{"id":"https://openalex.org/W2913343489","doi":"https://doi.org/10.1136/heartjnl-2018-bcs.10","title":"10 Marked differences in the pharmacokinetic and pharmacodynamic profiles of ticagrelor in patients undergoing treatment for ST elevation and non ST elevation myocardial infarction (stemi and nstemi)","display_name":"10 Marked differences in the pharmacokinetic and pharmacodynamic profiles of ticagrelor in patients undergoing treatment for ST elevation and non ST elevation myocardial infarction (stemi and nstemi)","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2913343489","doi":"https://doi.org/10.1136/heartjnl-2018-bcs.10","mag":"2913343489"},"language":"en","primary_location":{"id":"doi:10.1136/heartjnl-2018-bcs.10","doi":"https://doi.org/10.1136/heartjnl-2018-bcs.10","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2018-bcs.10","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acute Coronary Syndromes","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2436/621595","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087626274","display_name":"Nazish Khan","orcid":"https://orcid.org/0000-0003-4483-7390","observed_orcids":["https://orcid.org/0000-0003-4483-7390"]},"institutions":[{"id":"https://openalex.org/I4210154310","display_name":"The Royal Wolverhampton NHS Trust","ror":"https://ror.org/05pjd0m90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210154310"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nazish Khan","raw_affiliation_strings":["Department of Cardiology, The Royal Wolverhampton Hospitals NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The Royal Wolverhampton Hospitals NHS Trust","institution_ids":["https://openalex.org/I4210154310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040323927","display_name":"Vincent Amoah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154310","display_name":"The Royal Wolverhampton NHS Trust","ror":"https://ror.org/05pjd0m90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210154310"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vincent Amoah","raw_affiliation_strings":["Department of Cardiology, The Royal Wolverhampton Hospitals NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The Royal Wolverhampton Hospitals NHS Trust","institution_ids":["https://openalex.org/I4210154310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035014069","display_name":"Mike Cornes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800951516","display_name":"Worcestershire Acute Hospitals NHS Trust","ror":"https://ror.org/030zsh764","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800951516"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mike Cornes","raw_affiliation_strings":["Clinical Biochemistry Worcestershire Acute Hospitals NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biochemistry Worcestershire Acute Hospitals NHS Trust","institution_ids":["https://openalex.org/I2800951516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110587433","display_name":"Joe Martins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801954517","display_name":"Dudley Group NHS Foundation Trust","ror":"https://ror.org/014hmqv77","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801954517"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joe Martins","raw_affiliation_strings":["Department of Cardiology, The Dudley Group of Hospitals NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The Dudley Group of Hospitals NHS Trust","institution_ids":["https://openalex.org/I2801954517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088687379","display_name":"Ben Wrigley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154310","display_name":"The Royal Wolverhampton NHS Trust","ror":"https://ror.org/05pjd0m90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210154310"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ben Wrigley","raw_affiliation_strings":["Department of Cardiology, The Royal Wolverhampton Hospitals NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The Royal Wolverhampton Hospitals NHS Trust","institution_ids":["https://openalex.org/I4210154310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002907685","display_name":"Saib Khogali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154310","display_name":"The Royal Wolverhampton NHS Trust","ror":"https://ror.org/05pjd0m90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210154310"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Saib Khogali","raw_affiliation_strings":["Department of Cardiology, The Royal Wolverhampton Hospitals NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The Royal Wolverhampton Hospitals NHS Trust","institution_ids":["https://openalex.org/I4210154310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028349353","display_name":"Alan Michael Nevill","orcid":"https://orcid.org/0000-0003-0506-3652","observed_orcids":["https://orcid.org/0000-0003-0506-3652"]},"institutions":[{"id":"https://openalex.org/I119664326","display_name":"University of Wolverhampton","ror":"https://ror.org/01k2y1055","country_code":"GB","type":"education","lineage":["https://openalex.org/I119664326"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan