{"id":"https://openalex.org/W2913508807","doi":"https://doi.org/10.1038/s41398-019-0373-1","title":"Stress dynamically regulates co-expression networks of glucocorticoid receptor-dependent MDD and SCZ risk genes","display_name":"Stress dynamically regulates co-expression networks of glucocorticoid receptor-dependent MDD and SCZ risk genes","publication_year":2019,"publication_date":"2019-01-29","ids":{"openalex":"https://openalex.org/W2913508807","doi":"https://doi.org/10.1038/s41398-019-0373-1","mag":"2913508807","pmid":"https://pubmed.ncbi.nlm.nih.gov/30696808","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6351530"},"language":"en","primary_location":{"id":"doi:10.1038/s41398-019-0373-1","doi":"https://doi.org/10.1038/s41398-019-0373-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-019-0373-1","pdf_url":"https://www.nature.com/articles/s41398-019-0373-1.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41398-019-0373-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110596786","display_name":"Christoph A. Zimmermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph A. Zimmermann","raw_affiliation_strings":["Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057945787","display_name":"Janine Arloth","orcid":"https://orcid.org/0000-0003-3825-4279","observed_orcids":["https://orcid.org/0000-0003-3825-4279"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janine Arloth","raw_affiliation_strings":["Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027928292","display_name":"Sara Santarelli","orcid":"https://orcid.org/0000-0002-9427-5317","observed_orcids":["https://orcid.org/0000-0002-9427-5317"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sara Santarelli","raw_affiliation_strings":["Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022884053","display_name":"Anne Loeschner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne L\u00f6schner","raw_affiliation_strings":["Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109082165","display_name":"Peter C Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Weber","raw_affiliation_strings":["Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058281761","display_name":"Mathias V. Schmidt","orcid":"https://orcid.org/0000-0002-3788-2268","observed_orcids":["https://orcid.org/0000-0002-3788-2268"]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias V. Schmidt","raw_affiliation_strings":["Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3788-2268","affiliations":[{"raw_affiliation_string":"Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048617845","display_name":"Dietmar Spengler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dietmar Spengler","raw_affiliation_strings":["Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany","institution_ids":["https://openalex.org/I4210145969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017312170","display_name":"Elisabeth B. Binder","orcid":"https://orcid.org/0000-0001-7088-6618","observed_orcids":["https://orcid.org/0000-0001-7088-6618"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210145969","display_name":"Max Planck Institute of Psychiatry","ror":"https://ror.org/04dq56617","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210145969"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Elisabeth B. Binder","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia. binder@psych.mpg.de","Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. binder@psych.mpg.de","Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia. binder@psych.mpg.de","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. binder@psych.mpg.de","institution_ids":["https://openalex.org/I4210145969"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017312170"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210145969"],"apc_list":{"value":4095,"currency":"USD","value_usd":4095},"apc_paid":{"value":4095,"currency":"USD","value_usd":4095},"fwci":1.6329,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.77352941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"41","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9300000071525574},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.890999972820282},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":1.0},{"id":"https://openalex.org/keywords/childhood-adversity","display_name":"childhood adversity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"gene co-expression network","score":0.6690000295639038},{"id":"https://openalex.org/keywords/social-support","display_name":"social support","score":0.7720000147819519},{"id":"https://openalex.org/keywords/social-stress","display_name":"social stress","score":0.671999990940094},{"id":"https://openalex.org/keywords/ventral-hippocampus","display_name":"ventral hippocampus","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":1.0},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.7750945091247559},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.5366740822792053},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.523910641670227},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4663865566253662},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4455031454563141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44358065724372864},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4400222599506378},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.4236270785331726},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.421131432056427},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4195910692214966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2293890118598938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19605258107185364},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19395416975021362},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1664278507232666},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1272411346435547},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.09275311231613159}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010286","descriptor_name":"Paraventricular Hypothalamic Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41398-019-0373-1","doi":"https://doi.org/10.1038/s41398-019-0373-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-019-0373-1","pdf_url":"https://www.nature.com/articles/s41398-019-0373-1.