{"id":"https://openalex.org/W2912909030","doi":"https://doi.org/10.3233/blc-180198","title":"Intravesical Therapy \u2013 BCG and Beyond","display_name":"Intravesical Therapy \u2013 BCG and Beyond","publication_year":2019,"publication_date":"2019-01-31","ids":{"openalex":"https://openalex.org/W2912909030","doi":"https://doi.org/10.3233/blc-180198","mag":"2912909030"},"language":"en","primary_location":{"id":"doi:10.3233/blc-180198","doi":"https://doi.org/10.3233/blc-180198","is_oa":true,"landing_page_url":"https://doi.org/10.3233/blc-180198","pdf_url":"https://content.iospress.com:443/download/bladder-cancer/blc180198?id=bladder-cancer%2Fblc180198","source":{"id":"https://openalex.org/S4210208690","display_name":"Bladder Cancer","issn_l":"2352-3727","issn":["2352-3727","2352-3735"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bladder Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://content.iospress.com:443/download/bladder-cancer/blc180198?id=bladder-cancer%2Fblc180198","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037985318","display_name":"H. Barton Grossman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. Barton Grossman","raw_affiliation_strings":["Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052301584","display_name":"Donald L. Lamm","orcid":"https://orcid.org/0000-0002-1859-6688","observed_orcids":["https://orcid.org/0000-0002-1859-6688"]},"institutions":[{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Lamm","raw_affiliation_strings":["University of Arizona College of Medicine, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona College of Medicine, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4405259572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075804863","display_name":"Gottfrid Sj\u00f6dahl","orcid":"https://orcid.org/0000-0002-7869-0473","observed_orcids":["https://orcid.org/0000-0002-7869-0473"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gottfrid Sj\u00f6dahl","raw_affiliation_strings":["Department of Translational Medicine, Lund University, Malm\u00f6, Sweden","Department of Urology, Sk\u00e5ne University Hospital, Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Medicine, Lund University, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Department of Urology, Sk\u00e5ne University Hospital, Lund, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003263712","display_name":"Michael A. O\u2019Donnell","orcid":"https://orcid.org/0000-0001-7202-6427","observed_orcids":["https://orcid.org/0000-0001-7202-6427"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael O\u2019Donnell","raw_affiliation_strings":["University of Iowa Carver College of Medicine, Department of Urology, Iowa City, IA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa Carver College of Medicine, Department of Urology, Iowa City, IA, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001308517","display_name":"Noah M. Hahn","orcid":"https://orcid.org/0000-0002-1016-9024","observed_orcids":["https://orcid.org/0000-0002-1016-9024"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noah Hahn","raw_affiliation_strings":["Johns Hopkins Greenberg Bladder Cancer Institute, Baltimore, MD, USA","The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Greenberg Bladder Cancer Institute, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034005227","display_name":"Ashish M. Kamat","orcid":"https://orcid.org/0000-0003-3546-9928","observed_orcids":["https://orcid.org/0000-0003-3546-9928"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish Kamat","raw_affiliation_strings":["Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5037985318"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.4817,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.63913802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"5","issue":"1","first_page":"73","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravesical-therapy","display_name":"intravesical therapy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/non-muscle-invasive-bladder-cancer","display_name":"non-muscle-invasive bladder cancer","score":0.8840000033378601},{"id":"https://openalex.org/keywords/bcg","display_name":"BCG","score":0.7139999866485596},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6959999799728394},{"id":"https://openalex.org/keywords/bcg-toxicity","display_name":"BCG