{"id":"https://openalex.org/W2913627156","doi":"https://doi.org/10.1016/j.bpj.2018.11.1667","title":"A Network of Endogenous Metabolites Modulates Programmed Death-Ligand 1 (PD-L1) Expression in Monocytic Leukemia","display_name":"A Network of Endogenous Metabolites Modulates Programmed Death-Ligand 1 (PD-L1) Expression in Monocytic Leukemia","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2913627156","doi":"https://doi.org/10.1016/j.bpj.2018.11.1667","mag":"2913627156"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2018.11.1667","doi":"https://doi.org/10.1016/j.bpj.2018.11.1667","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.1667","pdf_url":"http://www.cell.com/article/S0006349518329321/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349518329321/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059966935","display_name":"Amelia Palermo","orcid":"https://orcid.org/0000-0001-5705-6521","observed_orcids":["https://orcid.org/0000-0001-5705-6521"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amelia Palermo","raw_affiliation_strings":["Center for Metabolomics, The Scripps Research Institute, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Metabolomics, The Scripps Research Institute, San Diego, CA, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074744296","display_name":"Stephan H. Spangenberg","orcid":"https://orcid.org/0009-0007-5822-505X","observed_orcids":["https://orcid.org/0009-0007-5822-505X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephan Spangenberg","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, San Diego, CA, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047002632","display_name":"Carlos Guijas","orcid":"https://orcid.org/0000-0001-7993-3388","observed_orcids":["https://orcid.org/0000-0001-7993-3388"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Guijas","raw_affiliation_strings":["Center for Metabolomics, The Scripps Research Institute, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Metabolomics, The Scripps Research Institute, San Diego, CA, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049449840","display_name":"Luke L. Lairson","orcid":"https://orcid.org/0000-0001-6701-996X","observed_orcids":["https://orcid.org/0000-0001-6701-996X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke Lairson","raw_affiliation_strings":["Department of Chemistry, The Scripps Research Institute, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Scripps Research Institute, San Diego, CA, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067311581","display_name":"Gary E. Siuzdak","orcid":"https://orcid.org/0000-0002-4749-0014","observed_orcids":["https://orcid.org/0000-0002-4749-0014"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Siuzdak","raw_affiliation_strings":["Center for Metabolomics and Department of Molecular and Computational Biology, The Scripps Research Institute, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Metabolomics and Department of Molecular and Computational Biology, The Scripps Research Institute, San Diego, CA, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01255174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"3","first_page":"308a","last_page":"308a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.21660000085830688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.04500000178813934,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.8849999904632568},{"id":"https://openalex.org/keywords/acute-monocytic-leukemia","display_name":"acute monocytic leukemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/thp-1-cells","display_name":"THP-1 cells","score":0.9660000205039978},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.6919999718666077},{"id":"https://openalex.org/keywords/endogenous-metabolites","display_name":"endogenous metabolites","score":0.8769999742507935},{"id":"https://openalex.org/keywords/interferon-gamma-stimulation","display_name":"interferon-gamma stimulation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.9369999766349792},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":1.0},{"id":"https://openalex.org/keywords/prooxidant-antioxidant-balance","display_name":"prooxidant-antioxidant balance","score":0.921999990940094},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cancer-immunotherapy-resistance","display_name":"cancer immunotherapy resistance","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C2780943621","wikidata":"https://www.wikidata.org/wiki/Q1313618","display_name":"Monocytic leukemia","level":3,"score":0.7095488905906677},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5927278399467468},{"id":"https://openalex.org/C204258353","wikidata":"https://www.wikidata.org/wiki/Q7670282","display_name":"THP1 cell line","level":3,"score":0.5785860419273376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5673678517341614},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5149784684181213},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49706438183784485},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4595467448234558},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4505395293235779},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.447441428899765},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.446444034576416},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.43555474281311035},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4242985248565674},{"id":"https://openalex.org/C2776170302","wikidata":"https://www.wikidata.org/wiki/Q4677938","display_name":"Acute monocytic leukemia","level":3,"score":0.4168851971626282},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4133298397064209},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.40135276317596436},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.31013262271881104},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2978751063346863},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29383429884910583},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2599527835845947},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19123148918151855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18864431977272034},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17236468195915222},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.16125664114952087},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11016899347305298}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2018.11.1667","doi":"https://doi.org/10.1016/j.bpj.2018.11.1667","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.1667","pdf_url":"http://www.cell.com/article/S0006349518329321/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2018.11.1667","doi":"https://doi.org/10.1016/j.bpj.2018.11.1667","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.1667","pdf_url":"http://www.cell.com/article/S0006349518329321/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913627156.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4376873049","https://openalex.org/W4384701033","https://openalex.org/W4394991999","https://openalex.org/W2954790536","https://openalex.org/W7167072774","https://openalex.org/W4226178357","https://openalex.org/W2991008288","https://openalex.org/W2942515595","https://openalex.org/W2885135447","https://openalex.org/W3003206492"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2019-02-21T00:00:00"}
