{"id":"https://openalex.org/W2913679667","doi":"https://doi.org/10.1007/s11033-019-04672-3","title":"Calendula arvensis L. as an anti-cancer agent against breast cancer cell lines","display_name":"Calendula arvensis L. as an anti-cancer agent against breast cancer cell lines","publication_year":2019,"publication_date":"2019-02-11","ids":{"openalex":"https://openalex.org/W2913679667","doi":"https://doi.org/10.1007/s11033-019-04672-3","mag":"2913679667","pmid":"https://pubmed.ncbi.nlm.nih.gov/30756331"},"language":"en","primary_location":{"id":"doi:10.1007/s11033-019-04672-3","doi":"https://doi.org/10.1007/s11033-019-04672-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-019-04672-3","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048674577","display_name":"Nael Abutaha","orcid":"https://orcid.org/0000-0002-1887-7789","observed_orcids":["https://orcid.org/0000-0002-1887-7789"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Nael Abutaha","raw_affiliation_strings":["Bioproducts Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia. nabutaha@ksu.edu.sa","Bioproducts Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioproducts Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia. nabutaha@ksu.edu.sa","institution_ids":["https://openalex.org/I28022161"]},{"raw_affiliation_string":"Bioproducts Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042128468","display_name":"Fahd Ali Nasr","orcid":"https://orcid.org/0000-0002-6496-7822","observed_orcids":["https://orcid.org/0000-0002-6496-7822"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Fahd A. Nasr","raw_affiliation_strings":["Medicinal Aromatic, and Poisonous Plants Research Centre, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Aromatic, and Poisonous Plants Research Centre, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015869885","display_name":"Mohammed Mousa Al-Zharani","orcid":"https://orcid.org/0000-0002-0810-4803","observed_orcids":["https://orcid.org/0000-0002-0810-4803"]},"institutions":[{"id":"https://openalex.org/I240666556","display_name":"Imam Mohammad ibn Saud Islamic University","ror":"https://ror.org/05gxjyb39","country_code":"SA","type":"education","lineage":["https://openalex.org/I240666556"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Al-Zahrani Mohammed","raw_affiliation_strings":["College of Science, Biology Department, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Science, Biology Department, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I240666556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057758924","display_name":"Abdelhabib Semlali","orcid":"https://orcid.org/0000-0002-1643-0377","observed_orcids":["https://orcid.org/0000-0002-1643-0377","https://orcid.org/0000-0002-5797-8304"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"AbdelHabib Semlali","raw_affiliation_strings":["Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de M\u00e9decine Dentaire, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de M\u00e9decine Dentaire, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103217591","display_name":"Fahd Abdu Al-Mekhlafi","orcid":"https://orcid.org/0000-0002-8190-7901","observed_orcids":["https://orcid.org/0000-0002-8190-7901"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Fahd A. Al-Mekhlafi","raw_affiliation_strings":["Bioproducts Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioproducts Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072687917","display_name":"Muhammad A. Wadaan","orcid":"https://orcid.org/0000-0003-3643-7928","observed_orcids":["https://orcid.org/0000-0003-3643-7928"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohamed A. Wadaan","raw_affiliation_strings":["Bioproducts Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioproducts Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048674577"],"corresponding_institution_ids":["https://openalex.org/I28022161"],"apc_list":{"value":3140,"currency":"USD","value_usd":3140},"apc_paid":null,"fwci":3.2821,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.91084713,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"46","issue":"2","first_page":"2187","last_page":"2196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.18039999902248383,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.12729999423027039,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calendula-arvensis","display_name":"Calendula arvensis","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7839999794960022},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9940000176429749},{"id":"https://openalex.org/keywords/caspase-3-7","display_name":"caspase 3/7","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cell-migration-inhibition","display_name":"cell migration inhibition","score":0.9390000104904175},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/linolenic-acid","display_name":"linolenic