{"id":"https://openalex.org/W2913069665","doi":null,"title":"Evaluation of carboplatin-impregnated calcium sulfate hemihydrate beads as a local treatment option for feline injection site-associated sarcomas","display_name":"Evaluation of carboplatin-impregnated calcium sulfate hemihydrate beads as a local treatment option for feline injection site-associated sarcomas","publication_year":2018,"publication_date":"2018-04-27","ids":{"openalex":"https://openalex.org/W2913069665","mag":"2913069665"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/101244","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/101244","pdf_url":"http://hdl.handle.net/2142/101244","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2142/101244","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050761272","display_name":"Elizabeth A. Maxwell","orcid":"https://orcid.org/0000-0002-8201-040X","observed_orcids":["https://orcid.org/0000-0002-8201-040X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elizabeth A. Maxwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5050761272"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/local-chemotherapy","display_name":"local chemotherapy","score":0.5329999923706055},{"id":"https://openalex.org/keywords/drug-elution","display_name":"drug elution","score":0.6380000114440918},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.628000020980835},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cancer-cell-viability","display_name":"tumor cell viability","score":0.5379999876022339},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.37400001287460327},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.3869999945163727},{"id":"https://openalex.org/keywords/implantable-drug-delivery-systems","display_name":"implantable drug delivery","score":0.47699999809265137},{"id":"https://openalex.org/keywords/local-tumor-control","display_name":"local tumor control","score":0.5460000038146973},{"id":"https://openalex.org/keywords/marginal-excision","display_name":"marginal excision","score":0.5600000023841858},{"id":"https://openalex.org/keywords/radical-resection","display_name":"radical resection","score":0.5379999876022339},{"id":"https://openalex.org/keywords/cancer-recurrence-prevention","display_name":"tumor recurrence prevention","score":0.3179999887943268},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.7860275506973267},{"id":"https://openalex.org/C2777690519","wikidata":"https://www.wikidata.org/wiki/Q3144923","display_name":"Hemihydrate","level":3,"score":0.6407605409622192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.563249409198761},{"id":"https://openalex.org/C3018125106","wikidata":"https://www.wikidata.org/wiki/Q432083","display_name":"Injection site","level":2,"score":0.43972715735435486},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.23014616966247559},{"id":"https://openalex.org/C2779229104","wikidata":"https://www.wikidata.org/wiki/Q82658","display_name":"Gypsum","level":2,"score":0.21260970830917358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1994619369506836},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1607568860054016},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1355164647102356},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.11725729703903198},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/101244","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/101244","pdf_url":"http://hdl.handle.net/2142/101244","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2913069665","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/101244","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/101244","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2142/101244","pdf_url":"http://hdl.handle.net/2142/101244","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913069665.pdf","grobid_xml":"https://content.openalex.org/works/W2913069665.