{"id":"https://openalex.org/W2913697365","doi":"https://doi.org/10.3390/cancers11020147","title":"A Simplified Genomic Profiling Approach Predicts Outcome in Metastatic Colorectal Cancer","display_name":"A Simplified Genomic Profiling Approach Predicts Outcome in Metastatic Colorectal Cancer","publication_year":2019,"publication_date":"2019-01-27","ids":{"openalex":"https://openalex.org/W2913697365","doi":"https://doi.org/10.3390/cancers11020147","mag":"2913697365","pmid":"https://pubmed.ncbi.nlm.nih.gov/30691222","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6406354"},"language":"en","primary_location":{"id":"doi:10.3390/cancers11020147","doi":"https://doi.org/10.3390/cancers11020147","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers11020147","pdf_url":"https://www.mdpi.com/2072-6694/11/2/147/pdf?version=1548922147","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/11/2/147/pdf?version=1548922147","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065676249","display_name":"Carlo Capalbo","orcid":"https://orcid.org/0000-0001-8445-6782","observed_orcids":["https://orcid.org/0000-0001-8445-6782"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Capalbo","raw_affiliation_strings":["Department of Medical Oncology Sant\u2019 Andrea Hospital, I-00189 Rome, Italy","Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Sant\u2019 Andrea Hospital, I-00189 Rome, Italy","institution_ids":["https://openalex.org/I4210125574"]},{"raw_affiliation_string":"Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034571700","display_name":"Francesca Belardinilli","orcid":"https://orcid.org/0000-0003-4966-7044","observed_orcids":["https://orcid.org/0000-0003-4966-7044"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Belardinilli","raw_affiliation_strings":["Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070623531","display_name":"Domenico Raimondo","orcid":"https://orcid.org/0000-0002-1780-7295","observed_orcids":["https://orcid.org/0000-0002-1780-7295"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Raimondo","raw_affiliation_strings":["Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1780-7295","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015294553","display_name":"Edoardo Milanetti","orcid":"https://orcid.org/0000-0002-3046-5170","observed_orcids":["https://orcid.org/0000-0002-3046-5170"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Edoardo Milanetti","raw_affiliation_strings":["Department of Physics, University La Sapienza, 00185 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, University La Sapienza, 00185 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017669867","display_name":"Umberto Malapelle","orcid":"https://orcid.org/0000-0003-3211-9957","observed_orcids":["https://orcid.org/0000-0003-3211-9957"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Umberto Malapelle","raw_affiliation_strings":["Department of Public Health, University Federico II, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, University Federico II, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065532659","display_name":"Pasquale Pisapia","orcid":"https://orcid.org/0000-0002-6429-0620","observed_orcids":["https://orcid.org/0000-0002-6429-0620"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pasquale Pisapia","raw_affiliation_strings":["Department of Public Health, University Federico II, 80131 Naples, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6429-0620","affiliations":[{"raw_affiliation_string":"Department of Public Health, University Federico II, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022482451","display_name":"Valentina Magri","orcid":"https://orcid.org/0000-0001-7312-2904","observed_orcids":["https://orcid.org/0000-0001-7312-2904"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Magri","raw_affiliation_strings":["Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012312536","display_name":"Alessandra Anna Prete","orcid":"https://orcid.org/0000-0002-6263-9278","observed_orcids":["https://orcid.org/0000-0002-6263-9278"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Prete","raw_affiliation_strings":["Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050556936","display_name":"Silvia Pecorari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Pecorari","raw_affiliation_strings":["Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013579030","display_name":"Mariarosaria Colella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariarosaria Colella","raw_affiliation_strings":["Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044213949","display_name":"Anna Coppa","orcid":"https://orcid.org/0000-0001-9758-5444","observed_orcids":["https://orcid.org/0000-0001-9758-5444"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Coppa","raw_affiliation_strings":["Department of Experimental Medicine, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9758-5444","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028920246","display_name":"Caterina