{"id":"https://openalex.org/W2913636593","doi":"https://doi.org/10.1016/j.jphs.2019.01.003","title":"Oxyresveratrol protects human lens epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis by activation of Akt/HO-1 pathway","display_name":"Oxyresveratrol protects human lens epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis by activation of Akt/HO-1 pathway","publication_year":2019,"publication_date":"2019-01-22","ids":{"openalex":"https://openalex.org/W2913636593","doi":"https://doi.org/10.1016/j.jphs.2019.01.003","mag":"2913636593","pmid":"https://pubmed.ncbi.nlm.nih.gov/30709701"},"language":"en","primary_location":{"id":"doi:10.1016/j.jphs.2019.01.003","doi":"https://doi.org/10.1016/j.jphs.2019.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2019.01.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1347861319300064/pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1347861319300064/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009426777","display_name":"Xin Hu","orcid":"https://orcid.org/0000-0002-2715-5534","observed_orcids":["https://orcid.org/0000-0002-2715-5534"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Hu","raw_affiliation_strings":["Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China. Electronic address: huxin1981kf@163.com","Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China. Electronic address: huxin1981kf@163.com","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]},{"raw_affiliation_string":"Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037264827","display_name":"Yuan-Yuan Liang","orcid":"https://orcid.org/0000-0002-9497-9517","observed_orcids":["https://orcid.org/0000-0002-9497-9517"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Liang","raw_affiliation_strings":["Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012680152","display_name":"Bo Zhao","orcid":"https://orcid.org/0000-0001-8320-2000","observed_orcids":["https://orcid.org/0000-0001-8320-2000"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Zhao","raw_affiliation_strings":["Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101501062","display_name":"Yongyi Wang","orcid":"https://orcid.org/0009-0009-1330-4971","observed_orcids":["https://orcid.org/0009-0009-1330-4971","https://orcid.org/0000-0003-0297-8232"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongyi Wang","raw_affiliation_strings":["Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophtalmology, Huaihe Hospital of Henan University, Kaifeng 475000, PR China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009426777"],"corresponding_institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"],"apc_list":{"value":1000,"currency":"USD","value_usd":1000},"apc_paid":{"value":1000,"currency":"USD","value_usd":1000},"fwci":1.4497,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.80870641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"139","issue":"3","first_page":"166","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.2443999946117401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.2443999946117401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.21899999678134918,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.11550000309944153,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxyresveratrol","display_name":"oxyresveratrol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/human-lens-epithelial-cells","display_name":"human lens epithelial cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.9470000267028809},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9399999976158142},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8209999799728394},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.5199999809265137},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.8180000185966492},{"id":"https://openalex.org/keywords/zinc-protoporphyrin","display_name":"zinc protoporphyrin","score":0.8870000243186951}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.860567569732666},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.8459991216659546},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6844698190689087},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6571218967437744},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6131415367126465},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6018504500389099},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5382840633392334},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.494749516248703},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.48970964550971985},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.47298774123191833},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.46396198868751526},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.4490360915660858},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40371400117874146},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3904799222946167},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35399961471557617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21147406101226807}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011524","descriptor_name":"Protoporphyrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jphs.2019.01.003","doi":"https://doi.org/10.1016/j.jphs.2019.