Nevill","raw_affiliation_strings":["University of Wolverhampton Faculty of Education, Health and Wellbeing"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wolverhampton Faculty of Education, Health and Wellbeing","institution_ids":["https://openalex.org/I119664326"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019775900","display_name":"James M. Cotton","orcid":"https://orcid.org/0000-0001-6548-2723","observed_orcids":["https://orcid.org/0000-0001-6548-2723"]},"institutions":[{"id":"https://openalex.org/I4210154310","display_name":"The Royal Wolverhampton NHS Trust","ror":"https://ror.org/05pjd0m90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210154310"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Cotton","raw_affiliation_strings":["Department of Cardiology, The Royal Wolverhampton Hospitals NHS Trust"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The Royal Wolverhampton Hospitals NHS Trust","institution_ids":["https://openalex.org/I4210154310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7127,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.75507298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":92},"biblio":{"volume":null,"issue":null,"first_page":"A9","last_page":"A10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ticagrelor","display_name":"ticagrelor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/p2y12-inhibitors","display_name":"P2Y12 inhibitors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/st-elevation-myocardial-infarction","display_name":"ST-elevation myocardial infarction","score":0.9259999990463257},{"id":"https://openalex.org/keywords/non-st-elevation-myocardial-infarction","display_name":"non-ST-elevation myocardial infarction","score":0.9710000157356262},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9950000047683716},{"id":"https://openalex.org/keywords/platelet-inhibition","display_name":"platelet aggregation inhibition","score":0.6549999713897705},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.6340000033378601},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ar-c124910xx","display_name":"AR-C124910XX","score":0.7879999876022339},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"plasma concentration","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2780890252","wikidata":"https://www.wikidata.org/wiki/Q420542","display_name":"Ticagrelor","level":4,"score":0.9668646454811096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9172399640083313},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.7702534198760986},{"id":"https://openalex.org/C49059817","wikidata":"https://www.wikidata.org/wiki/Q14916330","display_name":"P2Y12","level":4,"score":0.6992710828781128},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.6914076209068298},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6740110516548157},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.6491877436637878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5806901454925537},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.513482391834259},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.49991536140441895},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.47653302550315857},{"id":"https://openalex.org/C35294091","wikidata":"https://www.wikidata.org/wiki/Q6663385","display_name":"Loading dose","level":2,"score":0.46742647886276245},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.45552074909210205},{"id":"https://openalex.org/C149151106","wikidata":"https://www.wikidata.org/wiki/Q4677569","display_name":"Active metabolite","level":3,"score":0.44240429997444153},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3515186607837677}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/heartjnl-2018-bcs.10","doi":"https://doi.org/10.1136/heartjnl-2018-bcs.10","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2018-bcs.10","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acute Coronary Syndromes","raw_type":"proceedings-article"},{"id":"pmh:oai:wlv.openrepository.com:2436/621595","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2436/621595","pdf_url":null,"source":{"id":"https://openalex.org/S4306401000","display_name":"Wolverhampton Intellectual Repository and E-Theses (University of Wolverhampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119664326","host_organization_name":"University of Wolverhampton","host_organization_lineage":["https://openalex.org/I119664326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"104","raw_type":"Journal article"}],"best_oa_location":{"id":"pmh:oai:wlv.openrepository.com:2436/621595","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2436/621595","pdf_url":null,"source":{"id":"https://openalex.org/S4306401000","display_name":"Wolverhampton Intellectual Repository and E-Theses (University of Wolverhampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119664326","host_organization_name":"University of Wolverhampton","host_organization_lineage":["https://openalex.org/I119664326"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"104","raw_type":"Journal