{"id":"https://openalex.org/W2913376338","doi":"https://doi.org/10.1182/blood-2018-99-113169","title":"Baseline and on-Treatment Bone Marrow Microenvironments Predict Myeloma Patient Outcomes and Inform Potential Intervention Strategies","display_name":"Baseline and on-Treatment Bone Marrow Microenvironments Predict Myeloma Patient Outcomes and Inform Potential Intervention Strategies","publication_year":2018,"publication_date":"2018-11-29","ids":{"openalex":"https://openalex.org/W2913376338","doi":"https://doi.org/10.1182/blood-2018-99-113169","mag":"2913376338"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2018-99-113169","doi":"https://doi.org/10.1182/blood-2018-99-113169","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-113169","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088847006","display_name":"Samuel A. Danziger","orcid":"https://orcid.org/0000-0002-5669-414X","observed_orcids":["https://orcid.org/0000-0002-5669-414X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Samuel A Danziger","raw_affiliation_strings":["Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065697770","display_name":"Mark T. McConnell","orcid":"https://orcid.org/0000-0003-0978-2291","observed_orcids":["https://orcid.org/0000-0003-0978-2291"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mark McConnell","raw_affiliation_strings":["Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053392706","display_name":"Jake Gockley","orcid":"https://orcid.org/0000-0001-7993-5308","observed_orcids":["https://orcid.org/0000-0001-7993-5308"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jake Gockley","raw_affiliation_strings":["Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030964833","display_name":"Mary H. Young","orcid":"https://orcid.org/0000-0003-2921-6107","observed_orcids":["https://orcid.org/0000-0003-2921-6107"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mary Young","raw_affiliation_strings":["Immuno-Oncology Thematic Center of Excellence, Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immuno-Oncology Thematic Center of Excellence, Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015328438","display_name":"Adam Rosenthal","orcid":"https://orcid.org/0000-0002-6936-3665","observed_orcids":["https://orcid.org/0000-0002-6936-3665"]},"institutions":[{"id":"https://openalex.org/I4210101190","display_name":"Cancer Research And Biostatistics","ror":"https://ror.org/01575p865","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210101190"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adam Rosenthal","raw_affiliation_strings":["Cancer Research and Biostatistics, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research and Biostatistics, Seattle, WA","institution_ids":["https://openalex.org/I4210101190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011438142","display_name":"Frank Schmitz","orcid":"https://orcid.org/0000-0002-9090-0277","observed_orcids":["https://orcid.org/0000-0002-9090-0277"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Frank Schmitz","raw_affiliation_strings":["Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087598092","display_name":"David J. Reiss","orcid":"https://orcid.org/0000-0001-5392-3034","observed_orcids":["https://orcid.org/0000-0001-5392-3034"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David Reiss","raw_affiliation_strings":["Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001424327","display_name":"Phillip Farmer","orcid":"https://orcid.org/0000-0003-1448-1346","observed_orcids":["https://orcid.org/0000-0003-1448-1346"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Phil Farmer","raw_affiliation_strings":["Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090728387","display_name":"Cody Ashby","orcid":"https://orcid.org/0000-0002-9361-0283","observed_orcids":["https://orcid.org/0000-0002-9361-0283"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cody Ashby","raw_affiliation_strings":["Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007618693","display_name":"Michael Bauer","orcid":"https://orcid.org/0000-0003-2498-7295","observed_orcids":["https://orcid.org/0000-0003-2498-7295"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Bauer","raw_affiliation_strings":["Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090044223","display_name":"Frits van Rhee","orcid":"https://orcid.org/0000-0001-9959-1282","observed_orcids":["https://orcid.org/0000-0001-9959-1282"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frits van Rhee","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034560778","display_name":"Faith E. Davies","orcid":"https://orcid.org/0000-0002-3971-2393","observed_orcids":["https://orcid.org/0000-0002-3971-2393"]},"institutions":[{"id":"https://openalex.org/I102401767","display_name":"University