Bonfiglio","orcid":"https://orcid.org/0000-0002-8650-348X","observed_orcids":["https://orcid.org/0000-0002-8650-348X"]},"institutions":[{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Caterina Bonfiglio","raw_affiliation_strings":["National Institute of Gastroenterology-Research Hospital, IRCCS \u201cS. de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Gastroenterology-Research Hospital, IRCCS \u201cS. de Bellis\u201d, Castellana Grotte, 70013 Bari, Italy","institution_ids":["https://openalex.org/I4210155710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087350000","display_name":"Arianna Nicolussi","orcid":"https://orcid.org/0000-0001-7737-2580","observed_orcids":["https://orcid.org/0000-0001-7737-2580"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Arianna Nicolussi","raw_affiliation_strings":["Department of Experimental Medicine, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075370584","display_name":"Virginia Valentini","orcid":"https://orcid.org/0000-0003-3393-7185","observed_orcids":["https://orcid.org/0000-0003-3393-7185"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Virginia Valentini","raw_affiliation_strings":["Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075421946","display_name":"Alessandra Tessitore","orcid":"https://orcid.org/0000-0002-7663-2210","observed_orcids":["https://orcid.org/0000-0002-7663-2210"]},"institutions":[{"id":"https://openalex.org/I26415053","display_name":"University of L'Aquila","ror":"https://ror.org/01j9p1r26","country_code":"IT","type":"education","lineage":["https://openalex.org/I26415053"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Tessitore","raw_affiliation_strings":["Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy","institution_ids":["https://openalex.org/I26415053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053515048","display_name":"Beatrice Cardinali","orcid":"https://orcid.org/0000-0002-3333-3384","observed_orcids":["https://orcid.org/0000-0002-3333-3384"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155481","display_name":"Institute of Cell Biology and Neurobiology","ror":"https://ror.org/040xhth73","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210155481"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Cardinali","raw_affiliation_strings":["Institute of Cell Biology and Neurobiology, National Research Council, Campus A. Buzzati-Traverso, 00015 Monterotondo Scalo, Italy"],"raw_orcid":"https://orcid.org/0000-0002-3333-3384","affiliations":[{"raw_affiliation_string":"Institute of Cell Biology and Neurobiology, National Research Council, Campus A. Buzzati-Traverso, 00015 Monterotondo Scalo, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210155481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016010009","display_name":"Marialaura Petroni","orcid":"https://orcid.org/0000-0002-6021-1657","observed_orcids":["https://orcid.org/0000-0002-6021-1657"]},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marialaura Petroni","raw_affiliation_strings":["Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, Italy","institution_ids":["https://openalex.org/I30771326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012691987","display_name":"Paola Infante","orcid":"https://orcid.org/0000-0003-0682-3916","observed_orcids":["https://orcid.org/0000-0003-0682-3916"]},"institutions":[{"id":"https://openalex.org/I30771326","display_name":"Italian Institute of Technology","ror":"https://ror.org/042t93s57","country_code":"IT","type":"facility","lineage":["https://openalex.org/I30771326"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Infante","raw_affiliation_strings":["Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161 Rome, Italy","institution_ids":["https://openalex.org/I30771326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021477463","display_name":"Matteo Santoni","orcid":"https://orcid.org/0000-0001-7340-6173","observed_orcids":["https://orcid.org/0000-0001-7340-6173"]},"institutions":[{"id":"https://openalex.org/I4403386718","display_name":"Ospedale di Macerata","ror":"https://ror.org/019jb9m51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4403386718"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Santoni","raw_affiliation_strings":["Oncology Unit, Macerata Hospital, 62012 Macerata, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit, Macerata Hospital, 62012 Macerata, Italy","institution_ids":["https://openalex.org/I4403386718"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041977580","display_name":"Marco Filetti","orcid":"https://orcid.org/0000-0002-4734-7541","observed_orcids":["https://orcid.org/0000-0002-4734-7541"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Filetti","raw_affiliation_strings":["Department of Medical Oncology Sant\u2019 Andrea Hospital, I-00189 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Sant\u2019 Andrea Hospital, I-00189 Rome, Italy","institution_ids":["https://openalex.org/I4210125574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018000720","display_name":"Valeria