{"id":"https://openalex.org/W2913271237","doi":"https://doi.org/10.2217/imt-2018-0107","title":"First-Line Checkpoint Inhibitors for Wild-Type Advanced Non-Small-Cell Cancer: A Pair-Wise And Network Meta-Analysis","display_name":"First-Line Checkpoint Inhibitors for Wild-Type Advanced Non-Small-Cell Cancer: A Pair-Wise And Network Meta-Analysis","publication_year":2019,"publication_date":"2019-01-25","ids":{"openalex":"https://openalex.org/W2913271237","doi":"https://doi.org/10.2217/imt-2018-0107","mag":"2913271237","pmid":"https://pubmed.ncbi.nlm.nih.gov/30678553"},"language":"en","primary_location":{"id":"doi:10.2217/imt-2018-0107","doi":"https://doi.org/10.2217/imt-2018-0107","is_oa":false,"landing_page_url":"https://doi.org/10.2217/imt-2018-0107","pdf_url":null,"source":{"id":"https://openalex.org/S71887004","display_name":"Immunotherapy","issn_l":"1750-743X","issn":["1750-743X","1750-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100638600","display_name":"Xiaojian Wang","orcid":"https://orcid.org/0000-0002-5073-389X","observed_orcids":["https://orcid.org/0000-0002-5073-389X"]},"institutions":[{"id":"https://openalex.org/I4210139852","display_name":"Shantou Central Hospital","ror":"https://ror.org/04jmrra88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139852"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Jian Wang","raw_affiliation_strings":["Department of Pharmacy, Shantou Central Hospital, Shantou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shantou Central Hospital, Shantou, China","institution_ids":["https://openalex.org/I4210139852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004843192","display_name":"Jia-Zhou Lin","orcid":"https://orcid.org/0000-0001-9307-4794","observed_orcids":["https://orcid.org/0000-0001-9307-4794"]},"institutions":[{"id":"https://openalex.org/I4210091098","display_name":"Cancer Hospital of Shantou University Medical College","ror":"https://ror.org/00a53nq42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210091098"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Zhou Lin","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, China","institution_ids":["https://openalex.org/I4210091098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104129702","display_name":"Shuhan Yu","orcid":"https://orcid.org/0009-0000-8755-0934","observed_orcids":["https://orcid.org/0009-0000-8755-0934"]},"institutions":[{"id":"https://openalex.org/I4210139852","display_name":"Shantou Central Hospital","ror":"https://ror.org/04jmrra88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139852"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu-Han Yu","raw_affiliation_strings":["Department of Medical Oncology, Shantou Central Hospital, Shantou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shantou Central Hospital, Shantou, China","institution_ids":["https://openalex.org/I4210139852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102355654","display_name":"Sheng\u2010Xi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139852","display_name":"Shantou Central Hospital","ror":"https://ror.org/04jmrra88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139852"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng-Xi Wu","raw_affiliation_strings":["Department of Radiation Oncology, Shantou Central Hospital, Shantou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Shantou Central Hospital, Shantou, China","institution_ids":["https://openalex.org/I4210139852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101790634","display_name":"He-San Luo","orcid":"https://orcid.org/0000-0003-4153-7683","observed_orcids":["https://orcid.org/0000-0003-4153-7683"]},"institutions":[{"id":"https://openalex.org/I4210139852","display_name":"Shantou Central Hospital","ror":"https://ror.org/04jmrra88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139852"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"He-San Luo","raw_affiliation_strings":["Department of Radiation Oncology, Shantou Central Hospital, Shantou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Shantou Central Hospital, Shantou, China","institution_ids":["https://openalex.org/I4210139852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020717005","display_name":"Ze-Sen Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139852","display_name":"Shantou Central Hospital","ror":"https://ror.org/04jmrra88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139852"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze-Sen Du","raw_affiliation_strings":["Department of Surgical Oncology, Shantou Central Hospital, Shantou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Shantou Central Hospital, Shantou, China","institution_ids":["https://openalex.org/I4210139852"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002667081","display_name":"Xu\u2010Yuan Li","orcid":"https://orcid.org/0000-0003-2674-0974","observed_orcids":["https://orcid.org/0000-0003-2674-0974"]},"institutions":[{"id":"https://openalex.org/I4210139852","display_name":"Shantou Central Hospital","ror":"https://ror.org/04jmrra88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139852"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu-Yuan Li","raw_affiliation_strings":["Department of Medical Oncology, Shantou Central Hospital, Shantou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shantou Central