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W63178514","https://openalex.org/W79563679","https://openalex.org/W1619940129","https://openalex.org/W1967302565","https://openalex.org/W1969607556","https://openalex.org/W1972137945","https://openalex.org/W1985593715","https://openalex.org/W2000145541","https://openalex.org/W2028156849","https://openalex.org/W2028307569","https://openalex.org/W2038870052","https://openalex.org/W2045243966","https://openalex.org/W2054654995","https://openalex.org/W2060174407","https://openalex.org/W2070642813","https://openalex.org/W2071827206","https://openalex.org/W2072645819","https://openalex.org/W2074761825","https://openalex.org/W2084060773","https://openalex.org/W2088704237","https://openalex.org/W2094403311","https://openalex.org/W2096671785","https://openalex.org/W2104911332","https://openalex.org/W2115155929","https://openalex.org/W2115352852","https://openalex.org/W2127846308","https://openalex.org/W2139006136","https://openalex.org/W2144697576","https://openalex.org/W2152210518","https://openalex.org/W2153147895","https://openalex.org/W2165651539","https://openalex.org/W2181049752","https://openalex.org/W2225328146","https://openalex.org/W2233556253","https://openalex.org/W2317752158","https://openalex.org/W2409531891","https://openalex.org/W2547729113","https://openalex.org/W2604273829","https://openalex.org/W2609660670","https://openalex.org/W2790312610","https://openalex.org/W4390363748","https://openalex.org/W4391200682"],"related_works":["https://openalex.org/W2767227845","https://openalex.org/W3000526389","https://openalex.org/W3187099568","https://openalex.org/W29391624","https://openalex.org/W79563679","https://openalex.org/W2790312610","https://openalex.org/W1973609019","https://openalex.org/W3097451645","https://openalex.org/W2782616712","https://openalex.org/W3095942561"],"abstract_inverted_index":{"Experiment":[0,228,484],"1:":[1],"Objective:":[2,230],"To":[3,231,487],"determine":[4],"the":[5,131,165,219,293,307,323,326,329,362,385,388,440,459,489,528,543,546,593,703],"in":[6,147,191,198,309,328,361,369,374,448,479,503,523,624,641,657,663,711,725],"vitro":[7],"chemosensitivity":[8],"of":[9,22,134,167,180,195,208,218,235,266,277,316,331,334,387,406,434,443,461,475,493,533,545,580,595,607,628,681,714],"feline":[10],"injection":[11],"site-associated":[12],"sarcoma":[13],"(FISAS)":[14],"cells":[15,69,112,140,197,623,710],"to":[16,80,123,189,446,470,542,569,618,631,652,708],"carboplatin":[17,74,117,168,181,259],"concentrations":[18,169,187,422,466,606,627,661],"generated":[19],"by":[20,206,223,404,687],"elution":[21],"carboplatin-impregnated":[23,238,494],"calcium":[24,239,495,643],"sulfate":[25,240,496],"hemihydrate":[26,241,497],"(C-I":[27,242,498],"CSH)":[28,243,499],"beads.":[29,174],"Sample:":[30,250,506],"Five":[31],"immortalized":[32],"cell":[33,43,158],"lines":[34],"from":[35,78,121,171,182,237,384,391,414,566,592],"histologically":[36],"confirmed,":[37],"primary":[38,220],"FISASs.":[39],"Procedures:":[40,263],"For":[41,102],"each":[42,51,59,276,343,392],"line,":[44],"one":[45],"96-well":[46],"microplate":[47],"was":[48,95,128,279,338,394,399,539,558,685],"used":[49,453],"for":[50,72,87,115,342,346,401,423,473,560,576,621,720],"time":[52,601],"point":[53],"(24,":[54],"48,":[55,89,348],"72":[56,91,350],"hours).":[57],"In":[58],"microplate,":[60],"3":[61,105,340,632],"wells":[62,106],"were":[63,85,107,141,145,163,269,304,320,359,517,574,609,644,650,672],"seeded":[64,108],"with":[65,371,481,727],"~7.5":[66],"x":[67,110],"103":[68],"per":[70,113],"well":[71,114],"every":[73,116],"treatment":[75,118],"added,":[76,119],"ranging":[77,120],"5":[79,122,382],"450":[81,124],"\u00b5M.":[82,125],"Microculture":[83],"plates":[84],"incubated":[86],"24,":[88,347],"or":[90,215,222,299,729],"hours.":[92],"Drug":[93],"efficacy":[94],"assessed":[96],"via":[97],"a":[98,397,455],"bioreductive":[99],"fluorometric":[100],"assay.":[101],"apoptosis":[103],"analysis,":[104],"with~5":[109],"104":[111],"Flow":[126],"cytometry":[127],"performed":[129,540],"and":[130,137,153,176,271,286,349,365,367,381,396,430,491,530,548,553,556,578,586,603,634,638,677],"relative":[132],"percentages":[133],"viable,":[135],"apoptotic,":[136],"late":[138],"apoptotic/necrotic":[139],"reported.":[142],"All":[143],"experiments":[144],"run":[146],"triplicates.":[148],"Results:":[149,411,598],"Carboplatin":[150],"exerted":[151],"dose-dependent":[152],"time-dependent":[154],"effects":[155],"on":[156,306,674],"FISAS":[157,196,622,709],"viability.":[159],"The":[160,336],"IC50":[161],"values":[162],"within":[164],"range":[166],"eluted":[170],"C-I":[172,183,209,301,415,476,514,682,691,721],"CSH":[173,184,210,302,416,477,515