Colicchia","orcid":"https://orcid.org/0000-0001-5290-5379","observed_orcids":["https://orcid.org/0000-0001-5290-5379"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Colicchia","raw_affiliation_strings":["Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043250067","display_name":"Paola Paci","orcid":"https://orcid.org/0000-0002-9393-2047","observed_orcids":["https://orcid.org/0000-0002-9393-2047"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210162062","display_name":"Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti","ror":"https://ror.org/054ye0e45","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210162062"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Paci","raw_affiliation_strings":["Institute for Systems Analysis and Computer Science \u201cAntonio Ruberti\u201d, National Research Council, 00185 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9393-2047","affiliations":[{"raw_affiliation_string":"Institute for Systems Analysis and Computer Science \u201cAntonio Ruberti\u201d, National Research Council, 00185 Rome, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I4210162062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032411611","display_name":"Silvia Mezi","orcid":"https://orcid.org/0000-0003-4746-2678","observed_orcids":["https://orcid.org/0000-0003-4746-2678"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Mezi","raw_affiliation_strings":["Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028024983","display_name":"Flavia Longo","orcid":"https://orcid.org/0000-0002-0549-4877","observed_orcids":["https://orcid.org/0000-0002-0549-4877"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavia Longo","raw_affiliation_strings":["Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091286114","display_name":"Enrico Cortesi","orcid":"https://orcid.org/0000-0002-8671-0155","observed_orcids":["https://orcid.org/0000-0002-8671-0155"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Cortesi","raw_affiliation_strings":["Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Oncological and Pathological Sciences, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042989547","display_name":"Paolo Marchetti","orcid":"https://orcid.org/0000-0002-9064-8761","observed_orcids":["https://orcid.org/0000-0002-9064-8761"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Marchetti","raw_affiliation_strings":["Department of Medical Oncology Sant\u2019 Andrea Hospital, I-00189 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9064-8761","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology Sant\u2019 Andrea Hospital, I-00189 Rome, Italy","institution_ids":["https://openalex.org/I4210125574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032330087","display_name":"Giancarlo Troncone","orcid":"https://orcid.org/0000-0003-1630-5805","observed_orcids":["https://orcid.org/0000-0003-1630-5805","https://orcid.org/0000-0001-9033-6998"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giancarlo Troncone","raw_affiliation_strings":["Department of Public Health, University Federico II, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, University Federico II, 80131 Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013703740","display_name":"Diana Bellavia","orcid":"https://orcid.org/0000-0001-5728-2537","observed_orcids":["https://orcid.org/0000-0001-5728-2537"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Diana Bellavia","raw_affiliation_strings":["Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052670103","display_name":"Gianluca Canettieri","orcid":"https://orcid.org/0000-0001-6694-2613","observed_orcids":["https://orcid.org/0000-0001-6694-2613"]},"institutions":[{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianluca Canettieri","raw_affiliation_strings":["Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","Pasteur Institute-Cenci Bolognetti Foundation, 00161 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6694-2613","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Pasteur Institute-Cenci Bolognetti Foundation, 00161 Rome, Italy","institution_ids":["https://openalex.org/I4210153523"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013727905","display_name":"Giuseppe Giannini","orcid":"https://orcid.org/0000-0003-0299-4056","observed_orcids":["https://orcid.org/0000-0003-0299-4056"]},"institutions":[{"id":"https://openalex.org/I4210153523","display_name":"Istituto Pasteur","ror":"https://ror.org/051v7w268","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210153523"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giuseppe Giannini","raw_affiliation_strings":["Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","Pasteur Institute-Cenci Bolognetti Foundation, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Pasteur Institute-Cenci Bolognetti Foundation, 00161 Rome, Italy","institution_ids":["https://openalex.org/I4210153523"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5013727905","https://openalex.org/A5052670103"],"corresponding_institution_ids":["https://openalex.org/I4210153523","https://openalex.org/I861853513"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":1.011,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.76074378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"2","first_page":"147","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/genomic-profiling","display_name":"genomic