{"id":"https://openalex.org/W2913123771","doi":"https://doi.org/10.1093/ecco-jcc/jjaa004","title":"Treatment of Perianal Fistulas in Crohn\u2019s Disease, Seton Versus Anti-TNF Versus Surgical Closure Following Anti-TNF [PISA]: A Randomised Controlled Trial","display_name":"Treatment of Perianal Fistulas in Crohn\u2019s Disease, Seton Versus Anti-TNF Versus Surgical Closure Following Anti-TNF [PISA]: A Randomised Controlled Trial","publication_year":2020,"publication_date":"2020-01-09","ids":{"openalex":"https://openalex.org/W2913123771","doi":"https://doi.org/10.1093/ecco-jcc/jjaa004","mag":"2913123771","pmid":"https://pubmed.ncbi.nlm.nih.gov/31919501"},"language":"en","primary_location":{"id":"doi:10.1093/ecco-jcc/jjaa004","doi":"https://doi.org/10.1093/ecco-jcc/jjaa004","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjaa004","pdf_url":"https://academic.oup.com/ecco-jcc/article-pdf/doi/10.1093/ecco-jcc/jjaa004/32634125/jjaa004.pdf","source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/ecco-jcc/article-pdf/doi/10.1093/ecco-jcc/jjaa004/32634125/jjaa004.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060522553","display_name":"Karin A. T. G. M. Wasmann","orcid":"https://orcid.org/0000-0003-2295-238X","observed_orcids":["https://orcid.org/0000-0003-2295-238X"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Karin A Wasmann","raw_affiliation_strings":["Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050621572","display_name":"E. Joline de Groof","orcid":"https://orcid.org/0000-0002-7191-4964","observed_orcids":["https://orcid.org/0000-0002-7191-4964"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E Joline de Groof","raw_affiliation_strings":["Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076529837","display_name":"Merel Elisabeth Stellingwerf","orcid":"https://orcid.org/0000-0002-8447-6254","observed_orcids":["https://orcid.org/0000-0002-8447-6254"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Merel E Stellingwerf","raw_affiliation_strings":["Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-8447-6254","affiliations":[{"raw_affiliation_string":"Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057899912","display_name":"Geert D\u2019Haens","orcid":"https://orcid.org/0000-0003-2784-4046","observed_orcids":["https://orcid.org/0000-0003-2784-4046"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Geert R D\u2019Haens","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052219587","display_name":"Cyriel Y. Ponsioen","orcid":"https://orcid.org/0000-0001-5203-0453","observed_orcids":["https://orcid.org/0000-0001-5203-0453"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Cyriel Y Ponsioen","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069015142","display_name":"Krisztina Barbara Gecse","orcid":"https://orcid.org/0000-0003-4830-142X","observed_orcids":["https://orcid.org/0000-0003-4830-142X"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Krisztina B Gecse","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084817085","display_name":"Marcel G. W. Dijkgraaf","orcid":"https://orcid.org/0000-0003-0750-8790","observed_orcids":["https://orcid.org/0000-0003-0750-8790"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marcel G W Dijkgraaf","raw_affiliation_strings":["Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046884577","display_name":"Michael F. Gerhards","orcid":"https://orcid.org/0000-0001-6588-4917","observed_orcids":["https://orcid.org/0000-0001-6588-4917","https://orcid.org/0000-0002-2202-3268"]},"institutions":[{"id":"https://openalex.org/I4210105568","display_name":"OLVG","ror":"https://ror.org/01d02sf11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210105568"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michael F Gerhards","raw_affiliation_strings":["Department of Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210105568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101625172","display_name":"Jeroen M. Jansen","orcid":"https://orcid.org/0000-0002-7639-9527","observed_orcids":["https://orcid.org/0000-0002-7639-9527"]},"institutions":[{"id":"https://openalex.org/I4210105568","display_name":"OLVG","ror":"https://ror.org/01d02sf11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210105568"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen M Jansen","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210105568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108469299","display_name":"Apollo Pronk","orcid":"https://orcid.org/0000-0001-9777-7921","observed_orcids":["https://orcid.org/0000-0001-9777-7921"]},"institutions":[{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Apollo Pronk","raw_affiliation_strings":["Department of Surgery, Diakonessenhuis, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Diakonessenhuis, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210106388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059119457","display_name":"Sebastiaan A.C. van Tuyl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106388","display_name":"Diakonessenhuis hospital","ror":"https://ror.org/01nrpzj54","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210106388"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sebastiaan