of Arkansas at Little Rock","ror":"https://ror.org/04fttyv97","country_code":"US","type":"education","lineage":["https://openalex.org/I102401767"]},{"id":"https://openalex.org/I2799656382","display_name":"University of Arkansas Medical Center","ror":"https://ror.org/005k4dn45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799656382"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faith E. Davies","raw_affiliation_strings":["Myeloma Institute, University of Arkansas, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas, Little Rock, AR","institution_ids":["https://openalex.org/I102401767","https://openalex.org/I2799656382","https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087775484","display_name":"Maurizio Zangari","orcid":"https://orcid.org/0000-0002-1720-3854","observed_orcids":["https://orcid.org/0000-0002-1720-3854"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurizio Zangari","raw_affiliation_strings":["Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003642204","display_name":"Nathan M. Petty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nathan Petty","raw_affiliation_strings":["Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013364487","display_name":"Wilbert B. Copeland","orcid":"https://orcid.org/0000-0002-9616-6341","observed_orcids":["https://orcid.org/0000-0002-9616-6341"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wilbert B. Copeland","raw_affiliation_strings":["Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010450706","display_name":"Brian A. Fox","orcid":"https://orcid.org/0000-0001-6620-3853","observed_orcids":["https://orcid.org/0000-0001-6620-3853"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brian A. Fox","raw_affiliation_strings":["Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040237587","display_name":"Antje Hoering","orcid":"https://orcid.org/0000-0002-4709-3027","observed_orcids":["https://orcid.org/0000-0002-4709-3027"]},"institutions":[{"id":"https://openalex.org/I4210101190","display_name":"Cancer Research And Biostatistics","ror":"https://ror.org/01575p865","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210101190"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Antje Hoering","raw_affiliation_strings":["Seattle Cancer Research and Biostatistics, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Cancer Research and Biostatistics, Seattle, WA","institution_ids":["https://openalex.org/I4210101190"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alison Fitch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alison Fitch","raw_affiliation_strings":["Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076815798","display_name":"Katie Newhall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katie Newhall","raw_affiliation_strings":["Immuno-Oncology Thematic Center of Excellence, Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immuno-Oncology Thematic Center of Excellence, Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000879635","display_name":"Bart Barlogie","orcid":"https://orcid.org/0000-0001-6116-1017","observed_orcids":["https://orcid.org/0000-0001-6116-1017"]},"institutions":[{"id":"https://openalex.org/I4390039328","display_name":"Tisch Cancer Institute","ror":"https://ror.org/0317dzj93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I4390039328","https://openalex.org/I98704320"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bart Barlogie","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY","institution_ids":["https://openalex.org/I4390039328","https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042516164","display_name":"Brian A. Walker","orcid":"https://orcid.org/0000-0002-8615-6254","observed_orcids":["https://orcid.org/0000-0002-8615-6254"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A Walker","raw_affiliation_strings":["Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081730157","display_name":"Matthew W. B. Trotter","orcid":"https://orcid.org/0000-0003-3702-915X","observed_orcids":["https://orcid.org/0000-0003-3702-915X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matthew Trotter","raw_affiliation_strings":["Celgene Institute for Translational Research Europe (CITRE), Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Institute for Translational Research Europe (CITRE), Seville, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060358617","display_name":"Rob Hershberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387155837","display_name":"Celgene (United States)","ror":"https://ror.org/0527yg379","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812","https://openalex.org/I4387155837"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rob