,683,692,722],"Conclusion":[175],"Clinical":[177,431,536,678],"Relevance:":[178,432],"Elution":[179],"beads":[185,211,244,252,303,327,417,478,500,516,684,693],"generate":[186],"sufficient":[188],"result":[190],"50%":[192],"growth":[193],"inhibition":[194],"vitro.":[199,625,712],"Local":[200],"tumor":[201,221,226],"control":[202],"might":[203,467],"be":[204,452,468,619,718],"achieved":[205],"implantation":[207,224,474,502],"immediately":[212],"following":[213],"radical":[214],"marginal":[216],"excision":[217],"without":[225],"resection.":[227],"2:":[229],"characterize":[232],"spatial":[233,441],"release":[234,700],"platinum":[236,402,444,465,561,581,608,629,660,701],"using":[245],"an":[246],"agarose":[247,268,294,357],"tissue":[248,605,648,670],"phantom.":[249],"3-mm-diameter":[251],"(n":[253],"=":[254],"60)":[255],"containing":[256,665],"4.6":[257],"mg":[258,261],"(2.4":[260],"platinum)/bead.":[262],"18":[264],"L":[265,333],"1%":[267],"prepared":[270],"poured":[272],"into":[273,519,695,702],"36":[274,314],"containers,":[275],"which":[278,655],"10":[280,282,284,300],"X":[281,283],"cm":[285,383,425],"filled":[287],"half":[288],"full":[289],"(0.5":[290,318],"L/container).":[291],"After":[292],"solidified,":[295],"1,":[296,377],"3,":[297,379,550,583],"6,":[298],"placed":[305,321],"agar":[308,317],"defined":[310],"patterns.":[311],"An":[312],"additional":[313],"blocks":[315,358],"L/block)":[319],"atop":[322],"beads,":[324],"positioning":[325],"center":[330,386],"1":[332,567],"agar.":[335],"experiment":[337],"replicated":[339],"times":[341,565],"bead":[344,596,723],"pattern":[345],"hours,":[351],"respectively.":[352],"At":[353,599],"these":[354],"times,":[355],"representative":[356],"sectioned":[360],"x-,":[363],"y-,":[364],"z-planes":[366],"labeled":[368],"accordance":[370],"their":[372],"positions":[373],"shells":[375],"radiating":[376],"2,":[378],"4,":[380],"blocks.":[389],"Agarose":[390,450],"shell":[393],"homogenized,":[395],"sample":[398],"submitted":[400],"analysis":[403,579],"use":[405],"inductively":[407],"coupled":[408],"plasma-mass":[409],"spectroscopy.":[410],"Platinum":[412],"diffused":[413],"at":[418,549,563,582,589,705],"predicted":[419],"anticancer":[420],"cytotoxic":[421,620,707],"2-5":[424],"radial":[426],"source":[427],"length.":[428],"Conclusions":[429,676],"Results":[433],"this":[435],"study":[436,547],"provided":[437],"information":[438],"regarding":[439],"distribution":[442],"expected":[445],"occur":[447],"vivo.":[449],"may":[451],"as":[454],"diffusion":[456],"model,":[457],"mimicking":[458],"characteristics":[460],"subcutaneous":[462,647,667,730],"tissues.":[463],"Measured":[464],"useful":[469],"guide":[471],"patterns":[472,525],"animals":[480,726],"susceptible":[482],"neoplasms.":[483],"3:":[485],"Objectives:":[486],"evaluate":[488],"pharmacokinetics":[490],"safety":[492],"after":[501],"healthy":[504,508,688],"cats":[505,511],"Six":[507],"adult":[509,689],"research":[510],"Procedure:":[512],"Three":[513],"implanted":[518,694],"individual":[520],"muscle":[521,654,696,715],"pockets":[522,697,716],"specific":[524,564,590],"over":[526,611],"both":[527],"right":[529],"left":[531],"hemithoraces":[532],"all":[534,600],"cats.":[535,690],"laboratory":[537],"testing":[538],"prior":[541],"beginning":[544],"7,":[551,584],"14,":[552,585],"21":[554,570,587,612],"days,":[555],"serum":[557,642],"analyzed":[559],"content":[562],"hour":[568],"days.":[571],"Tissue":[572],"samples":[573,649,664],"obtained":[575],"histopathology":[577],"days":[588,613],"distances":[591],"sites":[594],"implantation.":[597],"points":[602],"distances,":[604],"sustained":[610],"but":[614],"below":[615],"levels":[616,706],"reported":[617],"Serum":[626],"increased":[630],"hours":[633],"then":[635],"decreased":[636],"sharply,":[637],"mild":[639],"abnormalities":[640],"noted.":[645],"Some":[646],"found":[651],"contain":[653],"resulted":[656],"significantly":[658],"higher":[659],"than":[662],"only":[666],"fat.":[668],"Minimal":[669],"changes":[671],"noted":[673],"histopathology.":[675],"Significance:":[679],"Implantation":[680],"well-tolerated":[686],"did":[698],"not":[699],"subcutis":[704],"Use":[713],"should":[717],"reevaluated":[719],"placement":[724],"dermal":[728],"tumors.":[731]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2019-02-21T00:00:00"}