{"id":"https://openalex.org/W2913705017","doi":"https://doi.org/10.1182/blood-2018-99-112397","title":"Immunoglobulin Variable Region Gene Sequences Reveal N-Glycosylation Motifs As an Early and Stable Event in Follicular Lymphoma Pathology","display_name":"Immunoglobulin Variable Region Gene Sequences Reveal N-Glycosylation Motifs As an Early and Stable Event in Follicular Lymphoma Pathology","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2913705017","doi":"https://doi.org/10.1182/blood-2018-99-112397","mag":"2913705017"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-112397","doi":"https://doi.org/10.1182/blood-2018-99-112397","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-112397","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029419556","display_name":"Mariette Odabashian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mariette Odabashian","raw_affiliation_strings":["Barts Cancer Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Cancer Institute, London, United Kingdom","institution_ids":["https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023382026","display_name":"Emanuela Carlotti","orcid":"https://orcid.org/0000-0002-2794-9131","observed_orcids":["https://orcid.org/0000-0002-2794-9131"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Emanuela Carlotti","raw_affiliation_strings":["Inst. of Cancer, Barts & The London School of Med., London, GBR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inst. of Cancer, Barts & The London School of Med., London, GBR","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110225444","display_name":"Shamzah Araf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shamzah Araf","raw_affiliation_strings":["Barts Cancer Institute, London, United Kingdom","Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Cancer Institute, London, United Kingdom","institution_ids":["https://openalex.org/I4405264518"]},{"raw_affiliation_string":"Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055238920","display_name":"Jessica Okosun","orcid":"https://orcid.org/0000-0001-6021-5044","observed_orcids":["https://orcid.org/0000-0001-6021-5044"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jessica Okosun","raw_affiliation_strings":["Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078295579","display_name":"Francesco Forconi","orcid":"https://orcid.org/0000-0002-2211-1831","observed_orcids":["https://orcid.org/0000-0002-2211-1831"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francesco Forconi","raw_affiliation_strings":["Cancer Sciences Unit, Haematological Oncology Group, University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Sciences Unit, Haematological Oncology Group, University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047140412","display_name":"Freda K. Stevenson","orcid":"https://orcid.org/0000-0002-0933-5021","observed_orcids":["https://orcid.org/0000-0002-0933-5021"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Freda K Stevenson","raw_affiliation_strings":["Cancer Sciences Unit, University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Sciences Unit, University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067154165","display_name":"John G. Gribben","orcid":"https://orcid.org/0000-0002-8505-7430","observed_orcids":["https://orcid.org/0000-0002-8505-7430"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John G. Gribben","raw_affiliation_strings":["Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047655557","display_name":"Maria Calaminici","orcid":"https://orcid.org/0000-0003-4094-1633","observed_orcids":["https://orcid.org/0000-0003-4094-1633"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Maria Calaminici","raw_affiliation_strings":["Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075721950","display_name":"Sergey V. Krysov","orcid":"https://orcid.org/0000-0002-1006-4089","observed_orcids":["https://orcid.org/0000-0002-1006-4089"]},"institutions":[{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sergey Krysov","raw_affiliation_strings":["Barts Cancer Institute, London, GBR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Cancer Institute, London, GBR","institution_ids":["https://openalex.org/I4405264518"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023382026","https://openalex.org/A5029419556","https://openalex.org/A5047655557","https://openalex.org/A5055238920","https://openalex.org/A5075721950"],"corresponding_institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405264518"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"4101","last_page":"4101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immunoglobulin-variable-region","display_name":"immunoglobulin variable region","score":0.7129999995231628},{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"somatic hypermutation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/b-cell-receptor","display_name":"B cell receptor","score":0.6880000233650208},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tumor-subclones","display_name":"tumor subclones","score":0.7599999904632568},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8230000138282776},{"id":"https://openalex.org/keywords/high-mannose-oligosaccharides","display_name":"high-mannose