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2019.01.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1347861319300064/pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:30709701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30709701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:585df92c18f24d6eb745e9b29a7b507a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/585df92c18f24d6eb745e9b29a7b507a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacological Sciences, Vol 139, Iss 3, Pp 166-173 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jphs.2019.01.003","doi":"https://doi.org/10.1016/j.jphs.2019.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jphs.2019.01.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1347861319300064/pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913636593.pdf","grobid_xml":"https://content.openalex.org/works/W2913636593.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W172014278","https://openalex.org/W561799589","https://openalex.org/W1481503027","https://openalex.org/W1702561121","https://openalex.org/W1978112315","https://openalex.org/W1984921762","https://openalex.org/W1985941510","https://openalex.org/W1988016180","https://openalex.org/W1999235431","https://openalex.org/W2005904261","https://openalex.org/W2012758462","https://openalex.org/W2022202335","https://openalex.org/W2036373599","https://openalex.org/W2038568474","https://openalex.org/W2047792367","https://openalex.org/W2057440904","https://openalex.org/W2063762959","https://openalex.org/W2066948273","https://openalex.org/W2069565098","https://openalex.org/W2100678906","https://openalex.org/W2114262974","https://openalex.org/W2123215356","https://openalex.org/W2135325107","https://openalex.org/W2171834594","https://openalex.org/W2255670512","https://openalex.org/W2300690896","https://openalex.org/W2319703877","https://openalex.org/W2328362198","https://openalex.org/W2527470201","https://openalex.org/W2547168867","https://openalex.org/W2547446348","https://openalex.org/W2701493750","https://openalex.org/W2762993139","https://openalex.org/W2776079342","https://openalex.org/W2787900809","https://openalex.org/W6685182766"],"related_works":["https://openalex.org/W2171834594","https://openalex.org/W2348835287","https://openalex.org/W2388187004","https://openalex.org/W2300690896","https://openalex.org/W2171797784","https://openalex.org/W4285011041","https://openalex.org/W1978112315","https://openalex.org/W2742509994","https://openalex.org/W4389334875","https://openalex.org/W2124486018"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1,40,117,171,183],"induced":[2,115],"by":[3,53,61,80,99,125,160],"hydrogen":[4],"peroxide":[5],"(H2O2)":[6],"triggers":[7],"human":[8],"lens":[9],"epithelial":[10],"cell":[11,112],"(HLEC)":[12],"apoptosis":[13,42,119,173,185],"and":[14,25,41,45,74,91,101,114,118,132,139,146,172,184],"initiates":[15],"cataract":[16],"formation.":[17],"Oxyresveratrol":[18],"(Oxy)":[19],"was":[20,51,59,78],"reported":[21],"to":[22,108],"possess":[23],"antioxidant":[24],"free":[26],"radical":[27],"scavenging":[28],"activities.":[29],"Herein,":[30],"we":[31],"investigated":[32],"the":[33,46,63,149,157,165,188,192],"effects":[34,166],"of":[35,65,87,156,167,195],"Oxy":[36,129,147,168,179,196],"on":[37,169],"H2O2-induced":[38,181,198],"oxidative":[39,57,116,170,182],"in":[43,120,135,152,174],"HLECs":[44],"associated":[47],"mechanisms.":[48],"Cell":[49],"viability":[50],"detected":[52],"MTT":[54],"assay.":[55],"The":[56,84],"damage":[58],"assessed":[60],"measuring":[62],"activities":[64],"superoxide":[66],"dismutases-1":[67],"(SOD-1),":[68],"catalase":[69],"(CAT),":[70],"glutathione":[71],"reductase":[72],"(GSH),":[73],"malondialdehyde":[75],"(MDA).":[76],"Apoptosis":[77],"analyzed":[79],"flow":[81],"cytometry":[82],"analysis.":[83],"changed":[85],"expressions":[86,134,141],"heme":[88],"oxygenase-1":[89],"(HO-1)":[90],"protein":[92],"kinase":[93],"B":[94],"(Akt)":[95],"pathways":[96],"were":[97,123],"evaluated":[98],"qRT-PCR":[100],"western":[102],"blot.":[103],"We":[104],"found":[105],"that":[106],"exposure":[107],"H2O2":[109],"dose-dependently":[110],"reduced":[111],"viability,":[113],"HLECs,":[121],"which":[122],"reversed":[124],"pretreatment":[126],"with":[127],"Oxy.":[128],"increased":[130],"p-Akt":[131],"HO-1":[133,140],"H2O2-stimulated":[136,153,175],"HLECs.":[137,154,176],"Akt":[138],"form":[142],"a":[143],"regulatory":[144],"axis":[145],"activated":[148],"Akt/HO-1":[150,158,189],"pathway":[151,159],"Inhibition":[155],"LY294002":[161],"or":[162],"ZnPP":[163],"attenuated":[164],"In":[177],"conclusion,":[178],"protected":[180],"through":[186],"activating":[187],"pathway,":[190],"suggesting":[191],"protective":[193],"effect":[194],"against":[197],"cataract.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-02-21T00:00:00"}
