{"id":"https://openalex.org/W2913452844","doi":null,"title":"Regulation of Mitochondrial Dynamics and Quality Control in Mammalian Cells","display_name":"Regulation of Mitochondrial Dynamics and Quality Control in Mammalian Cells","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2913452844","mag":"2913452844"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:20.500.14332/30156","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/30156","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Andrew S. Moore","orcid":"https://orcid.org/0000-0001-8062-1779","observed_orcids":["https://orcid.org/0000-0001-8062-1779"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andrew S. Moore","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8062-1779","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7407000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.2531999945640564,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.847000002861023},{"id":"https://openalex.org/keywords/mitochondrial-quality-control","display_name":"mitochondrial quality control","score":0.949999988079071},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mitochondrial-fission-and-fusion","display_name":"mitochondrial fission and fusion","score":0.824999988079071},{"id":"https://openalex.org/keywords/actin-waves","display_name":"actin waves","score":0.6959999799728394},{"id":"https://openalex.org/keywords/mitochondrial-inheritance","display_name":"mitochondrial inheritance","score":0.6769999861717224},{"id":"https://openalex.org/keywords/mitochondrial-turnover","display_name":"mitochondrial turnover","score":0.39800000190734863},{"id":"https://openalex.org/keywords/als-mutations","display_name":"ALS mutations","score":0.48899999260902405},{"id":"https://openalex.org/keywords/optineurin","display_name":"optineurin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.5431011319160461},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5241934657096863},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.49256616830825806},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4038754105567932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3787655830383301},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37052208185195923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3409232795238495},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14934676885604858},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11903378367424011},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repository.upenn.edu:20.500.14332/30156","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/30156","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},{"id":"pmh:oai:repository.upenn.edu:dissertations-15061","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI10978186","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"pmh:oai:repository.upenn.edu:edissertations-4948","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/edissertations/3162","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},{"id":"mag:2913452844","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=15061&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7135345689","https://openalex.org/W3003873380","https://openalex.org/W2796053268","https://openalex.org/W4388421996","https://openalex.org/W2525948328","https://openalex.org/W4396696683","https://openalex.org/W4396512048","https://openalex.org/W2022328887","https://openalex.org/W2090711760","https://openalex.org/W2231164629"],"abstract_inverted_index":{"Mitochondria":[0],"are":[1,223],"conserved":[2],"eukaryotic":[3],"organelles":[4],"that":[5,28,82,175,221,230],"carry":[6],"out":[7],"myriad":[8],"cellular":[9],"functions":[10],"including":[11],"energy":[12],"generation,":[13],"reactive":[14],"oxygen":[15],"species":[16],"signaling,":[17],"and":[18,80,89,166,186,215,262,278],"lipid":[19],"synthesis.":[20],"In":[21,47,95],"metazoans,":[22],"mitochondria":[23,44,126,140,169,222,257,276,296],"form":[24],"dense,":[25],"reticular":[26],"networks":[27,127,258,277],"must":[29],"be":[30],"maintained":[31],"through":[32,124,226,255],"rigorous":[33],"quality":[34],"control":[35],"mechanisms.":[36],"Here,":[37],"we":[38,50,73,98,115,200,219,245],"describe":[39],"three":[40],"distinct":[41],"aspects":[42],"of":[43,55,60,70,77,120,131,139,162,183,204,250,265,269,274,282,295,303],"network":[45,109,206,297],"homeostasis.":[46],"chapter":[48,96,198],"3,":[49],"investigate":[51,116],"the":[52,58,75,86,104,154,163,167,241,300],"spatiotemporal":[53],"dynamics":[54,110],"mitophagy,":[56],"tracking":[57],"association":[59],"autophagy":[61],"machinery":[62],"with":[63,92,137,280],"individual":[64],"damaged":[65],"mitochondria.":[66],"Using":[67,211],"a":[68,100,117,129,142,159,202,247,292],"range":[69],"damage":[71],"paradigms,":[72],"dissect":[74],"kinetics":[76],"mitochondrial":[78,108,149,164,184,188,205,266],"turnover":[79],"demonstrate":[81],"ALS-linked":[83],"mutations":[84],"in":[85,111,197,208],"proteins":[87],"Optineurin":[88],"TBK1":[90],"interfere":[91],"efficient":[93],"mitophagy.":[94],"5,":[97],"characterize":[99],"mechanism":[101,203],"by":[102],"which":[103,190],"actin":[105,121,134,155,177,242,252,270],"cytoskeleton":[106],"regulates":[107],"interphase":[112,125],"cells.":[113,210],"Specifically,":[114,244],"traveling":[118,248],"wave":[119,135,156,249],"filaments":[122,253],"propagating":[123,254],"at":[128,141,259],"rate":[130],"~5\u00b5m/min.":[132],"This":[133],"associates":[136],"20%":[138],"given":[143],"time,":[144],"where":[145],"it":[146],"transiently":[147],"promotes":[148,272],"fission.":[150],"After":[151],"3-5":[152],"minutes,":[153],"travels":[157],"to":[158,193,286],"neighboring":[160],"region":[161],"network,":[165],"fragmented":[168],"fuse":[170],"back":[171],"together.":[172],"We":[173,228],"hypothesize":[174],"cycling":[176],"waves":[178],"function":[179],"as":[180],"constitutive":[181],"regulators":[182],"length":[185],"prevent":[187],"hyperfusion":[189],"is":[191,233],"linked":[192],"cell":[194,305],"senescence.":[195],"Finally,":[196],"6,":[199],"identify":[201,246],"inheritance":[207],"somatic":[209],"spinning":[212],"disk":[213],"confocal":[214],"lattice":[216],"light-sheet":[217],"microscopy,":[218],"determine":[220],"highly":[224],"dynamic":[225],"mitosis.":[227],"find":[229],"this":[231],"motility":[232],"not":[234],"dependent":[235],"on":[236,240],"microtubules,":[237],"but":[238],"rather":[239],"cytoskeleton.":[243],"sub-cortical":[251],"metaphase":[256,275],"~15":[260],"\u00b5m/min":[261],"promoting":[263],"bursts":[264],"motility.":[267],"Inhibition":[268],"polymerization":[271],"aggregation":[273],"interferes":[279],"mixing":[281],"mtDNA":[283],"nucleoids":[284],"prior":[285],"division.":[287],"Together":[288],"these":[289],"results":[290],"provide":[291],"detailed":[293],"picture":[294],"maintenance":[298],"throughout":[299],"life":[301],"cycle":[302],"mammalian":[304],"lines.":[306]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2019-02-21T00:00:00"}