{"id":"https://openalex.org/W2913387902","doi":"https://doi.org/10.1200/jco.2019.37.4_suppl.704","title":"Neoadjuvant treatment in a Mexican cohort of patients with locally advanced rectal cancer: Oncologic outcomes and prognostic factors.","display_name":"Neoadjuvant treatment in a Mexican cohort of patients with locally advanced rectal cancer: Oncologic outcomes and prognostic factors.","publication_year":2019,"publication_date":"2019-01-29","ids":{"openalex":"https://openalex.org/W2913387902","doi":"https://doi.org/10.1200/jco.2019.37.4_suppl.704","mag":"2913387902"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2019.37.4_suppl.704","doi":"https://doi.org/10.1200/jco.2019.37.4_suppl.704","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.4_suppl.704","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026043515","display_name":"Zuleyma Nieto Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"ZULEYMA NIETO GARCIA","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052916559","display_name":"Edgar Omar Martos-Armendariz","orcid":"https://orcid.org/0000-0002-0994-9621","observed_orcids":["https://orcid.org/0000-0002-0994-9621"]},"institutions":[{"id":"https://openalex.org/I200267027","display_name":"Universidad Ju\u00e1rez del Estado de Durango","ror":"https://ror.org/02w0sqd02","country_code":"MX","type":"education","lineage":["https://openalex.org/I200267027"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Edgar Omar Martos Armend\u00e1riz","raw_affiliation_strings":["Facultad de Ciencias de la Salud, Universidad Ju\u00e1rez del Estado de Durango, G\u00f3mez Palacio, DG, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facultad de Ciencias de la Salud, Universidad Ju\u00e1rez del Estado de Durango, G\u00f3mez Palacio, DG, Mexico;","institution_ids":["https://openalex.org/I200267027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026965806","display_name":"Vanessa Rosas Camargo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Vanessa Rosas Camargo","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015995999","display_name":"Christian Hayde\u00e9 Flores Balc\u00e1zar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Christian Hayde\u00e9 Flores Balc\u00e1zar","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064112154","display_name":"M\u00f3nica Isabel Meneses Medina","orcid":"https://orcid.org/0000-0002-8643-1113","observed_orcids":["https://orcid.org/0000-0002-8643-1113"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Isabel Meneses Medina","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035565401","display_name":"Noel Salgado\u2010Nesme","orcid":"https://orcid.org/0000-0002-3559-5070","observed_orcids":["https://orcid.org/0000-0002-3559-5070"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Noel Salgado Nesme","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035973419","display_name":"Artemio Garcia-Badiola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Artemio Garc\u00eda Badiola","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078926715","display_name":"Mariana Licano-Zubiate","orcid":"https://orcid.org/0000-0002-5951-1089","observed_orcids":["https://orcid.org/0000-0002-5951-1089"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mariana Licano Zubiate","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021962389","display_name":"Laura Esther Luna Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Laura Esther Luna Gonz\u00e1lez","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015887913","display_name":"Juan Alberto Garay Mora","orcid":"https://orcid.org/0000-0002-3758-5087","observed_orcids":["https://orcid.org/0000-0002-3758-5087"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Juan Alberto Garay Mora","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, DF, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086478424","display_name":"Armando Gamboa Dom\u00ednguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Armando Gamboa Dom\u00ednguez","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011450963","display_name":"Fidel David Huitzil Melendez","orcid":"https://orcid.org/0000-0003-4143-9186","observed_orcids":["https://orcid.org/0000-0003-4143-9186"]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Fidel David Huitzil Melendez","raw_affiliation_strings":["Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico, Mexico;","institution_ids":["https://openalex.org/I4210097900"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"4_suppl","first_page":"704","last_page":"704"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locally-advanced-rectal-cancer","display_name":"locally advanced rectal cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neoadjuvant-chemoradiotherapy","display_name":"neoadjuvant chemoradiotherapy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/total-neoadjuvant-therapy","display_name":"total neoadjuvant therapy","score":0.9549999833106995},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/folfox4","display_name":"FOLFOX4","score":0.9580000042915344},{"id":"https://openalex.org/keywords/total-mesorectal-excision","display_name":"total mesorectal excision","score":0.9750000238418579},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.7979999780654907},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9700000286102295},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.8289999961853027},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.5299999713897705},{"id":"https://openalex.org/keywords/lymph-node-recurrence","display_name":"lymph node recurrence","score":0.5680000185966492},{"id":"https://openalex.org/keywords/protective-ileostomy","display_name":"protective ileostomy","score":0.6439999938011169},{"id":"https://openalex.org/keywords/mexican-patients","display_name":"Mexican