{"id":"https://openalex.org/W2913307374","doi":"https://doi.org/10.1002/advs.201801233","title":"Inhibition of CaMKII\u03b1 Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation","display_name":"Inhibition of CaMKII\u03b1 Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation","publication_year":2019,"publication_date":"2019-02-10","ids":{"openalex":"https://openalex.org/W2913307374","doi":"https://doi.org/10.1002/advs.201801233","mag":"2913307374","pmid":"https://pubmed.ncbi.nlm.nih.gov/31016106","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6468974"},"language":"en","primary_location":{"id":"doi:10.1002/advs.201801233","doi":"https://doi.org/10.1002/advs.201801233","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.201801233","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.201801233","source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.201801233","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074391954","display_name":"Jing Xu","orcid":"https://orcid.org/0000-0003-3368-7673","observed_orcids":["https://orcid.org/0000-0003-3368-7673"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Xu","raw_affiliation_strings":["Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100773101","display_name":"Hongsheng Wang","orcid":"https://orcid.org/0000-0003-0079-0236","observed_orcids":["https://orcid.org/0000-0003-0079-0236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongsheng Wang","raw_affiliation_strings":["Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023767895","display_name":"Yi Bo Hu","orcid":"https://orcid.org/0000-0001-5484-2834","observed_orcids":["https://orcid.org/0000-0001-5484-2834"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210103894","display_name":"Hefei National Center for Physical Sciences at Nanoscale","ror":"https://ror.org/01jeedh73","country_code":"CN","type":"facility","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366","https://openalex.org/I4210103894"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Hu","raw_affiliation_strings":["Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, 96 Jinzhai Street, Hefei, 230026 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, 96 Jinzhai Street, Hefei, 230026 P. R. China","institution_ids":["https://openalex.org/I126520041","https://openalex.org/I4210103894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067842712","display_name":"Yu Shrike Zhang","orcid":"https://orcid.org/0000-0002-0045-0808","observed_orcids":["https://orcid.org/0000-0002-0045-0808","https://orcid.org/0000-0002-2291-2022"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Shrike Zhang","raw_affiliation_strings":["Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139 USA","Shanghai Bone Tumor Institution  100 Haining Street Shanghai 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA, 02139 USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Shanghai Bone Tumor Institution  100 Haining Street Shanghai 200080 P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033595397","display_name":"Longping Wen","orcid":"https://orcid.org/0000-0003-0384-4578","observed_orcids":["https://orcid.org/0000-0003-0384-4578"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longping Wen","raw_affiliation_strings":["School of Medicine, South China University of Technology, Nanobio Laboratory, Institutes for Life Sciences, South China University of Technology, 381 Wushan Street, Guangzhou, 510006 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, South China University of Technology, Nanobio Laboratory, Institutes for Life Sciences, South China University of Technology, 381 Wushan Street, Guangzhou, 510006 P. R. China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fei Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Yin","raw_affiliation_strings":["Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031953394","display_name":"Zhuoying Wang","orcid":"https://orcid.org/0000-0002-8121-5286","observed_orcids":["https://orcid.org/0000-0002-8121-5286","https://orcid.org/0009-0001-4281-4497"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuoying Wang","raw_affiliation_strings":["Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yingchao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yingchao Zhang","raw_affiliation_strings":["Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School  65 Landsdowne Street Cambridge MA 02139 USA","Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School  65 Landsdowne Street Cambridge MA 02139 USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028383555","display_name":"Suoyuan Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suoyuan Li","raw_affiliation_strings":["Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089549630","display_name":"Yanyan Miao","orcid":"https://orcid.org/0000-0002-6817-4117","observed_orcids":["https://orcid.org/0000-0002-6817-4117"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyan Miao","raw_affiliation_strings":["Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, 135 West Xingang Street, Guangzhou, 510275 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, 135 West Xingang Street, Guangzhou, 510275 P. R. China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102266430","display_name":"Binhui Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Binhui Lin","raw_affiliation_strings":["Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112307174","display_name":"Dongqing Zuo","orcid":"https://orcid.org/0000-0002-6684-9467","observed_orcids":["https://orcid.org/0000-0002-6684-9467"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dongqing Zuo","raw_affiliation_strings":["Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048069511","display_name":"Gangyang Wang","orcid":"https://orcid.org/0000-0003-1560-7684","observed_orcids":["https://orcid.org/0000-0003-1560-7684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gangyang Wang","raw_affiliation_strings":["Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023751554","display_name":"Min