Hospital, Shantou, China","institution_ids":["https://openalex.org/I4210139852"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7863,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.71558347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"11","issue":"4","first_page":"311","last_page":"320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9101999998092651,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.07580000162124634,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9710000157356262},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6600000262260437},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.6129999756813049},{"id":"https://openalex.org/keywords/treatment-efficacy-ranking","display_name":"treatment efficacy ranking","score":0.8029999732971191},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6940000057220459},{"id":"https://openalex.org/keywords/treatment-related-mortality","display_name":"non-relapse mortality","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.9465152025222778},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6966794729232788},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.686377227306366},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6854351758956909},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6528393030166626},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5816755890846252},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5568230152130127},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5447779893875122},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5337266325950623},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.46448570489883423},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39883899688720703},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2336706519126892},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.18829888105392456}],"mesh":[{"descriptor_ui":"D000077594","descriptor_name":"Nivolumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2217/imt-2018-0107","doi":"https://doi.org/10.2217/imt-2018-0107","is_oa":false,"landing_page_url":"https://doi.org/10.2217/imt-2018-0107","pdf_url":null,"source":{"id":"https://openalex.org/S71887004","display_name":"Immunotherapy","issn_l":"1750-743X","issn":["1750-743X","1750-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"journal-article"},{"id":"pmid:30678553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30678553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1495967812","https://openalex.org/W2001902820","https://openalex.org/W2033672531","https://openalex.org/W2037139573","https://openalex.org/W2048974336","https://openalex.org/W2075535893","https://openalex.org/W2104347254","https://openalex.org/W2124427232","https://openalex.org/W2136859769","https://openalex.org/W2145835533","https://openalex.org/W2147415023","https://openalex.org/W2147700937","https://openalex.org/W2156353875","https://openalex.org/W2166316862","https://openalex.org/W2187430385","https://openalex.org/W2198093519","https://openalex.org/W2215953110","https://openalex.org/W2288894747","https://openalex.org/W2293064244","https://openalex.org/W2293531514","https://openalex.org/W2460378650","https://openalex.org/W2527905628","https://openalex.org/W2529904548","https://openalex.org/W2557730509","https://openalex.org/W2559382297","https://openalex.org/W2559861554","https://openalex.org/W2561459036","https://openalex.org/W2567564314","https://openalex.org/W2569740680","https://openalex.org/W2591239368","https://openalex.org/W2606495925","https://openalex.org/W2610994169","https://openalex.org/W2635951006","https://openalex.org/W2747774814","https://openalex.org/W2748246139","https://openalex.org/W2777461561","https://openalex.org/W2783897381","https://openalex.org/W2796582438","https://openalex.org/W2797675588","https://openalex.org/W2805354595","https://openalex.org/W2806145489","https://openalex.org/W2806388842","https://openalex.org/W2807431877","https://openalex.org/W2885139325","https://openalex.org/W2885326465","https://openalex.org/W2887381926","https://openalex.org/W2892009523"],"related_works":["https://openalex.org/W3201553284","https://openalex.org/W2966528803","https://openalex.org/W3041182782","https://openalex.org/W2946950110","https://openalex.org/W2589103622","https://openalex.org/W2947501460","https://openalex.org/W2947577031","https://openalex.org/W2982362823","https://openalex.org/W4281724649","https://openalex.org/W2947290320"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"estimate":[2],"efficacy":[3],"of":[4,33,52],"checkpoint":[5,43],"inhibitors":[6],"and":[7,41,58,81],"rank":[8,27],"treatment":[9,28,98],"effects":[10],"in":[11],"non-small-cell":[12],"lung":[13],"cancer.":[14],"MATERIALS":[15],"&":[16],"METHODS:":[17],"Prospective":[18],"randomized":[19],"trials":[20,35],"were":[21,36],"included.":[22],"p-score":[23,51],"was":[24,59,91],"used":[25],"to":[26,61,93],"effects.":[29],"RESULTS:":[30],"A":[31],"total":[32],"nine":[34],"identified,":[37],"involving":[38],"5504":[39],"patients":[40,100],"three":[42],"inhibitors.":[44],"Pembrolizumab":[45,88],"plus":[46,89],"chemotherapy":[47,90],"had":[48,72],"the":[49,56,95],"highest":[50],"0.95":[53],"among":[54],"all":[55],"treatments,":[57],"superior":[60],"pembrolizumab":[62],"alone":[63],"(hazard":[64],"ratio:":[65],"0.87;":[66],"95%":[67],"CI:":[68],"0.79-0.95).":[69],"Combination":[70],"therapy":[71],"more":[73],"grade":[74],"3-5":[75],"adverse":[76],"events;":[77],"but":[78],"toxicity-related":[79],"discontinuation":[80],"treatment-related":[82],"death":[83],"did":[84],"not":[85],"increase.":[86],"CONCLUSION:":[87],"likely":[92],"be":[94],"most":[96],"effective":[97],"for":[99],"with":[101],"wild-type":[102],"advanced":[103],"NSCLC.":[104]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-02-21T00:00:00"}