profiling","score":0.7620000243186951},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.6769999861717224},{"id":"https://openalex.org/keywords/first-line-combination-therapy","display_name":"first-line combination therapy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.9559999704360962},{"id":"https://openalex.org/keywords/actionable-mutations","display_name":"actionable mutations","score":0.6620000004768372},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.8820000290870667},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.4659999907016754},{"id":"https://openalex.org/keywords/molecular-stratification","display_name":"molecular stratification","score":0.6299999952316284},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.6804441213607788},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6583864092826843},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.5617715120315552},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5128298401832581},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5094974637031555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45447808504104614},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43844565749168396},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.42979463934898376},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4284185767173767},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4241487681865692},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4100104570388794},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3911285996437073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3806058466434479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35162845253944397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3387623131275177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3173087239265442}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.3390/cancers11020147","doi":"https://doi.org/10.3390/cancers11020147","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers11020147","pdf_url":"https://www.mdpi.com/2072-6694/11/2/147/pdf?version=1548922147","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5409392","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6406354","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30691222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30691222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6406354","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6406354/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:iris.uniroma1.it:11573/1224164","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1224164","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1224164/1/Capalbo_A%20Simplified%20Genomic_2019.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.univaq.it:11697/131643","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11697/131643","pdf_url":"https://ricerca.univaq.it/bitstream/11697/131643/4/Capalbo_cancers_2019.pdf","source":{"id":"https://openalex.org/S7407055225","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi dell Aquila","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:6fff1ca25bfe4b2ea980205eb30b5578","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6fff1ca25bfe4b2ea980205eb30b5578","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 11, Iss 2, p 147 (2019)","raw_type":"article"},{"id":"pmh:oai:iris.unical.it:20.500.11770/363646","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/20.500.11770/363646","pdf_url":null,"source":{"id":"https://openalex.org/S4377196898","display_name":"Archive of Doctoral Theses and Digital Collections (University of Calabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45204951","host_organization_name":"University of Calabria","host_organization_lineage":["https://openalex.org/I45204951"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/cancers11020147","doi":"https://doi.org/10.3390/cancers11020147","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cancers11020147","pdf_url":"https://www.mdpi.com/2072-6694/11/2/147/pdf?version=1548922147","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3938853250","display_name":null,"funder_award_id":"IG #17734","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"},{"id":"https://openalex.org/G5329322851","display_name":null,"funder_award_id":"232/2016","funder_id":"https://openalex.org/F4320317295","funder_display_name":"Dipartimenti di Eccellenza"},{"id":"https://openalex.org/G5417130124","display_name":null,"funder_award_id":"232/2016","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G6023834934","display_name":null,"funder_award_id":"IG17575","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320317295","display_name":"Dipartimenti di Eccellenza","ror":null},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322750","display_name":"Istituto Pasteur-Fondazione Cenci Bolognetti","ror":"https://ror.org/051v7w268"},{"id":"https://openalex.org/F4320322823","display_name":"Fondazione Umberto Veronesi","ror":"https://ror.org/041g7jm83"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913697365.pdf","grobid_xml":"https://content.openalex.org/works/W2913697365.