{"id":"https://openalex.org/W2912912682","doi":"https://doi.org/10.1016/j.bpj.2018.11.1049","title":"Probing (UN)Folding Transition Paths of Fast-Folding Proteins by Single-Molecule Fluorescence: Exploring the Role of Secondary Structure, Fold Topology and Sequence","display_name":"Probing (UN)Folding Transition Paths of Fast-Folding Proteins by Single-Molecule Fluorescence: Exploring the Role of Secondary Structure, Fold Topology and Sequence","publication_year":2019,"publication_date":"2019-02-01","ids":{"openalex":"https://openalex.org/W2912912682","doi":"https://doi.org/10.1016/j.bpj.2018.11.1049","mag":"2912912682"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2018.11.1049","doi":"https://doi.org/10.1016/j.bpj.2018.11.1049","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.1049","pdf_url":"http://www.cell.com/article/S0006349518323142/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349518323142/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037585756","display_name":"Nivin Mothi","orcid":"https://orcid.org/0000-0003-3467-0849","observed_orcids":["https://orcid.org/0000-0003-3467-0849"]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nivin Mothi","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, University of California Merced, Merced, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, University of California Merced, Merced, CA, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044648862","display_name":"Mourad Sadqi","orcid":"https://orcid.org/0000-0003-3553-3408","observed_orcids":["https://orcid.org/0000-0003-3553-3408"]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mourad Sadqi","raw_affiliation_strings":["Department of Bioengineering, School of Engineering, University of California Merced, Merced, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, School of Engineering, University of California Merced, Merced, CA, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070803211","display_name":"V\u00edctor Mu\u00f1oz","orcid":"https://orcid.org/0000-0002-5683-1482","observed_orcids":["https://orcid.org/0000-0002-5683-1482"]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Munoz","raw_affiliation_strings":["Department of Bioengineering, School of Engineering, University of California Merced, Merced, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, School of Engineering, University of California Merced, Merced, CA, USA","institution_ids":["https://openalex.org/I156087764"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I156087764"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"3","first_page":"189a","last_page":"189a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.7649999856948853},{"id":"https://openalex.org/keywords/fast-folding-proteins","display_name":"fast-folding proteins","score":0.8320000171661377},{"id":"https://openalex.org/keywords/single-molecule-fret","display_name":"single-molecule FRET","score":0.9129999876022339},{"id":"https://openalex.org/keywords/free-diffusion","display_name":"free diffusion","score":0.6610000133514404},{"id":"https://openalex.org/keywords/free-energy-landscape","display_name":"free energy landscape","score":0.8420000076293945},{"id":"https://openalex.org/keywords/secondary-structure","display_name":"secondary structure","score":0.5320000052452087},{"id":"https://openalex.org/keywords/amino-acid-sequence","display_name":"amino acid sequence","score":0.6650000214576721},{"id":"https://openalex.org/keywords/three-stranded-beta-sheet","display_name":"three-stranded beta-sheet","score":0.6740000247955322},{"id":"https://openalex.org/keywords/alpha-helix","display_name":"alpha-helix","score":0.7749999761581421},{"id":"https://openalex.org/keywords/barrier-crossing","display_name":"barrier crossing","score":0.5730000138282776},{"id":"https://openalex.org/keywords/molecular-trajectories","display_name":"molecular trajectories","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.6365891695022583},{"id":"https://openalex.org/C206276672","wikidata":"https://www.wikidata.org/wiki/Q5164839","display_name":"Contact order","level":3,"score":0.6344714164733887},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.6128614544868469},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.608916163444519},{"id":"https://openalex.org/C199191878","wikidata":"https://www.wikidata.org/wiki/Q6504739","display_name":"Single-molecule experiment","level":3,"score":0.6002844572067261},{"id":"https://openalex.org/C96305047","wikidata":"https://www.wikidata.org/wiki/Q367473","display_name":"F\u00f6rster resonance energy transfer","level":3,"score":0.5924807786941528},{"id":"https://openalex.org/C142089489","wikidata":"https://www.wikidata.org/wiki/Q1053976","display_name":"Antiparallel (mathematics)","level":3,"score":0.5859371423721313},{"id":"https://openalex.org/C2781455991","wikidata":"https://www.wikidata.org/wiki/Q7523749","display_name":"Single-molecule FRET","level":4,"score":0.5697581768035889},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5596738457679749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.537510097026825},{"id":"https://openalex.org/C46449900","wikidata":"https://www.wikidata.org/wiki/Q5303170","display_name":"Downhill folding","level":4,"score":0.5038506388664246},{"id":"https://openalex.org/C162203774","wikidata":"https://www.wikidata.org/wiki/Q7181581","display_name":"Phi value analysis","level":3,"score":0.4673868417739868},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.44340693950653076},{"id":"https://openalex.org/C174507519","wikidata":"https://www.wikidata.org/wiki/Q5464306","display_name":"Folding funnel","level":5,"score":0.42196977138519287},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.39158928394317627},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.388150691986084},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.3647274374961853},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.31183090806007385},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.30117493867874146},{"id":"https://openalex.org/C19472624","wikidata":"https://www.wikidata.org/wiki/Q583851","display_name":"Native state","level":2,"score":0.15607789158821106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15225845575332642},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0900888741016388},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08192002773284912},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.07220876216888428},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2018.11.1049","doi":"https://doi.org/10.1016/j.bpj.2018.11.1049","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.1049","pdf_url":"http://www.cell.com/article/S0006349518323142/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2018.11.1049","doi":"https://doi.org/10.1016/j.bpj.2018.11.1049","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2018.11.1049","pdf_url":"http://www.cell.com/article/S0006349518323142/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912912682.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3004545749","https://openalex.org/W2074443308","https://openalex.org/W2299989600","https://openalex.org/W6929639992","https://openalex.org/W4391657350","https://openalex.org/W7042899830","https://openalex.org/W1994930724","https://openalex.org/W2552173643","https://openalex.org/W104626596","https://openalex.org/W3005009434"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2019-02-21T00:00:00"}