oligosaccharides","score":0.8029999732971191},{"id":"https://openalex.org/keywords/calcium-dependent-lectin","display_name":"calcium-dependent lectin","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"tumor evolution","score":0.37400001287460327},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2777609679","wikidata":"https://www.wikidata.org/wiki/Q5971015","display_name":"IGHV@","level":4,"score":0.8329024314880371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7696273326873779},{"id":"https://openalex.org/C2777058707","wikidata":"https://www.wikidata.org/wiki/Q123251","display_name":"Follicular lymphoma","level":3,"score":0.6918501853942871},{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.6711044311523438},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.48606184124946594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48114025592803955},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47553086280822754},{"id":"https://openalex.org/C3020196193","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Immunoglobulin gene","level":3,"score":0.4565467834472656},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.45101314783096313},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.450729101896286},{"id":"https://openalex.org/C96007430","wikidata":"https://www.wikidata.org/wiki/Q3776943","display_name":"Immunoglobulin heavy chain","level":3,"score":0.42235085368156433},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.3922731876373291},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35441017150878906},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.32639074325561523},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3253474235534668},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.2801320552825928},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20325544476509094},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.14949265122413635}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2018-99-112397","doi":"https://doi.org/10.1182/blood-2018-99-112397","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-112397","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/66877","doi":null,"is_oa":false,"landing_page_url":"https://qmro.qmul.ac.uk/xmlui/handle/123456789/66877","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Proceeding"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2963260614","https://openalex.org/W3000245490","https://openalex.org/W4409171427","https://openalex.org/W2248198747","https://openalex.org/W4386533160","https://openalex.org/W4310127272","https://openalex.org/W1978885182","https://openalex.org/W2038319519","https://openalex.org/W7098141659","https://openalex.org/W3204712036"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"Follicular":[2],"lymphoma":[3],"(FL)":[4],"cells":[5,81,102],"retain":[6,594],"expression":[7],"of":[8,18,33,43,65,82,100,110,150,169,268,296,311,327,343,374,389,396,406,443,453,461,472,578,600,611,633,651],"a":[9,55,325,339,440,450,470,481,538,608],"functional":[10,595],"B":[11],"cell":[12,614],"receptor":[13],"(BCR)":[14],"despite":[15,315],"the":[16,24,34,41,52,66,83,87,95,104,143,197,232,258,272,294,297,301,318,322,333,359,382,390,397,462,467,473,529,551,556,584,588,612,631,643],"loss":[17,405],"one":[19,290],"Ig":[20,144],"allele":[21],"due":[22],"to":[23,59,72,94,271,630],"hallmark":[25],"t14:18":[26],"translocation":[27],"and":[28,74,91,98,117,128,219,252,266,363,377,393,399,519,555,590,624,636,649],"ongoing":[29,328],"somatic":[30],"hypermutation":[31],"(SHM)":[32],"variable":[35,147],"genes":[36],"(V":[37],"genes)":[38],"which":[39,337],"increases":[40],"likelihood":[42],"crippling":[44],"mutations.":[45],"SHM":[46,264,341],"introduces":[47],"N-glycosylation":[48],"(N-gly)":[49],"motifs":[50,73,114,141,251,457,589,605],"within":[51,142,293,321,358],"V":[53],"genes,":[54],"feature":[56,471,540],"exclusively":[57],"restricted":[58],"germinal":[60],"centre":[61],"(GC)-derived":[62],"lymphomas.":[63],"Oligosaccharides":[64],"high":[67],"mannose":[68],"type":[69],"are":[70,115,447,487,505,537,562],"added":[71,591],"interact":[75],"with":[76,80,205,404,424,456,476],"calcium-dependent":[77],"lectins":[78],"associated":[79],"microenvironment.":[84],"This":[85,330,573],"activates":[86],"BCR":[88],"signalling":[89],"pathway":[90],"likely":[92],"contributes":[93],"survival,":[96],"retention":[97],"proliferation":[99],"tumor":[101,185,227,269,425,436,464,474,558],"in":[103,126,309,317,372,376,387,394,435,541,550,565],"GC.":[105],"Determining":[106],"at":[107,165,597],"what":[108],"stage":[109],"disease":[111,170,349,379,491,543,619],"evolution":[112],"N-gly":[113,250,291,355,429,534,622],"acquired":[116,533],"their":[118,124,129,547,625],"behaviour":[119],"during":[120,490],"progression":[121,171,492,650],"can":[122],"ascertain":[123],"importance":[125],"pathogenesis":[127],"potential":[130],"as":[131,224,324,469,493,507,544,606],"an":[132,182,432,634],"effective":[133],"therapeutic":[134],"target.":[135],"To":[136],"achieve":[137],"this,":[138,439],"we":[139],"analysed":[140,248