Mao","orcid":"https://orcid.org/0009-0003-6069-3443","observed_orcids":["https://orcid.org/0009-0003-6069-3443"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Mao","raw_affiliation_strings":["Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076310461","display_name":"Tao Zhang","orcid":"https://orcid.org/0000-0002-8440-9924","observed_orcids":["https://orcid.org/0000-0002-8440-9924"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Zhang","raw_affiliation_strings":["Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011786598","display_name":"Jianxun Ding","orcid":"https://orcid.org/0000-0002-5232-8863","observed_orcids":["https://orcid.org/0000-0002-5232-8863"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianxun Ding","raw_affiliation_strings":["Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022 P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-5232-8863","affiliations":[{"raw_affiliation_string":"Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022 P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023480337","display_name":"Yingqi Hua","orcid":"https://orcid.org/0000-0002-7277-0958","observed_orcids":["https://orcid.org/0000-0002-7277-0958"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingqi Hua","raw_affiliation_strings":["Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039499293","display_name":"Zhengdong Cai","orcid":"https://orcid.org/0000-0003-0824-4504","observed_orcids":["https://orcid.org/0000-0003-0824-4504"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhengdong Cai","raw_affiliation_strings":["Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Bone Tumor Institution, 100 Haining Street, Shanghai, 200080 P. R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5011786598","https://openalex.org/A5023480337","https://openalex.org/A5039499293"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I19820366","https://openalex.org/I4210092888","https://openalex.org/I4210135742"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":3.8172,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.95149864,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"6","issue":"8","first_page":"1801233","last_page":"1801233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10956","display_name":"Fullerene Chemistry and Applications","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10956","display_name":"Fullerene Chemistry and Applications","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.06790000200271606,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camkiialpha","display_name":"CaMKII\u03b1","score":0.8960000276565552},{"id":"https://openalex.org/keywords/autophagic-degradation","display_name":"autophagic degradation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.878000020980835},{"id":"https://openalex.org/keywords/kn-93","display_name":"KN-93","score":0.8320000171661377},{"id":"https://openalex.org/keywords/lysosomal-alkalinization","display_name":"lysosomal alkalinization","score":0.8550000190734863},{"id":"https://openalex.org/keywords/autophagosome-accumulation","display_name":"autophagosome accumulation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.5260000228881836},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.5440000295639038},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7954581379890442},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.661640465259552},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.65626060962677},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5309588313102722},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4533573389053345},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4483557343482971},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.44511541724205017},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.42000871896743774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3037503957748413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20259764790534973},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12268608808517456},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10586294531822205}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1002/advs.201801233","doi":"https://doi.org/10.1002/advs.201801233","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.201801233","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.201801233","source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5459760","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6468974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6468974","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6468974","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"},{"id":"pmid:31016106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31016106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/advs.201801233","doi":"https://doi.org/10.1002/advs.201801233","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.201801233","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.201801233","source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2354145263","display_name":null,"funder_award_id":"16CR3010A","funder_id":"https://openalex.org/F4320325338","funder_display_name":"Shanghai Hospital Development Center"},{"id":"https://openalex.org/G4433633844","display_name":"\u987a\u5e8f\u53cc\u91cd\u54cd\u5e94\u6027\u805a\u6c28\u57fa\u9178\u80f6\u675f\u534f\u540c\u7cbe\u51c6\u63a7\u5236\u7ec6\u80de\u5185\u836f\u7269\u91ca\u653e","funder_award_id":"51673190","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4519667896","display_name":null,"funder_award_id":"81502604","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5338714703","display_name":null,"funder_award_id":"20164Y0270","funder_id":"https://openalex.org/F4320326187","funder_display_name":"Health and Family Planning Commission of Sichuan