{"id":"https://openalex.org/W2913226767","doi":"https://doi.org/10.1016/j.bbmt.2018.12.452","title":"Reduced Oral Nutrition Contributes to Gastrointestinal Toxicity of Total Body Irradiation Via Changes to the Gut Microbiome","display_name":"Reduced Oral Nutrition Contributes to Gastrointestinal Toxicity of Total Body Irradiation Via Changes to the Gut Microbiome","publication_year":2019,"publication_date":"2019-01-31","ids":{"openalex":"https://openalex.org/W2913226767","doi":"https://doi.org/10.1016/j.bbmt.2018.12.452","mag":"2913226767"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbmt.2018.12.452","doi":"https://doi.org/10.1016/j.bbmt.2018.12.452","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2018.12.452","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbmt.2018.12.452","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029068529","display_name":"Zaker I. Schwabkey","orcid":"https://orcid.org/0000-0002-2010-0493","observed_orcids":["https://orcid.org/0000-0002-2010-0493"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaker Schwabkey","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008682190","display_name":"Diana H. Wiesnoski","orcid":"https://orcid.org/0000-0003-0546-8422","observed_orcids":["https://orcid.org/0000-0003-0546-8422"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Wiesnoski","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076406568","display_name":"Dung Pham","orcid":"https://orcid.org/0000-0002-0985-2109","observed_orcids":["https://orcid.org/0000-0002-0985-2109"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dung Pham","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher Sanchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Sanchez","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079164346","display_name":"Miriam R. Ortega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Ortega Turrubiates","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058607368","display_name":"Saira Ahmed","orcid":"https://orcid.org/0009-0007-0520-1089","observed_orcids":["https://orcid.org/0009-0007-0520-1089"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saira Ahmed","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050696603","display_name":"Jennifer L. Karmouch","orcid":"https://orcid.org/0000-0003-1148-1535","observed_orcids":["https://orcid.org/0000-0003-1148-1535","https://orcid.org/0009-0000-9360-4898"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Karmouch","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086836518","display_name":"Wen-Bin Tsai","orcid":"https://orcid.org/0000-0001-8210-5882","observed_orcids":["https://orcid.org/0000-0001-8210-5882"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-Bin Tsai","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078475971","display_name":"Chia\u2010Chi Chang","orcid":"https://orcid.org/0000-0003-0050-1705","observed_orcids":["https://orcid.org/0000-0003-0050-1705","https://orcid.org/0000-0001-5370-9433"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Chi Chang","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062402710","display_name":"Mohamed A. Jamal","orcid":"https://orcid.org/0000-0003-3404-2535","observed_orcids":["https://orcid.org/0000-0003-3404-2535"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Jamal","raw_affiliation_strings":["MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025089795","display_name":"Robert R. Jenq","orcid":"https://orcid.org/0000-0002-5434-439X","observed_orcids":["https://orcid.org/0000-0002-5434-439X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert R. Jenq","raw_affiliation_strings":["Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, MD Anderson Cancer Center, University of Texas, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, MD Anderson Cancer Center, University of Texas, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01220139,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"3","first_page":"S155","last_page":"S155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.984000027179718},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.996999979019165},{"id":"https://openalex.org/keywords/akkermansia-muciniphila","display_name":"Akkermansia muciniphila","score":0.9269999861717224},{"id":"https://openalex.org/keywords/bacteroides-thetaiotaomicron","display_name":"Bacteroides thetaiotaomicron","score":0.9980000257492065},{"id":"https://openalex.org/keywords/intestinal-barrier-function","display_name":"intestinal barrier function","score":0.9869999885559082},{"id":"https://openalex.org/keywords/colonic-mucus-layer","display_name":"colonic mucus layer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/prebiotic-supplementation","display_name":"prebiotic supplementation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/glucose-supplementation","display_name":"glucose supplementation","score":0.45500001311302185},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2775941767","wikidata":"https://www.wikidata.org/wiki/Q15020908","display_name":"Akkermansia muciniphila","level":3,"score":0.9277365803718567},{"id":"https://openalex.org/C2776109033","wikidata":"https://www.wikidata.org/wiki/Q3884023","display_name":"Akkermansia","level":4,"score":0.8224495649337769},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6300111413002014},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.5535436868667603},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5228571891784668},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4918406009674072},{"id":"https://openalex.org/C2777507495","wikidata":"https://www.wikidata.org/wiki/Q185317","display_name":"Cecum","level":2,"score":0.48941221833229065},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4747351109981537},{"id":"https://openalex.org/C2908934157","wikidata":"https://www.wikidata.org/wiki/Q798597","display_name":"Bacteroides