A C van Tuyl","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Diakonessenhuis, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Diakonessenhuis, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210106388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006256262","display_name":"David D. E. Zimmerman","orcid":"https://orcid.org/0000-0002-0393-9350","observed_orcids":["https://orcid.org/0000-0002-0393-9350"]},"institutions":[{"id":"https://openalex.org/I4210149554","display_name":"Elisabeth-TweeSteden Ziekenhuis","ror":"https://ror.org/04gpfvy81","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210149554"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"David D E Zimmerman","raw_affiliation_strings":["Department of Surgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands","institution_ids":["https://openalex.org/I4210149554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112037573","display_name":"Karlien F. Bruin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149554","display_name":"Elisabeth-TweeSteden Ziekenhuis","ror":"https://ror.org/04gpfvy81","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210149554"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Karlien F Bruin","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands","institution_ids":["https://openalex.org/I4210149554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025613587","display_name":"Antonino Spinelli","orcid":"https://orcid.org/0000-0002-1493-1768","observed_orcids":["https://orcid.org/0000-0002-1493-1768"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonino Spinelli","raw_affiliation_strings":["Department of Surgery, Humanitas Research Hospital and Humanitas University, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Humanitas Research Hospital and Humanitas University, Milan, Italy","institution_ids":["https://openalex.org/I1339471597","https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047563454","display_name":"Silvio Danese","orcid":"https://orcid.org/0000-0001-7341-1351","observed_orcids":["https://orcid.org/0000-0001-7341-1351"]},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvio Danese","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy","IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center- IRCCS-, Rozzano, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center- IRCCS-, Rozzano, Milan, Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113330536","display_name":"Jarmila D.W. van der Bilt","orcid":"https://orcid.org/0000-0003-0687-6778","observed_orcids":["https://orcid.org/0000-0003-0687-6778"]},"institutions":[{"id":"https://openalex.org/I4210117957","display_name":"Flevoziekenhuis","ror":"https://ror.org/02tqqrq23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210117957"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jarmila D W van der Bilt","raw_affiliation_strings":["Department of Surgery, Flevoziekenhuis, Almere, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Flevoziekenhuis, Almere, The Netherlands","institution_ids":["https://openalex.org/I4210117957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111879642","display_name":"Marco William Mundt","orcid":"https://orcid.org/0009-0008-6072-9430","observed_orcids":["https://orcid.org/0009-0008-6072-9430"]},"institutions":[{"id":"https://openalex.org/I4210117957","display_name":"Flevoziekenhuis","ror":"https://ror.org/02tqqrq23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210117957"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marco W Mundt","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Flevoziekenhuis, Almere, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Flevoziekenhuis, Almere, The Netherlands","institution_ids":["https://openalex.org/I4210117957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056187637","display_name":"Willem Adrianus Bemelman","orcid":"https://orcid.org/0000-0002-1037-9945","observed_orcids":["https://orcid.org/0000-0002-1037-9945"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Willem A Bemelman","raw_affiliation_strings":["Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067351502","display_name":"Christianne Johanna Buskens","orcid":"https://orcid.org/0000-0001-9425-8683","observed_orcids":["https://orcid.org/0000-0001-9425-8683"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Christianne J Buskens","raw_affiliation_strings":["Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5060522553","https://openalex.org/A5067351502"],"corresponding_institution_ids":["https://openalex.org/I4210151833"],"apc_list":{"value":4238,"currency":"EUR","value_usd":4790},"apc_paid":{"value":4238,"currency":"EUR","value_usd":4790},"fwci":10.6622,"has_fulltext":true,"cited_by_count":124,"citation_normalized_percentile":{"value":0.99053157,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"14","issue":"8","first_page":"1049","last_page":"1056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12518","display_name":"Diverticular Disease and Complications","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perianal-crohn-s-disease","display_name":"perianal Crohn's