patients","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9702119827270508},{"id":"https://openalex.org/C2777201421","wikidata":"https://www.wikidata.org/wiki/Q2445481","display_name":"Total mesorectal excision","level":4,"score":0.6042146682739258},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5864067077636719},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5643773078918457},{"id":"https://openalex.org/C2781171867","wikidata":"https://www.wikidata.org/wiki/Q3933360","display_name":"Abdominoperineal resection","level":4,"score":0.5598106384277344},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.5399837493896484},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5093320608139038},{"id":"https://openalex.org/C2778260052","wikidata":"https://www.wikidata.org/wiki/Q117636","display_name":"FOLFOX","level":5,"score":0.4847380816936493},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4480675160884857},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4445739686489105},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4339243173599243},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3714650273323059},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35626471042633057},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.2703445553779602},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.14848291873931885},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.13564985990524292}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2019.37.4_suppl.704","doi":"https://doi.org/10.1200/jco.2019.37.4_suppl.704","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2019.37.4_suppl.704","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4317863138","https://openalex.org/W7122440981","https://openalex.org/W3193537793","https://openalex.org/W4400884183","https://openalex.org/W4379282745","https://openalex.org/W2982110955","https://openalex.org/W2598496573","https://openalex.org/W4308193031","https://openalex.org/W4379336742","https://openalex.org/W3127346343"],"abstract_inverted_index":{"704":[0],"Background:":[1],"Preoperative":[2],"chemoradiotherapy":[3],"(CRT)":[4],"followed":[5,34,193],"by":[6,35,117,131,194],"total":[7],"mesorectal":[8],"excision":[9],"(TME)":[10],"and":[11,55,109,127,155,163,173,204,215,231,263,318,323,335],"adjuvant":[12],"chemotherapy":[13],"(CT)":[14],"is":[15,41,311],"the":[16,132,226,268,309],"standard":[17],"of":[18,31,61,267,316],"care":[19],"for":[20,122,190],"locally":[21],"advanced":[22],"rectal":[23],"cancer":[24],"(LARC).":[25],"Total":[26],"neoadjuvant":[27,51,90,328],"therapy":[28,329],"(TNT)":[29],"consists":[30],"induction":[32,185],"CT":[33,186],"CRT":[36,195],"prior":[37],"to":[38,105],"surgery.":[39,224],"This":[40],"an":[42],"alternative":[43],"strategy":[44,91],"recommended":[45],"in":[46,58,71,198],"guidelines.":[47],"Objective:":[48],"To":[49],"describe":[50],"strategies,":[52],"oncologic":[53],"outcomes":[54],"prognostic":[56,123],"factors":[57,124],"a":[59,68],"cohort":[60],"patients":[62],"(pts)":[63],"with":[64,82,88,187,202,229,270,275,307,313,333],"LARC":[65,83,308],"treated":[66,87],"at":[67,92],"referral":[69],"center":[70],"Mexico":[72],"City.":[73],"Methods:":[74],"We":[75],"retrospectively":[76],"reviewed":[77],"medical":[78],"records":[79],"from":[80,102],"pts":[81,138,160,228,269,274,306],"(T3-T4":[84],"or":[85],"N+)":[86],"any":[89],"Instituto":[93],"Nacional":[94],"de":[95],"Ciencias":[96],"M\u00e9dicas":[97],"y":[98],"Nutrici\u00f3n":[99],"\u201cSalvador":[100],"Zubir\u00e1n\u201d":[101],"January":[103],"2010":[104],"December":[106],"2015.":[107],"Clinical":[108,150],"pathological":[110],"information":[111],"was":[112,115,125,129,143,166,245,250,286,302],"registered.":[113],"Survival":[114],"estimated":[116],"Kaplan-Meier":[118],"method.":[119],"Univariate":[120],"analysis":[121],"performed":[126],"survival":[128,284,300],"compared":[130],"log":[133],"rank":[134],"test.":[135],"Results:":[136],"43":[137],"were":[139,148,161,178,254,289,330],"included.":[140],"Median":[141,248],"age":[142],"62":[144],"y/o":[145],"(19-83),":[146],"51%":[147],"female.":[149],"stage":[151],"(CS)":[152],"II":[153],"9%":[154],"CS":[156],"III":[157],"91%.":[158],"36":[159],"T3-4":[162],"N+(86%).":[164],"Localization":[165],"lower":[167],"third":[168,171,175],"30%,":[169],"middle":[170],"56%":[172],"upper":[174],"12%.":[176],"63%":[177],"moderately":[179],"differentiated":[180],"adenocarcinoma.":[181],"84%":[182],"had":[183,235],"TNT:":[184],"FOLFOX-4":[188],"regimen":[189],"3":[191],"months":[192],"(50.4":[196],"Gy":[197],"28":[199],"fractions":[200],"concurrently":[201],"fluoropyrimidines)":[203],"TME.":[205],"Surgery:":[206],"ultra-low":[207,230],"anterior":[208],"resection":[209,217],"(AR)":[210],"48%,":[211],"low":[212,232],"AR":[213],"28%":[214],"abdominoperineal":[216],"24%.":[218],"One":[219],"patient":[220,293],"did":[221],"not":[222],"accept":[223],"Of":[225],"32":[227],"AR,":[233],"94%":[234],"protective":[236],"ileostomy.":[237],"The":[238,281,297],"pathologic":[239],"complete":[240],"response":[241],"(pCR)":[242],"ypT0ypN0":[243],"rate":[244,285,301],"45%":[246],"(19/42).":[247],"follow-up":[249],"48":[251],"months.":[252],"There":[253,288],"8/42":[255],"recurrences":[256],"(19%):":[257],"local-only":[258],"2.3%,":[259],"systemic":[260],"only":[261],"12%":[262],"both":[264],"5%.":[265],"None":[266],"pCR":[271,317,322],"recurred.":[272],"All":[273],"residual":[276,324],"nodal":[277,325],"disease":[278,326],"recurred":[279],"(5/5).":[280],"5-year":[282,298],"relapse-free":[283],"73%.":[287],"6":[290],"deaths,":[291],"one":[292],"died":[294],"without":[295],"disease.":[296],"overall":[299],"83%.":[303],"Conclusions:":[304],"In":[305],"TNT":[310],"associated":[312,332],"high":[314],"rates":[315],"favorable":[319],"oncological":[320],"outcomes.":[321],"after":[327],"strongly":[331],"recurrence":[334],"survival.":[336]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2019-02-21T00:00:00"}