{"id":"https://openalex.org/W2912997222","doi":"https://doi.org/10.1194/jlr.s091744","title":"Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential","display_name":"Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential","publication_year":2019,"publication_date":"2019-01-28","ids":{"openalex":"https://openalex.org/W2912997222","doi":"https://doi.org/10.1194/jlr.s091744","mag":"2912997222","pmid":"https://pubmed.ncbi.nlm.nih.gov/30692142","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6399510"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.s091744","doi":"https://doi.org/10.1194/jlr.s091744","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.s091744","pdf_url":"http://www.jlr.org/content/60/3/464.full.pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jlr.org/content/60/3/464.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071553204","display_name":"G\u00e1bor Tigyi","orcid":"https://orcid.org/0000-0001-5371-171X","observed_orcids":["https://orcid.org/0000-0001-5371-171X"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210086422","display_name":"Memphis VA Medical Center","ror":"https://ror.org/000vjzq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086422","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gabor J. Tigyi","raw_affiliation_strings":["Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163 gtigyi@uthsc.edu","Research Division Veterans Affairs Medical Center, Memphis, TN 38104","RxBio Inc. Memphis, TN 38163","Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163 gtigyi@uthsc.edu","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Research Division Veterans Affairs Medical Center, Memphis, TN 38104","institution_ids":["https://openalex.org/I4210086422"]},{"raw_affiliation_string":"RxBio Inc. Memphis, TN 38163","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113446993","display_name":"Leonard R. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard R. Johnson","raw_affiliation_strings":["Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163","RxBio Inc. Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"RxBio Inc. Memphis, TN 38163","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032960258","display_name":"Sue \u00c7hin Lee","orcid":"https://orcid.org/0000-0002-7719-1648","observed_orcids":["https://orcid.org/0000-0002-7719-1648"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue Chin Lee","raw_affiliation_strings":["Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057108769","display_name":"Derek D. Norman","orcid":"https://orcid.org/0000-0002-5626-6399","observed_orcids":["https://orcid.org/0000-0002-5626-6399"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210086422","display_name":"Memphis VA Medical Center","ror":"https://ror.org/000vjzq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086422","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek D. Norman","raw_affiliation_strings":["Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163","Research Division Veterans Affairs Medical Center, Memphis, TN 38104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Research Division Veterans Affairs Medical Center, Memphis, TN 38104","institution_ids":["https://openalex.org/I4210086422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101924555","display_name":"Erzs\u00e9bet Szab\u00f3","orcid":"https://orcid.org/0000-0002-0647-6769","observed_orcids":["https://orcid.org/0000-0002-0647-6769"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erzsebet Szabo","raw_affiliation_strings":["Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076715598","display_name":"Andrea Balogh","orcid":"https://orcid.org/0000-0002-3007-0793","observed_orcids":["https://orcid.org/0000-0002-3007-0793"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Balogh","raw_affiliation_strings":["Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN 38163","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Karin Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karin Thompson","raw_affiliation_strings":["RxBio Inc. Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RxBio Inc. Memphis, TN 38163","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084020216","display_name":"Alyssa Boler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alyssa Boler","raw_affiliation_strings":["RxBio Inc. Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RxBio Inc. Memphis, TN 38163","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034269251","display_name":"W. Shannon McCool","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Shannon McCool","raw_affiliation_strings":["RxBio Inc. Memphis, TN 38163"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RxBio Inc. Memphis, TN 38163","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071553204"],"corresponding_institution_ids":["https://openalex.org/I160606119","https://openalex.org/I4210086422"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.4179,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.38694253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"60","issue":"3","first_page":"464","last_page":"474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysophosphatidic-acid","display_name":"lysophosphatidic acid","score":0.9929999709129333},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/lpa-signaling","display_name":"LPA