{"id":"https://openalex.org/W2913170358","doi":"https://doi.org/10.1038/s12276-019-0205-7","title":"Inhibition of \u03b2-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure\u2212activity relationship with a strong BBB permeability","display_name":"Inhibition of \u03b2-site amyloid precursor protein cleaving enzyme 1 and cholinesterases by pterosins via a specific structure\u2212activity relationship with a strong BBB permeability","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2913170358","doi":"https://doi.org/10.1038/s12276-019-0205-7","mag":"2913170358","pmid":"https://pubmed.ncbi.nlm.nih.gov/30755593","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6372667"},"language":"en","primary_location":{"id":"doi:10.1038/s12276-019-0205-7","doi":"https://doi.org/10.1038/s12276-019-0205-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-019-0205-7","pdf_url":"https://www.nature.com/articles/s12276-019-0205-7.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s12276-019-0205-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008385734","display_name":"Susoma Jannat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Susoma Jannat","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Medicine, Korea Molecular Medicine and Nutrition Research Institute, Korea University, Seoul, 02841, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, Korea Molecular Medicine and Nutrition Research Institute, Korea University, Seoul, 02841, Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044322881","display_name":"Anand Balupuri","orcid":"https://orcid.org/0000-0002-2904-0650","observed_orcids":["https://orcid.org/0000-0002-2904-0650"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Anand Balupuri","raw_affiliation_strings":["Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, 34134, Korea"],"raw_orcid":"https://orcid.org/0000-0002-2904-0650","affiliations":[{"raw_affiliation_string":"Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, 34134, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006362992","display_name":"Md Yousof Ali","orcid":"https://orcid.org/0000-0003-1488-5711","observed_orcids":["https://orcid.org/0000-0003-1488-5711"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I60158472","display_name":"Concordia University","ror":"https://ror.org/0420zvk78","country_code":"CA","type":"education","lineage":["https://openalex.org/I60158472"]}],"countries":["CA","KR"],"is_corresponding":false,"raw_author_name":"Md Yousof Ali","raw_affiliation_strings":["Center for Structural and Functional Genomic, Department of Biology, Faculty of Arts and Science, Concordia University, 7141 Sherbrooke St. W., Montreal, QC, H4B 1R6, Canada","Department of Biochemistry and Molecular Biology, College of Medicine, Korea Molecular Medicine and Nutrition Research Institute, Korea University, Seoul, 02841, Korea","Department of Chemistry and Biochemistry, Faculty of Arts and Science, Concordia University, 7141 Sherbrooke St. W., Montreal, QC, H4B 1R6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Structural and Functional Genomic, Department of Biology, Faculty of Arts and Science, Concordia University, 7141 Sherbrooke St. W., Montreal, QC, H4B 1R6, Canada","institution_ids":["https://openalex.org/I60158472"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, Korea Molecular Medicine and Nutrition Research Institute, Korea University, Seoul, 02841, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Faculty of Arts and Science, Concordia University, 7141 Sherbrooke St. W., Montreal, QC, H4B 1R6, Canada","institution_ids":["https://openalex.org/I60158472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030583130","display_name":"Seong Su Hong","orcid":"https://orcid.org/0000-0002-2498-7546","observed_orcids":["https://orcid.org/0000-0002-2498-7546"]},"institutions":[{"id":"https://openalex.org/I4405260488","display_name":"Gyeonggido Business and Science Accelerator","ror":"https://ror.org/03tpec229","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405260488"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seong Su Hong","raw_affiliation_strings":["Bio-Center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Korea"],"raw_orcid":"https://orcid.org/0000-0002-2498-7546","affiliations":[{"raw_affiliation_string":"Bio-Center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Korea","institution_ids":["https://openalex.org/I4405260488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056425639","display_name":"Chun Whan Choi","orcid":"https://orcid.org/0000-0003-4450-9813","observed_orcids":["https://orcid.org/0000-0003-4450-9813"]},"institutions":[{"id":"https://openalex.org/I4405260488","display_name":"Gyeonggido Business and Science Accelerator","ror":"https://ror.org/03tpec229","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405260488"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chun