{"id":"https://openalex.org/W2913239004","doi":"https://doi.org/10.1002/hep.29299","title":"Reply","display_name":"Reply","publication_year":2017,"publication_date":"2017-06-06","ids":{"openalex":"https://openalex.org/W2913239004","doi":"https://doi.org/10.1002/hep.29299","mag":"2913239004","pmid":"https://pubmed.ncbi.nlm.nih.gov/28586089"},"language":"en","primary_location":{"id":"doi:10.1002/hep.29299","doi":"https://doi.org/10.1002/hep.29299","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.29299","pdf_url":"https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.29299","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.29299","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038177258","display_name":"Jagpreet Chhatwal","orcid":"https://orcid.org/0000-0001-8741-4430","observed_orcids":["https://orcid.org/0000-0001-8741-4430"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jagpreet Chhatwal","raw_affiliation_strings":["Harvard Medical School,Boston,MA","Liver Center and Gastrointestinal Division,Massachusetts General Hospital,Boston,MA","Massachusetts General Hospital Institute for Technology Assessment,Boston,MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School,Boston,MA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Liver Center and Gastrointestinal Division,Massachusetts General Hospital,Boston,MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Institute for Technology Assessment,Boston,MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002104853","display_name":"Sumeyye Samur","orcid":"https://orcid.org/0009-0007-3980-8188","observed_orcids":["https://orcid.org/0009-0007-3980-8188"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumeyye Samur","raw_affiliation_strings":["Harvard Medical School,Boston,MA","Massachusetts General Hospital Institute for Technology Assessment,Boston,MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School,Boston,MA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital Institute for Technology Assessment,Boston,MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057012164","display_name":"Emily D. Bethea","orcid":"https://orcid.org/0000-0003-3759-8360","observed_orcids":["https://orcid.org/0000-0003-3759-8360"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Bethea","raw_affiliation_strings":["Harvard Medical School,Boston,MA","Liver Center and Gastrointestinal Division,Massachusetts General Hospital,Boston,MA","Massachusetts General Hospital Institute for Technology Assessment,Boston,MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School,Boston,MA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Liver Center and Gastrointestinal Division,Massachusetts General Hospital,Boston,MA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital Institute for Technology Assessment,Boston,MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035211037","display_name":"Raymond T. Chung","orcid":"https://orcid.org/0000-0003-1338-9564","observed_orcids":["https://orcid.org/0000-0003-1338-9564"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond T. Chung","raw_affiliation_strings":["Harvard Medical School,Boston,MA","Liver Center and Gastrointestinal Division,Massachusetts General Hospital,Boston,MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School,Boston,MA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Liver Center and Gastrointestinal Division,Massachusetts General Hospital,Boston,MA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"3","first_page":"1005","last_page":"1006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9190000295639038},{"id":"https://openalex.org/keywords/decompensated-cirrhosis","display_name":"decompensated cirrhosis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/liver-transplant-candidates","display_name":"liver transplant candidates","score":0.7200000286102295},{"id":"https://openalex.org/keywords/transplant-waiting-list","display_name":"transplant waiting list","score":0.7900000214576721},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.8579999804496765},{"id":"https://openalex.org/keywords/abo-blood-group","display_name":"ABO blood group system","score":0.8550000190734863},{"id":"https://openalex.org/keywords/fibrosing-cholestatic-hepatitis","display_name":"fibrosing cholestatic hepatitis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/retransplantation","display_name":"retransplantation","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.4860000014305115},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43314769864082336}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/hep.29299","doi":"https://doi.org/10.1002/hep.29299","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.29299","pdf_url":"https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.29299","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},{"id":"pmid:28586089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28586089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology (Baltimore, Md.)","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1002/hep.29299","doi":"https://doi.org/10.1002/hep.29299","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hep.29299","pdf_url":"https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.29299","source":{"id":"https://openalex.org/S156174673","display_name":"Hepatology","issn_l":"0270-9139","issn":["0270-9139","1527-3350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913239004.pdf","grobid_xml":"https://content.openalex.org/works/W2913239004.