{"id":"https://openalex.org/W2913016305","doi":"https://doi.org/10.1161/str.50.suppl_1.19","title":"Abstract 19: Immune-Response Contributes to Primary Cardiac Dysfunction After Intracerebral Hemorrhage","display_name":"Abstract 19: Immune-Response Contributes to Primary Cardiac Dysfunction After Intracerebral Hemorrhage","publication_year":2019,"publication_date":"2019-01-30","ids":{"openalex":"https://openalex.org/W2913016305","doi":"https://doi.org/10.1161/str.50.suppl_1.19","mag":"2913016305"},"language":"en","primary_location":{"id":"doi:10.1161/str.50.suppl_1.19","doi":"https://doi.org/10.1161/str.50.suppl_1.19","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.50.suppl_1.19","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Dept of Neurology, Henry Ford Hosp, Detroit, MI","Wei Li"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Neurology, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Wei Li","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020384051","display_name":"Tao Yan","orcid":"https://orcid.org/0000-0003-3138-4468","observed_orcids":["https://orcid.org/0000-0003-3138-4468"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Yan","raw_affiliation_strings":["Tianjin Med Univ General Hosp, Tianjin, China","Tao Yan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Med Univ General Hosp, Tianjin, China","institution_ids":["https://openalex.org/I2802534033","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Tao Yan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318912","display_name":"Linlin Li","orcid":"https://orcid.org/0000-0002-1438-2738","observed_orcids":["https://orcid.org/0000-0002-1438-2738"]},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlin Li","raw_affiliation_strings":["Tianjin Med Univ General Hosp, Tianjin, China","Linlin Li"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Med Univ General Hosp, Tianjin, China","institution_ids":["https://openalex.org/I2802534033","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Linlin Li","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064645750","display_name":"Poornima Venkat","orcid":"https://orcid.org/0000-0001-8938-663X","observed_orcids":["https://orcid.org/0000-0001-8938-663X"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Poornima Venkat","raw_affiliation_strings":["Dept of Neurology, Henry Ford Hosp, Detroit, MI","Poornima Venkat"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Neurology, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Poornima Venkat","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005508444","display_name":"Michael Chopp","orcid":"https://orcid.org/0000-0002-1948-4493","observed_orcids":["https://orcid.org/0000-0002-1948-4493"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Chopp","raw_affiliation_strings":["Dept of Neurology, Henry Ford Hosp, Detroit, MI","Michael Chopp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Neurology, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Michael Chopp","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101520599","display_name":"Zhili Chen","orcid":"https://orcid.org/0000-0003-3529-7994","observed_orcids":["https://orcid.org/0000-0003-3529-7994"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhili Chen","raw_affiliation_strings":["Dept of Neurology, Henry Ford Hosp, Detroit, MI","Zhili Chen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Neurology, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Zhili Chen","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032590045","display_name":"Julie Landschoot\u2010Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Landschoot-Ward","raw_affiliation_strings":["Dept of Neurology, Henry Ford Hosp, Detroit, MI","Julie Landschoot-Ward"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Neurology, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Julie Landschoot-Ward","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005605929","display_name":"Jieli Chen","orcid":"https://orcid.org/0000-0001-5446-9101","observed_orcids":["https://orcid.org/0000-0001-5446-9101"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jieli Chen","raw_affiliation_strings":["Dept of Neurology, Henry Ford Hosp, Detroit, MI","Jieli Chen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Neurology, Henry Ford Hosp, Detroit, MI","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"Jieli Chen","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.6563000082969666,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.6563000082969666,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.20509999990463257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":0.12870000302791595,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":1.0},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.8999999761581421},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.7950000166893005},{"id":"https://openalex.org/keywords/brain-heart-interaction","display_name":"heart-brain