{"id":"https://openalex.org/W2913403932","doi":"https://doi.org/10.1109/nanomed.2018.8641558","title":"Characterizing A549 Cell Line as an Epithelial Cell Monolayer Model for Pharmacokinetic Applications","display_name":"Characterizing A549 Cell Line as an Epithelial Cell Monolayer Model for Pharmacokinetic Applications","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2913403932","doi":"https://doi.org/10.1109/nanomed.2018.8641558","mag":"2913403932"},"language":"en","primary_location":{"id":"doi:10.1109/nanomed.2018.8641558","doi":"https://doi.org/10.1109/nanomed.2018.8641558","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nanomed.2018.8641558","pdf_url":null,"source":{"id":"https://openalex.org/S7407086612","display_name":"IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.arizona.edu/bitstream/10150/632152/1/NanoMed18_38.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035257605","display_name":"Timothy S. Frost","orcid":"https://orcid.org/0000-0003-0401-9289","observed_orcids":["https://orcid.org/0000-0003-0401-9289"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy S. Frost","raw_affiliation_strings":["University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043677467","display_name":"Linan Jiang","orcid":"https://orcid.org/0000-0003-4328-9003","observed_orcids":["https://orcid.org/0000-0003-4328-9003"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linan Jiang","raw_affiliation_strings":["University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061740418","display_name":"Yitshak Zohar","orcid":"https://orcid.org/0000-0001-9276-0119","observed_orcids":["https://orcid.org/0000-0001-9276-0119"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yitshak Zohar","raw_affiliation_strings":["University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":null,"apc_paid":null,"fwci":1.7391,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.89693593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"27","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/epithelial-monolayers","display_name":"epithelial monolayers","score":0.9039999842643738},{"id":"https://openalex.org/keywords/lung-epithelium","display_name":"lung epithelium","score":0.6669999957084656},{"id":"https://openalex.org/keywords/paracellular-transport","display_name":"paracellular transport","score":0.6460000276565552},{"id":"https://openalex.org/keywords/molecular-size-dependence","display_name":"molecular size dependence","score":0.7480000257492065},{"id":"https://openalex.org/keywords/diffusion-coefficient","display_name":"diffusion coefficient","score":0.8320000171661377},{"id":"https://openalex.org/keywords/transwell-assay","display_name":"transwell assay","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.800000011920929},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.7481733560562134},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.694466233253479},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5261948704719543},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.5181776285171509},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4659574627876282},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.45027676224708557},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.44661304354667664},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4400936961174011},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.43527621030807495},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.381369411945343},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3682889938354492},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2790832221508026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09887441992759705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07880407571792603},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07527366280555725},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.05225217342376709}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/nanomed.2018.8641558","doi":"https://doi.org/10.1109/nanomed.2018.8641558","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nanomed.2018.8641558","pdf_url":null,"source":{"id":"https://openalex.org/S7407086612","display_name":"IEEE International Conference on Nano/Molecular Medicine and Engineering (NANOMED)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED)","raw_type":"proceedings-article"},{"id":"pmh:oai:repository.arizona.edu:10150/632152","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/632152","pdf_url":"https://repository.arizona.edu/bitstream/10150/632152/1/NanoMed18_38.pdf","source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"30","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:repository.arizona.edu:10150/632152","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/632152","pdf_url":"https://repository.arizona.edu/bitstream/10150/632152/1/NanoMed18_38.pdf","source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"30","raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6175784004","display_name":null,"funder_award_id":"ABRC ADHS14-082983","funder_id":"https://openalex.org/F4320332140","funder_display_name":"Arizona Biomedical Research Commission"},{"id":"https://openalex.org/G7808933647","display_name":null,"funder_award_id":"ADHS14-082983","funder_id":"https://openalex.org/F4320332140","funder_display_name":"Arizona Biomedical Research Commission"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320332140","display_name":"Arizona Biomedical Research Commission","ror":"https://ror.org/01smpj292"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913403932.pdf","grobid_xml":"https://content.openalex.org/works/W2913403932.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W26381982","https://openalex.org/W71660379","https://openalex.org/W1542532616","https://openalex.org/W1984291280","https://openalex.org/W2076922024","https://openalex.org/W2078314973","https://openalex.org/W2089350615","https://openalex.org/W2164851115","https://openalex.org/W2168253538","https://openalex.org/W2273267066","https://openalex.org/W2280498146","https://openalex.org/W2538062797"],"related_works":["https://openalex.org/W3087173446","https://openalex.org/W2967537283","https://openalex.org/W2078768423","https://openalex.org/W2077548202","https://openalex.org/W26991484","https://openalex.org/W2088564490","https://openalex.org/W2782514758","https://openalex.org/W2803084733","https://openalex.org/W1999391804","https://openalex.org/W2069160817"],"abstract_inverted_index":{"Transport":[0],"of":[1,48,82,92],"three":[2],"different":[3],"molecules":[4,84],"across":[5],"a":[6,12,73,103],"porous":[7],"membrane,":[8],"with":[9,60,85],"and":[10,22],"without":[11],"confluent":[13,69],"A549":[14,26],"cell":[15,27,70],"monolayer,":[16],"has":[17,33],"been":[18,35],"investigated":[19],"in":[20,37],"Transwells":[21],"microfluidic":[23,100],"devices.":[24],"The":[25,51,68,95],"line":[28],"was":[29,56],"selected":[30],"since":[31],"it":[32],"extensively":[34],"utilized":[36],"toxicology":[38],"studies":[39],"due":[40,64],"to":[41,58,65,75],"its":[42],"potential":[43],"target":[44],"for":[45,106],"drug":[46],"delivery":[47],"macro":[49],"molecules.":[50,94],"measured":[52],"molecular":[53,62],"transport":[54,80,91],"rate":[55,81],"found":[57],"decrease":[59],"increasing":[61],"size":[63],"lower":[66],"diffusivity.":[67],"monolayer":[71],"presents":[72],"barrier":[74],"molecular,":[76],"significantly":[77],"reducing":[78],"the":[79,89,99],"larger":[83],"little":[86],"effect":[87],"on":[88],"paracellular":[90],"smaller":[93],"results":[96],"indicate":[97],"that":[98],"system":[101],"is":[102],"good":[104],"model":[105],"pharmacokinetic":[107],"applications.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-02-21T00:00:00"}