],"heavy":[145],"chain":[146],"gene":[148],"(IGHV)":[149],"tumor-related":[151],"subclones":[152,313,336,375,392,403,515,567,571],"across":[153,348,378],"temporal":[154],"FL":[155,162,542],"samples.":[156],"Method:":[157],"Genomic":[158],"DNA":[159,188],"from":[160,420],"three":[161,368],"patients":[163],"taken":[164,419],"different":[166,421],"time":[167,279,531],"points":[168],"were":[172,178,190,210,217,222,240,247,255,307,370,410,418],"analysed.":[173],"In":[174],"total,":[175],"8":[176],"samples":[177,281,417],"selected,":[179],"all":[180,407],"carrying":[181],"IGHV3":[183],"rearranged":[184],"clone.":[186],"IGHV":[187,274,295],"amplicons":[189],"sent":[191],"for":[192,249,282,412,528,617],"2x250bp":[193],"paired-end":[194],"sequencing":[195],"using":[196,257],"Miseq":[198],"Illumina":[199],"platform":[200],"(Genewiz,":[201],"NJ).":[202],"Tumor-related":[203],"reads":[204,229],"counts":[206],"greater":[207],"than":[208],"ten":[209],"selected":[211],"following":[212],"analysis":[213,500],"on":[214,231,262],"IMGT/HIGH-V-QUEST.":[215],"Reads":[216],"aligned":[218],"unique":[220,312],"sequences":[221],"assigned":[223],"subclones.":[225,454],"Additional":[226],"related":[228],"sequenced":[230],"Roche":[233],"454":[234],"Life":[235],"Sciences":[236],"Genome":[237],"Sequencer":[238],"FLX":[239],"available":[241],"(Patients":[242],"4":[243,286],"&":[244,287],"5).":[245],"Subclones":[246,455],"evolutionary":[253],"pathways":[254],"generated":[256],"IgTree":[259],"program,":[260],"based":[261],"intraclonal":[263],"profiles":[265],"homology":[267],"clones":[270,446,479,486,510],"germline":[273],"sequence.":[275],"Results:":[276],"The":[277,366,560,602],"earliest":[278],"point":[280],"Patient's":[283],"1,":[284],"3,":[285],"5":[288,416],"contained":[289,353],"site":[292,384],"MC":[298],"defined":[299],"by":[300],"largest":[302],"count":[303],"number.":[304],"These":[305,484],"sites":[306,356,369,409,423,504,518,536,561,623],"conserved":[308,371,386],">97%":[310,373],"(p<0.0001)":[314],"variations":[316],"nucleotide":[319],"sequence":[320],"region":[323],"result":[326],"SHM.":[329],"conservation":[331,548],"included":[332],"most":[334],"mutated":[335],"had":[338],"mean":[340],"rate":[342],"16.56%.":[344],"Conservation":[345],"was":[346,385],"maintained":[347],"events.":[350,498],"Patient":[351,413,415],"2":[352],"four":[354,408],"located":[357],"CDR1,":[360],"FR2,":[361],"CDR2,":[362],"FR3":[364,383],"regions.":[365],"first":[367,530],"events,":[380],"whereas":[381],"95.5%":[388],"diagnostic":[391],"~80%":[395],"relapsed":[398],"transformed":[400],"populations.":[401],"No":[402],"detected":[411],"2.":[414],"anatomical":[422],"populations":[426],"acquiring":[427],"distinct":[428],"motifs,":[430],"suggesting":[431,449],"early":[433,635],"divergence":[434],"evolution.":[437],"Despite":[438],"minor":[441,482],"population":[442,554],"motif":[444,468,477,508,535],"positive":[445,509],"shared,":[448],"trafficking":[451],"ability":[452],"made":[458],"up":[459],"\u226599%":[460],"total":[463],"count,":[465],"highlighting":[466],"bulk,":[475],"negative":[478,485,514],"representing":[480],"population.":[483],"presumably":[488,640],"lost":[489],"they":[494],"not":[495,521],"shared":[496],"between":[497],"Evolutionary":[499],"revealed":[501],"no":[502],"additional":[503,579],"gained":[506],"expand":[511],"while":[512,568],"rare":[513,569],"cannot":[516],"reacquire":[517],"do":[520],"undergo":[522],"further":[523],"diversification.":[524],"Conclusion:":[525],"We":[526],"report":[527],"that":[532,575],"clonal":[539],"seen":[545],"through":[546,642],"both":[549],"heterogeneous":[552],"subclonal":[553],"overall":[557],"mass.":[559],"also":[563],"retained":[564],"progression-associated":[566],"motif-negative":[570],"disappear.":[572],"suggests":[574],"although":[576],"acquisition":[577],"driver":[580],"mutations":[581],"may":[582,593,628],"dampen":[583],"tumor's":[585],"microenvironment":[586],"dependency,":[587],"mannoses":[592],"significance":[596],"later":[598],"stages":[599],"disease.":[601,652],"data":[603],"indicates":[604],"being":[607],"universal":[609],"event":[610],"reservoir":[613],"pool":[615],"responsible":[616],"propagating":[618],"episodes.":[620],"Targeting":[621],"interacting":[626],"partners":[627],"lead":[629],"disruption":[632],"vital":[637],"FL-microenvironment":[638],"interaction,":[639,645],"mediated":[641],"mannose-lectin":[644],"reducing":[646],"relapse":[647],"rates":[648],"Disclosures":[653],"Forconi:":[654],"Abbvie:":[655],"Consultancy;":[656],"Janssen-Cilag:":[657],"Consultancy.":[658],"Gribben:Abbvie:":[659],"Honoraria;":[660,662,664,666,683,688],"Roche:":[661],"Pharmacyclics:":[663],"Novartis:":[665],"Cancer":[667],"Research":[668,670,674,679,685,691,697,699,704],"UK:":[669],"Funding;":[671,675,680,686,692,700],"Wellcome":[672],"Trust:":[673],"Acerta":[676],"Pharma:":[677],"Honoraria,":[678,690,703],"TG":[681],"Therapeutics:":[682],"NIH:":[684],"Kite:":[687],"Janssen:":[689],"Unum:":[693],"Equity":[694],"Ownership;":[695],"Medical":[696],"Council:":[698],"Celgene:":[701],"Consultancy,":[702],"Funding.":[705]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-02-21T00:00:00"}
