{"id":"https://openalex.org/W2913609015","doi":"https://doi.org/10.1097/md.0000000000013044","title":"Pancreatitis cytosorbents (CytoSorb) inflammatory cytokine removal","display_name":"Pancreatitis cytosorbents (CytoSorb) inflammatory cytokine removal","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2913609015","doi":"https://doi.org/10.1097/md.0000000000013044","mag":"2913609015","pmid":"https://pubmed.ncbi.nlm.nih.gov/30681551","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6358351"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000013044","doi":"https://doi.org/10.1097/md.0000000000013044","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000013044","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000013044","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102891874","display_name":"Wolfgang Huber","orcid":"https://orcid.org/0000-0001-9086-7908","observed_orcids":["https://orcid.org/0000-0001-9086-7908"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wolfgang Huber","raw_affiliation_strings":["Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011006455","display_name":"Hana Alg\u00fcl","orcid":"https://orcid.org/0000-0002-5067-7031","observed_orcids":["https://orcid.org/0000-0002-5067-7031"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hana Alg\u00fcl","raw_affiliation_strings":["Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066208050","display_name":"Tobias Lahmer","orcid":"https://orcid.org/0000-0003-1008-5311","observed_orcids":["https://orcid.org/0000-0003-1008-5311"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Lahmer","raw_affiliation_strings":["Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064668609","display_name":"Ulrich Mayr","orcid":"https://orcid.org/0000-0002-5235-5327","observed_orcids":["https://orcid.org/0000-0002-5235-5327"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Mayr","raw_affiliation_strings":["Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015311895","display_name":"Miriam Lehmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Miriam Lehmann","raw_affiliation_strings":["Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473723","display_name":"Roland Michael Schmid","orcid":"https://orcid.org/0009-0000-8976-3300","observed_orcids":["https://orcid.org/0009-0000-8976-3300","https://orcid.org/0000-0002-6945-7581","https://orcid.org/0000-0002-5751-7313"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roland M. Schmid","raw_affiliation_strings":["Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik und Poliklinik II, Klinikum rechts der Isar; Technische Universit\u00e4t, M\u00fcnchen, Ismaninger Stra\u00dfe 22, D-81675 M\u00fcnchen","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110870278","display_name":"Andreas Faltlhauser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109620","display_name":"Klinikum Weiden","ror":"https://ror.org/02506kf89","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210109620"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Faltlhauser","raw_affiliation_strings":["Medizinische Klinik I, Kliniken Nordoberpfalz, Klinikum, Weiden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medizinische Klinik I, Kliniken Nordoberpfalz, Klinikum, Weiden, Germany","institution_ids":["https://openalex.org/I4210109620"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102891874"],"corresponding_institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":3.5367,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.92549148,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"98","issue":"4","first_page":"e13044","last_page":"e13044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-acute-pancreatitis","display_name":"severe acute pancreatitis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cytosorb","display_name":"CytoSorb","score":0.9660000205039978},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.8460000157356262},{"id":"https://openalex.org/keywords/transpulmonary-thermodilution","display_name":"transpulmonary thermodilution","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cytokine-levels","display_name":"cytokine levels","score":0.5450000166893005},{"id":"https://openalex.org/keywords/shock-reversal","display_name":"shock reversal","score":0.5040000081062317},{"id":"https://openalex.org/keywords/apache-ii","display_name":"APACHE II score","score":0.625},{"id":"https://openalex.org/keywords/organ-failure","display_name":"organ failure","score":0.4410000145435333},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.781000018119812},{"id":"https://openalex.org/keywords/interleukins","display_name":"interleukins","score":0.7820000052452087},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9709994196891785},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.6604989767074585},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.645240843296051},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6021419763565063},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.5492125749588013},{"id":"https://openalex.org/C2779915274","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal","level":2,"score":0.44026926159858704},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.4364233613014221},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4210558831691742},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34703928232192993},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32639914751052856}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D010195","descriptor_name":"Pancreatitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D018806","descriptor_name":"APACHE","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1097/md.0000000000013044","doi":"https://doi.org/10.1097/md.0000000000013044","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000013044","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5361924","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6358351","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30681551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30681551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Clinical Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:6358351","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6358351/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1544870","doi":null,"is_oa":true,"landing_page_url":"http://mediatum.ub.tum.de/node?id=1544870","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1590023","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1590023","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000013044","doi":"https://doi.org/10.1097/md.0000000000013044","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000013044","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7400589382","display_name":null,"funder_award_id":"HU 