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2403969263","https://openalex.org/W2417844027","https://openalex.org/W2547264935"],"related_works":["https://openalex.org/W2623376020","https://openalex.org/W2547264935","https://openalex.org/W2951350337","https://openalex.org/W2964418844","https://openalex.org/W4295028387","https://openalex.org/W2606416488","https://openalex.org/W2767127907","https://openalex.org/W2915875068","https://openalex.org/W2625606518","https://openalex.org/W3139058932"],"abstract_inverted_index":{"Potential":[0],"conflict":[1],"of":[2,20,26,38,53,90,96,109,184,220,244,269,287,309,329,339,370,469],"interest:":[3],"Nothing":[4],"to":[5,42,48,67,207,266,272,342,377,391,429,461],"report.":[6],"We":[7],"appreciate":[8],"Cholankeril":[9],"et":[10],"al.'s":[11],"interest":[12],"in":[13,131,147,158,169,192,210,216,229,290,354,362,366,448,463],"our":[14,39,132,185,202,230,291,314,335,355,449,453],"study":[15,40,133,231,235,402,454],"evaluating":[16],"the":[17,32,51,63,78,88,106,112,115,148,175,182,242,257,367,410,417,424,439,467],"optimal":[18],"timing":[19,52,468],"hepatitis":[21,346],"C":[22],"virus":[23],"(HCV)":[24],"treatment":[25,55,144,310,447],"decompensated":[27,172],"patients":[28,97,110,170,289,299,318,340],"with":[29,171,300,311,319],"cirrhosis":[30,173],"on":[31,77,111,174,188,241],"transplant":[33,92,176,380,397],"waiting":[34,113,177,394],"list.1":[35],"The":[36,337],"purpose":[37],"was":[41,145,227,351],"provide":[43],"a":[44,238,301,320,379,396,456,459],"guide":[45],"for":[46,81,87,105,117,124,141,360,395,442],"clinicians":[47,462],"help":[49],"determine":[50],"HCV":[54,69,143,163,288,326,446,470],"pre\u2010":[56],"versus":[57,167,385,399,444],"posttransplantation.":[58],"Our":[59,233,357,401],"model's":[60],"recommendations":[61],"that":[62,104,256,297,317,423],"threshold":[64,140,441],"below":[65],"which":[66],"treat":[68],"pretransplantation":[70,125,142,166,325,443],"is":[71,164,277,347],"between":[72,250],"23":[73],"and":[74,152,213,252,254,387,412,421,474],"27,":[75],"depending":[76],"United":[79],"Network":[80],"Organ":[82],"Sharing":[83],"(UNOS)":[84],"region,":[85],"holds":[86],"majority":[89,108],"liver":[91],"candidates.":[93],"Further":[94],"analysis":[95,240,262,406],"subdivided":[98],"by":[99,179,479],"ABO":[100],"blood":[101,154,180],"groups":[102],"demonstrated":[103],"vast":[107],"list,":[114],"Model":[116],"End\u2010Stage":[118],"Liver":[119],"Disease":[120],"(MELD)":[121],"score":[122,195,303,322],"thresholds":[123],"direct\u2010acting":[126],"antiviral":[127],"(DAA)":[128],"therapy":[129],"presented":[130],"remain":[134],"unchanged":[135],"(Fig.":[136],"1).":[137],"A":[138],"lower":[139],"observed":[146],"less":[149,389],"common":[150],"AB":[151],"B":[153],"groups.Figure":[155],"1:":[156],"Difference":[157],"life":[159],"years":[160],"(LY)":[161],"if":[162],"treated":[165],"posttransplantation":[168,445],"list":[178],"type.At":[181],"time":[183],"analysis,":[186],"data":[187,212,295],"2016":[189],"regional":[190],"variations":[191],"mean":[193],"MELD":[194,302,321,440,480],"at":[196],"LT":[197],"were":[198,374,388,426],"not":[199,278,284,332,352,427,437,458,477],"available.":[200],"However,":[201],"model":[203,315,358],"can":[204,263],"be":[205,264,483],"updated":[206],"accommodate":[208],"changes":[209],"UNOS":[211],"future":[214],"trends":[215],"transplantation":[217,268,411],"practice.":[218,280],"Transplantation":[219],"HCV\u2010positive":[221,225,246,270],"donor":[222,247],"grafts":[223,248,271],"into":[224,485],"recipients":[226],"included":[228,237,353,404],"model.":[232],"published":[234],"already":[236,403],"sensitivity":[239,405],"percentage":[243],"usable":[245],"ranging":[249],"5%":[251],"15%":[253],"found":[255,422],"results":[258,425],"remained":[259],"robust.":[260],"Future":[261],"constructed":[265],"incorporate":[267],"HCV\u2010negative":[273],"recipients;":[274],"however,":[275],"this":[276,350],"current":[279],"Although":[281],"we":[282,408],"did":[283],"consider":[285],"delisting":[286],"model,":[292],"recent":[293],"clinical":[294],"show":[296],"no":[298],">20":[304],"have":[305,333],"been":[306],"delisted":[307],"because":[308],"DAAs.2":[312],"Because":[313],"recommended":[316],"\u226423":[323],"receive":[324,378],"treatment,":[327],"consideration":[328,486],"\u201cdelisting\u201d":[330],"would":[331,436],"changed":[334,409],"conclusions.":[336],"number":[338],"expected":[341],"develop":[343],"fibrosing":[344],"cholestatic":[345],"low;":[348],"therefore,":[349],"study.":[356],"accounted":[359],"reduction":[361],"retransplantation":[363],"rates.":[364],"Candidates":[365],"postimplementation":[368],"era":[369],"Regional":[371,433],"Share":[372,434],"35":[373,435],"more":[375],"likely":[376,390],"within":[381],"90":[382],"days":[383],"(66%":[384],"59%),":[386],"die":[392],"while":[393,487],"(25%":[398],"32%).3":[400],"wherein":[407],"mortality":[413],"rates":[414],"\u00b125%":[415],"from":[416],"base":[418],"case":[419],"values":[420],"sensitive":[428],"these":[430],"parameters.":[431],"Therefore,":[432],"change":[438],"analysis.":[450],"In":[451],"conclusion,":[452],"provides":[455],"guide,":[457],"directive,":[460],"making":[464,488],"decisions":[465],"about":[466],"treatment.":[471],"Patient":[472],"preferences":[473],"medical":[475],"urgency":[476],"captured":[478],"scores":[481],"should":[482],"taken":[484],"such":[489],"decisions.":[490]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2019-02-21T00:00:00"}