thetaiotaomicron","level":4,"score":0.47093716263771057},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4419451355934143},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3853936195373535},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3488006591796875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32875460386276245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2877189517021179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28455424308776855},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.10824722051620483},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bbmt.2018.12.452","doi":"https://doi.org/10.1016/j.bbmt.2018.12.452","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2018.12.452","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bbmt.2018.12.452","doi":"https://doi.org/10.1016/j.bbmt.2018.12.452","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbmt.2018.12.452","pdf_url":null,"source":{"id":"https://openalex.org/S59987174","display_name":"Transplantation and Cellular Therapy","issn_l":"1083-8791","issn":["1083-8791","1523-6536","2666-6367"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Blood and Marrow Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2911258274","https://openalex.org/W2973141205","https://openalex.org/W3200644121","https://openalex.org/W3093875586","https://openalex.org/W3208100646","https://openalex.org/W3029874760","https://openalex.org/W4403041824","https://openalex.org/W4223456394","https://openalex.org/W3208099330","https://openalex.org/W4417024267"],"abstract_inverted_index":{"Reduced":[0],"oral":[1,52,103,273,365],"nutrition":[2],"(RON)":[3],"is":[4,394],"common":[5],"after":[6],"cytotoxic":[7,388],"therapy":[8],"for":[9,130],"hematologic":[10],"malignancies.":[11],"We":[12,292],"examined":[13],"the":[14,66,121,200,268,287,298,301,311,331,375,387,391,400,431],"interplay":[15],"between":[16],"nutrition,":[17],"intestinal":[18,21,98,169,240,351,401,432],"bacteria":[19,77,191],"and":[20,58,80,94,152,206,223,225,281,307,356,393],"barrier":[22,99,170,352],"function":[23,100,171,353],"in":[24,51,65,137,163,199,264,286,314,321,340,399,427],"mouse":[25],"models":[26],"of":[27,38,42,75,90,97,123,128,143,149,189,219,232,243,254,270,272,290,310,326,330,350,374,386,406],"total":[28,368],"body":[29,92,369],"irradiation":[30,370],"(TBI).":[31],"By":[32],"3":[33,59],"days":[34,60],"following":[35,145,323,367],"9":[36,324],"Gy":[37,325],"a":[39,277,282],"single":[40],"dose":[41],"TBI,":[43,146,327],"C57BL/6":[44],"mice":[45,86,125,139,165,315,322],"had":[46],"an":[47,73,246,379],"approximately":[48],"50%":[49],"reduction":[50],"intake":[53,366],"(2g/day,":[54],"data":[55],"not":[56,108,175,259,305],"shown)":[57,306],"later":[61,336],"displayed":[62],"marked":[63],"changes":[64,141,398],"microbiome":[67,117,134],"by":[68,102,238,275,397],"16S":[69],"deep":[70],"sequencing,":[71],"including":[72,147,403],"expansion":[74,148],"mucolytic":[76,183],"Akkermansia":[78,150],"muciniphila":[79,151],"Bacteroides":[81,153],"thetaiotaomicron":[82,154],"(Fig":[83,155,166,204,213,228,318,344,354,360],"1).":[84,156],"These":[85],"lost":[87],"roughly":[88],"20%":[89],"their":[91],"weight":[93,342],"showed":[95,210],"compromise":[96,349],"assayed":[101],"challenge":[104],"with":[105,140,252,297,414,422],"FITC-dextran":[106],"(data":[107,174,258,304],"shown).":[109,176,260],"To":[110,177],"ask":[111],"if":[112],"RON":[113,180,203,266,317],"could":[114,181],"be":[115,250,384],"driving":[116],"changes,":[118],"we":[119,185,262],"limited":[120],"access":[122],"unirradiated":[124],"to":[126,249,372,383,410,430],"2g/day":[127],"chow":[129],"7":[131],"days.":[132],"The":[133,157],"was":[135,161,337],"perturbed":[136],"these":[138,164],"reminiscent":[142],"that":[144,294,381],"colonic":[158,190,207,302,376,412],"mucus":[159,312,377],"layer":[160,313],"thinned":[162],"2),":[167,205],"though":[168],"remained":[172],"intact":[173],"explore":[178],"how":[179],"favor":[182],"bacteria,":[184],"characterized":[186],"metabolic":[187],"activity":[188],"during":[192,202],"RON.":[193],"Bomb":[194],"calorimetry":[195],"demonstrated":[196],"reduced":[197,211,364,404],"substrates":[198],"cecum":[201],"luminal":[208],"pH":[209],"acidity":[212,413],"2).":[214,229],"IC-MS":[215],"quantified":[216],"lower":[217],"concentrations":[218],"acetate,":[220],"propionate,":[221],"butyrate,":[222],"lactate,":[224],"elevated":[226],"succinate":[227,257],"RNA":[230],"sequencing":[231],"stool":[233],"samples":[234],"revealed":[235],"broad":[236],"downregulation":[237],"several":[239],"bacterial":[241],"species":[242],"phosphoenolpyruvate":[244],"carboxykinase,":[245],"enzyme":[247],"known":[248],"associated":[251],"production":[253],"propionate":[255],"from":[256],"Finally,":[261],"evaluated":[263],"our":[265],"model":[267],"impact":[269],"administration":[271],"sugars":[274,416],"supplementing":[276],"well-absorbed":[278],"sugar":[279,285,295],"(glucose),":[280],"poorly-absorbed":[283],"prebiotic":[284,299,332,415],"drinking":[288],"water":[289],"mice.":[291],"found":[293],"supplementation":[296],"acidified":[300],"lumen":[303],"prevented":[308],"thinning":[309,373],"undergoing":[316],"3).":[319,361],"Additionally,":[320],"daily":[328],"dosing":[329],"started":[333],"24":[334],"hours":[335],"highly":[338],"effective":[339],"preventing":[341,428],"loss":[343],"3),":[345,355],"nearly":[346],"completely":[347],"abrogated":[348],"improved":[357],"overall":[358],"survival":[359],"In":[362],"summary,":[363],"contributes":[371],"layer,":[378],"effect":[380],"appears":[382],"independent":[385],"effects":[389],"on":[390],"host":[392],"rather":[395],"mediated":[396],"microbiome,":[402],"metabolism":[405],"organic":[407],"acids.":[408],"Strategies":[409],"restore":[411],"may":[417],"successfully":[418],"target":[419],"this":[420],"phenomenon":[421],"potential":[423],"clinical":[424],"benefits,":[425],"particularly":[426],"disruption":[429],"barrier.":[433]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2019-02-21T00:00:00"}