disease","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9553300142288208},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6922109723091125},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.6697102189064026},{"id":"https://openalex.org/C2776341189","wikidata":"https://www.wikidata.org/wiki/Q189470","display_name":"Fistula","level":2,"score":0.523465096950531},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5210292339324951},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5103325247764587},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4459215998649597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31813955307006836},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.31114596128463745}],"mesh":[{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000069285","descriptor_name":"Infliximab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000079424","descriptor_name":"Tumor Necrosis Factor Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010043","descriptor_name":"Outcome and Process Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010043","descriptor_name":"Outcome and Process Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010043","descriptor_name":"Outcome and Process Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010043","descriptor_name":"Outcome and Process Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012003","descriptor_name":"Rectal Fistula","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D012086","descriptor_name":"Reoperation","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D018447","descriptor_name":"Medical Futility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018447","descriptor_name":"Medical Futility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018447","descriptor_name":"Medical Futility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018447","descriptor_name":"Medical Futility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057239","descriptor_name":"Early Termination of Clinical Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057239","descriptor_name":"Early Termination of Clinical Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057239","descriptor_name":"Early Termination of Clinical Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057239","descriptor_name":"Early Termination of Clinical Trials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058106","descriptor_name":"Wound Closure Techniques","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D058106","descriptor_name":"Wound Closure Techniques","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D058106","descriptor_name":"Wound Closure Techniques","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D058106","descriptor_name":"Wound Closure Techniques","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D058106","descriptor_name":"Wound Closure Techniques","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D058106","descriptor_name":"Wound Closure Techniques","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D058106","descriptor_name":"Wound Closure Techniques","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D058106","descriptor_name":"Wound Closure Techniques","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D062072","descriptor_name":"Patient Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062072","descriptor_name":"Patient Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062072","descriptor_name":"Patient Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062072","descriptor_name":"Patient Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/ecco-jcc/jjaa004","doi":"https://doi.org/10.1093/ecco-jcc/jjaa004","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjaa004","pdf_url":"https://academic.oup.com/ecco-jcc/article-pdf/doi/10.1093/ecco-jcc/jjaa004/32634125/jjaa004.pdf","source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.3356856","doi":"https://doi.org/10.2139/ssrn.3356856","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.3356856","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:31919501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31919501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's & colitis","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/82cebd91-0a85-40b2-a1a1-857e44bcf88a","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/files/139505133/Treatment-of-perianal-fistulas-in-crohns-disease-seton-versus-anti-tnf-versus-surgical-closure-following-anti-tnf-pis.pdf","pdf_url":"https://pure.amsterdamumc.nl/ws/files/139505133/Treatment-of-perianal-fistulas-in-crohns-disease-seton-versus-anti-tnf-versus-surgical-closure-following-anti-tnf-pis.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7476637","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7476637","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Crohns Colitis","raw_type":"Text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/3f1e41f9-e0f7-49f4-9eca-31e67b8a9158","doi":null,"is_oa":true,"landing_page_url":"https://pure.amc.nl/en/publications/treatment-of-perianal-fistulas-in-crohns-disease-seton-versus-antitnf-versus-surgical-closure-following-antitnf-pisa-a-randomised-controlled-trial(3f1e41f9-e0f7-49f4-9eca-31e67b8a9158).