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5331886","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6351530","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6351530","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6351530","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Psychiatry","raw_type":"Text"},{"id":"pmid:30696808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30696808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.mpg.de:item_3346308","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/21.11116/0000-0009-803D-2","pdf_url":"https://hdl.handle.net/21.11116/0000-0013-0822-C","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:f7ed96e1badb4ef6bf719530d95295ed","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f7ed96e1badb4ef6bf719530d95295ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry, Vol 9, Iss 1, Pp 1-11 (2019)","raw_type":"article"},{"id":"pmh:oai:pure.mpg.de:item_3213462","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0006-0822-B","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41398-019-0373-1","doi":"https://doi.org/10.1038/s41398-019-0373-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-019-0373-1","pdf_url":"https://www.nature.com/articles/s41398-019-0373-1.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7414342234","display_name":null,"funder_award_id":"281338","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G8651133923","display_name":"Gene x environment interactions in affective disorders - elucidating molecular mechanisms","funder_award_id":"281338","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"}],"funders":[{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913508807.pdf","grobid_xml":"https://content.openalex.org/works/W2913508807.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W96975153","https://openalex.org/W178619957","https://openalex.org/W1010562381","https://openalex.org/W1731306270","https://openalex.org/W1761731026","https://openalex.org/W1763415643","https://openalex.org/W1958676502","https://openalex.org/W1970780234","https://openalex.org/W1979693429","https://openalex.org/W1985213868","https://openalex.org/W1987375729","https://openalex.org/W1993616000","https://openalex.org/W1998000745","https://openalex.org/W1998655644","https://openalex.org/W2022689242","https://openalex.org/W2023427033","https://openalex.org/W2040478973","https://openalex.org/W2051005796","https://openalex.org/W2052963268","https://openalex.org/W2059655841","https://openalex.org/W2060776482","https://openalex.org/W2062989629","https://openalex.org/W2070050178","https://openalex.org/W2090282154","https://openalex.org/W2100991928","https://openalex.org/W2103441770","https://openalex.org/W2110256992","https://openalex.org/W2121180999","https://openalex.org/W2121637331","https://openalex.org/W2126997165","https://openalex.org/W2129031013","https://openalex.org/W2139852368","https://openalex.org/W2144656637","https://openalex.org/W2163590618","https://openalex.org/W2169353806","https://openalex.org/W2179438025","https://openalex.org/W2201607793","https://openalex.org/W2330956628","https://openalex.org/W2345356016","https://openalex.org/W2350301951","https://openalex.org/W2353111961","https://openalex.org/W2500955566","https://openalex.org/W2511246692","https://openalex.org/W2520837155","https://openalex.org/W2586609285","https://openalex.org/W2746917316","https://openalex.org/W2765389138","https://openalex.org/W4211025465","https://openalex.org/W4256287931"],"related_works":["https://openalex.org/W7124423696","https://openalex.org/W4382934436","https://openalex.org/W3023887401","https://openalex.org/W2330956628","https://openalex.org/W4403283236","https://openalex.org/W2039593919","https://openalex.org/W7139927068","https://openalex.org/W4281389698","https://openalex.org/W4389040383","https://openalex.org/W2948215535"],"abstract_inverted_index":{"Early-life":[0],"adversity":[1,36],"is":[2,37],"an":[3],"important":[4],"risk":[5,23,76,221],"factor":[6],"for":[7,83,197,222],"major":[8],"depressive":[9],"disorder":[10],"(MDD)":[11],"and":[12,49,53,85,138,185,224,232,239],"schizophrenia":[13],"(SCZ)":[14],"that":[15,26,46,62,65,90,111,156,212],"interacts":[16],"with":[17],"genetic":[18,63,99,216],"factors":[19],"to":[20,56,122,193,220],"confer":[21],"disease":[22,125],"through":[24],"mechanisms":[25],"are":[27,72],"still":[28],"insufficiently":[29],"understood.":[30],"One":[31],"downstream":[32],"effect":[33],"of":[34,40,117,132,135,159,195,215,230],"early-life":[35,123],"the":[38,91,114,130,182,186,198,210],"activation":[39],"glucocorticoid":[41],"receptor":[42],"(GR)-dependent":[43],"gene":[44,68],"networks":[45],"drive":[47],"acute":[48],"long-term":[50],"adaptive":[51],"behavioral":[52],"cellular":[54],"responses":[55],"stress.":[57],"We":[58,109,154],"have":[59],"previously":[60,191],"shown":[61,192],"variants":[64,77,100,217],"moderate":[66],"GR-induced":[67],"transcription":[69],"(GR-response":[70],"eSNPs)":[71],"significantly":[73],"enriched":[74],"among":[75],"from":[78],"genome-wide":[79],"association":[80],"studies":[81],"(GWASs)":[82],"MDD":[84,223],"SCZ.":[86],"Here,":[87],"we":[88,128],"show":[89],"63":[92],"transcripts":[93],"regulated":[94],"by":[95,226],"these":[96],"disease-associated":[97],"functional":[98],"form":[101],"a":[102,150,167,213],"tight":[103],"glucocorticoid-responsive":[104],"co-expression":[105],"network":[106],"(termed":[107],"GCN).":[108],"hypothesized":[110],"changes":[112,173],"in":[113,166,177],"correlation":[115],"structure":[116,165],"this":[118],"GCN":[119,143,164,172,237],"may":[120,218],"contribute":[121,219],"adversity-associated":[124],"risk.":[126],"Therefore,":[127],"analyzed":[129],"effects":[131,229],"different":[133,157],"qualities":[134,158],"social":[136,160,234],"support":[137,209],"stress":[139,199],"throughout":[140],"life":[141],"on":[142,236],"formation":[144,238],"across":[145],"distinct":[146],"brain":[147,169,189],"regions":[148,190],"using":[149],"translational":[151],"mouse":[152],"model.":[153],"observed":[155],"experience":[161],"substantially":[162],"affect":[163],"highly":[168],"region-specific":[170],"manner.":[171],"were":[174],"predominantly":[175],"found":[176],"two":[178,188],"functionally":[179],"interconnected":[180],"regions,":[181],"ventral":[183],"hippocampus":[184],"hypothalamus,":[187],"be":[194],"relevance":[196],"response,":[200],"as":[201,203],"well":[202],"psychiatric":[204],"disorders.":[205],"Overall,":[206],"our":[207],"results":[208],"hypothesis":[211],"subset":[214],"SCZ":[225],"altering":[227],"circuit-level":[228],"early":[231],"adult":[233],"experiences":[235],"structure.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-02-21T00:00:00"}