Province"},{"id":"https://openalex.org/G5418518884","display_name":"\u53ef\u6ce8\u5c04\u7535\u6d3b\u6027\u805a\u79bb\u5b50\u590d\u5408\u6c34\u51dd\u80f6\u4f9d\u6b21\u91ca\u653e\u6297\u708e\u836f\u4e0e\u795e\u7ecf\u8c03\u8282\u5242\u4fee\u590d\u810a\u9ad3\u635f\u4f24","funder_award_id":"51673187","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5822889189","display_name":null,"funder_award_id":"51603204","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6390095069","display_name":"\u805a\u6c28\u57fa\u9178\u7eb3\u7c73\u51dd\u80f6\u6355\u83b7\u80bf\u7624\u6297\u539f\u7ed3\u5408\u514d\u75ab\u8c03\u8282\u5242\u534f\u540c\u589e\u5f3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597","funder_award_id":"51873207","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6848765200","display_name":null,"funder_award_id":"81702973","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G724049119","display_name":null,"funder_award_id":"81672651","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8191914387","display_name":null,"funder_award_id":"20164Y0270","funder_id":"https://openalex.org/F4320328346","funder_display_name":"Shanghai Municipal Health and Family Planning Commission"},{"id":"https://openalex.org/G8917687533","display_name":null,"funder_award_id":"81501584","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325338","display_name":"Shanghai Hospital Development Center","ror":"https://ror.org/02zrtve16"},{"id":"https://openalex.org/F4320326187","display_name":"Health and Family Planning Commission of Sichuan Province","ror":null},{"id":"https://openalex.org/F4320328346","display_name":"Shanghai Municipal Health and Family Planning Commission","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913307374.pdf","grobid_xml":"https://content.openalex.org/works/W2913307374.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W232921416","https://openalex.org/W1458902100","https://openalex.org/W1505296146","https://openalex.org/W1506633809","https://openalex.org/W1523693806","https://openalex.org/W1814764479","https://openalex.org/W1970661950","https://openalex.org/W1979181492","https://openalex.org/W1981945129","https://openalex.org/W1989051519","https://openalex.org/W1991621909","https://openalex.org/W1996708800","https://openalex.org/W2014918593","https://openalex.org/W2021499254","https://openalex.org/W2023338943","https://openalex.org/W2025665129","https://openalex.org/W2034117525","https://openalex.org/W2039114882","https://openalex.org/W2039171477","https://openalex.org/W2041009706","https://openalex.org/W2046250764","https://openalex.org/W2046889690","https://openalex.org/W2054140181","https://openalex.org/W2055971882","https://openalex.org/W2062402743","https://openalex.org/W2066437531","https://openalex.org/W2067249311","https://openalex.org/W2080637633","https://openalex.org/W2114899816","https://openalex.org/W2118444707","https://openalex.org/W2135312502","https://openalex.org/W2139619092","https://openalex.org/W2152462290","https://openalex.org/W2153535991","https://openalex.org/W2155687923","https://openalex.org/W2160560939","https://openalex.org/W2164031380","https://openalex.org/W2177430595","https://openalex.org/W2223071637","https://openalex.org/W2223695276","https://openalex.org/W2276765123","https://openalex.org/W2290256202","https://openalex.org/W2313174391","https://openalex.org/W2313437382","https://openalex.org/W2317669166","https://openalex.org/W2351208027","https://openalex.org/W2410918492","https://openalex.org/W2625059079","https://openalex.org/W2724202256","https://openalex.org/W2725186180","https://openalex.org/W2737816679","https://openalex.org/W2743254891","https://openalex.org/W4237557241"],"related_works":["https://openalex.org/W2939773830","https://openalex.org/W2021499254","https://openalex.org/W2027013223","https://openalex.org/W1972651273","https://openalex.org/W2998793527","https://openalex.org/W2041009706","https://openalex.org/W2158460113","https://openalex.org/W2060572306","https://openalex.org/W1975159760","https://openalex.org/W2150481553"],"abstract_inverted_index":{"Fullerene":[0],"C60":[1],"nanocrystals":[2],"(nano-C60)":[3],"possess":[4],"various":[5],"attractive":[6],"bioactivities,":[7],"including":[8,29],"autophagy":[9],"induction":[10],"and":[11,48,54,70,120,122,137,158],"calcium/calmodulin-dependent":[12],"protein":[13,22],"kinase":[14,23],"II\u03b1":[15],"(CaMKII\u03b1)":[16],"activation.":[17],"CaMKII\u03b1":[18,37,52,74,79,94,103,115,172],"is":[19,61,160],"a":[20,84,182],"multifunctional":[21],"involved":[24],"in":[25,42,75,81,148,163],"many":[26],"cellular":[27],"processes":[28],"tumor":[30],"progression;":[31],"however,":[32],"the":[33,49,98,107,124,176,187],"biological":[34],"effects":[35],"of":[36,73,93,110,114,127,156,178,190],"activity":[38,53,95,116],"modulated":[39],"by":[40,96],"nano-C60":[41,60,90,159],"tumors":[43],"have":[44],"not":[45],"been":[46],"reported,":[47],"relationship":[50],"between":[51],"autophagic":[55,138,179],"degradation":[56,125,139],"remains":[57],"unclear.":[58],"Herein,":[59],"demonstrated":[62],"to":[63,130,143],"elicit":[64],"reactive":[65],"oxygen":[66],"species":[67],"(ROS)-dependent":[68],"cytotoxicity":[69,88],"persistent":[71],"activation":[72],"osteosarcoma":[76],"(OS)":[77],"cells.":[78],"activation,":[80],"turn,":[82],"produces":[83],"protective":[85],"effect":[86,109],"against":[87],"from":[89],"itself.":[91],"Inhibition":[92],"either":[97],"chemical":[99],"inhibitor":[100],"KN-93":[101,157],"or":[102],"knockdown":[104],"dramatically":[105],"promotes":[106],"anti-OS":[108,154],"nano-C60.":[111,191],"Moreover,":[112],"inhibition":[113],"causes":[117],"lysosomal":[118],"alkalinization":[119],"enlargement,":[121],"impairs":[123],"function":[126],"lysosomes,":[128],"leading":[129],"autophagosome":[131,135],"accumulation.":[132],"Importantly,":[133],"excessive":[134],"accumulation":[136],"blocking":[140],"are":[141],"shown":[142],"play":[144],"an":[145,164],"important":[146],"role":[147],"KN-93-enhanced-OS":[149],"cell":[150],"death.":[151],"The":[152,168],"synergistic":[153],"efficacy":[155,189],"further":[161],"revealed":[162],"OS-xenografted":[165],"murine":[166],"model.":[167],"results":[169],"demonstrate":[170],"that":[171],"inhibition,":[173],"along":[174],"with":[175],"suppression":[177],"degradation,":[180],"presents":[181],"promising":[183],"strategy":[184],"for":[185],"improving":[186],"antitumor":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":6}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2019-02-21T00:00:00"}