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Crohn's & colitis, 14(8), 1049 - 1056. Elsevier","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/119581","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/119581","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/ecco-jcc/jjaa004","doi":"https://doi.org/10.1093/ecco-jcc/jjaa004","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjaa004","pdf_url":"https://academic.oup.com/ecco-jcc/article-pdf/doi/10.1093/ecco-jcc/jjaa004/32634125/jjaa004.pdf","source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G3005776638","display_name":null,"funder_award_id":"837002002","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G7608314772","display_name":null,"funder_award_id":"210270","funder_id":"https://openalex.org/F4320312926","funder_display_name":"Crohn's and Colitis Foundation"},{"id":"https://openalex.org/G7703713152","display_name":null,"funder_award_id":"510270","funder_id":"https://openalex.org/F4320312926","funder_display_name":"Crohn's and Colitis Foundation"}],"funders":[{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320314828","display_name":"European Society of Coloproctology","ror":"https://ror.org/04fscsb26"},{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913123771.pdf","grobid_xml":"https://content.openalex.org/works/W2913123771.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W169909737","https://openalex.org/W1560595865","https://openalex.org/W1625912164","https://openalex.org/W1991158789","https://openalex.org/W2086781058","https://openalex.org/W2093662765","https://openalex.org/W2105423417","https://openalex.org/W2122113760","https://openalex.org/W2130345070","https://openalex.org/W2139347841","https://openalex.org/W2154072446","https://openalex.org/W2251103812","https://openalex.org/W2272079729","https://openalex.org/W2326330820","https://openalex.org/W2337491308","https://openalex.org/W2413861456","https://openalex.org/W2484699560","https://openalex.org/W2792619654","https://openalex.org/W2981158081"],"related_works":["https://openalex.org/W2355769538","https://openalex.org/W2081816252","https://openalex.org/W2373885168","https://openalex.org/W2112436308","https://openalex.org/W2362391294","https://openalex.org/W3139914494","https://openalex.org/W1556819926","https://openalex.org/W3214521508","https://openalex.org/W3179965273","https://openalex.org/W2151333571"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,63,106,156,194,209],"Aims":[3],"Most":[4],"patients":[5,49,126,165],"with":[6,13,29,50,61,65,79,84,127,185],"perianal":[7,51,81,206,255],"Crohn\u2019s":[8,52,82,256],"fistula":[9],"receive":[10],"medical":[11],"treatment":[12,23,140,182,216,230,245,253],"anti-tumour":[14],"necrosis":[15],"factor":[16],"[TNF],":[17],"but":[18],"the":[19,122,162,173,186,214,222,251],"results":[20,240],"of":[21,38,125,161,179,211,227],"anti-TNF":[22,62,101,193],"have":[24],"not":[25,232,247],"been":[26],"directly":[27],"compared":[28,60,64],"chronic":[30,45,94,228,243],"seton":[31,46,95,229,244],"drainage":[32,47,96],"or":[33],"surgical":[34,66,108,196],"closure.":[35,67],"The":[36,118,168,239],"aim":[37],"this":[39],"study":[40,169],"was":[41,72,121,170,183,231],"to":[42,137],"assess":[43],"if":[44],"for":[48,97,103,234,254],"disease":[53,207],"fistulas":[54,83],"would":[55],"result":[56],"in":[57,74,144,205,221],"less":[58],"re-interventions,":[59],"Methods":[68],"This":[69],"randomised":[70],"trial":[71],"performed":[73],"19":[75],"European":[76],"centres.":[77],"Patients":[78,133],"high":[80],"a":[85,114,138,145],"single":[86],"internal":[87],"opening":[88],"were":[89,142,166,218],"randomly":[90],"assigned":[91],"to:":[92],"i]":[93],"1":[98,104],"year;":[99,105],"ii]":[100],"therapy":[102],"iii]":[107],"closure":[109,197],"after":[110],"2":[111],"months":[112],"under":[113],"short":[115],"course":[116],"anti-TNF.":[117],"primary":[119],"outcome":[120,236],"cumulative":[123],"number":[124],"fistula-related":[128],"re-intervention[s]":[129],"at":[130],"1.5":[131],"years.":[132],"declining":[134],"randomisation":[135],"due":[136],"specific":[139],"preference":[141],"included":[143],"parallel":[146],"prospective":[147,224],"PISA":[148,223],"registry":[149],"cohort.":[150],"Results":[151],"Between":[152],"September":[153],"14,":[154],"2013":[155],"November":[157],"20,":[158],"2017,":[159],"44":[160],"126":[163],"planned":[164],"randomised.":[167],"stopped":[171],"by":[172],"data":[174],"safety":[175],"monitoring":[176],"board":[177],"because":[178],"futility.":[180],"Seton":[181],"associated":[184],"highest":[187],"re-intervention":[188],"rate":[189],"[10/15,":[190],"versus":[191],"6/15":[192],"3/14":[195],"patients,":[198],"p":[199],"=":[200],"0.02].":[201],"No":[202],"substantial":[203],"differences":[204],"activity":[208],"quality":[210],"life":[212],"between":[213],"three":[215],"groups":[217],"observed.":[219],"Interestingly,":[220],"registry,":[225],"inferiority":[226],"observed":[233],"any":[235],"measure.":[237],"Conclusions":[238],"imply":[241],"that":[242],"should":[246],"be":[248],"recommended":[249],"as":[250],"sole":[252],"fistulas.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}