acid","score":0.9409999847412109},{"id":"https://openalex.org/keywords/phenols","display_name":"phenols","score":0.6439999938011169},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticancer-phytochemicals","display_name":"anticancer phytochemicals","score":0.8090000152587891},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.7269355058670044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7129831314086914},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.7072513103485107},{"id":"https://openalex.org/C2780847017","wikidata":"https://www.wikidata.org/wiki/Q826533","display_name":"Soxhlet extractor","level":3,"score":0.6044262647628784},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5938422679901123},{"id":"https://openalex.org/C2776312796","wikidata":"https://www.wikidata.org/wiki/Q145930","display_name":"Calendula officinalis","level":2,"score":0.487169474363327},{"id":"https://openalex.org/C2781144210","wikidata":"https://www.wikidata.org/wiki/Q172275","display_name":"Chloroform","level":2,"score":0.44903939962387085},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.38172677159309387},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34237590432167053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28925836086273193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08875000476837158},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.08613312244415283}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008519","descriptor_name":"Medicine, Traditional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018547","descriptor_name":"Plant Stems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018547","descriptor_name":"Plant Stems","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020838","descriptor_name":"Calendula","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020838","descriptor_name":"Calendula","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D035264","descriptor_name":"Flowers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035264","descriptor_name":"Flowers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11033-019-04672-3","doi":"https://doi.org/10.1007/s11033-019-04672-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11033-019-04672-3","pdf_url":null,"source":{"id":"https://openalex.org/S197962172","display_name":"Molecular Biology Reports","issn_l":"0301-4851","issn":["0301-4851","1573-4978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology Reports","raw_type":"journal-article"},{"id":"pmid:30756331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30756331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5770949881","display_name":null,"funder_award_id":"RG-1439-030","funder_id":"https://openalex.org/F4320321145","funder_display_name":"King Saud University"}],"funders":[{"id":"https://openalex.org/F4320321145","display_name":"King Saud University","ror":"https://ror.org/02f81g417"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W37002919","https://openalex.org/W1512210608","https://openalex.org/W1517881884","https://openalex.org/W1539363692","https://openalex.org/W1598408991","https://openalex.org/W1601953196","https://openalex.org/W1965256404","https://openalex.org/W1965912776","https://openalex.org/W1980065892","https://openalex.org/W1980387702","https://openalex.org/W1984543627","https://openalex.org/W1987900135","https://openalex.org/W1988398656","https://openalex.org/W1991865867","https://openalex.org/W1997835558","https://openalex.org/W2004313584","https://openalex.org/W2006219011","https://openalex.org/W2008757142","https://openalex.org/W2011287127","https://openalex.org/W2022233074","https://openalex.org/W2030694827","https://openalex.org/W2034269086","https://openalex.org/W2036515304","https://openalex.org/W2043337384","https://openalex.org/W2046277450","https://openalex.org/W2061670261","https://openalex.org/W2061801920","https://openalex.org/W2076182668","https://openalex.org/W2077603511","https://openalex.org/W2079169655","https://openalex.org/W2079733845","https://openalex.org/W2087834797","https://openalex.org/W2090102760","https://openalex.org/W2090458427","https://openalex.org/W2100592123","https://openalex.org/W2120334551","https://openalex.org/W2130986416","https://openalex.org/W2134295452","https://openalex.org/W2140539173","https://openalex.org/W2153803831","https://openalex.org/W2154930168","https://openalex.org/W2163429445","https://openalex.org/W2170507464","https://openalex.org/W2182851294","https://openalex.org/W2185983093","https://openalex.org/W2189401845","https://openalex.org/W2390438424","https://openalex.org/W2463877695","https://openalex.org/W2465691026"],"related_works":["https://openalex.org/W3165490393","https://openalex.org/W3174205221","https://openalex.org/W4388841525","https://openalex.org/W2186527075","https://openalex.org/W2767459570","https://openalex.org/W3014985135","https://openalex.org/W2056420140","https://openalex.org/W7214276926","https://openalex.org/W4380083502","https://openalex.org/W4308866230"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-02-21T00:00:00"}