{"id":"https://openalex.org/W2913449079","doi":"https://doi.org/10.1016/j.jaci.2018.12.984","title":"Omalizumab in Patients with Severe Asthma and Persistent Sputum Eosinophilia","display_name":"Omalizumab in Patients with Severe Asthma and Persistent Sputum Eosinophilia","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2913449079","doi":"https://doi.org/10.1016/j.jaci.2018.12.984","mag":"2913449079"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2018.12.984","doi":"https://doi.org/10.1016/j.jaci.2018.12.984","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.12.984","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ucalgary.scholaris.ca/bitstreams/1a0b9b2f-3dd6-4329-869c-edab90078c87/download","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075416098","display_name":"Manali Mukherjee","orcid":"https://orcid.org/0000-0002-7924-7211","observed_orcids":["https://orcid.org/0000-0002-7924-7211"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Manali Mukherjee","raw_affiliation_strings":["Firestone Institute for Respiratory Health, Hamilton, ON, Canada","McMaster University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Firestone Institute for Respiratory Health, Hamilton, ON, Canada","institution_ids":[]},{"raw_affiliation_string":"McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080761198","display_name":"Melanie Kjarsgaard","orcid":"https://orcid.org/0000-0003-0660-8482","observed_orcids":["https://orcid.org/0000-0003-0660-8482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melanie Kjarsgaard","raw_affiliation_strings":["Firestone Institute for Respiratory Health, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Firestone Institute for Respiratory Health, Hamilton, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038119081","display_name":"Katherine Radford","orcid":"https://orcid.org/0000-0002-9734-6213","observed_orcids":["https://orcid.org/0000-0002-9734-6213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine Radford","raw_affiliation_strings":["Firestone Institute for Respiratory Health, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Firestone Institute for Respiratory Health, Hamilton, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034326725","display_name":"Chynna Huang","orcid":"https://orcid.org/0000-0001-5179-0872","observed_orcids":["https://orcid.org/0000-0001-5179-0872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chynna Huang","raw_affiliation_strings":["Firestone Institute for Respiratory Health, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Firestone Institute for Respiratory Health, Hamilton, ON, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029497606","display_name":"Richard Leigh","orcid":"https://orcid.org/0009-0007-8959-2899","observed_orcids":["https://orcid.org/0009-0007-8959-2899"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Richard Leigh","raw_affiliation_strings":["University of Calgary, Calgary, AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Calgary, Calgary, AB, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112909482","display_name":"Del Dorscheid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Del Dorscheid","raw_affiliation_strings":["University of British Columbia, Vancouver, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of British Columbia, Vancouver, ON, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091305347","display_name":"Catherine Lemi\u00e8re","orcid":"https://orcid.org/0000-0003-3667-9628","observed_orcids":["https://orcid.org/0000-0003-3667-9628"]},"institutions":[{"id":"https://openalex.org/I4210141135","display_name":"H\u00f4pital du Sacr\u00e9-C\u0153ur de Montr\u00e9al","ror":"https://ror.org/03ey0g045","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210141135"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Catherine Lemiere","raw_affiliation_strings":["Hopital Du Sacre-Coeur, Montreal, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Du Sacre-Coeur, Montreal, QC, Canada","institution_ids":["https://openalex.org/I4210141135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087705837","display_name":"Louis\u2010Philippe Boulet","orcid":"https://orcid.org/0000-0003-3485-9393","observed_orcids":["https://orcid.org/0000-0003-3485-9393"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Louis-Philippe Boulet","raw_affiliation_strings":["Laval University, Quebec City, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laval University, Quebec City, QC, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048737172","display_name":"Susan Waserman","orcid":"https://orcid.org/0000-0002-2136-5995","observed_orcids":["https://orcid.org/0000-0002-2136-5995"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Susan Waserman","raw_affiliation_strings":["McMaster University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022260354","display_name":"James G. Martin","orcid":"https://orcid.org/0000-0001-7574-5363","observed_orcids":["https://orcid.org/0000-0001-7574-5363","https://orcid.org/0000-0001-9789-4466"]},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"James G. Martin","raw_affiliation_strings":["8Meakins-Christie Laboratories, Research Institute of the MUHC, Montreal, QC, Canada","Mcgill University, Montreal, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Meakins-Christie