Whan Choi","raw_affiliation_strings":["Bio-Center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Korea","institution_ids":["https://openalex.org/I4405260488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086449586","display_name":"Yun\u2010Hyeok Choi","orcid":"https://orcid.org/0000-0002-0909-0677","observed_orcids":["https://orcid.org/0000-0002-0909-0677"]},"institutions":[{"id":"https://openalex.org/I4405260488","display_name":"Gyeonggido Business and Science Accelerator","ror":"https://ror.org/03tpec229","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405260488"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun-Hyeok Choi","raw_affiliation_strings":["Bio-Center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Korea","institution_ids":["https://openalex.org/I4405260488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015158338","display_name":"Jin\u2010Mo Ku","orcid":"https://orcid.org/0000-0003-0218-810X","observed_orcids":["https://orcid.org/0000-0003-0218-810X"]},"institutions":[{"id":"https://openalex.org/I4405260488","display_name":"Gyeonggido Business and Science Accelerator","ror":"https://ror.org/03tpec229","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405260488"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin-Mo Ku","raw_affiliation_strings":["Bio-Center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Korea","institution_ids":["https://openalex.org/I4405260488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073850293","display_name":"Woo Jung Kim","orcid":"https://orcid.org/0000-0002-4963-4819","observed_orcids":["https://orcid.org/0000-0002-4963-4819"]},"institutions":[{"id":"https://openalex.org/I4405260488","display_name":"Gyeonggido Business and Science Accelerator","ror":"https://ror.org/03tpec229","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405260488"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo Jung Kim","raw_affiliation_strings":["Bio-Center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Center, Gyeonggido Business & Science Accelerator, Suwon, 16229, Korea","institution_ids":["https://openalex.org/I4405260488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062917563","display_name":"Jae Yoon Leem","orcid":"https://orcid.org/0000-0001-6639-7950","observed_orcids":["https://orcid.org/0000-0001-6639-7950"]},"institutions":[{"id":"https://openalex.org/I7446070","display_name":"Woosuk University","ror":"https://ror.org/00emz0366","country_code":"KR","type":"education","lineage":["https://openalex.org/I7446070"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Yoon Leem","raw_affiliation_strings":["College of Pharmacy, Woosuk University, Wanju, Jeonbuk, 55338, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Woosuk University, Wanju, Jeonbuk, 55338, Korea","institution_ids":["https://openalex.org/I7446070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103252650","display_name":"Ju Eun Kim","orcid":"https://orcid.org/0000-0002-7056-3234","observed_orcids":["https://orcid.org/0000-0002-7056-3234"]},"institutions":[{"id":"https://openalex.org/I7446070","display_name":"Woosuk University","ror":"https://ror.org/00emz0366","country_code":"KR","type":"education","lineage":["https://openalex.org/I7446070"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju Eun Kim","raw_affiliation_strings":["College of Pharmacy, Woosuk University, Wanju, Jeonbuk, 55338, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Woosuk University, Wanju, Jeonbuk, 55338, Korea","institution_ids":["https://openalex.org/I7446070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101451281","display_name":"Abinash Chandra Shrestha","orcid":"https://orcid.org/0009-0005-0077-1563","observed_orcids":["https://orcid.org/0009-0005-0077-1563"]},"institutions":[{"id":"https://openalex.org/I7446070","display_name":"Woosuk University","ror":"https://ror.org/00emz0366","country_code":"KR","type":"education","lineage":["https://openalex.org/I7446070"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Abinash Chandra Shrestha","raw_affiliation_strings":["College of Pharmacy, Woosuk University, Wanju, Jeonbuk, 55338, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Woosuk University, Wanju, Jeonbuk, 55338, Korea","institution_ids":["https://openalex.org/I7446070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090591703","display_name":"Ha Neul Ham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7446070","display_name":"Woosuk University","ror":"https://ror.org/00emz0366","country_code":"KR","type":"education","lineage":["https://openalex.org/I7446070"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ha Neul Ham","raw_affiliation_strings":["College of Pharmacy, Woosuk University, Wanju, Jeonbuk, 55338, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Woosuk University, Wanju, Jeonbuk, 