{"id":"https://openalex.org/W2912708143","doi":"https://doi.org/10.14309/00000434-201710001-00396","title":"Utility of Prolonged 96-hour Wireless pH Monitoring on Diagnosis of GERD and Assessment of Response to PPI Therapy","display_name":"Utility of Prolonged 96-hour Wireless pH Monitoring on Diagnosis of GERD and Assessment of Response to PPI Therapy","publication_year":2017,"publication_date":"2017-10-01","ids":{"openalex":"https://openalex.org/W2912708143","doi":"https://doi.org/10.14309/00000434-201710001-00396","mag":"2912708143"},"language":"en","primary_location":{"id":"doi:10.14309/00000434-201710001-00396","doi":"https://doi.org/10.14309/00000434-201710001-00396","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201710001-00396","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019662201","display_name":"Jai Eun Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jai Eun Lee","raw_affiliation_strings":["Medical College of Georgia/Augusta University, Augusta, GA","\"; Medical College of Georgia/Augusta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Georgia/Augusta University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"\"; Medical College of Georgia/Augusta University","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064911207","display_name":"Pornchai Leelasinjaroen","orcid":"https://orcid.org/0000-0003-4109-9898","observed_orcids":["https://orcid.org/0000-0003-4109-9898"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pornchai Leelasinjaroen","raw_affiliation_strings":["Medical College of Georgia, Augusta, GA","\"Medical College of Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Georgia, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"\"Medical College of Georgia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111578645","display_name":"Arie Mack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arie Mack","raw_affiliation_strings":["Medical College of Georgia/Augusta University, Augusta, GA","\"; Medical College of Georgia/Augusta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Georgia/Augusta University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"\"; Medical College of Georgia/Augusta University","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057500644","display_name":"Amol Sharma","orcid":"https://orcid.org/0000-0002-5843-1220","observed_orcids":["https://orcid.org/0000-0002-5843-1220"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amol Sharma","raw_affiliation_strings":["Medical College of Georgia/Augusta University, Augusta, GA","\"; Medical College of Georgia/Augusta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Georgia/Augusta University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"\"; Medical College of Georgia/Augusta University","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087483674","display_name":"Satish S.C. Rao","orcid":"https://orcid.org/0000-0002-4446-8452","observed_orcids":["https://orcid.org/0000-0002-4446-8452"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satish Rao","raw_affiliation_strings":["Medical College of Georgia/Augusta University, Augusta, GA","\"; Medical College of Georgia/Augusta University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Georgia/Augusta University, Augusta, GA","institution_ids":["https://openalex.org/I25041050"]},{"raw_affiliation_string":"\"; Medical College of Georgia/Augusta University","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35848714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":null,"first_page":"S212","last_page":"S213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.753000020980835},{"id":"https://openalex.org/keywords/wireless-ph-monitoring","display_name":"wireless pH monitoring","score":0.734000027179718},{"id":"https://openalex.org/keywords/ambulatory-ph-monitoring","display_name":"ambulatory pH monitoring","score":0.7360000014305115},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/esophageal-acid-exposure","display_name":"esophageal acid exposure","score":0.9850000143051147},{"id":"https://openalex.org/keywords/capsule-endoscopy","display_name":"capsule endoscopy","score":0.6520000100135803},{"id":"https://openalex.org/keywords/demeester-score","display_name":"DeMeester score","score":0.7440000176429749},{"id":"https://openalex.org/keywords/refractory-gerd","display_name":"refractory GERD","score":0.6259999871253967},{"id":"https://openalex.org/keywords/atypical-presentation","display_name":"atypical presentation","score":0.4860000014305115},{"id":"https://openalex.org/keywords/treatment-titration","display_name":"treatment titration","score":0.30399999022483826},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.6169999837875366},{"id":"https://openalex.org/keywords/patient-satisfaction","display_name":"patient satisfaction","score":0.31299999356269836},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9458473920822144},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.7824671268463135},{"id":"https://openalex.org/C2779949763","wikidata":"https://www.wikidata.org/wiki/Q4446828","display_name":"Esophageal pH