{"id":"https://openalex.org/W2913271846","doi":"https://doi.org/10.1093/humrep/dez005","title":"The risk of birth defects is not associated with semen parameters or mode of conception in offspring of men visiting a reproductive health clinic","display_name":"The risk of birth defects is not associated with semen parameters or mode of conception in offspring of men visiting a reproductive health clinic","publication_year":2019,"publication_date":"2019-01-28","ids":{"openalex":"https://openalex.org/W2913271846","doi":"https://doi.org/10.1093/humrep/dez005","mag":"2913271846","pmid":"https://pubmed.ncbi.nlm.nih.gov/30753581","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6443112"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/dez005","doi":"https://doi.org/10.1093/humrep/dez005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/dez005","pdf_url":"https://academic.oup.com/humrep/article-pdf/34/4/733/28257632/dez005.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/humrep/article-pdf/34/4/733/28257632/dez005.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024599210","display_name":"Alexander W. Pastuszak","orcid":"https://orcid.org/0000-0002-6740-8348","observed_orcids":["https://orcid.org/0000-0002-6740-8348"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander W Pastuszak","raw_affiliation_strings":["Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069678653","display_name":"Amin S. Herati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amin S Herati","raw_affiliation_strings":["The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018901819","display_name":"Michael L. Eisenberg","orcid":"https://orcid.org/0000-0001-5482-0141","observed_orcids":["https://orcid.org/0000-0001-5482-0141"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L Eisenberg","raw_affiliation_strings":["Department of Urology, Stanford University School of Medicine, Palo Alto, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-5482-0141","affiliations":[{"raw_affiliation_string":"Department of Urology, Stanford University School of Medicine, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108567927","display_name":"Cenk Cengiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cenk Cengiz","raw_affiliation_strings":["Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA","Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005400915","display_name":"Peter H. Langlois","orcid":"https://orcid.org/0000-0001-6765-4963","observed_orcids":["https://orcid.org/0000-0001-6765-4963"]},"institutions":[{"id":"https://openalex.org/I1343568078","display_name":"Texas Department of State Health Services","ror":"https://ror.org/022zknp80","country_code":"US","type":"government","lineage":["https://openalex.org/I1343568078"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter H Langlois","raw_affiliation_strings":["Texas Department of State Health Services, Birth Defects Epidemiology and Surveillance Branch, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Department of State Health Services, Birth Defects Epidemiology and Surveillance Branch, Austin, TX, USA","institution_ids":["https://openalex.org/I1343568078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040923993","display_name":"Taylor P. Kohn","orcid":"https://orcid.org/0000-0002-2807-4998","observed_orcids":["https://orcid.org/0000-0002-2807-4998"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor P Kohn","raw_affiliation_strings":["Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088539818","display_name":"Dolores J. Lamb","orcid":"https://orcid.org/0000-0002-4389-5065","observed_orcids":["https://orcid.org/0000-0002-4389-5065"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dolores J Lamb","raw_affiliation_strings":["Department of Urology, Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087500960","display_name":"Larry I. Lipshultz","orcid":"https://orcid.org/0000-0001-8676-7285","observed_orcids":["https://orcid.org/0000-0001-8676-7285"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry I Lipshultz","raw_affiliation_strings":["Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA","Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5024599210"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":{"value":4097,"currency":"EUR","value_usd":4630},"apc_paid":null,"fwci":1.4344,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.79855079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"34","issue":"4","first_page":"733","last_page":"739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.14550000429153442,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.03009999915957451,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.9959999918937683},{"id":"https://openalex.org/keywords/semen-parameters","display_name":"semen