Laboratories, Research Institute of the MUHC, Montreal, QC, Canada","institution_ids":["https://openalex.org/I2801766832"]},{"raw_affiliation_string":"Mcgill University, Montreal, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058199788","display_name":"Parameswaran K. Nair","orcid":"https://orcid.org/0000-0002-1041-9492","observed_orcids":["https://orcid.org/0000-0002-1041-9492"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Parameswaran K. Nair","raw_affiliation_strings":["Firestone Institute for Respiratory Health, Hamilton, ON, Canada","McMaster University, Hamilton, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Firestone Institute for Respiratory Health, Hamilton, ON, Canada","institution_ids":[]},{"raw_affiliation_string":"McMaster University, Hamilton, ON, Canada","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.343,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.60124736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"143","issue":"2","first_page":"AB434","last_page":"AB434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omalizumab","display_name":"omalizumab","score":1.0},{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sputum-eosinophilia","display_name":"sputum eosinophilia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/anti-ige-monoclonal-antibody","display_name":"anti-IgE monoclonal antibody","score":0.9549999833106995},{"id":"https://openalex.org/keywords/steroid-sparing-effect","display_name":"steroid-sparing effect","score":0.8809999823570251},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.8510000109672546},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8823407888412476},{"id":"https://openalex.org/C2778564945","wikidata":"https://www.wikidata.org/wiki/Q415392","display_name":"Omalizumab","level":4,"score":0.8697920441627502},{"id":"https://openalex.org/C2781142857","wikidata":"https://www.wikidata.org/wiki/Q5420174","display_name":"Exhaled nitric oxide","level":4,"score":0.7259469628334045},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.7240526080131531},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6519266366958618},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.61414635181427},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5218847393989563},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.5179099440574646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5118962526321411},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.49374184012413025},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.45724180340766907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44507983326911926},{"id":"https://openalex.org/C88675164","wikidata":"https://www.wikidata.org/wiki/Q22677314","display_name":"Eosinophil cationic protein","level":4,"score":0.43893763422966003},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3535114526748657},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1745423972606659},{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.14494848251342773},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.1157052218914032},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0925242006778717},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jaci.2018.12.984","doi":"https://doi.org/10.1016/j.jaci.2018.12.984","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaci.2018.12.984","pdf_url":null,"source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},{"id":"pmh:doi:10.11575/prism/45510","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/110140","pdf_url":"https://ucalgary.scholaris.ca/bitstreams/1a0b9b2f-3dd6-4329-869c-edab90078c87/download","source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"pmh:doi:10.11575/prism/45510","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/110140","pdf_url":"https://ucalgary.scholaris.ca/bitstreams/1a0b9b2f-3dd6-4329-869c-edab90078c87/download","source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308970","display_name":"Teva Pharmaceutical Industries","ror":"https://ror.org/01wfv3m53"},{"id":"https://openalex.org/F4320310297","display_name":"Canadian Allergy, Asthma and Immunology Foundation","ror":"https://ror.org/026ssdh77"},{"id":"https://openalex.org/F4320323175","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913449079.pdf","grobid_xml":"https://content.openalex.org/works/W2913449079.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2460087939","https://openalex.org/W2027541305","https://openalex.org/W2140994897","https://openalex.org/W2900203670","https://openalex.org/W2899695757","https://openalex.org/W1985017750","https://openalex.org/W1775950842","https://openalex.org/W4214729149","https://openalex.org/W7096268926","https://openalex.org/W7100205854"],"abstract_inverted_index":{"Omalizumab":[0],"(anti-IgE":[1],"monoclonal":[2],"antibody)":[3],"is":[4],"the":[5],"first":[6],"approved":[7],"biologic":[8],"for":[9],"treating":[10],"allergic":[11],"asthma.":[12],"It\u2019s":[13],"steroid-sparing":[14],"effect":[15],"by":[16],"monitoring":[17],"steroid-responsive":[18],"biomarkers":[19],"such":[20],"as":[21],"sputum":[22],"eosinophils":[23],"has":[24],"not":[25],"been":[26],"investigated":[27],"in":[28],"randomized":[29],"clinical":[30],"trials.":[31]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-02-21T00:00:00"}