monitoring","level":5,"score":0.7623221278190613},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.7078629732131958},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.6620310544967651},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.6145869493484497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5217769742012024},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.49211591482162476},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3235184848308563},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25001901388168335}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/00000434-201710001-00396","doi":"https://doi.org/10.14309/00000434-201710001-00396","is_oa":false,"landing_page_url":"https://doi.org/10.14309/00000434-201710001-00396","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2980167361","https://openalex.org/W2978378574","https://openalex.org/W2737598885","https://openalex.org/W1527576976","https://openalex.org/W2977866436","https://openalex.org/W2944562845","https://openalex.org/W2338751781","https://openalex.org/W2022073611","https://openalex.org/W1821651633","https://openalex.org/W4240950487"],"abstract_inverted_index":{"Introduction:":[0],"Ambulatory":[1],"pH":[2,50,72,93,316,346,374,394],"monitoring":[3,51,94,347],"evaluates":[4],"pathological":[5],"esophageal":[6,140,208,239,300,339,355],"acid":[7,141,153,209,240,301,340,356,416],"exposure":[8,142,210,241,302,357,417],"and":[9,53,79,123,133,149,156,181,187,245,274,306,323,326,350,360,367,379],"refluxsymptom":[10],"association":[11],"in":[12,24,204,267,295,338,415,428],"patients":[13,25,165,200,233,251,270,277,334,370,390,404],"with":[14,211,255,261,335,395,411],"GERD.":[15,387],"Oftentimes,":[16],"the":[17,22,65,121,191],"testing":[18],"results":[19],"can":[20],"guide":[21],"management":[23],"who":[26,36,88],"are":[27],"refractory":[28],"to":[29,63,83,113,120,124,178,264,408,426],"proton":[30],"pump":[31],"inhibitor":[32],"(PPI)":[33],"therapy":[34,116,129,266,410],"or":[35],"have":[37],"atypical":[38],"symptoms.":[39],"Currently,":[40],"limited":[41],"information":[42],"is":[43,348],"known":[44],"about":[45],"utility":[46,66],"of":[47,59,67,77,81,139,173,190,197,207,230,238,248,269,276,287,299,315,353,369,373,386,389,393,403],"prolonged":[48,68],"ambulatory":[49],"off":[52,359],"on":[54,130,213,242,252,271,278,330,361,376],"PPI":[55,84,115,128,256,265,362,409],"therapy.":[56,85,257,363],"The":[57,136],"aim":[58],"this":[60],"study":[61,122],"was":[62,103],"evaluate":[64],"96":[69,90,343],"hr":[70,91,344],"wireless":[71,92,101,345],"monitoring,":[73],"both":[74,358],"for":[75,144,333],"diagnosis":[76],"GERD":[78],"assessment":[80,352],"response":[82,263,407],"Methods:":[86],"Patients":[87,110],"underwent":[89],"over":[95],"2":[96,189],"years":[97],"were":[98,111,159],"assessed.":[99],"A":[100],"capsule":[102,182],"affixed":[104],"endoscopically,":[105],"6":[106],"cm":[107],"above":[108],"cardia.":[109],"instructed":[112],"stop":[114],"7":[117,246],"days":[118],"prior":[119],"resume":[125],"their":[126],"usual":[127],"day":[131,134,146,185,188,215,217,221,243,253,272,279,304,307,332,377,380],"3":[132,244,273,378],"4.":[135,280,308],"percent":[137,205,236,297,313],"time":[138,206,237,298,314,325,418],"(pH<4)":[143],"each":[145,214,331],"during":[147,318],"supine":[148,319],"upright":[150,321],"positions,":[151],"other":[152],"reflux":[154],"parameters":[155],"GI":[157],"symptoms":[158],"reviewed.":[160],"Results:":[161],"We":[162,364],"evaluated":[163],"29":[164,198],"(mean":[166],"age":[167],"46.9":[168],"yrs,":[169],"M/F=10/19)":[170],"after":[171],"exclusion":[172],"5":[174],"incomplete":[175],"studies":[176,192],"due":[177],"battery":[179],"malfunction":[180],"detachment.":[183],"On":[184],"1":[186,218,305],"(off":[193],"PPI),":[194],"19":[195,231,249],"out":[196,229,247],"(66%)":[199],"showed":[201,291,371,391,405],"abnormal":[202,336],"increase":[203,337,414],">4%":[212],"(mean=12.65%,":[216],"&":[219],"mean=11.87%,":[220],"2)":[222],"Table":[223],"1.":[224],"Of":[225],"these":[226],"patients,":[227],"12":[228],"(63%)":[232],"had":[234],"normal":[235],"(37%)":[250],"4":[254,381],"This":[258],"change":[259,427],"correlated":[260],"adequate":[262,384],"36%":[268,366],"63%":[275,368],"Using":[281],"a":[282,412],"Kruskal-Wallis":[283],"one":[284],"way":[285],"analysis":[286,290],"variance,":[288],"our":[289],"statistically":[292],"significant":[293],"difference":[294],"median":[296],"between":[303],"(Figure":[309],"1).FigureTable:":[310],"Table.":[311],"Mean":[312],"<4":[317],"position,":[320,322],"total":[324],"mean":[327],"DeMeester":[328],"Score":[329],"exposureConclusion:":[341],"Prolonged":[342],"feasible":[349],"allows":[351],"distal":[354],"found":[365],"normalization":[372,392],"profile":[375],"respectively,":[382],"indicating":[383,399],"control":[385],"21%":[388],"poor":[396],"symptom":[397,423],"correlation,":[398,424],"likely":[400],"hypersensitivity.":[401],"16%":[402],"inadequate":[406],"persistent":[413],"as":[419,421],"well":[420],"positive":[422],"leading":[425],"management.":[429]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-02-21T00:00:00"}