parameters","score":0.8709999918937683},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.7649999856948853},{"id":"https://openalex.org/keywords/sperm-quality","display_name":"semen quality","score":0.828000009059906},{"id":"https://openalex.org/keywords/mode-of-conception","display_name":"mode of conception","score":0.8870000243186951},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.953000009059906},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.9110000133514404},{"id":"https://openalex.org/keywords/intracytoplasmic-sperm-injection","display_name":"intracytoplasmic sperm injection","score":0.9769999980926514},{"id":"https://openalex.org/keywords/sperm-concentration","display_name":"sperm concentration","score":0.6389999985694885},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.9959999918937683},{"id":"https://openalex.org/keywords/live-birth","display_name":"live birth","score":0.4860000014305115},{"id":"https://openalex.org/keywords/offspring-outcomes","display_name":"offspring outcomes","score":0.4000000059604645},{"id":"https://openalex.org/keywords/fertility-treatment-outcomes","display_name":"infertility treatment outcomes","score":0.36800000071525574}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7121742963790894},{"id":"https://openalex.org/C2778093475","wikidata":"https://www.wikidata.org/wiki/Q9715","display_name":"Semen","level":2,"score":0.703630805015564},{"id":"https://openalex.org/C2778080409","wikidata":"https://www.wikidata.org/wiki/Q2916689","display_name":"Semen quality","level":3,"score":0.663053035736084},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.6440173983573914},{"id":"https://openalex.org/C2777338322","wikidata":"https://www.wikidata.org/wiki/Q280156","display_name":"Male infertility","level":4,"score":0.6241706609725952},{"id":"https://openalex.org/C2777589648","wikidata":"https://www.wikidata.org/wiki/Q1501844","display_name":"Semen analysis","level":4,"score":0.5255383849143982},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.5137220621109009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4838894307613373},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.46948108077049255},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.46597716212272644},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.45588645339012146},{"id":"https://openalex.org/C2776210078","wikidata":"https://www.wikidata.org/wiki/Q351870","display_name":"Reproductive medicine","level":3,"score":0.4501969814300537},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.45001405477523804},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.44180822372436523},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.41081008315086365},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3792189955711365},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3770766258239746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3401920795440674},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.2728661596775055},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2330770492553711},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11284515261650085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10121968388557434},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005220","descriptor_name":"Fathers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007248","descriptor_name":"Infertility, Male","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009035","descriptor_name":"Mothers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013076","descriptor_name":"Sperm Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013081","descriptor_name":"Sperm Motility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013781","descriptor_name":"Texas","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020554","descriptor_name":"Sperm Injections, Intracytoplasmic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034121","descriptor_name":"Reproductive Health Services","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/humrep/dez005","doi":"https://doi.org/10.1093/humrep/dez005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/dez005","pdf_url":"https://academic.oup.com/humrep/article-pdf/34/4/733/28257632/dez005.