Hershberg","raw_affiliation_strings":["Celgene Corporation, Summit, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Summit, NJ","institution_ids":["https://openalex.org/I4387155837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026255927","display_name":"Andrew Dervan","orcid":"https://orcid.org/0000-0002-6482-8654","observed_orcids":["https://orcid.org/0000-0002-6482-8654"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andrew Dervan","raw_affiliation_strings":["Immuno-Oncology Thematic Center of Excellence, Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immuno-Oncology Thematic Center of Excellence, Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006116532","display_name":"Alexander V. Ratushny","orcid":"https://orcid.org/0000-0002-1701-4084","observed_orcids":["https://orcid.org/0000-0002-1701-4084"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alexander Ratushny","raw_affiliation_strings":["Celgene Corporation, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celgene Corporation, Seattle, WA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100632493","display_name":"Gareth John Morgan","orcid":"https://orcid.org/0000-0002-4271-6360","observed_orcids":["https://orcid.org/0000-0002-4271-6360","https://orcid.org/0000-0002-1275-2010","https://orcid.org/0000-0001-7073-2723"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gareth Morgan","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5001424327","https://openalex.org/A5003642204","https://openalex.org/A5006116532","https://openalex.org/A5010450706","https://openalex.org/A5011438142","https://openalex.org/A5013364487","https://openalex.org/A5015328438","https://openalex.org/A5026255927","https://openalex.org/A5030964833","https://openalex.org/A5040237587","https://openalex.org/A5053392706","https://openalex.org/A5060358617","https://openalex.org/A5065697770","https://openalex.org/A5076815798","https://openalex.org/A5081730157","https://openalex.org/A5087598092","https://openalex.org/A5088847006","https://openalex.org/A5090728387"],"corresponding_institution_ids":["https://openalex.org/I4210101190","https://openalex.org/I4387155837","https://openalex.org/I79620101"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"Supplement 1","first_page":"1882","last_page":"1882"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cell-of-origin","display_name":"cell of origin","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cell-of-origin-deconvolution","display_name":"cell of origin deconvolution","score":0.5699999928474426},{"id":"https://openalex.org/keywords/gene-expression-deconvolution","display_name":"gene expression deconvolution","score":0.5329999923706055},{"id":"https://openalex.org/keywords/immune-cell-composition","display_name":"immune cell composition","score":0.3540000021457672},{"id":"https://openalex.org/keywords/stromal-cells","display_name":"stromal cells","score":0.7429999709129333},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.5889999866485596},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4449999928474426},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8040000200271606},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9520000219345093},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6779999732971191},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6305052042007446},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6020261645317078},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5419470071792603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5155827403068542},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4738764464855194},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.46227937936782837},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4442584216594696},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4179564118385315},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4001918137073517},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3749011158943176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36720913648605347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3581903576850891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.314918577671051},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2148652970790863},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08899503946304321},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood-2018-99-113169","doi":"https://doi.org/10.1182/blood-2018-99-113169","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2018-99-113169","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3096086667","https://