signaling","score":0.6359999775886536},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.42899999022483826},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.4869999885559082},{"id":"https://openalex.org/keywords/genotoxic-stress","display_name":"genotoxic stress","score":0.8550000190734863},{"id":"https://openalex.org/keywords/secretory-diarrhea","display_name":"secretory diarrhea","score":0.8149999976158142},{"id":"https://openalex.org/keywords/radioprotectors","display_name":"radioprotective agents","score":0.7820000052452087},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.7149999737739563},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.921999990940094},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2776661833","wikidata":"https://www.wikidata.org/wiki/Q2823281","display_name":"Lysophosphatidic acid","level":3,"score":0.9644157886505127},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5583293437957764},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5062560439109802},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4785780906677246},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46543779969215393},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42362987995147705},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42145463824272156},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.4207044243812561},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41414526104927063},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4087224304676056},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3946681618690491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35629090666770935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17705076932907104}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049368","descriptor_name":"Receptors, Lysophosphatidic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049368","descriptor_name":"Receptors, Lysophosphatidic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049368","descriptor_name":"Receptors, Lysophosphatidic Acid","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1194/jlr.s091744","doi":"https://doi.org/10.1194/jlr.s091744","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.s091744","pdf_url":"http://www.jlr.org/content/60/3/464.full.pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5990177","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6399510","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6399510","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6399510","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Lipid Res","raw_type":"Text"},{"id":"pmid:30692142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30692142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dd2862db5ea048c895cc375c8a81db97","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dd2862db5ea048c895cc375c8a81db97","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 60, Iss 3, Pp 464-474 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.s091744","doi":"https://doi.org/10.1194/jlr.s091744","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.s091744","pdf_url":"http://www.jlr.org/content/60/3/464.full.pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1038118768","display_name":"Analysis of Radiomitigative Cell Signaling","funder_award_id":"R01AI080405","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1058133092","display_name":"Anticancer Strategies Targeting the Autotaxin-LPA Receptor Axis","funder_award_id":"R01CA092160","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1613657302","display_name":null,"funder_award_id":"1101BX001187","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G2685927603","display_name":null,"funder_award_id":"HHSO100201100036C","funder_id":"https://openalex.org/F4320333299","funder_display_name":"Biomedical Advanced Research and Development Authority"},{"id":"https://openalex.org/G3765334253","display_name":"IND-Enabling Preclinical Development of a New Radiomitigator","funder_award_id":"U01AI107331","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4769500593","display_name":"Preclinical Development of a GI Radiation Countermeasure","funder_award_id":"RC2AI087550","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7184282590","display_name":null,"funder_award_id":"I01 BX001187","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8199159189","display_name":"The anti-diarrheal potential of a LPA analog Rx100","funder_award_id":"R43DK105719","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333299","display_name":"Biomedical Advanced Research and Development Authority","ror":"https://ror.org/029y69023"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912997222.pdf","grobid_xml":"https://content.openalex.org/works/W2912997222.