interaction","score":0.8980000019073486},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9929999709129333},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neurological-deficit","display_name":"neurological deficit","score":0.49399998784065247},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9479114413261414},{"id":"https://openalex.org/C2777094939","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hemorrhage","level":3,"score":0.6984871625900269},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6614859104156494},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.6584524512290955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46291500329971313},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41434401273727417},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.34405505657196045},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33989542722702026},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.27583688497543335},{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.16536512970924377}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/str.50.suppl_1.19","doi":"https://doi.org/10.1161/str.50.suppl_1.19","is_oa":false,"landing_page_url":"https://doi.org/10.1161/str.50.suppl_1.19","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3002722566","https://openalex.org/W2900511816","https://openalex.org/W2996733994","https://openalex.org/W2901393645","https://openalex.org/W4387453579","https://openalex.org/W3110703783","https://openalex.org/W4307298807","https://openalex.org/W3047799792","https://openalex.org/W4396624225","https://openalex.org/W4388097344"],"abstract_inverted_index":{"Background:":[0],"Cardiac":[1,95],"damage":[2],"may":[3,305],"occur":[4],"after":[5,73,79,106,162,175,311],"stroke":[6],"in":[7,26,40,46,189,256,269,301],"the":[8,27,35,38,190,212,257,270,297],"absence":[9,28],"of":[10,29,37,262,299],"primary":[11,30],"cardiac":[12,24,31,44,138,143,168,241,252,285],"diseases.":[13],"In":[14],"this":[15],"study,":[16],"we":[17],"investigated":[18],"whether":[19,68],"intracerebral":[20],"hemorrhage":[21],"(ICH)":[22],"induces":[23,276,284],"dysfunction":[25,45,139,242,286],"disease,":[32],"and":[33,103,109,115,133,136,153,159,170,185,192,202,233,246,254,265,278,287],"evaluated":[34],"role":[36],"immune-response":[39],"mediating":[41],"post":[42],"ICH":[43,56,89,125,220,223,273],"mice.":[47],"Methods:":[48],"Adult":[49],"male":[50],"C57BL/6J":[51],"mice":[52,126,226],"were":[53,117],"subjected":[54],"to":[55,121,219,307],"by":[57,99,141,147,296],"blood":[58,64],"injection":[59],"or":[60],"sham":[61,86,122],"control":[62,123,221],"without":[63],"injection.":[65],"To":[66],"identify":[67],"immunoresponse":[69],"mediates":[70],"brain-heart":[71,308],"interaction":[72,310],"ICH,":[74,304],"splenectomy":[75,93,225,300],"was":[76,97],"performed":[77],"immediately":[78],"ICH.":[80,107,163,312],"The":[81],"experimental":[82],"groups":[83],"include:":[84],"1)":[85,130,230],"control;":[87],"2)":[88,164,248],"group;":[90],"3)":[91,177,259],"ICH+":[92],"(n=10-16/group).":[94],"function":[96,145],"measured":[98,146],"echocardiography":[100],"at":[101,157,172,214],"7":[102,158,215],"28":[104,160,173],"days":[105,161,174,216],"Neurological":[108],"cognitive":[110,134,234,279],"functional":[111,235,280],"tests,":[112],"flow":[113],"cytometry":[114],"immunostaining":[116],"performed.":[118],"Results:":[119],"Compared":[120,218],"mice,":[124,222],"exhibit":[127],"significantly":[128,228],"(p<0.05):":[129,229],"increased":[131,137,165,178,193,244],"neurological":[132,232,277],"deficits,":[135],"identified":[140],"decreased":[142,249,260,266],"contractile":[144],"left":[148],"ventricular":[149],"ejection":[150],"fraction":[151],"(LVEF)":[152],"fractional":[154],"shortening":[155],"(FS)":[156],"cardiomyocyte":[166,250],"apoptosis,":[167,251],"hypertrophy":[169,255],"fibrosis":[171,253],"ICH;":[176],"inflammatory":[179,194,288],"factor":[180],"monocyte":[181],"chemotactic":[182],"protein-1":[183],"(MCP-1)":[184],"matrix":[186],"metalloproteinase-9":[187],"expression":[188,268],"heart":[191,213],"cell":[195,289],"(macrophages:CD45":[196],"+":[197,199,201,204,206,208],"/CD11b":[198,205],"/F480":[200],"neutrophil:CD45":[203],"/Ly6G":[207],")":[209],"infiltration":[210,261,290],"into":[211,291],"post-ICH.":[217],"with":[224,243,303],"exhibited":[227],"improved":[231],"outcome":[236],"as":[237,239,294],"well":[238],"attenuated":[240],"LVEF":[245],"LVFS;":[247],"heart;":[258],"immune":[263],"cells":[264],"MCP-1":[267],"heart.":[271,292],"Conclusions:":[272],"not":[274],"only":[275],"deficit,":[281],"but":[282],"also":[283],"Immune-response,":[293],"evidenced":[295],"effects":[298],"conjunction":[302],"contribute":[306],"adverse":[309]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-02-21T00:00:00"}