55338, Korea","institution_ids":["https://openalex.org/I7446070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066401603","display_name":"Kee-Ho Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088603","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210088603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kee-Ho Lee","raw_affiliation_strings":["Division of Radiation Cancer Research, Korea Institute of Radiological and Biomedical Sciences, Seoul, 01812, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Cancer Research, Korea Institute of Radiological and Biomedical Sciences, Seoul, 01812, Korea","institution_ids":["https://openalex.org/I4210088603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424844","display_name":"Dong\u2010Min Kim","orcid":"https://orcid.org/0000-0001-6373-0922","observed_orcids":["https://orcid.org/0000-0001-6373-0922","https://orcid.org/0000-0003-4404-6214"]},"institutions":[{"id":"https://openalex.org/I70591777","display_name":"Jeonju University","ror":"https://ror.org/015v9d997","country_code":"KR","type":"education","lineage":["https://openalex.org/I70591777"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong Min Kim","raw_affiliation_strings":["Department of Creative Arts Psychotherapy, College of Cultural Convergence, Jeonju University, Jeonju, 55069, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Creative Arts Psychotherapy, College of Cultural Convergence, Jeonju University, Jeonju, 55069, Korea","institution_ids":["https://openalex.org/I70591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077108846","display_name":"Nam Sook Kang","orcid":"https://orcid.org/0000-0002-7854-0256","observed_orcids":["https://orcid.org/0000-0002-7854-0256"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Nam Sook Kang","raw_affiliation_strings":["Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, 34134, Korea. nskang@cnu.ac.kr","Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, 34134, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, 34134, Korea. nskang@cnu.ac.kr","institution_ids":["https://openalex.org/I196345858"]},{"raw_affiliation_string":"Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, 34134, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006730218","display_name":"Gil Hong Park","orcid":"https://orcid.org/0000-0002-7879-6729","observed_orcids":["https://orcid.org/0000-0002-7879-6729"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Gil Hong Park","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, College of Medicine, Korea Molecular Medicine and Nutrition Research Institute, Korea University, Seoul, 02841, Korea. ghpark@korea.ac.kr","Department of Biochemistry and Molecular Biology, College of Medicine, Korea Molecular Medicine and Nutrition Research Institute, Korea University, Seoul, 02841, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, Korea Molecular Medicine and Nutrition Research Institute, Korea University, Seoul, 02841, Korea. ghpark@korea.ac.kr","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, College of Medicine, Korea Molecular Medicine and Nutrition Research Institute, Korea University, Seoul, 02841, Korea","institution_ids":["https://openalex.org/I197347611"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5006730218","https://openalex.org/A5077108846"],"corresponding_institution_ids":["https://openalex.org/I196345858","https://openalex.org/I197347611"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":{"value":3150,"currency":"USD","value_usd":3150},"fwci":3.1484,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.91232877,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"51","issue":"2","first_page":"1","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.09860000014305115,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pterosins","display_name":"pterosins","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pteridium-aquilinum","display_name":"Pteridium aquilinum","score":0.9480000138282776},{"id":"https://openalex.org/keywords/bace1-inhibition","display_name":"BACE1 inhibition","score":0.9020000100135803},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.8840000033378601},{"id":"https://openalex.org/keywords/butyrylcholinesterase","display_name":"butyrylcholinesterase","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8949999809265137},{"id":"https://openalex.org/keywords/multitarget-directed-ligands","display_name":"multi-target-directed ligands","score":0.8379999995231628},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.9139999747276306},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8379999995231628},{"id":"https://openalex.org/keywords/amyloid-beta-secretion","display_name":"amyloid-beta secretion","score":0.6930000185966492},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.5839999914169312},{"id":"https://openalex.org/keywords/mixed-inhibition","display_name":"mixed-type