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W419222977","https://openalex.org/W1520348090","https://openalex.org/W1531820450","https://openalex.org/W1553367038","https://openalex.org/W1578788161","https://openalex.org/W1664264312","https://openalex.org/W1853389060","https://openalex.org/W1966691517","https://openalex.org/W1967073988","https://openalex.org/W1967840305","https://openalex.org/W1970976992","https://openalex.org/W1971822253","https://openalex.org/W1973892716","https://openalex.org/W1979871496","https://openalex.org/W1981501419","https://openalex.org/W1982949972","https://openalex.org/W1984888890","https://openalex.org/W1985551319","https://openalex.org/W1985619989","https://openalex.org/W1990316472","https://openalex.org/W1995374814","https://openalex.org/W2003431563","https://openalex.org/W2006662870","https://openalex.org/W2011683784","https://openalex.org/W2014609417","https://openalex.org/W2016206520","https://openalex.org/W2018046936","https://openalex.org/W2019356432","https://openalex.org/W2023277555","https://openalex.org/W2029192296","https://openalex.org/W2029476967","https://openalex.org/W2031408824","https://openalex.org/W2031602421","https://openalex.org/W2033539965","https://openalex.org/W2039346157","https://openalex.org/W2043809142","https://openalex.org/W2045797774","https://openalex.org/W2054440394","https://openalex.org/W2058610825","https://openalex.org/W2058983824","https://openalex.org/W2060022944","https://openalex.org/W2060302226","https://openalex.org/W2060715963","https://openalex.org/W2062171000","https://openalex.org/W2068640899","https://openalex.org/W2068902035","https://openalex.org/W2072580989","https://openalex.org/W2085581523","https://openalex.org/W2088947064","https://openalex.org/W2090847689","https://openalex.org/W2090977730","https://openalex.org/W2091466360","https://openalex.org/W2093054034","https://openalex.org/W2101809518","https://openalex.org/W2117003397","https://openalex.org/W2117356851","https://openalex.org/W2118332885","https://openalex.org/W2120298716","https://openalex.org/W2123412206","https://openalex.org/W2142409978","https://openalex.org/W2143542751","https://openalex.org/W2149054264","https://openalex.org/W2152897468","https://openalex.org/W2161184363","https://openalex.org/W2164044124","https://openalex.org/W2165379587","https://openalex.org/W2165904313","https://openalex.org/W2166617029","https://openalex.org/W2167445075","https://openalex.org/W2263484855","https://openalex.org/W2374725955","https://openalex.org/W2580973827","https://openalex.org/W2581419557","https://openalex.org/W2587069867","https://openalex.org/W2745155021","https://openalex.org/W2779753586","https://openalex.org/W2792967638","https://openalex.org/W2810266890","https://openalex.org/W2886921109","https://openalex.org/W2892900371"],"related_works":["https://openalex.org/W2129351604","https://openalex.org/W2140190850","https://openalex.org/W1977254310","https://openalex.org/W1969870436","https://openalex.org/W2031725647","https://openalex.org/W1984888890","https://openalex.org/W2083180345","https://openalex.org/W2311505786","https://openalex.org/W2157654722","https://openalex.org/W3204333887"],"abstract_inverted_index":{"The":[0,37,182],"growth":[1],"factor-like":[2],"lipid":[3,99],"mediator,":[4],"lysophosphatidic":[5],"acid":[6],"(LPA),":[7],"is":[8,24,41],"a":[9,83,166],"potent":[10],"signaling":[11,23,66],"molecule":[12],"that":[13,56,73,143],"influences":[14],"numerous":[15],"physiologic":[16],"and":[17,80,134,137,156,173,191],"pathologic":[18],"processes.":[19],"Manipulation":[20],"of":[21,25,39,45,48,76,97,185],"LPA":[22,31,40,65,115,139,144,162,186],"growing":[26],"pharmacotherapeutic":[27],"interest,":[28],"especially":[29],"because":[30],"resembles":[32],"compounds":[33],"with":[34,117],"drug-like":[35],"features.":[36],"action":[38],"mediated":[42],"through":[43],"activation":[44],"multiple":[46],"types":[47],"molecular":[49],"targets,":[50],"including":[51,153],"six":[52],"G":[53],"protein-coupled":[54],"receptors":[55],"are":[57],"clear":[58],"targets":[59],"for":[60,170,200],"drug":[61],"development.":[62],"However,":[63],"the":[64,93],"has":[67],"been":[68],"linked":[69],"to":[70,160],"pathological":[71],"responses":[72],"include":[74],"promotion":[75],"fibrosis,":[77],"atherogenesis,":[78],"tumorigenesis,":[79],"metastasis.":[81],"Thus,":[82],"question":[84],"arises:":[85],"Can":[86],"we":[87],"harness,":[88],"in":[89,120],"an":[90,114],"LPA-like":[91],"drug,":[92],"many":[94],"beneficial":[95],"activities":[96],"this":[98],"without":[100],"eliciting":[101],"its":[102],"dreadful":[103],"actions?":[104],"We":[105,141],"developed":[106],"octadecyl":[107],"thiophosphate":[108],"(OTP;":[109],"subsequently":[110],"licensed":[111],"as":[112],"Rx100),":[113],"mimic":[116],"higher":[118],"stability":[119],"vivo":[121],"than":[122],"LPA.":[123],"This":[124],"article":[125],"highlights":[126],"progress":[127],"made":[128],"toward":[129],"developing":[130],"analogs":[131],"like":[132,189],"OTP":[133,190],"exploring":[135],"prosurvival":[136],"regenerative":[138],"signaling.":[140],"determined":[142],"prevents":[145],"cell":[146],"death":[147],"triggered":[148],"by":[149,178],"various":[150],"cellular":[151],"stresses,":[152],"genotoxic":[154],"stressors,":[155],"rescues":[157],"cells":[158],"condemned":[159],"apoptosis.":[161],"2":[163,187],"agonists":[164,188],"provide":[165],"new":[167],"treatment":[168],"option":[169],"secretory":[171],"diarrhea":[172],"reduce":[174],"gastric":[175],"erosion":[176],"caused":[177],"nonsteroidal":[179],"anti-inflammatory":[180],"drugs.":[181],"potential":[183],"uses":[184],"sulfamoyl":[192],"benzoic":[193],"acid-based":[194],"radioprotectins":[195],"must":[196],"be":[197],"further":[198],"explored":[199],"therapeutic":[201],"uses.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-02-21T00:00:00"}