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6057473","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6443112","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6443112","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6443112","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Reprod","raw_type":"Text"},{"id":"pmid:30753581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30753581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/humrep/dez005","doi":"https://doi.org/10.1093/humrep/dez005","is_oa":true,"landing_page_url":"https://doi.org/10.1093/humrep/dez005","pdf_url":"https://academic.oup.com/humrep/article-pdf/34/4/733/28257632/dez005.pdf","source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2188091633","display_name":null,"funder_award_id":"#U01DD000494","funder_id":"https://openalex.org/F4320317529","funder_display_name":"Texas Department of State Health Services"},{"id":"https://openalex.org/G434871884","display_name":"TEXAS CENTER FOR BIRTH DEFECTS RESEARCH AND PREVENTION","funder_award_id":"U01DD000494","funder_id":"https://openalex.org/F4320332162","funder_display_name":"Centers for Disease Control and Prevention"},{"id":"https://openalex.org/G5015564949","display_name":"Characterization of the Role of NELL1 in the Predisposition to Peyronie's and Dupuytren's Diseases.","funder_award_id":"K08DK115835","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7309933976","display_name":"K-12: Male Reproductive Health Research (MRHR) Career Development Program at BCM","funder_award_id":"K12HD073917","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320306113","display_name":"U.S. Department of State","ror":"https://ror.org/03vvynj75"},{"id":"https://openalex.org/F4320308976","display_name":"Urology Care Foundation","ror":"https://ror.org/00sbaqa70"},{"id":"https://openalex.org/F4320317529","display_name":"Texas Department of State Health Services","ror":"https://ror.org/022zknp80"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913271846.pdf","grobid_xml":"https://content.openalex.org/works/W2913271846.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1536578923","https://openalex.org/W1969127101","https://openalex.org/W1977027676","https://openalex.org/W1997352429","https://openalex.org/W2026702047","https://openalex.org/W2030683004","https://openalex.org/W2030837258","https://openalex.org/W2033589672","https://openalex.org/W2033756310","https://openalex.org/W2041132632","https://openalex.org/W2041277094","https://openalex.org/W2055859834","https://openalex.org/W2066312343","https://openalex.org/W2077140741","https://openalex.org/W2086745876","https://openalex.org/W2103141827","https://openalex.org/W2107315915","https://openalex.org/W2113393026","https://openalex.org/W2115865270","https://openalex.org/W2120720124","https://openalex.org/W2126503856","https://openalex.org/W2155835604","https://openalex.org/W2297953774","https://openalex.org/W2394780319","https://openalex.org/W2528781671","https://openalex.org/W2617800152","https://openalex.org/W2916802183","https://openalex.org/W4239166088","https://openalex.org/W4285719527","https://openalex.org/W6711751497"],"related_works":["https://openalex.org/W2040823791","https://openalex.org/W3093108057","https://openalex.org/W6940144216","https://openalex.org/W6902439815","https://openalex.org/W2791411224","https://openalex.org/W2072275675","https://openalex.org/W2113393026","https://openalex.org/W7098261236","https://openalex.org/W2572619939","https://openalex.org/W2903805289"],"abstract_inverted_index":{"STUDY":[0,99,462],"QUESTION:":[1],"What":[2],"is":[3,29,85,121,447,531,562],"the":[4,91,106,138,176,198,242,249,345,363,431,440,454,469,479,491,509,517,523,548,550,581],"relationship":[5,32,455],"between":[6,33,158,175,200,214,280,294,456],"semen":[7,34,134,203,217,284,367,393,420,458],"parameters":[8,35,234,368],"and":[9,36,81,117,160,178,186,202,219,224,230,251,283,297,314,328,460,500,505,514,516,555,557],"birth":[10,231],"defect":[11,37],"(BD)":[12],"rates":[13,38,282,334,415],"in":[14,39,75,137,173,344,466,565,574],"offspring":[15,150],"of":[16,48,56,72,108,119,141,168,182,221,253,266,304,323,365,376,399,406,424,433,442,526,535,553,580,586],"men":[17,24,170],"evaluated":[18],"for":[19,227,248,290,404,497,511],"infertility?":[20],"SUMMARY":[21],"ANSWER:":[22],"Among":[23],"undergoing":[25],"infertility":[26,326,436],"evaluation,":[27],"there":[28],"no":[30],"significant":[31,276],"live":[40,349],"or":[41,94,287,352,422],"still":[42,353],"births,":[43],"even":[44],"when":[45,449],"considering":[46],"mode":[47,118,220,322,398,423],"conception.":[49,425],"WHAT":[50],"IS":[51],"KNOWN":[52],"ALREADY:":[53],"Approximately":[54],"15%":[55],"couples":[57,76,451],"have":[58],"fertility":[59],"difficulties,":[60],"with":[61,123,133,148,185,271,391,419],"up":[62],"to":[63,90,210,373,386,522],"a":[64,128,166,272,532,541,568,584],"50%":[65],"male":[66,97,109,434],"factor":[67,110,435],"contribution.":[68],"An":[69],"increased":[70],"risk":[71],"BDs":[73,190,201,298,342],"exists":[74],"using":[