openalex.org/W4405039187","https://openalex.org/W2885543432","https://openalex.org/W3097563879","https://openalex.org/W4393096435","https://openalex.org/W4285600990","https://openalex.org/W2985817614","https://openalex.org/W4389231101","https://openalex.org/W2980475309","https://openalex.org/W4387005085"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"The":[2,283,464,516],"multiple":[3],"myeloma":[4,650],"(MM)":[5],"tumor":[6,200,413],"microenvironment":[7],"(TME)":[8],"strongly":[9],"influences":[10],"patient":[11,306,604,627,651],"outcomes":[12,286,315,419,632,670],"as":[13,256,393,395],"evidenced":[14],"by":[15,289,296,363,610],"the":[16,43,53,106,112,121,140,151,164,175,203,241,355,407,412,421,471,489,503,575,589,613,647],"success":[17],"of":[18,45,55,65,81,115,127,153,238,243,358,466,473,488,502,528,533,577,603,616,644,649,711,723,742,802,830,838,853],"immunomodulatory":[19],"therapies.":[20],"To":[21],"develop":[22],"precision":[23],"immunotherapeutic":[24],"approaches,":[25],"it":[26],"is":[27,361],"essential":[28],"to":[29,110,149,207,300,325,351,439,455,483,646,658,668,836,844],"identify":[30],"and":[31,36,47,71,100,117,167,189,211,271,304,367,372,388,399,487,498,522,530,540,548,556,561,579,623,633,653,662,832],"enumerate":[32],"TME":[33,220,253,357,403,645],"cell":[34,50,156,191,302,374],"types":[35,51,157],"understand":[37],"their":[38],"dynamics.":[39],"Methods":[40],"We":[41,599],"estimated":[42,162,198],"population":[44],"immune":[46,116,353,510,591,622],"other":[48,329,345,352,443,459,509,553],"non-tumor":[49,129],"during":[52,249,639],"course":[54],"MM":[56,85],"treatment":[57,257,482],"at":[58,88],"a":[59,168,297],"single":[60],"institution":[61],"using":[62,139,163],"gene":[63,130,169,224],"expression":[64,131,170,225],"paired":[66,204],"CD138-selected":[67],"bone":[68,73,187],"marrow":[69,74],"aspirates":[70,107],"whole":[72],"(WBM)":[75],"core":[76],"biopsies":[77],"from":[78,105,209,227,479,606],"867":[79,229],"samples":[80,205,230,468,655],"436":[82],"newly":[83],"diagnosed":[84],"patients":[86,244,425,474,491,506],"collected":[87],"5":[89,186,233,291,360,428,477,505],"time":[90,135],"points:":[91],"pre-treatment":[92,497],"(N=354),":[93],"post-induction":[94],"(N=245),":[95],"post-transplant":[96,499],"(N=83),":[97],"post-consolidation":[98],"(N=51),":[99],"post-maintenance":[101],"(N=134).":[102],"Expression":[103],"profiles":[104,132,609],"were":[108,161,261,287],"used":[109],"infer":[111],"transcriptome":[113,608],"contribution":[114],"stromal":[118,624],"cells":[119,201,547,570],"in":[120,158,202,232,245,280,426,475,563,588,626,636,817,840],"WBM":[122],"array":[123],"data.":[124],"Unsupervised":[125],"clustering":[126],"these":[128,159],"across":[133],"all":[134,228],"points":[136],"was":[137,382,581,593],"performed":[138],"R":[141],"package":[142],"ConsensusClusterPlus":[143],"with":[144,185,263,341,583,595,629],"Bayesian":[145],"Information":[146],"Criterion":[147],"(BIC)":[148],"select":[150],"number":[152,472],"clusters.":[154],"Individual":[155],"TMEs":[160,605],"DCQ":[165],"algorithm":[166],"signature":[171],"matrix":[172,179],"based":[173],"on":[174,223,707,719,738,790,806,815],"published":[176],"LM22":[177],"leukocyte":[178],"(Newman":[180],"et":[181],"al.,":[182],"2015)":[183],"augmented":[184],"marrow-":[188],"myeloma-specific":[190],"types.":[192],"Results":[193],"Our":[194,618],"deconvolution":[195],"approach":[196],"accurately":[197],"percent":[199],"compared":[206,324,340,438,454],"estimates":[208],"microscopy":[210],"flow":[212],"cytometry":[213],"(PCC":[214],"=":[215,218,269,276,293,321,332,337,348,435,446,451,462],"0.63,":[216],"RMSE":[217],"9.99%).":[219],"clusters":[221,235,254,260,518,538,554,602,628,638],"built":[222],"data":[226],"resulted":[231],"unsupervised":[234],"covering":[236],"91%":[237],"samples.":[239,282],"While":[240],"fraction":[242,615],"each":[246],"cluster":[247,312,381],"changed":[248],"treatment,":[250],"no":[251],"new":[252],"emerged":[255],"progressed.":[258],"These":[259],"associated":[262,582,594],"progression":[264],"free":[265],"survival":[266,273,307],"(PFS)":[267],"(p-Val":[268,275],"0.020)":[270],"overall":[272],"(OS)":[274],"0.067)":[277],"when":[278,406],"measured":[279],"pre-transplant":[281],"most":[284],"striking":[285],"represented":[288],"Cluster":[290,359,427,476,504,514],"(N":[292],"106)":[294],"characterized":[295,362],"low":[298,364],"innate":[299],"adaptive":[301,590],"ratio":[303],"shortened":[305],"(Figure":[308],"1,":[309],"2).":[310],"This":[311],"had":[313,525,542,558],"worse":[314,431],"than":[316],"others":[317],"(estimated":[318],"mean":[319,335,433,449],"PFS":[320,434,521],"58":[322],"months":[323,327,339,343,437,441,453,457],"71+