliation_strings":["BMT Division, Department of Medicine, University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BMT Division, Department of Medicine, University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102870989","display_name":"Koichi Akashi","orcid":"https://orcid.org/0000-0001-7763-5723","observed_orcids":["https://orcid.org/0000-0001-7763-5723"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Akashi","raw_affiliation_strings":["Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084311979","display_name":"Dong\u2010Er Zhang","orcid":"https://orcid.org/0000-0003-2541-6443","observed_orcids":["https://orcid.org/0000-0003-2541-6443"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong-Er Zhang","raw_affiliation_strings":["Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology & Division of Biological Sciences, University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004918190","https://openalex.org/A5014787512","https://openalex.org/A5017089248","https://openalex.org/A5035260690","https://openalex.org/A5039398008","https://openalex.org/A5089109876","https://openalex.org/A5102843809","https://openalex.org/A5112134025"],"corresponding_institution_ids":["https://openalex.org/I135598925","https://openalex.org/I36258959"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"885","last_page":"885"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-polyadenylation","display_name":"alternative polyadenylation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.8489999771118164},{"id":"https://openalex.org/keywords/aml1-eto-fusion-gene","display_name":"AML1-ETO fusion gene","score":0.9139999747276306},{"id":"https://openalex.org/keywords/polyadenylation-site-usage","display_name":"polyadenylation site usage","score":0.925000011920929},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.921999990940094},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7300000190734863},{"id":"https://openalex.org/keywords/rna-isoforms","display_name":"RNA isoforms","score":0.3319999873638153},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.5199999809265137},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.6974420547485352},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.6922944784164429},{"id":"https://openalex.org/C2778274637","wikidata":"https://www.wikidata.org/wiki/Q5510282","display_name":"Fusion transcript","level":4,"score":0.586899995803833},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5803552865982056},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.5773878693580627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5735447406768799},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.548800528049469},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.5393391251564026},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5250827074050903},{"id":"https://openalex.org/C12464233","wikidata":"https://www.wikidata.org/wiki/Q937624","display_name":"Five prime untranslated region","level":5,"score":0.4527743458747864},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4485619068145752},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4432598650455475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4211791157722473},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.4121250510215759},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.39301711320877075},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2814655900001526},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19412466883659363}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-119199","doi":"https://doi.org/10.1182/blood-2018-99-119199","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-119199","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3122388228","https://openalex.org/W2980668679","https://openalex.org/W3196969402","https://openalex.org/W4392245007","https://openalex.org/W3154988157","https://openalex.org/W2916580767","https://openalex.org/W2995257060","https://openalex.org/W3100644542","https://openalex.org/W2955951220","https://openalex.org/W3201686167"],"abstract_inverted_index":{"Abstract":[0],"Alternative":[1],"polyadenylation":[2,97,388,560],"(APA)":[3],"can":[4,103,168],"alter":[5],"the":[6,24,54,70,79,134,139,190,264,332,340,345,360,440,559,572],"three":[7],"prime":[8],"untranslated":[9],"region":[10],"(3'UTR)":[11],"length":[12,35,90,285,565],"of":[13,26,56,58,91,267,294,301,313,319,334,348,363,464,481,493,527,538,544,550,566,601],"mRNAs,":[14],"crucial":[15],"for":[16],"regulating":[17],"mRNA":[18,107,287,405,583],"metabolism":[19],"and":[20,38,77,115,129,148,163,194,209,216,222,254,274,289,323,344,387,401,430,460,483,506,547,570,585,592,609,612],"gene":[21,171,296,442,496,574,582,604],"expression.":[22,172,297],"Despite":[23],"prevalence":[25],"APA":[27,37,57,102,372,492],"post-transcriptional":[28],"regulation":[29],"in":[30,33,62,75,105,142,160,189,326,377,398,412,457,485,533,552,589],"cancers,":[31],"changes":[32,159],"3'UTR":[34,86,111,137,166,224,243,251,270,284,304,316,337,342,365,395,454,505,541,564,575,599,613],"by":[36,306,375,576],"its":[39],"contribution":[40],"to":[41,204,419,444,511,607,620],"leukemia":[42,65,416,622],"development":[43],"have":[44],"not":[45],"been":[46],"thoroughly":[47],"studied.":[48],"In":[49],"this":[50,364],"study,":[51],"we":[52,155,367,468,489,556],"demonstrated":[53],"significance":[55],"leukemic":[59,215,349,494,567],"fusion":[60,82,170,295,350,495,568,573,581,603],"genes":[61,351],"acute":[63],"myelogenous":[64],"(AML)":[66],"development.":[67],"T(8;21)":[68],"is":[69,138,290,530],"most":[71],"common":[72],"chromosomal":[73],"abnormality":[74],"AML":[76,145,187,205,379,414,465,518],"encodes":[78],"AML1-ETO":[80,482],"(AE)":[81],"gene.":[83],"The":[84,173,298],"AE":[85,121,135,165,202,220,241,249,268,283,302,314,321,335,404,445,453,458,472],"has":[87,499],"a":[88,227,354,461,477,617],"full":[89],"5.2kb":[92,126],"that":[93,101,120,158,180,240,282,331,384,436,450,471,558,598],"contains":[94],"4":[95],"canonical":[96,501],"sites":[98],"(PAS),":[99],"such":[100],"result":[104],"several":[106],"isoforms":[108],"with":[109,186],"varying":[110],"lengths.":[112],"However,":[113],"RNA-seq":[114],"absolute":[116],"quantification":[117],"qPCR":[118],"revealed":[119,179,435],"mainly":[122],"uses":[123],"2":[124,500],"PAS:":[125],"(long":[127],"3'UTR)":[128],"3.7kb":[130],"(short":[131],"3'UTR).":[132,509],"Moreover,":[133,233],"short":[136,250,303,336,504,524],"major":[140],"isoform":[141],"both":[143,590],"t(8;21)":[144,378,413,486],"primary":[146],"patients":[147],"cell":[149,175,380,519,587],"lines.":[150,381],"Based":[151],"on":[152],"these":[153,195,214],"findings,":[154],"next":[156],"hypothesize":[157],"PAS":[161,305,338,346,502],"usage":[162,225,343,347,396,614],"thus":[164],"length,":[167],"modulate":[169],"single":[174],"based":[176],"dynamic":[177],"array":[178],"AE+":[181,197,217,591],"non-leukemic":[182,196,218],"differentiated":[183],"cells":[184,198,417,422,516],"coexisted":[185],"blasts":[188,206],"diagnostic":[191],"bone":[192],"marrow":[193],"expressed":[199,411],"much":[200,245],"lower":[201],"compared":[203,418],"(monocytes,":[207],"0.19-fold":[208],"granulocytes,":[210],"0.11-fold,":[211],"p<0.001).":[212,278],"Among":[213],"cells,":[219,514],"expression":[221],"long":[223,242,269,315,341,394,508,540],"showed":[226,239,439,536],"significant":[228],"negative":[229],"correlation":[230],"(R2=0.64,":[231],"p<0.01).":[232,257],"half-life":[234,247],"assay":[235,261],"using":[236],"actinomycin":[237],"D":[238],"had":[244],"shorter":[246],"than":[248],"(0.8":[252],"hour":[253],"2.8":[255],"hours,":[256],"A":[258],"dual":[259],"reporter":[260],"also":[262,427,469,490,531],"presented":[263],"predominant":[265],"repression":[266],"(3.7":[271],"kb:":[272,276],"0.31":[273],"5.2":[275],"0.08,":[277],"These":[279,328,447,595],"data":[280,448],"suggest":[281,449,597],"affects":[286],"stability":[288,459,584],"an":[291,311,324,548],"important":[292],"indicator":[293],"selective":[299],"inhibition":[300,333],"morpholino":[307],"antisense":[308],"oligonucleotide":[309],"caused":[310],"increase":[312,325,537,549],"usage,":[317,542],"decrease":[318,543],"total":[320,399],"expression,":[322,475,546],"apoptosis.":[327],"results":[329,596],"indicate":[330],"increases":[339],"could":[352],"be":[353,616],"potential":[355],"therapeutic":[356],"target.":[357],"To":[358],"find":[359],"key":[361],"regulator":[362,561],"change,":[366],"comprehensively":[368],"knocked":[369],"down":[370,578],"all":[371],"machinery":[373],"members":[374],"shRNA":[376],"We":[382],"discovered":[383],"CPSF1":[385,408,425,437,451,474,484,562,579,611],"(cleavage":[386],"specific":[389],"factor":[390],"1)":[391],"knockdown":[392,426,438],"increased":[393],"(37%":[397],"AE)":[400],"down-regulated":[402],"overall":[403],"(0.47-fold).":[406],"Importantly,":[407,467],"was":[409],"highly":[410],"patients'":[415],"healthy":[420,512],"CD34+":[421,513],"(2.7-fold,":[423],"p=0.01).":[424],"promoted":[428],"apoptosis":[429,551],"Gene":[431],"Set":[432],"Enrichment":[433],"Analysis":[434],"similar":[441],"signature":[443],"knockdown.":[446],"promotes":[452],"shortening,":[455],"resulting":[456],"growth":[462,588],"advantage":[463],"cells.":[466,554],"found":[470],"regulates":[473],"suggesting":[476],"positive":[478],"feedback":[479],"loop":[480],"AML.":[487],"Finally,":[488],"checked":[491],"MLL-AF9,":[497],"which":[498,529],"(0.1kb":[503],"0.7kb":[507],"Compared":[510],"THP-1":[515,553],"(MLL-AF9+":[517],"line)":[520],"predominantly":[521],"used":[522],"MLL-AF9":[523,539,545],"3'UTR.":[525],"Knockdown":[526],"CPSF1,":[528],"up-regulated":[532],"MLL-associated":[534],"AML,":[535],"Collectively,":[555],"conclude":[557],"controls":[563],"transcripts,":[569],"extending":[571],"knocking":[577],"reduces":[580],"restricts":[586],"MLL-AF9+":[593],"AMLs.":[594],"shortening":[600],"oncogenic":[602],"transcripts":[605],"contributes":[606],"leukemogenesis":[608],"controlling":[610],"may":[615],"useful":[618],"approach":[619],"inhibit":[621],"progression.":[623],"Disclosures":[624],"Akashi:":[625],"Pfizer:":[626],"Research":[627,631,636,642,649,653,656,660,663,666,670,674,677,682,686],"Funding;":[628,632,650,654,657,661,664,667,671,675,683],"Taiho":[629],"Pharmaceutical:":[630,652,685],"Kyowa":[633],"Hakko":[634],"Kirin:":[635],"Funding,":[637,643,678],"Speakers":[638,644,679],"Bureau;":[639,645,680],"Bristol-Myers":[640],"Squibb:":[641],"Eli":[646],"Lilly":[647],"Japan:":[648],"Otsuka":[651],"Eisai:":[655],"Astellas":[658],"Pharma:":[659,673],"MSD:":[662],"sanofi:":[665],"Novartis":[668],"pharma:":[669],"Chugai":[672],"Celgene:":[676],"Asahi-kasei:":[681],"Ono":[684],"Funding.":[687]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-02-21T00:00:00"}