inhibition","score":0.8349999785423279},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6259999871253967},{"id":"https://openalex.org/keywords/natural-product-drug-discovery","display_name":"natural product drug discovery","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C2779101902","wikidata":"https://www.wikidata.org/wiki/Q22679015","display_name":"Butyrylcholinesterase","level":5,"score":0.8139709234237671},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.6987248659133911},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5924444198608398},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5675420165061951},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5603125691413879},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5262205600738525},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.46005791425704956},{"id":"https://openalex.org/C2779059548","wikidata":"https://www.wikidata.org/wiki/Q383701","display_name":"Ach\u00e9","level":4,"score":0.385689377784729},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.329446941614151},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18380069732666016}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016282","descriptor_name":"Aspartic Acid Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s12276-019-0205-7","doi":"https://doi.org/10.1038/s12276-019-0205-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-019-0205-7","pdf_url":"https://www.nature.com/articles/s12276-019-0205-7.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5378318","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6372667","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:30755593","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30755593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6372667","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6372667/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Mol Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5ae3be2dc39f46c2984bc757d6b01c33","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5ae3be2dc39f46c2984bc757d6b01c33","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Experimental and Molecular Medicine, Vol 51, Iss 2, Pp 1-18 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s12276-019-0205-7","doi":"https://doi.org/10.1038/s12276-019-0205-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-019-0205-7","pdf_url":"https://www.nature.com/articles/s12276-019-0205-7.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317035","display_name":"Korea University Medicine","ror":"https://ror.org/02cs2sd33"},{"id":"https://openalex.org/F4320321373","display_name":"Korea University","ror":"https://ror.org/047dqcg40"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913170358.pdf","grobid_xml":"https://content.openalex.org/works/W2913170358.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1480424806","https://openalex.org/W1487926242","https://openalex.org/W1501358501","https://openalex.org/W1518671319","https://openalex.org/W1526205344","https://openalex.org/W1537934758","https://openalex.org/W1561647671","https://openalex.org/W1575834956","https://openalex.org/W1600934558","https://openalex.org/W1604272660","https://openalex.org/W1957558887","https://openalex.org/W1968121507","https://openalex.org/W1971048984","https://openalex.org/W1971352874","https://openalex.org/W1980458121","https://openalex.org/W1981737096","https://openalex.org/W1981775239","https://openalex.org/W1985215852","https://openalex.org/W1987285401","https://openalex.org/W1989972829","https://openalex.org/W1995592726","https://openalex.org/W2004349171","https://openalex.org/W2008757745","https://openalex.org/W2017327362","https://openalex.org/W2017930992","https://openalex.org/W2026075028","https://openalex.org/W2026976753","https://openalex.org/W2028733293","https://openalex.org/W2033386084","https://openalex.org/W2036007751","https://openalex.org/W2037083212","https://openalex.org/W2038416797","https://openalex.org/W2039851764","https://openalex.org/W2041921010","https://openalex.org/W2042368905","https://openalex.org/W2047418563","https://openalex.org/W2060080453","https://openalex.org/W2060153789","https://openalex.org/W2062225334","https://openalex.org/W2062572062","https://openalex.org/W2065457701","https://openalex.org/W2073471715","https://openalex.org/W2075304800","https://openalex.org/W2075778898","https://openalex.org/W2076425642","https://openalex.org/W2077023698","https://openalex.org/W2078779360","https://openalex.org/W2078944820","https://openalex.org/W2086708877","https://openalex.org/W2096410114","https://openalex.org/W2096457412","https://openalex.org/W2105668062","https://openalex.org/W2108398795","https://openalex.org/W2111863354","https://openalex.org/W2112006614","https://openalex.org/W2114918609","https://openalex.org/W2118413978","https://openalex.org/W2124681501","https://openalex.org/W2124781790","https://openalex.org/W2131819352