":[326,440],"for":[328,344,386,420,442,458,492,671],"clusters,":[330,346,354,444,460],"p-Val":[331,347,445,461],"0.002;":[333],"estimate":[334,448],"OS":[336,450,523],"105":[338],"113+":[342],"0.040).":[349],"Compared":[350],"adaptive-skewed":[356],"granulocyte":[365],"populations":[366],"high":[368,390],"antigen-presenting,":[369],"CD8":[370,534],"T,":[371],"B":[373],"populations.":[375],"As":[376],"might":[377],"be":[378],"expected,":[379],"this":[380,402,642],"also":[383],"significantly":[384,410,430],"enriched":[385],"ISS3":[387],"GEP70":[389],"risk":[391],"patients,":[392],"well":[394],"Del1p,":[396],"Del1q,":[397],"t12;14,":[398],"t14:16.":[400],"Importantly,":[401],"persisted":[404],"even":[405],"induction":[408],"therapy":[409],"reduced":[411],"load":[414],"(Table":[415],"1).":[416],"At":[417],"post-induction,":[418],"69":[422],"/":[423],"245":[424],"remain":[429],"(estimate":[432],"56":[436],"0.004;":[447],"100":[452],"121+":[456],"0.002).":[463],"analysis":[465,648],"on-treatment":[467,654],"showed":[469],"that":[470],"decreases":[478],"30%":[480],"before":[481],"12%":[484],"after":[485],"transplant,":[486],"63":[490],"whom":[493],"we":[494],"have":[495],"both":[496],"samples,":[500],"18/20":[501],"moved":[507],"into":[508,513],"clusters;":[511],"13":[512],"4.":[515],"non-5":[517],"(with":[519],"better":[520],"overall)":[524],"higher":[526],"amounts":[527,532],"granulocytes":[529,578],"lower":[531],"T":[535],"cells.":[536],"Some":[537],"(1":[539],"4)":[541],"increased":[543,559],"natural":[544],"killer":[545],"(NK)":[546],"decreased":[549],"dendritic":[550],"cells,":[551],"while":[552,586],"(2":[555],"3)":[557],"adipocytes":[560,580],"increases":[562,587],"M2":[564],"macrophages":[565],"(Cluster":[566,571],"2)":[567],"or":[568,713,725,744],"NK":[569],"3).":[572],"Taken":[573],"together,":[574],"gain":[576],"improved":[584],"outcome,":[585],"compartment":[592],"poorer":[596],"outcome.":[597],"Conclusions":[598],"identified":[600,620],"distinct":[601],"bulk":[607],"computationally":[611],"estimating":[612],"CD138-":[614],"TMEs.":[617],"findings":[619],"differential":[621],"compositions":[625],"opposing":[630],"clinical":[631],"tracked":[634],"membership":[635],"those":[637],"treatment.":[640],"Adding":[641],"layer":[643],"baseline":[652],"enables":[656],"us":[657],"formulate":[659],"biological":[660],"hypotheses":[661],"may":[663],"eventually":[664],"guide":[665],"therapeutic":[666],"interventions":[667],"improve":[669],"patients.":[672],"Disclosures":[673],"Danziger:":[674],"Celgene":[675,854],"Corporation:":[676,681,684,687,692,697,751,756,761,766,855,860,868,873],"Employment,":[677,688,693,698,752,757,762,767,856,861,869,874],"Equity":[678,689,694,699,753,758,763,768,857,862,870,875],"Ownership.":[679,690,695,700,754,759,764,769,858,871,876],"McConnell:Celgene":[680],"Employment.":[682,685],"Gockley:Celgene":[683],"Young:Celgene":[686],"Schmitz:Celgene":[691],"Reiss:Celgene":[696],"Davies:MMRF:":[701],"Honoraria;":[702,730,734,879,883],"Celgene:":[703,884],"Consultancy,":[704,717,736,748,771,797,878,882,885],"Honoraria,":[705,886],"Membership":[706,718,737],"an":[708,720,739],"entity's":[709,721,740],"Board":[710,722,741],"Directors":[712,724,743],"advisory":[714,726,745],"committees;":[715,727,746],"Amgen:":[716],"TRM":[728],"Oncology:":[729],"Abbvie:":[731],"Consultancy;":[732],"ASH:":[733],"Takeda:":[735],"Janssen:":[747,889],"Honoraria.":[749],"Copeland:Celgene":[750],"Fox:Celgene":[755],"Fitch:Celgene":[760],"Newhall:Celgene":[765],"Barlogie:Celgene:":[770],"Research":[772,783,798,849,887,890],"Funding;":[773,799,888],"Dana":[774],"Farber":[775],"Cancer":[776],"Institute:":[777],"Other:":[778,785,793,809,819],"travel":[779,786,794,810,820],"stipend;":[780,787,795,811,821],"Multiple":[781,807],"Myeloma":[782,822,845],"Foundation:":[784],"International":[788,804],"Workshop":[789],"Waldenstr\u00f6m's":[791],"Macroglobulinemia:":[792],"Millenium:":[796],"European":[800],"School":[801],"Haematology-":[803],"Conference":[805],"Myeloma:":[808],"ComtecMed-":[812],"World":[813],"Congress":[814],"Controversies":[816],"Hematology:":[818],"Health,":[823,846],"LLC:":[824],"Patents":[825,864],"&":[826,865],"Royalties:":[827],":":[828],"Co-inventor":[829],"patents":[831],"patent":[833],"applications":[834],"related":[835],"use":[837],"GEP":[839],"cancer":[841],"medicine":[842],"licensed":[843],"LLC.":[847],"Trotter:Celgene":[848],"SL":[850],"(Spain),":[851],"part":[852],"Hershberg:Celgene":[859],"Ownership,":[863],"Royalties.":[866],"Dervan:Celgene":[867],"Ratushny:Celgene":[872],"Morgan:Takeda:":[877],"Bristol-Myers":[880],"Squibb:":[881],"Funding.":[891]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2019-02-21T00:00:00"}