77,151],"ART,":[78,329],"particularly":[79],"IVF":[80],"ICSI,":[82],"but":[83],"it":[84],"unknown":[86],"if":[87,105],"this":[88,163],"related":[89],"ART":[92],"procedures":[93],"an":[95,300],"underlying":[96],"factor.":[98],"DESIGN,":[100],"SIZE,":[101],"DURATION:":[102],"To":[103,196],"determine":[104,197,211],"severity":[107,432],"infertilty,":[111],"as":[112],"assessed":[113],"via":[114],"sperm":[115,295],"quality":[116,421,459],"conception,":[120,324],"associated":[122,390,418],"BD":[124,215,281,333,414],"rates,":[125,216],"we":[126,205],"performed":[127],"retrospective":[129],"cohort":[130],"study.":[131],"Fathers":[132],"analysis":[135,383],"data":[136,157,396],"Baylor":[139],"College":[140],"Medicine":[142],"Semen":[143,233],"Database":[144],"(BCMSD)":[145],"were":[146,171,191,235,269],"linked":[147],"their":[149],"Texas":[152,524],"Birth":[153],"Defects":[154],"Registry":[155],"(TBDFR)":[156],"1999":[159],"2009.":[161],"In":[162,263],"10-year":[164],"period,":[165],"total":[167,181,264,315],"1382":[169],"identified":[172,270],"linkage":[174],"BCMSD":[177],"TBDFR.":[179],"A":[180],"109":[183,379],"infants":[184,188,268,351],"2115":[187],"without":[189],"identified.":[192],"PARTICIPANTS/MATERIALS,":[193],"SETTING,":[194],"METHODS:":[195],"association":[199,277,293],"parameters,":[204,218,285],"used":[206],"hierarchical":[207],"linear":[208],"modeling":[209],"odds":[212,301],"ratios":[213],"conception":[222,400],"before":[223,286],"after":[225,288,355],"adjustment":[226,289],"paternal,":[228],"maternal":[229],"covariates.":[232,291],"stratified":[236],"based":[237],"on":[238,369],"thresholds":[239],"defined":[240],"by":[241,468,506,540],"WHO":[243],"fifth":[244],"edition":[245],"laboratory":[246],"manual":[247],"examination":[250],"processing":[252],"human":[254],"semen.":[255],"MAIN":[256],"RESULTS":[257],"AND":[258],"THE":[259,412],"ROLE":[260],"OF":[261,411],"CHANCE:":[262],"4.9%":[265],"2224":[267,407],"BD.":[273],"No":[274],"statistically":[275],"was":[278,384,401],"observed":[279],"The":[292,426],"concentration":[296],"demonstrated":[299],"ratio":[302],"(OR)":[303],"1.07":[305],"(95%":[306],"confidence":[307],"interval:":[308],"0.63-1.83);":[309],"motility:":[310],"OR":[311,318],"0.91":[312],"(0.52-2.22);":[313],"motile":[316],"count:":[317],"1.21":[319],"(0.70-2.08).":[320],"Likewise,":[321],"including":[325],"treatment":[327],"did":[330,360],"not":[331,361,402,417,438],"affect":[332],"(P":[335],">":[336],"0.05).":[337],"LIMITATIONS,":[338],"REASONS":[339],"FOR":[340],"CAUTION:":[341],"recorded":[343],"TBDFR":[346],"only":[347],"include":[348],"born":[350],"births":[354],"20":[356,374],"weeks,":[357],"our":[358,381],"study":[359,428],"evaluate":[362],"effect":[364],"impaired":[366,457],"developmental":[370],"defects":[371],"prior":[372],"weeks":[375],"gestation.":[377],"With":[378],"BDs,":[380],"statistical":[382],"powered":[385],"detect":[387],"moderate":[388],"differences":[389],"particular":[392],"parameters.":[394],"Additionally,":[395],"about":[397,453],"available":[403],"1053":[405],"births.":[408],"WIDER":[409],"IMPLICATIONS":[410],"FINDINGS:":[413],"are":[416],"current":[427],"suggests":[429],"that":[430],"does":[437],"impact":[439],"rate":[441],"congenital":[443],"anomalies.":[444],"This":[445,560],"information":[446],"important":[448],"counseling":[450],"concerned":[452],"BDs.":[461],"FUNDING/COMPETING":[463],"INTEREST(S):":[464],"Supported":[465],"part":[467,566],"NIH":[470,503],"Men's":[471],"Reproductive":[472],"Health":[473,499,528,536],"Research":[474,483],"(MRHR)":[475],"K12":[476,481],"HD073917":[477],"(D.J.L.),":[478,488,504],"Multidisciplinary":[480],"Urologic":[482],"(KURe)":[484],"Career":[485,543],"Development":[486,544],"Program":[487],"P01HD36289":[489],"from":[490,508,547,549],"Eunice":[492],"Kennedy":[493],"Shriver":[494],"National":[495,533,551],"Institute":[496,552],"Child":[498],"Human":[501],"Development,":[502],"U01DD000494":[507],"Centers":[510],"Disease":[512],"Control":[513],"Prevention":[515],"Title":[518],"V":[519],"Block":[520],"Grant":[521],"Department":[525],"State":[527],"Services.":[529],"A.W.P.":[530],"Institutes":[534],"K08":[537],"Scholar":[538],"supported":[539,564],"Mentored":[542],"Award":[545,576],"(K08DK115835-01)":[546],"Diabetes":[554],"Digestive":[556],"Kidney":[558],"Diseases.":[559],"work":[561],"also":[563],"through":[567],"Urology":[569,575],"Care":[570],"Foundation":[571],"Rising":[572],"Stars":[573],"(to":[577],"A.W.P.)":[578],"None":[579],"authors":[582],"has":[583],"conflict":[585],"interest.":[587],"TRIAL":[588],"REGISTRATION":[589],"NUMBER:":[590],"Not":[591],"applicable.":[592]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-02-21T00:00:00"}