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W16131775","https://openalex.org/W1018331845","https://openalex.org/W1934094702","https://openalex.org/W1977775137","https://openalex.org/W2001906547","https://openalex.org/W2005348280","https://openalex.org/W2016680388","https://openalex.org/W2049304175","https://openalex.org/W2057623977","https://openalex.org/W2085633477","https://openalex.org/W2095201384","https://openalex.org/W2112570485","https://openalex.org/W2112727687","https://openalex.org/W2133399075","https://openalex.org/W2135800465","https://openalex.org/W2143743735","https://openalex.org/W2144425748","https://openalex.org/W2147041307","https://openalex.org/W2157769714","https://openalex.org/W2159443313","https://openalex.org/W2262414037","https://openalex.org/W2345976564","https://openalex.org/W2421455087","https://openalex.org/W2531319683","https://openalex.org/W2560375214","https://openalex.org/W2594373254","https://openalex.org/W2606920054","https://openalex.org/W2614443510","https://openalex.org/W2622499649","https://openalex.org/W2739301023","https://openalex.org/W2739632265","https://openalex.org/W2749845723","https://openalex.org/W2754509848","https://openalex.org/W2771697619","https://openalex.org/W2783494975","https://openalex.org/W2791410762","https://openalex.org/W2799712560","https://openalex.org/W2884914363","https://openalex.org/W2906962335","https://openalex.org/W2911188335"],"related_works":["https://openalex.org/W3023494706","https://openalex.org/W4403430441","https://openalex.org/W4296009440","https://openalex.org/W2810242231","https://openalex.org/W4396772271","https://openalex.org/W4288038416","https://openalex.org/W3212211812","https://openalex.org/W7172270687","https://openalex.org/W3088849787","https://openalex.org/W4388594451"],"abstract_inverted_index":{"The":[0,23,160],"response":[1,154,196],"of":[2,20,47,70,84,89,105,137,183,192,244,251],"metastatic":[3],"colorectal":[4],"cancer":[5],"(mCRC)":[6],"to":[7,43,66,155,201],"the":[8,17,21,45,184,194,212,224,228,249,252],"first-line":[9,75,156,253],"conventional":[10,76,157,254],"combination":[11,158,255],"therapy":[12],"is":[13,197],"highly":[14],"variable,":[15],"reflecting":[16],"elevated":[18,37],"heterogeneity":[19,28,50],"disease.":[22],"genetic":[24,117],"alterations":[25],"underlying":[26],"this":[27,123],"have":[29],"been":[30],"thoroughly":[31],"characterized":[32],"through":[33],"omic":[34],"approaches":[35],"requiring":[36],"efforts":[38],"and":[39,86,126,236],"costs.":[40],"In":[41,230],"order":[42],"translate":[44],"knowledge":[46],"CRC":[48],"molecular":[49,124,141,147],"into":[51,121],"a":[52,58,68,82,152,234,240],"practical":[53],"clinical":[54],"approach,":[55],"we":[56,133,232],"utilized":[57],"simplified":[59,241],"Next":[60],"Generation":[61],"Sequencing":[62],"(NGS)":[63],"based":[64],"platform":[65],"screen":[67],"cohort":[69],"77":[71],"patients":[72,99,138,166,178,202,219,246],"treated":[73],"with":[74,115,151,190,203],"therapy.":[77,256],"Samples":[78],"were":[79,112],"sequenced":[80],"using":[81],"panel":[83],"hotspots":[85],"targeted":[87],"regions":[88],"22":[90,104],"genes":[91,225],"commonly":[92],"involved":[93],"in":[94,165,177,181,218,223,227],"CRC.":[95],"This":[96],"revealed":[97],"51":[98],"carrying":[100,139,168,179],"actionable":[101],"gene":[102],"mutations,":[103],"which":[106],"carried":[107],"druggable":[108],"alterations.":[109,118],"These":[110],"mutations":[111,169,180,191,222],"frequently":[113],"associated":[114,150,189],"additional":[116],"To":[119],"take":[120],"account":[122],"complexity":[125],"assisted":[127],"by":[128],"an":[129],"unbiased":[130],"bioinformatic":[131],"analysis,":[132],"defined":[134],"three":[135,146],"subgroups":[136,148],"distinct":[140],"patterns.":[142],"We":[143],"demonstrated":[144],"these":[145],"are":[149],"different":[153],"therapies.":[159],"best":[161],"outcome":[162],"was":[163],"achieved":[164],"exclusively":[167],"on":[170],"TP53":[171],"and/or":[172],"RAS":[173],"genes.":[174],"By":[175],"contrast,":[176],"any":[182,221],"other":[185],"genes,":[186],"alone":[187],"or":[188],"TP53/RAS,":[193],"expected":[195],"much":[198],"worse":[199],"compared":[200],"exclusive":[204],"TP53/RAS":[205],"mutations.":[206],"Additionally,":[207],"our":[208],"data":[209],"indicate":[210],"that":[211,247],"standard":[213],"approach":[214,238],"has":[215],"limited":[216],"efficacy":[217,250],"without":[220],"included":[226],"panel.":[229],"conclusion,":[231],"identified":[233],"reliable":[235],"easy-to-use":[237],"for":[239],"molecular-based":[242],"stratification":[243],"mCRC":[245],"predicts":[248]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-02-21T00:00:00"}