1707/2-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323383","display_name":"Technische Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/02kkvpp62"},{"id":"https://openalex.org/F4320332159","display_name":"CytoSorbents Europe","ror":"https://ror.org/029hqf550"},{"id":"https://openalex.org/F4320335384","display_name":"Faculty of Medicine, Munich University of Technology","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1635189712","https://openalex.org/W1974264470","https://openalex.org/W1978325397","https://openalex.org/W1989867559","https://openalex.org/W2011006489","https://openalex.org/W2011400811","https://openalex.org/W2054107809","https://openalex.org/W2067388781","https://openalex.org/W2076220074","https://openalex.org/W2083318204","https://openalex.org/W2104557215","https://openalex.org/W2130362571","https://openalex.org/W2138579645","https://openalex.org/W2138590470","https://openalex.org/W2139999422","https://openalex.org/W2145758369","https://openalex.org/W2164317678","https://openalex.org/W2604992200","https://openalex.org/W2620252006","https://openalex.org/W2624207474","https://openalex.org/W2945849628"],"related_works":["https://openalex.org/W4213099311","https://openalex.org/W2909001594","https://openalex.org/W4402375437","https://openalex.org/W7172110062","https://openalex.org/W2068066800","https://openalex.org/W2360285342","https://openalex.org/W2835230386","https://openalex.org/W4416757785","https://openalex.org/W2938989086","https://openalex.org/W2997973332"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acute":[1],"pancreatitis":[2],"(AP)":[3],"usually":[4],"has":[5],"a":[6,10,137,190,316,327],"mild":[7],"course":[8],"with":[9,91,131,163,169,177,205,285,326],"mortality":[11,32,84],"rate":[12],"below":[13],"1%.":[14],"However,":[15],"around":[16,36],"10%":[17],"of":[18,33,40,48,68,85,96,125,145,151,158,192,198,209,254,270,324],"patients":[19,168,176,201,276],"develop":[20],"severe":[21],"AP":[22],"(SAP)":[23],"involving":[24],"extra-pancreatic":[25],"tissues":[26],"and":[27,51,65,87,122,143,182,229,249,257,260,299],"other":[28,310],"organ":[29,53],"systems.":[30],"The":[31,38],"SAP":[34,41,86,179,294,325],"is":[35,42,99,148,222,233],"42%.":[37],"outcome":[39,264],"closely":[43],"related":[44],"to":[45,154,239,281],"the":[46,82,109,140,149,156,196,214,234,268,271,278,296,300,321],"development":[47],"systemic":[49,92],"inflammation":[50],"consecutive":[52,160,207],"failures.":[54],"Most":[55],"current":[56],"therapies":[57],"including":[58,136],"fluid":[59],"resuscitation,":[60],"antimicrobial":[61],"therapy,":[62],"drainage":[63],"procedures,":[64],"endoscopic":[66],"management":[67],"complications":[69],"are":[70,244],"symptomatic":[71],"rather":[72],"than":[73],"causative":[74],"approaches,":[75],"except":[76],"sphincterotomy":[77],"for":[78],"gallstone":[79],"pancreatitis.":[80],"Regarding":[81],"high":[83],"its":[88],"close":[89],"association":[90],"inflammation,":[93],"extracorporeal":[94],"removal":[95],"inflammatory":[97,114],"mediators":[98],"an":[100],"appealing":[101],"approach.":[102],"Several":[103],"recent":[104,291],"studies":[105,292],"have":[106],"demonstrated":[107],"that":[108,129],"CytoSorb":[110,132,164,313],"adsorber":[111],"effectively":[112],"eliminates":[113],"cytokines,":[115],"such":[116],"as":[117],"IL-1\u00df,":[118],"IL-6,":[119],"IL-8,":[120],"IL-10,":[121],"TNF-alpha.":[123],"Some":[124],"these":[126],"trials":[127],"suggested":[128],"therapy":[130],"might":[133],"improve":[134],"outcome,":[135,242],"reduction":[138],"in":[139,167,213,274,293,307,320],"vasopressor":[141,215],"dosage":[142,231],"reversal":[144],"shock.Therefore,":[146],"it":[147],"objective":[150],"this":[152,240],"study":[153,174,333],"evaluate":[155],"effectiveness":[157],"2":[159,206],"24":[161],"h-treatments":[162],"on":[165,336],"hemodynamics":[166,308],"early":[170,178,322],"SAP.":[171],"METHODS:":[172],"This":[173,332],"includes":[175],"(APACHE-II":[180],"\u226510)":[181],"transpulmonary":[183],"thermodilution":[184],"hemodynamic":[185,287],"monitoring":[186,288],"(PiCCO;":[187],"EV-1000)":[188],"within":[189,295],"maximum":[191],"seven":[193],"days":[194],"from":[195,224,277,290],"onset":[197],"pain.":[199],"Eligible":[200],"will":[202,266],"be":[203],"treated":[204],"periods":[208],"CytoSorb.":[210],"A":[211,304],"20%-improvement":[212],"dependency":[216],"index":[217],"(VDI)":[218],"-":[219,232],"which":[220],"relates":[221],"derived":[223],"mean":[225],"arterial":[226],"pressure":[227],"(MAP)":[228],"catecholamine":[230],"primary":[235,272],"outcome.":[236],"In":[237],"addition":[238],"clinical":[241],"there":[243],"several":[245],"laboratory":[246],"(cytokine":[247],"levels)":[248],"translational":[250],"endpoints":[251],"(including":[252],"multiplex-ELISAs":[253],"numerous":[255],"anti-":[256],"pro-inflammatory":[258],"cytokines/chemokines":[259],"DNA":[261],"analyses).":[262],"Primary":[263],"analysis":[265],"compare":[267],"incidence":[269],"endpoint":[273],"30":[275],"intervention":[279],"group":[280],"60":[282],"matched":[283],"controls":[284],"advanced":[286],"recruited":[289],"same":[297,301],"setting":[298],"centers.":[302],"DISCUSSION:":[303],"potential":[305],"improvement":[306],"and/or":[309],"outcomes":[311],"by":[312],"would":[314],"provide":[315],"new":[317],"therapeutic":[318],"option":[319],"treatment":[323],"pathophysiological":[328],"rationale.":[329],"TRIAL":[330],"REGISTRATION:":[331],"was":[334],"registered":[335],"March":[337],"17,":[338],"2017":[339],"(ClinicalTrials.gov":[340],"Identifier:":[341],"NCT03082469).":[342],"URL:":[343],"https://clinicaltrials.gov/ct2/show/NCT03082469.":[344],"VERSION:":[345],"V_PACIFIC_1.0":[346],"September":[347],"30,":[348],"2018.":[349]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-02-21T00:00:00"}