toxicity","score":0.6650000214576721},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.6809999942779541},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5160152912139893},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37578344345092773},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3230575919151306}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3233/blc-180198","doi":"https://doi.org/10.3233/blc-180198","is_oa":true,"landing_page_url":"https://doi.org/10.3233/blc-180198","pdf_url":"https://content.iospress.com:443/download/bladder-cancer/blc180198?id=bladder-cancer%2Fblc180198","source":{"id":"https://openalex.org/S4210208690","display_name":"Bladder Cancer","issn_l":"2352-3727","issn":["2352-3727","2352-3735"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bladder Cancer","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:0a90c8acc5514f36b1dda5f9ace9e024","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0a90c8acc5514f36b1dda5f9ace9e024","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bladder Cancer, Vol 5 (2019)","raw_type":"article"},{"id":"pmh:oai:lup.lub.lu.se:1b82633d-9241-46f1-a248-46eca88fe1c9","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1b82633d-9241-46f1-a248-46eca88fe1c9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2352-3727","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3233/blc-180198","doi":"https://doi.org/10.3233/blc-180198","is_oa":true,"landing_page_url":"https://doi.org/10.3233/blc-180198","pdf_url":"https://content.iospress.com:443/download/bladder-cancer/blc180198?id=bladder-cancer%2Fblc180198","source":{"id":"https://openalex.org/S4210208690","display_name":"Bladder Cancer","issn_l":"2352-3727","issn":["2352-3727","2352-3735"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bladder Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912909030.pdf","grobid_xml":"https://content.openalex.org/works/W2912909030.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W229384513","https://openalex.org/W594984707","https://openalex.org/W1488187260","https://openalex.org/W1980368600","https://openalex.org/W1993058104","https://openalex.org/W2002045993","https://openalex.org/W2012206066","https://openalex.org/W2021492361","https://openalex.org/W2022598724","https://openalex.org/W2025005853","https://openalex.org/W2029780593","https://openalex.org/W2043283767","https://openalex.org/W2045846742","https://openalex.org/W2055653191","https://openalex.org/W2056606413","https://openalex.org/W2108974158","https://openalex.org/W2114002545","https://openalex.org/W2124614719","https://openalex.org/W2128388706","https://openalex.org/W2139962826","https://openalex.org/W2152206210","https://openalex.org/W2155212834","https://openalex.org/W2159759416","https://openalex.org/W2333193688","https://openalex.org/W2396217311","https://openalex.org/W2401301013","https://openalex.org/W2410979595","https://openalex.org/W2426844253","https://openalex.org/W2588621824","https://openalex.org/W2599812325","https://openalex.org/W2604963516","https://openalex.org/W2620920447","https://openalex.org/W2623181236","https://openalex.org/W2763670669","https://openalex.org/W2765431857","https://openalex.org/W3132426763","https://openalex.org/W4243650202"],"related_works":["https://openalex.org/W2116026480","https://openalex.org/W2014065879","https://openalex.org/W1516408312","https://openalex.org/W4414152850","https://openalex.org/W2917562662","https://openalex.org/W2736801117","https://openalex.org/W2922242753","https://openalex.org/W2547065851","https://openalex.org/W2908904380","https://openalex.org/W3002208273"],"abstract_inverted_index":{"Non-muscle":[0],"invasive":[1,38],"bladder":[2,39,82],"cancer":[3,83],"is":[4,64],"marked":[5],"by":[6],"frequent":[7],"recurrences":[8],"and":[9,70,90],"a":[10],"risk":[11],"for":[12,28,34,75],"progression":[13],"to":[14,55,67],"life":[15],"threatening":[16],"disease.":[17],"Intravesical":[18],"Bacillus":[19],"Calmette\u2013Gu\u00e9rin":[20],"(BCG),":[21],"one":[22],"of":[23,81,93],"the":[24,31],"earliest":[25],"effective":[26,73],"immunotherapies":[27],"cancer,":[29],"remains":[30],"current":[32],"standard":[33],"treating":[35],"high-risk":[36],"non-muscle":[37],"cancer.":[40],"Optimal":[41],"treatment":[42,62],"with":[43,52],"BCG":[44],"includes":[45],"periodic":[46],"3":[47],"weekly":[48],"maintenance":[49],"instillations,":[50],"often":[51],"dose":[53],"reduction":[54],"minimize":[56],"toxicity.":[57],"However,":[58],"despite":[59],"its":[60],"efficacy,":[61],"failure":[63],"common.":[65],"Efforts":[66],"provide":[68],"alternate":[69],"potentially":[71],"more":[72],"therapy":[74],"this":[76],"disease":[77],"include":[78],"increased":[79],"understanding":[80],"through":[84],"molecular":[85],"profiling,":[86],"multi-agent":[87],"intravesical":[88],"chemotherapy,":[89],"novel":[91],"forms":[92],"immunotherapy.":[94]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2019-02-21T00:00:00"}