","https://openalex.org/W2133019124","https://openalex.org/W2138206059","https://openalex.org/W2157461655","https://openalex.org/W2158534713","https://openalex.org/W2159866533","https://openalex.org/W2162815565","https://openalex.org/W2167591585","https://openalex.org/W2169356930","https://openalex.org/W2177321685","https://openalex.org/W2228203932","https://openalex.org/W2258663952","https://openalex.org/W2310468402","https://openalex.org/W2325356125","https://openalex.org/W2329696749","https://openalex.org/W2337256556","https://openalex.org/W2408922740","https://openalex.org/W2411797827","https://openalex.org/W2414707881","https://openalex.org/W2414724543","https://openalex.org/W2419125106","https://openalex.org/W2465260549","https://openalex.org/W2770020522","https://openalex.org/W2785340737","https://openalex.org/W2969438869","https://openalex.org/W3014251530","https://openalex.org/W4247759744"],"related_works":["https://openalex.org/W2810309666","https://openalex.org/W2592351707","https://openalex.org/W2794546769","https://openalex.org/W4390640055","https://openalex.org/W2766865280","https://openalex.org/W2989057790","https://openalex.org/W3115328295","https://openalex.org/W2525284277","https://openalex.org/W4412599922","https://openalex.org/W4382932889"],"abstract_inverted_index":{"We":[0],"extracted":[1,182],"15":[2],"pterosin":[3,238],"derivatives":[4,239],"from":[5,152,183],"Pteridium":[6],"aquilinum":[7],"that":[8,155,168,237],"inhibited":[9,30],"\u03b2-site":[10,245],"amyloid":[11,246],"precursor":[12,159,247],"protein":[13,160,248],"cleaving":[14,249],"enzyme":[15,250],"1":[16],"(BACE1)":[17],"and":[18,34,43,50,56,59,76,100,106,118,141,202,228,253,268],"cholinesterases":[19],"involved":[20],"in":[21,255,303],"the":[22,63,88,92,114,119,147,187,213,242,260,273,284,307],"pathogenesis":[23],"of":[24,40,91,98,113,134,149,189,215,244,306],"Alzheimer\u2019s":[25,194],"disease":[26,195],"(AD).":[27,196],"(2R)-Pterosin":[28,67,122,139],"B":[29,68,123,140],"BACE1,":[31,57,104],"acetylcholinesterase":[32,252],"(AChE)":[33],"butyrylcholinesterase":[35,254],"(BChE)":[36],"with":[37,129,193],"an":[38,130,209],"IC50":[39,65],"29.6,":[41],"16.2":[42],"48.1":[44],"\u00b5M,":[45],"respectively.":[46],"The":[47],"Ki":[48],"values":[49],"binding":[51,86,110],"energies":[52],"(kcal/mol)":[53],"between":[54],"pterosins":[55,117,170],"AChE,":[58,85,105],"BChE":[60,77,107],"corresponded":[61],"to":[62,87,271,279,282,297],"respective":[64],"values.":[66],"was":[69],"a":[70,81,125,200,205,256],"noncompetitive":[71,101],"inhibitor":[72,83],"against":[73,84],"human":[74,157],"BACE1":[75],"as":[78,80],"well":[79],"mixed-type":[82,99],"active":[89],"sites":[90],"corresponding":[93],"enzymes.":[94],"Molecular":[95],"docking":[96],"simulation":[97],"inhibitors":[102],"for":[103,174,178,212],"indicated":[108],"novel":[109],"site-directed":[111],"inhibition":[112],"enzymes":[115,191],"by":[116,221],"structure\u2212activity":[120],"relationship.":[121],"exhibited":[124],"strong":[126],"BBB":[127],"permeability":[128,132],"effective":[131],"(Pe)":[133],"60.3\u00d710\u22126":[135],"cm/s":[136],"on":[137],"PAMPA-BBB.":[138],"(2R,3":[142],"R)-pteroside":[143],"C":[144],"significantly":[145],"decreased":[146],"secretion":[148],"A\u03b2":[150],"peptides":[151],"neuroblastoma":[153],"cells":[154],"overexpressed":[156],"\u03b2-amyloid":[158],"at":[161],"500":[162],"\u03bcM.":[163],"Conclusively,":[164],"our":[165],"study":[166,219],"suggested":[167],"several":[169],"are":[171],"potential":[172],"scaffolds":[173],"multitarget-directed":[175,206],"ligands":[176],"(MTDLs)":[177],"AD":[179,198,301],"therapeutics.":[180,217],"Compounds":[181],"bracken":[184],"fern":[185],"block":[186],"activity":[188,243],"three":[190],"associated":[192],"Because":[197],"is":[199,208,277],"complex":[201],"multifactorial":[203],"disease,":[204],"approach":[207],"attractive":[210],"strategy":[211],"development":[214],"disease-modifying":[216],"A":[218],"led":[220],"Gil":[222],"Hong":[223],"Park,":[224],"Korea":[225],"University,":[226,234],"Seoul,":[227],"Nam":[229],"Sook":[230],"Kang,":[231],"Chungnam":[232],"National":[233],"Daejon,":[235],"revealed":[236],"could":[240],"reduce":[241],"1,":[251],"concentration-dependent":[257],"manner.":[258],"Furthermore,":[259],"fern-extracted":[261],"compounds":[262],"did":[263],"not":[264],"cause":[265],"cellular":[266],"toxicity":[267],"were":[269],"able":[270],"cross":[272],"blood\u2013brain":[274],"barrier,":[275],"which":[276],"impermeable":[278],"most":[280],"drugs,":[281],"reach":[283],"brain.":[285],"Future":[286],"studies":[287],"will":[288],"determine":[289],"whether":[290],"they":[291],"can":[292],"be":[293],"developed":[294],"into":[295],"drugs":[296],"simultaneously":[298],"engage":[299],"various":[300],"targets":[302],"animal":[304],"models":[305],"disease.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-02-21T00:00:00"}