article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409947585","https://openalex.org/W1807736252","https://openalex.org/W3048097852","https://openalex.org/W2058243285","https://openalex.org/W2191932889","https://openalex.org/W2608624727","https://openalex.org/W2583941334","https://openalex.org/W2419244186","https://openalex.org/W2091107667","https://openalex.org/W2170029016"],"abstract_inverted_index":{"Introduction":[0],"Ticagrelor,":[1,302],"an":[2,238,337,371,410],"orally":[3],"administered,":[4],"direct":[5],"acting,":[6],"reversible":[7],"P2Y12":[8,66,122,309,332],"receptor":[9],"inhibitor,":[10],"provides":[11],"faster":[12],"onset":[13,376],"and":[14,41,56,94,112,126,151,170,179,184,254,284,358,364,379,421],"greater":[15],"levels":[16,424],"of":[17,45,90,146,166,168,233,271,314,341,361,374,377,382,388,399,402,406,425,432],"platelet":[18,224,318,426],"inhibition":[19,310,319,427],"when":[20],"compared":[21],"to":[22,35,50,99,416],"clopidogrel.":[23],"Current":[24],"data":[25],"indicates":[26,133],"a":[27,61,87,134,252,329,389],"reduced":[28],"antiplatelet":[29,136,256,338],"effect":[30,44,240,257,339],"in":[31,158,214,248,275,303,324,434],"STEMI.":[32,390],"We":[33],"sought":[34],"determine":[36],"the":[37,192,312,351,375,385,429],"early":[38],"pharmacokinetic":[39],"(PK)":[40],"pharmacodynamic":[42],"(PD)":[43],"ticagrelor":[46,95,147,234,344,383],"loading":[47,88],"doses":[48],"administered":[49,86],"patients":[51,68,79,84,204,221,325],"undergoing":[52],"PCI":[53],"for":[54,76,296],"STEMI":[55,71,220,276,304,435],"NSTEMI.":[57,327],"Methods":[58],"This":[59],"is":[60,226,241,258,294,320,345,370],"single":[62],"centre":[63],"non-randomised":[64],"study.":[65],"naive":[67],"presenting":[69],"with":[70,160,326],"or":[72,409],"NSTEMI":[73,250,278],"were":[74,85,127,140,189,208],"considered":[75,200],"inclusion.":[77],"All":[78],"gave":[80],"informed":[81],"consent.":[82],"Enrolled":[83],"dose":[89],"aspirin":[91],"300":[92],"mg":[93,97,236],"180":[96,235],"prior":[98],"PCI.":[100],"Blood":[101],"was":[102,199],"sampled":[103],"at":[104,228,244,260,311],"20":[105,229],"min,":[106],"coronary":[107],"balloon":[108],"time,":[109],"1":[110,177],"hour":[111],"4":[113,245,289],"hours":[114],"after":[115],"loading.":[116],"PD":[117,217],"results":[118],"are":[119,176,212,273],"expressed":[120],"as":[121],"reaction":[123],"units":[124],"(PRU)":[125],"assessed":[128,141],"using":[129,155,195],"VerifyNow.":[130],"A":[131,291],"PRU>208":[132],"sub-optimal":[135],"response.":[137],"PK":[138,266],"properties":[139],"by":[142,397],"measuring":[143],"plasma":[144,185,269,359],"concentration":[145],"parent":[148],"compound":[149],"(T-PC)":[150],"active":[152,172],"metabolite":[153],"(T-AM)":[154,175],"liquid":[156],"chromatography":[157],"tandem":[159],"mass":[161],"spectrometry.":[162],"The":[163,355],"lower":[164],"limits":[165],"quantification":[167],"T-PC":[169,272,363],"its":[171],"metabolite,":[173],"AR-C124910XX":[174],"ng/ml":[178,181],"2.5":[180],"respectively.":[182],"PRU":[183,357],"concentrations":[186,270,298,360],"over":[187],"time":[188,262],"tested":[190],"between":[191],"two":[193],"groups":[194],"2-way":[196],"ANOVA.":[197],"p<0.05":[198],"significant.":[201],"Results":[202],"30":[203],"(15":[205],"STEMI/15":[206],"NSTEMI)":[207],"recruited.":[209],"Baseline":[210],"characteristics":[211],"described":[213],"Table":[215],"1.":[216],"analysis":[218,267],"In":[219,316],"high":[222],"residual":[223],"reactivity":[225],"seen":[227,259],"min":[230],"following":[231],"administration":[232,405],"(256\u00b113.1),":[237],"attenuated":[239],"also":[242],"observed":[243,274],"hours.":[246,290],"However,":[247],"our":[249],"patients,":[251],"marked":[253],"rapid":[255,323],"all":[261],"points":[263],"(figure":[264,299],"1).":[265],"Low":[268],"vs":[277,281],"patients;":[279],"(9.0\u00b14.1)":[280],"(22.8\u00b110.3),":[282],"p=0.225":[283],"this":[285],"trend":[286,293],"continues":[287],"until":[288],"similar":[292],"noted":[295],"T-AM":[297,365],"2).":[300],"Conclusion":[301],"does":[305],"not":[306],"provide":[307,422],"adequate":[308,423],"point":[313],"reperfusion.":[315],"contrast":[317],"significantly":[321],"more":[322],"Although":[328],"directly":[330],"acting":[331],"inhibitor":[333],"that":[334,367],"can":[335],"exert":[336],"independent":[340],"metabolic":[342],"biotransformation,":[343],"still":[346],"reliant":[347],"upon":[348],"absorption":[349,369,392,420],"via":[350],"gastrointestinal":[352],"(GI)":[353],"tract.":[354],"sub-therapeutic":[356],"both":[362],"indicate":[366],"GI":[368,391,419],"important":[372],"determinant":[373],"action":[378],"clinical":[380],"efficacy":[381],"during":[384,428],"acute":[386,430],"phase":[387,431],"may":[393],"be":[394],"further":[395],"impaired":[396],"co-administration":[398],"morphine.":[400],"Modification":[401],"formulation":[403],"e.g":[404],"chewed/orodispersible":[407],"tablets":[408],"intravenous":[411],"agent":[412],"(cangrelor)":[413],"could":[414],"help":[415],"overcome":[417],"delayed":[418],"presentation":[433],"patients.":[436]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2019-02-21T00:00:00"}